Open Access

Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review)

  • Authors:
    • Jing Zhang
    • Li Jing
    • Menghan Li
    • Lingfeng He
    • Zhigang Guo
  • View Affiliations

  • Published online on: April 1, 2019     https://doi.org/10.3892/mmr.2019.10111
  • Pages: 3963-3971
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Histone arginine methylation is a universal post‑translational modification that has been implicated in multiple cellular and sub‑cellular processes, including pre‑mRNA splicing, DNA damage signaling, mRNA translation, cell signaling and cell death. Despite these important roles, the understanding of its regulation with respect to certain other modifications, such as phosphorylation and acetylation, is very poor. Thus far, few histone arginine demethylases have been identified in mammalian cells, compared with nine protein arginine methyltransferases (PRMTs) that have been reported. Studies have reported that aberrant histone arginine methylation is strongly associated with carcinogenesis and metastasis. This increases the requirement for understanding the regulation of histone arginine demethylation. The present review summarizes the published studies and provides further insights into histone arginine methylases and demethylases.
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May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang J, Jing L, Li M, He L and Guo Z: Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review). Mol Med Rep 19: 3963-3971, 2019
APA
Zhang, J., Jing, L., Li, M., He, L., & Guo, Z. (2019). Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review). Molecular Medicine Reports, 19, 3963-3971. https://doi.org/10.3892/mmr.2019.10111
MLA
Zhang, J., Jing, L., Li, M., He, L., Guo, Z."Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review)". Molecular Medicine Reports 19.5 (2019): 3963-3971.
Chicago
Zhang, J., Jing, L., Li, M., He, L., Guo, Z."Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review)". Molecular Medicine Reports 19, no. 5 (2019): 3963-3971. https://doi.org/10.3892/mmr.2019.10111