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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June-2019 Volume 19 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review)

Xiang Shi, Jingjing Wang, Yu Lei, Caofan Cong, Dailin Tan, Xianrong Zhou
Pages: 4529-4535
Published online on: 03 April 2019

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Article Open Access

The 15d‑PGJ2 hydrogel ameliorates atopic dermatitis through suppression of the immune response

Marcelo H. Napimoga, Juliana T. Clemente‑Napimoga, Nina M. Machabanski, Maria Eduarda A. Juliani, Pedro Henrique B. C. Acras, Cristina G. Macedo, Henrique B. Abdalla, Antônio José de Pinho , Andresa B. Soares, Marcelo Sperandio, Daniele R. de Araújo
Pages: 4536-4544
Published online on: 11 April 2019

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Article Open Access

Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma

Qun Li, Liang Ma, Zhenhua Wu, Guoli Wang, Qi Huang, Zhisen Shen, Rui Yu
Pages: 4545-4552
Published online on: 04 April 2019

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Article Open Access

Alamandine attenuates long‑term hypertension‑induced cardiac fibrosis independent of blood pressure

Lan Wang, Chi Liu, Xiru Chen, Peng Li
Pages: 4553-4560
Published online on: 15 April 2019

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Article Open Access

MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ

Yang Shu, Junpeng Long, Weixiong Guo, Wei Ye
Pages: 4561-4568
Published online on: 03 April 2019

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Article Open Access

Effects of granulocyte colony‑stimulating factor on rabbit carotid and porcine heart models of chronic obliterative arterial disease

Zhaohui Hu, Zhisong Chen, Yiping Wang, Jinfa Jiang, Gary Tse, Wenjun Xu, Junbo Ge, Bing Sun
Pages: 4569-4578
Published online on: 03 April 2019

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Article Open Access

YB1 protects cardiac myocytes against H2O2‑induced injury via suppression of PIAS3 mRNA and phosphorylation of STAT3

Shiqi Wang, Fuwei He, Zhenwei Li, Yewen Hu, Ning Huangfu, Xiaomin Chen
Pages: 4579-4588
Published online on: 03 April 2019

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Article Open Access

Quercetin suppresses glomerulosclerosis and TGF‑β signaling in a rat model

Yifan Liu, Enlai Dai, Jing Yang
Pages: 4589-4596
Published online on: 03 April 2019

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Article Open Access

Decreased expression of ubiquilin‑1 following neonatal hypoxia‑ischemic brain injury in mice

Li Luo, Yilin Liu, Xing Tu, Xuxin Ren, Wenyan Zhao, Jing Liu, Li Zhang, Weiqiang Chen, Pei Zhang, Weicai Wang, Lanhai Lü, Mengxia Wang
Pages: 4597-4602
Published online on: 15 April 2019

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Article Open Access

Hypercholesterolaemia increases the risk of high‑turnover osteoporosis in men

Yanman Zhou, Tuo Deng, Haiqing Zhang, Qingbo Guan, Hongqiang Zhao, Chunxiao Yu, Shanshan Shao, Meng Zhao, Jin Xu
Pages: 4603-4612
Published online on: 04 April 2019

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Article Open Access

Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer

Jian‑Feng Zhang, Wei Jiang, Qian‑Feng Zhang, Xiao‑Ling Kuai, Zhen‑Biao Mao, Zhi‑Wei Wang
Pages: 4613-4622
Published online on: 04 April 2019

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Article Open Access

Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture

Zhenglu Wang, Bowen Bi, Hongli Song, Lei Liu, Hong Zheng, Shusen Wang, Zhongyang Shen
Pages: 4623-4630
Published online on: 12 April 2019

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Article Open Access

Prediction of IER5 structure and function using a bioinformatics approach

Qiang Xiong, Xiaoyan Jiang, Xiaodan Liu, Pingkun Zhou, Kuke Ding
Pages: 4631-4636
Published online on: 15 April 2019

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Article Open Access

Arbutin promotes MC3T3‑E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/β‑catenin signaling pathway

Xiangji Man, Liyu Yang, Shengye Liu, Lei Yang, Mingyang Li, Qin Fu
Pages: 4637-4644
Published online on: 04 April 2019

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Article Open Access

Low‑intensity pulsed ultrasound promotes apoptosis and inhibits angiogenesis via p38 signaling‑mediated endoplasmic reticulum stress in human endothelial cells

Zhongping Su, Tianhua Xu, Yaqing Wang, Xiasheng Guo, Juan Tu, Dong Zhang, Xiangqing Kong, Yanhui Sheng, Wei Sun
Pages: 4645-4654
Published online on: 05 April 2019

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Article Open Access

MicroRNA‑144‑3p may participate in the pathogenesis of preeclampsia by targeting Cox‑2

Suwei Hu, Jie Li, Ming Tong, Qian Li, Yong Chen, Hongmei Lu, Yixiong Wang, Lingfeng Min
Pages: 4655-4662
Published online on: 11 April 2019

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Article Open Access

lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis

Chuan Cui, Xing Wang, Xiao‑Ming Shang, Li Li, Yi Ma, Guo‑Yu Zhao, Yu‑Xin Song, Xue‑Bin Geng, Bi‑Qiong Zhao, Mei‑Rong Tian, Hong‑Ling Wang
Pages: 4663-4672
Published online on: 05 April 2019

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Article Open Access

Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells

Yayun Liu, Lu Liao, Yong Chen, Fengmei Han
Pages: 4673-4684
Published online on: 05 April 2019

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Article Open Access

Comprehensive analysis of differentially expressed profiles and reconstruction of a competing endogenous RNA network in papillary renal cell carcinoma

Qing Luo, Meng Cui, Qinfu Deng, Jinbo Liu
Pages: 4685-4696
Published online on: 05 April 2019

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Article Open Access

Comprehensive analysis of the aberrantly expressed lncRNA‑associated ceRNA network in breast cancer

Tayier Tuersong, Linlin Li, Zumureti Abulaiti, Shumei Feng
Pages: 4697-4710
Published online on: 15 April 2019

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Case Report Open Access

Novel variants in the KERA gene cause autosomal recessive cornea plana in a Chinese family: A case report

Chengzi Huang, Xigui Long, Can Peng, Pengsiyuan Lin, Hu Tan, Weigang Lv, Lingqian Wu
Pages: 4711-4718
Published online on: 11 April 2019

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Article Open Access

Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells

Tao Wang, Ruiqiao Yan, Xiaoyuan Xu, Huan Yu, Jianfang Wu, Yaofang Yang, Weidong Li
Pages: 4719-4726
Published online on: 08 April 2019

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Article Open Access

Effect of integrin β1 in the treatment of stress urinary incontinence by electrical stimulation

Yang Li, Bing‑Shu Li, Cheng Liu, Sha‑Sha Hong, Jie Min, Ming Hu, Jian‑Ming Tang, Su‑Ting Li, Ting‑Ting Wang, Hui‑Xin Zhou, Li Hong
Pages: 4727-4734
Published online on: 10 April 2019

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Article Open Access

Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice

Wanlin Xu, Limin Liu, Hao Lu, Jinye Fu, Chenping Zhang, Wenjun Yang, Shukun Shen
Pages: 4735-4742
Published online on: 11 April 2019

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Article Open Access

Interleukin‑17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages

Lu Song, Jingyi Tan, Zhongxiu Wang, Peihui Ding, Qi Tang, Mengjiao Xia, Yingming Wei, Lili Chen
Pages: 4743-4752
Published online on: 11 April 2019

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Article Open Access

Astaxanthin inhibits homocysteine‑induced endothelial cell dysfunction via the regulation of the reactive oxygen species‑dependent VEGF‑VEGFR2‑FAK signaling pathway

Xian‑Jun Wang, Da‑Chen Tian, Feng‑Wen Wang, Meng‑Hao Zhang, Cun‑Dong Fan, Wang Chen, Mei‑Hong Wang, Xiao‑Yan Fu, Jin‑Kui Ma
Pages: 4753-4760
Published online on: 12 April 2019

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Article Open Access

Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer

Naiqi Huang, Zuli Wu, Hong Hong, Xiangming Wang, Fengqiang Yang, Hengguo Li
Pages: 4761-4769
Published online on: 05 April 2019

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Article Open Access

A novel resveratrol analog PA19 attenuates obesity‑induced cardiac and renal injury by inhibiting inflammation and inflammatory cell infiltration

Wenxin Zhang, Hongjin Chen, Chuchu Sun, Beibei Wu, Bin Bai, Hui Liu, Xiaoou Shan, Guang Liang, Yali Zhang
Pages: 4770-4778
Published online on: 12 April 2019

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Article Open Access

miRNA‑15a‑5p facilitates the bone marrow stem cell apoptosis of femoral head necrosis through the Wnt/β‑catenin/PPARγ signaling pathway

Wan‑Li Zhang, Cheng‑Tao Chi, Xiang‑Hui Meng, Shao‑Dong Liang
Pages: 4779-4787
Published online on: 04 April 2019

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Article Open Access

Novel agent #2714 potently inhibits lung cancer growth by suppressing cell proliferation and by inducing apoptosis in vitro and in vivo

Wenjie Lu, Qianqian Sun, Bo Chen, Yan Li, Youzhi Xu, Siying Wang
Pages: 4788-4796
Published online on: 02 April 2019

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Article Open Access

Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction

Qianwen Zhao, Jie Yang, Baolin Liu, Fang Huang, Yuehua Li
Pages: 4797-4805
Published online on: 04 April 2019

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Article Open Access

Signature microRNAs and long noncoding RNAs in laryngeal cancer recurrence identified using a competing endogenous RNA network

Zhengyi Tang, Ganguan Wei, Longcheng Zhang, Zhiwen Xu
Pages: 4806-4818
Published online on: 10 April 2019

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Article Open Access

miR‑27b‑3p and miR‑607 cooperatively regulate BLM gene expression by directly targeting the 3'‑UTR in PC3 cells

Yinglian Chen, Jiafu Zhao, Zhiqiang Duan, Ting Gong, Wei Chen, Sainan Wang, Houqiang Xu
Pages: 4819-4831
Published online on: 05 April 2019

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Article Open Access

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A resting‑state functional magnetic resonance imaging study

Yi Shao, Qing‑Hai Li, Biao Li, Qi Lin, Ting Su, Wen‑Qing Shi, Pei‑Wen  Zhu, Qing Yuan, Yong‑Qiang Shu, Ying He, Wen‑Feng Liu, Lei Ye
Pages: 4832-4840
Published online on: 10 April 2019

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Article Open Access

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway Retraction in /10.3892/mmr.2025.13549

Min Chen, Jin‑Min Wang, Dong Wang, Rong Wu, Hong‑Wei Hou
Pages: 4841-4851
Published online on: 03 April 2019

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Article Open Access

Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons

Shan Yang, Peng Wu, Jianwen Xiao, Li Jiang
Pages: 4852-4862
Published online on: 10 April 2019

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Article Open Access

Caffeic acid phenethyl ester attenuates nuclear factor‑κB‑mediated inflammatory responses in Müller cells and protects against retinal ganglion cell death

Yanwen Jia, Shengqun Jiang, Chen Chen, Guohua Lu, Yang Xie, Xincheng Sun, Liqin Huang
Pages: 4863-4871
Published online on: 11 April 2019

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Article Open Access

Paroxysmal spasticity of lower extremities as the initial symptom in two siblings with maple syrup urine disease

Yi‑Dan Liu, Xu Chu, Rui‑Hua Liu, Ying Sun, Qing‑Xia Kong, Qiu‑Bo Li
Pages: 4872-4880
Published online on: 05 April 2019

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Article Open Access

High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC

Li Sun, Jing Sun, Jun‑Ding Song
Pages: 4881-4889
Published online on: 10 April 2019

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Article Open Access

Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway

Bing Bao, Man‑Qing Zhang, Zhi‑Ying Chen, Xiang‑Bing Wu, Zhong‑Bing Xia, Jing‑Yan Chai, Xiao‑Ping Yin
Pages: 4890-4896
Published online on: 10 April 2019

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Article Open Access

Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β

Yichen Yin, Caihui Cha, Fengming Wu, Jiong Li, Sumei Li, Xiaonan Zhu, Jifeng Zhang, Guoqing Guo
Pages: 4897-4905
Published online on: 12 April 2019

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Article Open Access

Comprehensive genomic and prognostic analysis of the IL‑17 family genes in lung cancer

Tingting Liao, Jinshuo Fan, Zhilei Lv, Juanjuan Xu, Feng Wu, Guanghai Yang, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Sufei Wang, Yang Jin
Pages: 4906-4918
Published online on: 15 April 2019

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Article

Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration

Qun Zhou, Xuelu Jiang, Wei Yan, Xiaoqing Dou
Pages: 4919-4926
Published online on: 03 April 2019

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Article

Role of lncRNA uc.457 in the differentiation and maturation of cardiomyocytes

Qijun Zhang, Zijie Cheng, Zhangbin Yu, Chun Zhu, Lingmei Qian
Pages: 4927-4934
Published online on: 04 April 2019

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Article

MicroRNA‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells

Yue Li, Long Zhao, Yafei Qi, Xianghong Yang
Pages: 4935-4945
Published online on: 16 April 2019

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Article

miR‑210‑3p regulates cell growth and affects cisplatin sensitivity in human ovarian cancer cells via targeting E2F3

Yue Jin, Jun Wei, Shaoting Xu, Fang Guan, Lijun Yin, Haibin Zhu
Pages: 4946-4954
Published online on: 04 April 2019

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Article

Exogenous oestradiol benzoate induces male mice azoospermia through modulation of oxidative stress and testicular metabolic cooperation

Jianghua Le, Xiaocan Lei, Yanping Ren, Zhipeng Li, Haoyan Tu, Fangya Ding, Xiaodong Yi, Yi Zhou, Qingyou Liu, Shun Zhang
Pages: 4955-4963
Published online on: 16 April 2019

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Article

Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway

Linlin Lu, Shousheng Liu, Quanjiang Dong, Yongning Xin
Pages: 4964-4972
Published online on: 02 April 2019

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Article

SIRT4 suppresses the PI3K/Akt/NF‑κB signaling pathway and attenuates HUVEC injury induced by oxLDL

Yu Tao, Songping Yu, Min Chao, Yang Wang, Jianhua Xiong, Hengli Lai
Pages: 4973-4979
Published online on: 12 April 2019

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Article

Expression and potential regulation of miRNA‑431 during lung development of Sprague‑Dawley rats

Zhong‑Yi Sun, Yan‑Qing Shen, Xiao‑Qing Chen, Xiao‑Yu Zhou, Rui Cheng, Zhi‑Dan Bao, Yang Yang
Pages: 4980-4988
Published online on: 11 April 2019

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Article

Neuroprotective effects of lithium on a chronic MPTP mouse model of Parkinson's disease via regulation of α‑synuclein methylation

Qing Zhao, Hui Liu, Jiwei Cheng, Yudan Zhu, Qian Xiao, Yu Bai, Jie Tao
Pages: 4989-4997
Published online on: 11 April 2019

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Article

Long noncoding RNA PURPL promotes cell proliferation in liver cancer by regulating p53

Xueyan Fu, Yawei Wang, Gang Wu, Wanchuan Zhang, Shaolin Xu, Wenqing Wang
Pages: 4998-5006
Published online on: 12 April 2019

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Article

(3R)‑5,6,7‑trihydroxy‑3‑isopropyl‑3‑methylisochroman‑1‑one attenuates cardiac dysfunction via the apelin/APJ signaling pathway

Mei Ding, Lianyue Guan, Chunmei Zhang, Ping Yang, Hailing Yang
Pages: 5007-5014
Published online on: 03 April 2019

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Article

Acute exposure to 3‑deoxyglucosone at high glucose levels impairs insulin secretion from β‑cells by downregulating the sweet taste receptor signaling pathway

Xiudao Song, Guoqiang Liang, Min Shi, Liang Zhou, Fei Wang, Lurong Zhang, Fei Huang, Guorong Jiang
Pages: 5015-5022
Published online on: 15 April 2019

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Article

Downregulation of DCC sensitizes multiple myeloma cells to bortezomib treatment

Dorival Mendes Rodrigues‑Junior, Thaís Priscila Biassi, Gabriela Estrela de Albuquerque, Viviane Carlin, Marcus Vinicius Buri, Joel Machado‑Junior, Andre Luiz Vettore
Pages: 5023-5029
Published online on: 09 April 2019

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Article

Novel CLCN7 mutations cause autosomal dominant osteopetrosis type II and intermediate autosomal recessive osteopetrosis

Li Li, Shan-Shan Lv, Chun Wang, Hua Yue, Zhen-Lin Zhang
Pages: 5030-5038
Published online on: 03 April 2019

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Article

Combination of ions promotes cell migration via extracellular signal‑regulated kinase 1/2 signaling pathway in human gingival fibroblasts

Kimiko Yamaguchi‑Ueda, Yuki Akazawa, Keita Kawarabayashi, Asuna Sugimoto, Hiroshi Nakagawa, Aya Miyazaki, Rika Kurogoushi, Kokoro Iwata, Takamasa Kitamura, Aya Yamada, Tomokazu Hasegawa, Satoshi Fukumoto, Tsutomu Iwamoto
Pages: 5039-5045
Published online on: 08 April 2019

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Review Open Access

Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review)

Xueling Cui, Shumi Shang, Xinran Lv, Jing Zhao, Yan Qi, Zhonghui Liu
Pages: 5053-5062
Published online on: 30 April 2019

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Article Open Access

Clinical significance of miRNA‑1 and its potential target gene network in lung squamous cell carcinoma

Xiaojiao Li, Meijiao Qin, Jiacheng Huang, Jie Ma, Xiaohua Hu
Pages: 5063-5078
Published online on: 19 April 2019

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Article Open Access

SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein

Jiangwei Chen, Xuanyin Chen, Xiaodong Chen, Haiying Sun, Dong Yang
Pages: 5079-5086
Published online on: 22 April 2019

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Article Open Access

Inhibitory effect of 17β‑estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2

Quan Liu, Rui Li, Guanjun Chen, Jianming Wang, Bingfeng Hu, Chaofei Li, Xiaohuan Zhu, Yunxia Lu
Pages: 5087-5096
Published online on: 24 April 2019

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CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long‑Qiao Cao, Ya‑Nan Wang, Ming Liang, Mei‑Zhou Pan
Pages: 5097-5104
Published online on: 30 April 2019

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Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway

Junwei Shen, Yunchen Sun, Si Shen, Xu Luo, Jie Chen, Liang Zhu
Pages: 5105-5114
Published online on: 19 April 2019

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3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells

Jin He, Tao Huang, Lin Zhao
Pages: 5115-5122
Published online on: 22 April 2019

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Human platelet lysate as an alternative to fetal bovine serum for culture and endothelial differentiation of human amniotic fluid mesenchymal stem cells

Waleephan Tancharoen, Sirinda Aungsuchawan, Peraphan Pothacharoen, Kanokkan Bumroongkit, Chaniporn Puaninta, Nathaporn Pangjaidee, Suteera Narakornsak, Runchana Markmee, Tanongsak Laowanitwattana, Chawapon Thaojamnong
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miR‑148 family members are putative biomarkers for sepsis

Lei Dong, Hongwei Li, Shunli Zhang, Guanzheng Yang
Pages: 5133-5141
Published online on: 19 April 2019

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Carbon monoxide releasing molecule‑2 (CORM‑2)‑liberated CO ameliorates acute pancreatitis

Yishu Liu, Xu Wang, Xiaohan Xu, Weiting Qin, Bingwei Sun
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Article

MicroRNA‑195 triggers neuroinflammation in Parkinson's disease in a Rho‑associated kinase 1‑dependent manner

Yi Ren, Huajie Li, Wei Xie, Ning Wei, Meng Liu
Pages: 5153-5161
Published online on: 19 April 2019

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Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin‑resistant breast cancer cells

Chunjie Wen, Lijuan Fu, Jiafeng Huang, Yi Dai, Bin Wang, Ge Xu, Lanxiang Wu, Honghao Zhou
Pages: 5162-5168
Published online on: 22 April 2019

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Article

Effect of endoplasmic reticulum stress involved in manganese‑induced neurotoxicity in rats

Cailian Wu, Guandou Yuan, Ruikang Mo, Yanning Huang, Tiantian Luo, Jin Wang
Pages: 5169-5176
Published online on: 19 April 2019

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Article

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions

Zhiyang Zhu, Jianhua Yu, Weiguo Lin, Haijun Tang, Weiguang Zhang, Baochun Lu
Pages: 5177-5184
Published online on: 22 April 2019

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Article

Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits

Fang Wang, Ying Yang, Xuhui Ji, Xiong Tao, Yuhang Wang, Changmiao Wang
Pages: 5185-5194
Published online on: 24 April 2019

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Article Open Access

MicroRNA‑93 regulates angiogenesis in peripheral arterial disease by targeting CDKN1A

Xiaojun Shu, Youjun Mao, Zhengfei Li, Wenhui Wang, Yaowen Chang, Shengye Liu, Xiao‑Qiang Li
Pages: 5195-5202
Published online on: 25 April 2019

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Article Open Access

MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression Retraction in /10.3892/mmr.2026.13831

Yingying Shi, Luping Wang, Pijun Yu, Yi Liu, Wei Chen
Pages: 5203-5210
Published online on: 24 April 2019

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Article

Role of autophagy in LPS‑induced inflammation in INS‑1 cells

Li‑Bo Zhu, Ming‑Ming Cao, Jun Wang, Ying Su, Wei Jiang, Guo‑Dong Liu, Yan‑Bo Li
Pages: 5211-5218
Published online on: 19 April 2019

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Article

Role of feline sarcoma‑related protein in the viability and apoptosis of bladder cancer cells

Xudong Hu, Zhiwen Guo, Jifei Xu, Xiangbao Mei, Manhua Bi, Fang Jiang, Dexin Yu, Caiyun Zhong
Pages: 5219-5226
Published online on: 30 April 2019

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Article Open Access

miR‑125b‑mediated regulation of cell proliferation through the Jagged‑1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis

Min Pan, Yao Huang, Xiaofang Zhu, Xiangfei Lin, Dan Luo
Pages: 5227-5236
Published online on: 24 April 2019

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Article Open Access

A five lncRNA signature for prognosis prediction in hepatocellular carcinoma

Yongqiang Sun, Fangfang Zhang, Lifu Wang, Xueai Song, Jing Jing, Fan Zhang, Simiao Yu, Honghong Liu
Pages: 5237-5250
Published online on: 30 April 2019

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Trichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2

Xiaoqing Jian, Le Qu, Yunlin Wang, Qianlei Zou, Qing Zhao, Shuang Chen, Xinghua Gao, Hongduo Chen, Chundi He
Pages: 5251-5262
Published online on: 24 April 2019

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Screening of underlying genetic biomarkers for ankylosing spondylitis

Xutao Fan, Bao Qi, Longfei Ma, Fengyu Ma
Pages: 5263-5274
Published online on: 24 April 2019

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Article Open Access

LINC01638 silencing inhibits cancer cell proliferation in colorectal adenocarcinoma through interaction with RUNX2Retraction in /10.3892/mmr.2021.11875

Wenying Zhuo, Dengdi Hu, Xihua Chen, Tian Zhang
Pages: 5275-5280
Published online on: 25 April 2019

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Article Open Access

Identification of time‑series differentially expressed genes and pathways associated with heart failure post‑myocardial infarction using integrated bioinformatics analysis

Xuefei Li, Bin Li, Hong Jiang
Pages: 5281-5290
Published online on: 24 April 2019

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Article Open Access

Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways

Jianliang Pang, Peiyang Hu, Junwei Wang, Jinsong Jiang, Jifu Lai
Pages: 5291-5300
Published online on: 30 April 2019

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Article

Downregulation of miR‑186 promotes the proliferation and drug resistance of glioblastoma cells by targeting Twist1

Yifeng Xiong, Rensheng Chen, Lizhen Wang, Shanshan Wang, Yi Tu, Lei Zhu, Chunliang Wang
Pages: 5301-5308
Published online on: 30 April 2019

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Bioinformatics identification of lncRNA biomarkers associated with the progression of esophageal squamous cell carcinoma

Jun Yu, Xiaoliu Wu, Kaidan Huang, Ming Zhu, Xiaomei Zhang, Yuanying Zhang, Senqing Chen, Xinyu Xu, Qin Zhang
Pages: 5309-5320
Published online on: 02 May 2019

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Article Open Access

High hydrostatic pressure induces apoptosis of retinal ganglion cells via regulation of the NGF signalling pathway

Hongji Liu, Wei Wang, Xiang Li, Chao Huang, Zongduan Zhang, Mingyue Yuan, Xiangyu Li
Pages: 5321-5334
Published online on: 30 April 2019

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Article Open Access

Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis

Da‑Wei Liu, Ya‑Nan Zhang, Hai‑Juan Hu, Pu‑Qiang Zhang, Wei Cui
Pages: 5335-5344
Published online on: 25 April 2019

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miR‑216a exacerbates TGF‑β‑induced myofibroblast transdifferentiation via PTEN/AKT signaling

Chuan Qu, Xin Liu, Tianxin Ye, Linglin Wang, Steven Liu, Xingyu Zhou, Gang Wu, Jian Lin, Shaobo Shi, Bo Yang
Pages: 5345-5352
Published online on: 30 April 2019

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Article

A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice

Naoki Ishii, Takujiro Homma, Ren Watanabe, Naoko Kimura, Motoko Ohnishi, Takayasu Kobayashi, Junichi Fujii
Pages: 5353-5360
Published online on: 25 April 2019

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Article

Genetic variant in the promoter region of microRNA‑137 reduces the warfarin maintenance dose in patients with atrial fibrillation

Zhen Tian, Yushuang Yang, Zhaohui Feng, Donghui Wu, Wei Yang, Dongna Liu
Pages: 5361-5367
Published online on: 30 April 2019

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Article Open Access

Potential use of Pichia pastoris strain SMD1168H expressing DNA topoisomerase I in the screening of potential anti‑breast cancer agents

Jian Xin, Wan Nor Azlin Wan Mahtar, Poh Chiew Siah, Noorizan Miswan, Boon Yin Khoo
Pages: 5368-5376
Published online on: 30 April 2019

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Article Open Access

Salmonella infection leads to severe intestinal inflammation and increased CD4+FoxP3+ Treg cells in streptozotocin‑induced hyperglycemic mice

Shanlong Zhang, Meixiang Wang, Xuemei Wang, Helou Li, Hua Tang, Xiaojun Li
Pages: 5377-5385
Published online on: 25 April 2019

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Article

Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease‑activated receptor 2 in a murine model

Wubulikasimu Wulamu, Maimaiti Yisireyili, Aikebaier Aili, Kyosuke Takeshita, Aziguli Alimujiang, Aliyeguli Aipire, Yiliang Li, Yuan Jiang, Maimaitiaili Aizezi, Zanlin Li, Kelimu Abudureyimu
Pages: 5386-5396
Published online on: 25 April 2019

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Article Open Access

Long non‑coding RNA NORAD promotes cell proliferation and glycolysis in non‑small cell lung cancer by acting as a sponge for miR‑136‑5p

Wei Gao, Ting Weng, Lifang Wang, Bin Shi, Wenshu Meng, Xiaoyu Wang, Ying Wu, Liang Jin, Lijuan Fei
Pages: 5397-5405
Published online on: 30 April 2019

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Article Open Access

Identification of a long noncoding RNA signature to predict outcomes of glioblastoma

Depei Li, Jie Lu, Hong Li, Songtao Qi, Lei Yu
Pages: 5406-5416
Published online on: 24 April 2019

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Article Open Access

Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities

Zhimin Wang, Fang Li, Yuan Quan, Junye Shen
Pages: 5417-5423
Published online on: 25 April 2019

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Article Open Access

Ghrelin regulates sepsis‑induced rat acute gastric injury

Bin Li, Qingling Lin, Hong Guo, Liping Liu, Yumin Li
Pages: 5424-5432
Published online on: 30 April 2019

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Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence

Penghui Song, Jing Hu, Xijin Liu, Xuejun Deng
Pages: 5433-5439
Published online on: 30 April 2019

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Article Open Access

Berberine improves advanced glycation end products‑induced osteogenic differentiation responses in human periodontal ligament stem cells through the canonical Wnt/β‑catenin pathway

Li‑Na Zhang, Xu‑Xia Wang, Zhi Wang, Ke‑Yi Li, Bao‑Hua Xu, Jun Zhang
Pages: 5440-5452
Published online on: 25 April 2019

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Article

CD47 deficiency protects cardiomyocytes against hypoxia/reoxygenation injury by rescuing autophagic clearance

Yong Li, Kun Zhao, Pengyu Zong, Heling Fu, Yuan Zheng, Dan Bao, Yuan Yin, Qin Chen, Lu Lu, Youjin Dai, Daorong Hou, Xiangqing Kong
Pages: 5453-5463
Published online on: 25 April 2019

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Article

Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese patients

Noriaki Nagai, Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
Pages: 5464-5472
Published online on: 02 May 2019

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Journal Cover
July-2026 Volume 34 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Editorial Open Access

Regulatory mechanisms and therapeutic potential of N6-methyladenosine modification in retinal diseases (Review)

Wenyao Zhang, Jinying Chen, Jingxiang Zhong
Article Number: 213
Published online on: 29 May 2026

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Review Open Access

Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non‑coding RNAs in cutaneous fibrosis (Review)

Jinshun Li, Weiyun Liu, Jin Yang, Yanan Li
Article Number: 212
Published online on: 29 May 2026

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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review)

Xiaoyan Xue, Yongchang Lai, Shasha Song, Liping Wu, Lifang Wang
Article Number: 211
Published online on: 29 May 2026

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Retraction Open Access

[Retracted] Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells

Yuan Zeng, Ying Yang
Article Number: 210
Published online on: 27 May 2026

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FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression

Linyu Jin, Jing Zhang, Wenjing Wang, Nan Zhang, Yang Liu, Alin Tian, Weiwei Yin, Yongle Qiu
Article Number: 209
Published online on: 25 May 2026

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Review Open Access

Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)

Songhua Nan, Chaojie Peng, Xue Meng, Jingnan Jia, Fangfang Zhao, Yinglin Cui
Article Number: 208
Published online on: 22 May 2026

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Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review)

Hailing Zhang, Yongji Li, Yuan Liu, Danyi Feng, Letao Zhao, Ran Chen, Xiwu Zhang, Jinjin Dou
Article Number: 207
Published online on: 22 May 2026

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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review)

Yadi Ju, Xiaodan Chong, Weichen Ning, Yan Shi, Yangyang Li, Yihai Shi
Article Number: 206
Published online on: 22 May 2026

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Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review)

Chengzhi Cong, Yuan Wang, Jian Liu, Chao Jin
Article Number: 205
Published online on: 21 May 2026

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Review Open Access

Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

Fatima Zohra Attouahri, Imane Chaoui, Abdelilah Laraqui, Mohamed Rida Tagajdid, Mohammed Oukabli, Mohammed El Marjany, Meriem Khyatti, Mohammed Attaleb, Mouna Ababou, Khalid Ennibi, Khaoula Errafii, Mohammed El Mzibri
Article Number: 204
Published online on: 21 May 2026

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Epigenetic research methods and animal models for intervertebral disc degeneration (Review)

Xinliang Cui, Li Zeng, Wei Zhang, Leimin Xi, Rui Wang, Diff Jia, Safa, Haoyu Feng, Huidong Jia
Article Number: 203
Published online on: 21 May 2026

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Article Open Access

ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression

Jingyi Wang, Bin Yang, Shengzu Peng, Bin Yang
Article Number: 202
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] MicroRNA‑1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post‑​transcriptional suppression of Ihh expression  

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Article Number: 201
Published online on: 20 May 2026

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Review Open Access

Estrogen deficiency as a common driver and integrative mechanism in osteoporosis‑osteoarthritis comorbidity (Review)

Jian Cheng, Xiaodong Wu, Lu Zhao, Shuai Jiang, Wenjie Zhao, Weishuai Zhang
Article Number: 200
Published online on: 20 May 2026

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Review Open Access

Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review)

Qin Jiang, Yi Gong, Mimi Zhai, Tenglong Tang, Sushun Liu
Article Number: 199
Published online on: 20 May 2026

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Review Open Access

m6A modification in skeletal system diseases (Review)

Xi Xie, Chen Li, Haotian Zheng, Guang Gan, Xi Gao
Article Number: 198
Published online on: 19 May 2026

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Review Open Access

Dynamic regulation of the ‘mitochondria‑immune axis’ in myocardial infarction: Molecular mechanisms driving macrophage polarization through energy metabolism disorders (Review)

Yu Zhang, Hao Feng, Qin Wu, Shuxian Yang, Yundong Jiang, Houping Xu, Li Dong, Xiaolin Li, Hui Chen, Gang Luo
Article Number: 197
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway

Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
Article Number: 196
Published online on: 18 May 2026

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Review Open Access

Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review)

Changmei Wu, Jinjin Dou, Xiwu Zhang
Article Number: 195
Published online on: 18 May 2026

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Article Open Access

NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome

Jiajun Xie, Huina Zhang, Wenyue Shen, Juan Ye
Article Number: 194
Published online on: 18 May 2026

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Review Open Access

POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review)

Haotian Wu, Xianglin Dong
Article Number: 193
Published online on: 15 May 2026

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Emerging role of DYRK1A as a target in cardiovascular diseases (Review)

Liqing Yu, Qionghong Cheng, Jun Wu
Article Number: 192
Published online on: 15 May 2026

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Retraction Open Access

[Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Article Number: 191
Published online on: 05 May 2026

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Review Open Access

Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review)

Jingheng Song, Hongguo Cui, Peisen Yang, Yankai Xu, Yuanyuan Liu, Gang Zhang, Yangyang Liu, Aimin Tian, Jizhong Che, Hui Sun, Zhengchao Zhang
Article Number: 190
Published online on: 04 May 2026

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Article Open Access

Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

Juan Li, Siqin Zhou, Yu Wang, Guanghan Ou, Danli Yang, Liwen Shen
Article Number: 189
Published online on: 04 May 2026

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Review Open Access

Applications of humanized mice in Mycobacterium tuberculosis infections (Review)

Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, Haiyan Yang
Article Number: 188
Published online on: 04 May 2026

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Review Open Access

Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review)

Jiandong Hu, Mengli Jin, Zhihua Cao, Binbin Zheng, Yuan Zheng, Hao Shen
Article Number: 187
Published online on: 04 May 2026

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Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review)

Shilin Zhang, Zhenhua Li, Li Fu
Article Number: 186
Published online on: 04 May 2026

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Article Open Access

Effects of ALDH2 gene expression on the oxidative stress‑mediated NF‑κB/mTOR pathway in ketamine‑induced cystitis

Xiao Jian Xi, Yong Yao, Peng Gu, Min Hao Zhang
Article Number: 185
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Junchao Yao, Kebin Zheng, Xiang Zhang
Article Number: 184
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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Article Open Access

LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Article Open Access

Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Article Open Access

Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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Retraction Open Access

[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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Review Open Access

SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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