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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June-2019 Volume 19 Issue 6

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review)

Xiang Shi, Jingjing Wang, Yu Lei, Caofan Cong, Dailin Tan, Xianrong Zhou
Pages: 4529-4535
Published online on: 03 April 2019

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Article Open Access

The 15d‑PGJ2 hydrogel ameliorates atopic dermatitis through suppression of the immune response

Marcelo H. Napimoga, Juliana T. Clemente‑Napimoga, Nina M. Machabanski, Maria Eduarda A. Juliani, Pedro Henrique B. C. Acras, Cristina G. Macedo, Henrique B. Abdalla, Antônio José de Pinho , Andresa B. Soares, Marcelo Sperandio, Daniele R. de Araújo
Pages: 4536-4544
Published online on: 11 April 2019

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Article Open Access

Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma

Qun Li, Liang Ma, Zhenhua Wu, Guoli Wang, Qi Huang, Zhisen Shen, Rui Yu
Pages: 4545-4552
Published online on: 04 April 2019

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Article Open Access

Alamandine attenuates long‑term hypertension‑induced cardiac fibrosis independent of blood pressure

Lan Wang, Chi Liu, Xiru Chen, Peng Li
Pages: 4553-4560
Published online on: 15 April 2019

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Article Open Access

MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ

Yang Shu, Junpeng Long, Weixiong Guo, Wei Ye
Pages: 4561-4568
Published online on: 03 April 2019

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Article Open Access

Effects of granulocyte colony‑stimulating factor on rabbit carotid and porcine heart models of chronic obliterative arterial disease

Zhaohui Hu, Zhisong Chen, Yiping Wang, Jinfa Jiang, Gary Tse, Wenjun Xu, Junbo Ge, Bing Sun
Pages: 4569-4578
Published online on: 03 April 2019

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Article Open Access

YB1 protects cardiac myocytes against H2O2‑induced injury via suppression of PIAS3 mRNA and phosphorylation of STAT3

Shiqi Wang, Fuwei He, Zhenwei Li, Yewen Hu, Ning Huangfu, Xiaomin Chen
Pages: 4579-4588
Published online on: 03 April 2019

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Article Open Access

Quercetin suppresses glomerulosclerosis and TGF‑β signaling in a rat model

Yifan Liu, Enlai Dai, Jing Yang
Pages: 4589-4596
Published online on: 03 April 2019

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Article Open Access

Decreased expression of ubiquilin‑1 following neonatal hypoxia‑ischemic brain injury in mice

Li Luo, Yilin Liu, Xing Tu, Xuxin Ren, Wenyan Zhao, Jing Liu, Li Zhang, Weiqiang Chen, Pei Zhang, Weicai Wang, Lanhai Lü, Mengxia Wang
Pages: 4597-4602
Published online on: 15 April 2019

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Article Open Access

Hypercholesterolaemia increases the risk of high‑turnover osteoporosis in men

Yanman Zhou, Tuo Deng, Haiqing Zhang, Qingbo Guan, Hongqiang Zhao, Chunxiao Yu, Shanshan Shao, Meng Zhao, Jin Xu
Pages: 4603-4612
Published online on: 04 April 2019

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Article Open Access

Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer

Jian‑Feng Zhang, Wei Jiang, Qian‑Feng Zhang, Xiao‑Ling Kuai, Zhen‑Biao Mao, Zhi‑Wei Wang
Pages: 4613-4622
Published online on: 04 April 2019

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Article Open Access

Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture

Zhenglu Wang, Bowen Bi, Hongli Song, Lei Liu, Hong Zheng, Shusen Wang, Zhongyang Shen
Pages: 4623-4630
Published online on: 12 April 2019

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Article Open Access

Prediction of IER5 structure and function using a bioinformatics approach

Qiang Xiong, Xiaoyan Jiang, Xiaodan Liu, Pingkun Zhou, Kuke Ding
Pages: 4631-4636
Published online on: 15 April 2019

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Article Open Access

Arbutin promotes MC3T3‑E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/β‑catenin signaling pathway

Xiangji Man, Liyu Yang, Shengye Liu, Lei Yang, Mingyang Li, Qin Fu
Pages: 4637-4644
Published online on: 04 April 2019

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Article Open Access

Low‑intensity pulsed ultrasound promotes apoptosis and inhibits angiogenesis via p38 signaling‑mediated endoplasmic reticulum stress in human endothelial cells

Zhongping Su, Tianhua Xu, Yaqing Wang, Xiasheng Guo, Juan Tu, Dong Zhang, Xiangqing Kong, Yanhui Sheng, Wei Sun
Pages: 4645-4654
Published online on: 05 April 2019

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Article Open Access

MicroRNA‑144‑3p may participate in the pathogenesis of preeclampsia by targeting Cox‑2

Suwei Hu, Jie Li, Ming Tong, Qian Li, Yong Chen, Hongmei Lu, Yixiong Wang, Lingfeng Min
Pages: 4655-4662
Published online on: 11 April 2019

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Article Open Access

lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis

Chuan Cui, Xing Wang, Xiao‑Ming Shang, Li Li, Yi Ma, Guo‑Yu Zhao, Yu‑Xin Song, Xue‑Bin Geng, Bi‑Qiong Zhao, Mei‑Rong Tian, Hong‑Ling Wang
Pages: 4663-4672
Published online on: 05 April 2019

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Article Open Access

Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells

Yayun Liu, Lu Liao, Yong Chen, Fengmei Han
Pages: 4673-4684
Published online on: 05 April 2019

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Article Open Access

Comprehensive analysis of differentially expressed profiles and reconstruction of a competing endogenous RNA network in papillary renal cell carcinoma

Qing Luo, Meng Cui, Qinfu Deng, Jinbo Liu
Pages: 4685-4696
Published online on: 05 April 2019

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Article Open Access

Comprehensive analysis of the aberrantly expressed lncRNA‑associated ceRNA network in breast cancer

Tayier Tuersong, Linlin Li, Zumureti Abulaiti, Shumei Feng
Pages: 4697-4710
Published online on: 15 April 2019

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Case Report Open Access

Novel variants in the KERA gene cause autosomal recessive cornea plana in a Chinese family: A case report

Chengzi Huang, Xigui Long, Can Peng, Pengsiyuan Lin, Hu Tan, Weigang Lv, Lingqian Wu
Pages: 4711-4718
Published online on: 11 April 2019

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Article Open Access

Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells

Tao Wang, Ruiqiao Yan, Xiaoyuan Xu, Huan Yu, Jianfang Wu, Yaofang Yang, Weidong Li
Pages: 4719-4726
Published online on: 08 April 2019

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Article Open Access

Effect of integrin β1 in the treatment of stress urinary incontinence by electrical stimulation

Yang Li, Bing‑Shu Li, Cheng Liu, Sha‑Sha Hong, Jie Min, Ming Hu, Jian‑Ming Tang, Su‑Ting Li, Ting‑Ting Wang, Hui‑Xin Zhou, Li Hong
Pages: 4727-4734
Published online on: 10 April 2019

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Article Open Access

Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice

Wanlin Xu, Limin Liu, Hao Lu, Jinye Fu, Chenping Zhang, Wenjun Yang, Shukun Shen
Pages: 4735-4742
Published online on: 11 April 2019

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Article Open Access

Interleukin‑17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages

Lu Song, Jingyi Tan, Zhongxiu Wang, Peihui Ding, Qi Tang, Mengjiao Xia, Yingming Wei, Lili Chen
Pages: 4743-4752
Published online on: 11 April 2019

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Article Open Access

Astaxanthin inhibits homocysteine‑induced endothelial cell dysfunction via the regulation of the reactive oxygen species‑dependent VEGF‑VEGFR2‑FAK signaling pathway

Xian‑Jun Wang, Da‑Chen Tian, Feng‑Wen Wang, Meng‑Hao Zhang, Cun‑Dong Fan, Wang Chen, Mei‑Hong Wang, Xiao‑Yan Fu, Jin‑Kui Ma
Pages: 4753-4760
Published online on: 12 April 2019

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Article Open Access

Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer

Naiqi Huang, Zuli Wu, Hong Hong, Xiangming Wang, Fengqiang Yang, Hengguo Li
Pages: 4761-4769
Published online on: 05 April 2019

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Article Open Access

A novel resveratrol analog PA19 attenuates obesity‑induced cardiac and renal injury by inhibiting inflammation and inflammatory cell infiltration

Wenxin Zhang, Hongjin Chen, Chuchu Sun, Beibei Wu, Bin Bai, Hui Liu, Xiaoou Shan, Guang Liang, Yali Zhang
Pages: 4770-4778
Published online on: 12 April 2019

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Article Open Access

miRNA‑15a‑5p facilitates the bone marrow stem cell apoptosis of femoral head necrosis through the Wnt/β‑catenin/PPARγ signaling pathway

Wan‑Li Zhang, Cheng‑Tao Chi, Xiang‑Hui Meng, Shao‑Dong Liang
Pages: 4779-4787
Published online on: 04 April 2019

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Article Open Access

Novel agent #2714 potently inhibits lung cancer growth by suppressing cell proliferation and by inducing apoptosis in vitro and in vivo

Wenjie Lu, Qianqian Sun, Bo Chen, Yan Li, Youzhi Xu, Siying Wang
Pages: 4788-4796
Published online on: 02 April 2019

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Article Open Access

Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction

Qianwen Zhao, Jie Yang, Baolin Liu, Fang Huang, Yuehua Li
Pages: 4797-4805
Published online on: 04 April 2019

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Article Open Access

Signature microRNAs and long noncoding RNAs in laryngeal cancer recurrence identified using a competing endogenous RNA network

Zhengyi Tang, Ganguan Wei, Longcheng Zhang, Zhiwen Xu
Pages: 4806-4818
Published online on: 10 April 2019

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Article Open Access

miR‑27b‑3p and miR‑607 cooperatively regulate BLM gene expression by directly targeting the 3'‑UTR in PC3 cells

Yinglian Chen, Jiafu Zhao, Zhiqiang Duan, Ting Gong, Wei Chen, Sainan Wang, Houqiang Xu
Pages: 4819-4831
Published online on: 05 April 2019

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Article Open Access

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A resting‑state functional magnetic resonance imaging study

Yi Shao, Qing‑Hai Li, Biao Li, Qi Lin, Ting Su, Wen‑Qing Shi, Pei‑Wen  Zhu, Qing Yuan, Yong‑Qiang Shu, Ying He, Wen‑Feng Liu, Lei Ye
Pages: 4832-4840
Published online on: 10 April 2019

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Article Open Access

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway Retraction in /10.3892/mmr.2025.13549

Min Chen, Jin‑Min Wang, Dong Wang, Rong Wu, Hong‑Wei Hou
Pages: 4841-4851
Published online on: 03 April 2019

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Article Open Access

Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons

Shan Yang, Peng Wu, Jianwen Xiao, Li Jiang
Pages: 4852-4862
Published online on: 10 April 2019

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Article Open Access

Caffeic acid phenethyl ester attenuates nuclear factor‑κB‑mediated inflammatory responses in Müller cells and protects against retinal ganglion cell death

Yanwen Jia, Shengqun Jiang, Chen Chen, Guohua Lu, Yang Xie, Xincheng Sun, Liqin Huang
Pages: 4863-4871
Published online on: 11 April 2019

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Article Open Access

Paroxysmal spasticity of lower extremities as the initial symptom in two siblings with maple syrup urine disease

Yi‑Dan Liu, Xu Chu, Rui‑Hua Liu, Ying Sun, Qing‑Xia Kong, Qiu‑Bo Li
Pages: 4872-4880
Published online on: 05 April 2019

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Article Open Access

High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC

Li Sun, Jing Sun, Jun‑Ding Song
Pages: 4881-4889
Published online on: 10 April 2019

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Article Open Access

Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway

Bing Bao, Man‑Qing Zhang, Zhi‑Ying Chen, Xiang‑Bing Wu, Zhong‑Bing Xia, Jing‑Yan Chai, Xiao‑Ping Yin
Pages: 4890-4896
Published online on: 10 April 2019

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Article Open Access

Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β

Yichen Yin, Caihui Cha, Fengming Wu, Jiong Li, Sumei Li, Xiaonan Zhu, Jifeng Zhang, Guoqing Guo
Pages: 4897-4905
Published online on: 12 April 2019

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Article Open Access

Comprehensive genomic and prognostic analysis of the IL‑17 family genes in lung cancer

Tingting Liao, Jinshuo Fan, Zhilei Lv, Juanjuan Xu, Feng Wu, Guanghai Yang, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Sufei Wang, Yang Jin
Pages: 4906-4918
Published online on: 15 April 2019

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Article

Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration

Qun Zhou, Xuelu Jiang, Wei Yan, Xiaoqing Dou
Pages: 4919-4926
Published online on: 03 April 2019

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Article

Role of lncRNA uc.457 in the differentiation and maturation of cardiomyocytes

Qijun Zhang, Zijie Cheng, Zhangbin Yu, Chun Zhu, Lingmei Qian
Pages: 4927-4934
Published online on: 04 April 2019

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Article

MicroRNA‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells

Yue Li, Long Zhao, Yafei Qi, Xianghong Yang
Pages: 4935-4945
Published online on: 16 April 2019

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Article

miR‑210‑3p regulates cell growth and affects cisplatin sensitivity in human ovarian cancer cells via targeting E2F3

Yue Jin, Jun Wei, Shaoting Xu, Fang Guan, Lijun Yin, Haibin Zhu
Pages: 4946-4954
Published online on: 04 April 2019

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Article

Exogenous oestradiol benzoate induces male mice azoospermia through modulation of oxidative stress and testicular metabolic cooperation

Jianghua Le, Xiaocan Lei, Yanping Ren, Zhipeng Li, Haoyan Tu, Fangya Ding, Xiaodong Yi, Yi Zhou, Qingyou Liu, Shun Zhang
Pages: 4955-4963
Published online on: 16 April 2019

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Article

Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway

Linlin Lu, Shousheng Liu, Quanjiang Dong, Yongning Xin
Pages: 4964-4972
Published online on: 02 April 2019

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Article

SIRT4 suppresses the PI3K/Akt/NF‑κB signaling pathway and attenuates HUVEC injury induced by oxLDL

Yu Tao, Songping Yu, Min Chao, Yang Wang, Jianhua Xiong, Hengli Lai
Pages: 4973-4979
Published online on: 12 April 2019

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Article

Expression and potential regulation of miRNA‑431 during lung development of Sprague‑Dawley rats

Zhong‑Yi Sun, Yan‑Qing Shen, Xiao‑Qing Chen, Xiao‑Yu Zhou, Rui Cheng, Zhi‑Dan Bao, Yang Yang
Pages: 4980-4988
Published online on: 11 April 2019

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Article

Neuroprotective effects of lithium on a chronic MPTP mouse model of Parkinson's disease via regulation of α‑synuclein methylation

Qing Zhao, Hui Liu, Jiwei Cheng, Yudan Zhu, Qian Xiao, Yu Bai, Jie Tao
Pages: 4989-4997
Published online on: 11 April 2019

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Article

Long noncoding RNA PURPL promotes cell proliferation in liver cancer by regulating p53

Xueyan Fu, Yawei Wang, Gang Wu, Wanchuan Zhang, Shaolin Xu, Wenqing Wang
Pages: 4998-5006
Published online on: 12 April 2019

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Article

(3R)‑5,6,7‑trihydroxy‑3‑isopropyl‑3‑methylisochroman‑1‑one attenuates cardiac dysfunction via the apelin/APJ signaling pathway

Mei Ding, Lianyue Guan, Chunmei Zhang, Ping Yang, Hailing Yang
Pages: 5007-5014
Published online on: 03 April 2019

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Article

Acute exposure to 3‑deoxyglucosone at high glucose levels impairs insulin secretion from β‑cells by downregulating the sweet taste receptor signaling pathway

Xiudao Song, Guoqiang Liang, Min Shi, Liang Zhou, Fei Wang, Lurong Zhang, Fei Huang, Guorong Jiang
Pages: 5015-5022
Published online on: 15 April 2019

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Article

Downregulation of DCC sensitizes multiple myeloma cells to bortezomib treatment

Dorival Mendes Rodrigues‑Junior, Thaís Priscila Biassi, Gabriela Estrela de Albuquerque, Viviane Carlin, Marcus Vinicius Buri, Joel Machado‑Junior, Andre Luiz Vettore
Pages: 5023-5029
Published online on: 09 April 2019

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Article

Novel CLCN7 mutations cause autosomal dominant osteopetrosis type II and intermediate autosomal recessive osteopetrosis

Li Li, Shan-Shan Lv, Chun Wang, Hua Yue, Zhen-Lin Zhang
Pages: 5030-5038
Published online on: 03 April 2019

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Article

Combination of ions promotes cell migration via extracellular signal‑regulated kinase 1/2 signaling pathway in human gingival fibroblasts

Kimiko Yamaguchi‑Ueda, Yuki Akazawa, Keita Kawarabayashi, Asuna Sugimoto, Hiroshi Nakagawa, Aya Miyazaki, Rika Kurogoushi, Kokoro Iwata, Takamasa Kitamura, Aya Yamada, Tomokazu Hasegawa, Satoshi Fukumoto, Tsutomu Iwamoto
Pages: 5039-5045
Published online on: 08 April 2019

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Review Open Access

Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review)

Xueling Cui, Shumi Shang, Xinran Lv, Jing Zhao, Yan Qi, Zhonghui Liu
Pages: 5053-5062
Published online on: 30 April 2019

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Article Open Access

Clinical significance of miRNA‑1 and its potential target gene network in lung squamous cell carcinoma

Xiaojiao Li, Meijiao Qin, Jiacheng Huang, Jie Ma, Xiaohua Hu
Pages: 5063-5078
Published online on: 19 April 2019

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Article Open Access

SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein

Jiangwei Chen, Xuanyin Chen, Xiaodong Chen, Haiying Sun, Dong Yang
Pages: 5079-5086
Published online on: 22 April 2019

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Article Open Access

Inhibitory effect of 17β‑estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2

Quan Liu, Rui Li, Guanjun Chen, Jianming Wang, Bingfeng Hu, Chaofei Li, Xiaohuan Zhu, Yunxia Lu
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Published online on: 24 April 2019

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CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long‑Qiao Cao, Ya‑Nan Wang, Ming Liang, Mei‑Zhou Pan
Pages: 5097-5104
Published online on: 30 April 2019

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Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway

Junwei Shen, Yunchen Sun, Si Shen, Xu Luo, Jie Chen, Liang Zhu
Pages: 5105-5114
Published online on: 19 April 2019

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3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells

Jin He, Tao Huang, Lin Zhao
Pages: 5115-5122
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Human platelet lysate as an alternative to fetal bovine serum for culture and endothelial differentiation of human amniotic fluid mesenchymal stem cells

Waleephan Tancharoen, Sirinda Aungsuchawan, Peraphan Pothacharoen, Kanokkan Bumroongkit, Chaniporn Puaninta, Nathaporn Pangjaidee, Suteera Narakornsak, Runchana Markmee, Tanongsak Laowanitwattana, Chawapon Thaojamnong
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miR‑148 family members are putative biomarkers for sepsis

Lei Dong, Hongwei Li, Shunli Zhang, Guanzheng Yang
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Carbon monoxide releasing molecule‑2 (CORM‑2)‑liberated CO ameliorates acute pancreatitis

Yishu Liu, Xu Wang, Xiaohan Xu, Weiting Qin, Bingwei Sun
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Article

MicroRNA‑195 triggers neuroinflammation in Parkinson's disease in a Rho‑associated kinase 1‑dependent manner

Yi Ren, Huajie Li, Wei Xie, Ning Wei, Meng Liu
Pages: 5153-5161
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Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin‑resistant breast cancer cells

Chunjie Wen, Lijuan Fu, Jiafeng Huang, Yi Dai, Bin Wang, Ge Xu, Lanxiang Wu, Honghao Zhou
Pages: 5162-5168
Published online on: 22 April 2019

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Article

Effect of endoplasmic reticulum stress involved in manganese‑induced neurotoxicity in rats

Cailian Wu, Guandou Yuan, Ruikang Mo, Yanning Huang, Tiantian Luo, Jin Wang
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Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions

Zhiyang Zhu, Jianhua Yu, Weiguo Lin, Haijun Tang, Weiguang Zhang, Baochun Lu
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Article

Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits

Fang Wang, Ying Yang, Xuhui Ji, Xiong Tao, Yuhang Wang, Changmiao Wang
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MicroRNA‑93 regulates angiogenesis in peripheral arterial disease by targeting CDKN1A

Xiaojun Shu, Youjun Mao, Zhengfei Li, Wenhui Wang, Yaowen Chang, Shengye Liu, Xiao‑Qiang Li
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MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression Retraction in /10.3892/mmr.2026.13831

Yingying Shi, Luping Wang, Pijun Yu, Yi Liu, Wei Chen
Pages: 5203-5210
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Article

Role of autophagy in LPS‑induced inflammation in INS‑1 cells

Li‑Bo Zhu, Ming‑Ming Cao, Jun Wang, Ying Su, Wei Jiang, Guo‑Dong Liu, Yan‑Bo Li
Pages: 5211-5218
Published online on: 19 April 2019

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Article

Role of feline sarcoma‑related protein in the viability and apoptosis of bladder cancer cells

Xudong Hu, Zhiwen Guo, Jifei Xu, Xiangbao Mei, Manhua Bi, Fang Jiang, Dexin Yu, Caiyun Zhong
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Article Open Access

miR‑125b‑mediated regulation of cell proliferation through the Jagged‑1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis

Min Pan, Yao Huang, Xiaofang Zhu, Xiangfei Lin, Dan Luo
Pages: 5227-5236
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Article Open Access

A five lncRNA signature for prognosis prediction in hepatocellular carcinoma

Yongqiang Sun, Fangfang Zhang, Lifu Wang, Xueai Song, Jing Jing, Fan Zhang, Simiao Yu, Honghong Liu
Pages: 5237-5250
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Trichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2

Xiaoqing Jian, Le Qu, Yunlin Wang, Qianlei Zou, Qing Zhao, Shuang Chen, Xinghua Gao, Hongduo Chen, Chundi He
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Screening of underlying genetic biomarkers for ankylosing spondylitis

Xutao Fan, Bao Qi, Longfei Ma, Fengyu Ma
Pages: 5263-5274
Published online on: 24 April 2019

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LINC01638 silencing inhibits cancer cell proliferation in colorectal adenocarcinoma through interaction with RUNX2Retraction in /10.3892/mmr.2021.11875

Wenying Zhuo, Dengdi Hu, Xihua Chen, Tian Zhang
Pages: 5275-5280
Published online on: 25 April 2019

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Article Open Access

Identification of time‑series differentially expressed genes and pathways associated with heart failure post‑myocardial infarction using integrated bioinformatics analysis

Xuefei Li, Bin Li, Hong Jiang
Pages: 5281-5290
Published online on: 24 April 2019

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Article Open Access

Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways

Jianliang Pang, Peiyang Hu, Junwei Wang, Jinsong Jiang, Jifu Lai
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Article

Downregulation of miR‑186 promotes the proliferation and drug resistance of glioblastoma cells by targeting Twist1

Yifeng Xiong, Rensheng Chen, Lizhen Wang, Shanshan Wang, Yi Tu, Lei Zhu, Chunliang Wang
Pages: 5301-5308
Published online on: 30 April 2019

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Article Open Access

Bioinformatics identification of lncRNA biomarkers associated with the progression of esophageal squamous cell carcinoma

Jun Yu, Xiaoliu Wu, Kaidan Huang, Ming Zhu, Xiaomei Zhang, Yuanying Zhang, Senqing Chen, Xinyu Xu, Qin Zhang
Pages: 5309-5320
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Article Open Access

High hydrostatic pressure induces apoptosis of retinal ganglion cells via regulation of the NGF signalling pathway

Hongji Liu, Wei Wang, Xiang Li, Chao Huang, Zongduan Zhang, Mingyue Yuan, Xiangyu Li
Pages: 5321-5334
Published online on: 30 April 2019

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Article Open Access

Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis

Da‑Wei Liu, Ya‑Nan Zhang, Hai‑Juan Hu, Pu‑Qiang Zhang, Wei Cui
Pages: 5335-5344
Published online on: 25 April 2019

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miR‑216a exacerbates TGF‑β‑induced myofibroblast transdifferentiation via PTEN/AKT signaling

Chuan Qu, Xin Liu, Tianxin Ye, Linglin Wang, Steven Liu, Xingyu Zhou, Gang Wu, Jian Lin, Shaobo Shi, Bo Yang
Pages: 5345-5352
Published online on: 30 April 2019

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Article

A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice

Naoki Ishii, Takujiro Homma, Ren Watanabe, Naoko Kimura, Motoko Ohnishi, Takayasu Kobayashi, Junichi Fujii
Pages: 5353-5360
Published online on: 25 April 2019

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Article

Genetic variant in the promoter region of microRNA‑137 reduces the warfarin maintenance dose in patients with atrial fibrillation

Zhen Tian, Yushuang Yang, Zhaohui Feng, Donghui Wu, Wei Yang, Dongna Liu
Pages: 5361-5367
Published online on: 30 April 2019

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Potential use of Pichia pastoris strain SMD1168H expressing DNA topoisomerase I in the screening of potential anti‑breast cancer agents

Jian Xin, Wan Nor Azlin Wan Mahtar, Poh Chiew Siah, Noorizan Miswan, Boon Yin Khoo
Pages: 5368-5376
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Salmonella infection leads to severe intestinal inflammation and increased CD4+FoxP3+ Treg cells in streptozotocin‑induced hyperglycemic mice

Shanlong Zhang, Meixiang Wang, Xuemei Wang, Helou Li, Hua Tang, Xiaojun Li
Pages: 5377-5385
Published online on: 25 April 2019

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Article

Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease‑activated receptor 2 in a murine model

Wubulikasimu Wulamu, Maimaiti Yisireyili, Aikebaier Aili, Kyosuke Takeshita, Aziguli Alimujiang, Aliyeguli Aipire, Yiliang Li, Yuan Jiang, Maimaitiaili Aizezi, Zanlin Li, Kelimu Abudureyimu
Pages: 5386-5396
Published online on: 25 April 2019

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Article Open Access

Long non‑coding RNA NORAD promotes cell proliferation and glycolysis in non‑small cell lung cancer by acting as a sponge for miR‑136‑5p

Wei Gao, Ting Weng, Lifang Wang, Bin Shi, Wenshu Meng, Xiaoyu Wang, Ying Wu, Liang Jin, Lijuan Fei
Pages: 5397-5405
Published online on: 30 April 2019

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Identification of a long noncoding RNA signature to predict outcomes of glioblastoma

Depei Li, Jie Lu, Hong Li, Songtao Qi, Lei Yu
Pages: 5406-5416
Published online on: 24 April 2019

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Article Open Access

Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities

Zhimin Wang, Fang Li, Yuan Quan, Junye Shen
Pages: 5417-5423
Published online on: 25 April 2019

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Article Open Access

Ghrelin regulates sepsis‑induced rat acute gastric injury

Bin Li, Qingling Lin, Hong Guo, Liping Liu, Yumin Li
Pages: 5424-5432
Published online on: 30 April 2019

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Article Open Access

Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence

Penghui Song, Jing Hu, Xijin Liu, Xuejun Deng
Pages: 5433-5439
Published online on: 30 April 2019

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Article Open Access

Berberine improves advanced glycation end products‑induced osteogenic differentiation responses in human periodontal ligament stem cells through the canonical Wnt/β‑catenin pathway

Li‑Na Zhang, Xu‑Xia Wang, Zhi Wang, Ke‑Yi Li, Bao‑Hua Xu, Jun Zhang
Pages: 5440-5452
Published online on: 25 April 2019

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Article

CD47 deficiency protects cardiomyocytes against hypoxia/reoxygenation injury by rescuing autophagic clearance

Yong Li, Kun Zhao, Pengyu Zong, Heling Fu, Yuan Zheng, Dan Bao, Yuan Yin, Qin Chen, Lu Lu, Youjin Dai, Daorong Hou, Xiangqing Kong
Pages: 5453-5463
Published online on: 25 April 2019

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Article

Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese patients

Noriaki Nagai, Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
Pages: 5464-5472
Published online on: 02 May 2019

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Journal Cover
September-2026 Volume 34 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Chronic kidney disease‑associated encephalopathy: Clinical features, pathomechanisms and emerging therapeutic strategies (Review)

Nanling Zeng, Ling Jiang, Yang Zhang, Jian Liu, Qiong Zhang, Lishang Liao, Qiongdan Hu
Article Number: 259
Published online on: 21 July 2026

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Retraction Open Access

[Retracted] Emodin promotes the arrest of human lymphoma Raji cell proliferation through the UHRF1‑DNMT3A‑∆Np73 pathways

Yun Lin, Weiming Chen, Zhihong Wang, Pengwei Cai
Article Number: 258
Published online on: 20 July 2026

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Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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Expression of Concern Open Access

[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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Retraction Open Access

[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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Correction Open Access

[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Review Open Access

Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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Retraction Open Access

[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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Journal Cover
October-2026 Volume 34 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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Retraction Open Access

[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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Article Open Access

UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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