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Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence

  • Authors:
    • Penghui Song
    • Jing Hu
    • Xijin Liu
    • Xuejun Deng
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Neurology, Huaihe Hospital, Henan University, Kaifeng, Henan 475000, P.R. China, Department of Neurology, Ordos Center Hospital, Ordos, The Nei Mongol Autonomous Region 017000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5433-5439
    |
    Published online on: April 30, 2019
       https://doi.org/10.3892/mmr.2019.10202
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Abstract

Previous studies have indicated that the adenosine triphosphate‑sensitive homomeric P2X7 receptor (P2X7R) plays an important role and exhibits therapeutic potential in a number of brain disorders, including temporal lobe epilepsy (TLE). The aim of the present study was to assess the expression of P2X7R, glutamate (GLU) and glial fibrillary acidic protein (GFAP) in the temporal neocortex and hippocampus of rats with lithium‑pilocarpine‑induced epilepsy as well as in patients with intractable TLE. The results demonstrated that the levels of P2X7R, GLU and GFAP were significantly upregulated in rats with spontaneous recurrent seizures, whereas they were reduced in rats that were treated with brilliant blue G (BBG), a P2X7R antagonist. To the best of our knowledge, the present study is also the first to demonstrate that P2X7R expression was elevated in patients with intractable TLE. These findings suggest that P2X7R plays a key role in the development of TLE and that BBG treatment may be a promising therapeutic strategy for TLE.
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1 

Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P and Engel J Jr: Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 46:470–472. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Guangming Z, Wenjing Z, Jiuluan L, Zhaohui S, Bingqing Z, Gaoxiang S and Huancong Z: Long-term therapeutic effects of corticoamygdalohippocampectomy for bilateral mesial temporal lobe epilepsy. Surg Neurol Int. 4:1472013. View Article : Google Scholar : PubMed/NCBI

3 

Kandratavicius L, Ruggiero RN, Hallak JE, Garcia-Cairasco N and Leite JP: Pathophysiology of mood disorders in temporal lobe epilepsy. Rev Bras Psiquiatr. 34 (Suppl 2):S233–S245. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Braakman HM, Vaessen MJ, Jansen JF, Debeij-van Hall MH, de Louw A, Hofman PA, Vles JS, Aldenkamp AP and Backes WH: Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy. Epilepsia. 54:446–454. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Harden TK, Boyer JL and Nicholas RA: P2-purinergic receptors: Subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol. 35:541–579. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Zhang F, Pracheil T, Thornton J and Liu Z: Adenosine triphosphate (ATP) is a candidate signaling molecule in the mitochondria-to-nucleus retrograde response pathway. Genes (Basel). 4:86–100. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A and Volpini R: Purinergic P2X receptors: Structural models and analysis of ligand-target interaction. Eur J Med Chem. 89:561–580. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Booth JW, Tam FW and Unwin RJ: P2 purinoceptors: Renal pathophysiology and therapeutic potential. Clin Nephrol. 78:154–163. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Baines A, Parkinson K, Sim JA, Bragg L, Thompson CR and North RA: Functional properties of five Dictyostelium discoideum P2X receptors. J Biol Chem. 288:20992–21000. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Hopfner M, Lemmer K, Jansen A, Hanski C, Riecken EO, Gavish M, Mann B, Buhr H, Glassmeier G and Scherübl H: Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells. Biochem Biophys Res Commun. 251:811–817. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Grygorowicz T, Sulejczak D and Struzynska L: Expression of purinergic P2X7 receptor in rat brain during the symptomatic phase of experimental autoimmune encephalomyelitis and after recovery of neurological deficits. Acta Neurobiol Exp (Wars). 71:65–73. 2011.PubMed/NCBI

12 

Norenberg W, Schunk J, Fischer W, Sobottka H, Riedel T, Oliveira JF, Franke H and Illes P: Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia. Br J Pharmacol. 160:1941–1952. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Eleftheriadis T, Pissas G, Karioti A, Antoniadi G, Golfinopoulos S, Liakopoulos V, Mamara A, Speletas M, Koukoulis G and Stefanidis I: Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes. Hippokratia. 17:141–145. 2013.PubMed/NCBI

14 

Skaper SD, Debetto P and Giusti P: The P2X7 purinergic receptor: From physiology to neurological disorders. FASEB J. 24:337–345. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Héja L: Astrocytic target mechanisms in epilepsy. Curr Med Chem. 21:755–763. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Kuchukhidze G, Koppelstaetter F, Unterberger I, Dobesberger J, Walser G, Höfler J, Zamarian L, Haberlandt E, Rostasy K, Ortler M, et al: Midbrain-hindbrain malformations in patients with malformations of cortical development and epilepsy: A series of 220 patients. Epilepsy Res. 106:181–190. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lorigados-Pedre L, Morales-Chacon L, Pavón-Fuentes N, Serrano-Sánchez T, Robinson-Agramonte MA, García-Navarro ME and Bender-del Busto JE: Immunological disorders in epileptic patients are associated to the epileptogenic focus localization. Rev Neurol. 39:101–104. 2004.(In Spanish). PubMed/NCBI

19 

Peng WF, Ding J, Mao LY, Li X, Liang L, Chen CZ, Cheng WZ, Fan W and Wang X: Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy. Epilepsy Behav. 29:144–149. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Menon R, Radhakrishnan A and Radhakrishnan K: Status epilepticus. J Assoc Physicians India 61 (8 Suppl). S58–S63. 2013.

21 

Grabenstatter HL, Del AY, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ and Brooks-Kayal AR: The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 62:73–85. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Sakamoto K, Inukai M, Mori A and Nakahara T: Brilliant Blue G protects against photoreceptor injury in a murine endotoxin-induced uveitis model. Exp Eye Res. 177:45–49. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Bartlett R, Sluyter V, Watson D, Sluyter R and Yerbury JJ: P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice. PeerJ. 5:e30642017. View Article : Google Scholar : PubMed/NCBI

24 

Hussmann KL, Samuel MA, Kim KS, Diamond MS and Fredericksen BL: Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 87:2814–2822. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Benediktsson AM, Marrs GS, Tu JC, Worley PF, Rothstein JD, Bergles DE and Dailey ME: Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia. 60:175–188. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Kozela E, Juknat A and Vogel Z: Modulation of astrocyte activity by cannabidiol, a nonpsychoactive cannabinoid. Int J Mol Sci. 18(pii): E16692017. View Article : Google Scholar : PubMed/NCBI

27 

Shen HY, Sun H, Hanthorn MM, Zhi Z, Lan JQ, Poulsen DJ, Wang RK and Boison D: Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice. J Neurosurg. 120:628–638. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Peixoto-Santos JE, Velasco TR, Galvis-Alonso OY, Araujo D, Kandratavicius L, Assirati JA, Carlotti CG, Scandiuzzi RC, Santos AC and Leite JP: Temporal lobe epilepsy patients with severe hippocampal neuron loss but normal hippocampal volume: Extracellular matrix molecules are important for the maintenance of hippocampal volume. Epilepsia. 56:1562–1570. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Proper EA, Oestreicher AB, Jansen GH, Veelen CW, van Rijen PC, Gispen WH and de Graan PN: Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain 123 (Pt 1). 19–30. 2000.

30 

Swamy AH, Patel NL, Gadad PC, Koti BC, Patel UM, Thippeswamy AH and Manjula DV: Neuroprotective activity of pongamia pinnata in monosodium glutamate-induced neurotoxicity in rats. Indian J Pharm Sci. 75:657–663. 2013.PubMed/NCBI

31 

Zhu S and Paoletti P: Allosteric modulators of NMDA receptors: Multiple sites and mechanisms. Curr Opin Pharmacol. 20:14–23. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Jiang S, Wang YQ, Xu CF, Li YN, Guo R and Li L: Involvement of connexin43 in the infrasonic noise-induced glutamate release by cultured astrocytes. Neurochem Res. 39:833–842. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Morales I and Rodriguez M: Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity. Glia. 60:1481–1494. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Sheean RK, Lau CL, Shin YS, O'Shea RD and Beart PM: Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: Evidence following inhibition with rottlerin. Neuroscience. 254:335–346. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Lee ES, Sidoryk M, Jiang H, Yin Z and Aschner M: Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem. 110:530–544. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song P, Hu J, Liu X and Deng X: Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Mol Med Rep 19: 5433-5439, 2019.
APA
Song, P., Hu, J., Liu, X., & Deng, X. (2019). Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Molecular Medicine Reports, 19, 5433-5439. https://doi.org/10.3892/mmr.2019.10202
MLA
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19.6 (2019): 5433-5439.
Chicago
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19, no. 6 (2019): 5433-5439. https://doi.org/10.3892/mmr.2019.10202
Copy and paste a formatted citation
x
Spandidos Publications style
Song P, Hu J, Liu X and Deng X: Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Mol Med Rep 19: 5433-5439, 2019.
APA
Song, P., Hu, J., Liu, X., & Deng, X. (2019). Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Molecular Medicine Reports, 19, 5433-5439. https://doi.org/10.3892/mmr.2019.10202
MLA
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19.6 (2019): 5433-5439.
Chicago
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19, no. 6 (2019): 5433-5439. https://doi.org/10.3892/mmr.2019.10202
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