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Article

Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus

  • Authors:
    • Lina Liu
    • Jing Yan
    • Fei Ge
    • Xiangtao Xu
    • Jun Lu
    • Huilian Shi
    • Shuihong Li
    • Yue Zhao
    • Changzheng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China, Key Laboratory for Metabolic Diseases in Chinese Medicine, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Gastroenterology, Haian Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Haian, Jiangsu 226600, P.R. China, Department of Psychiatry and Imageology, Central People's Hospital of Zhanjiang Affiliated to Guangdong Medical University, Zhanjiang, Guangdong 524048, P.R. China, Department of Psychology and Key Laboratory of Psychological Assessment and Rehabilitation for Exceptional Children, Lingnan Normal University, Zhanjiang, Guangdong 524048, P.R. China
  • Pages: 332-340
    |
    Published online on: May 10, 2019
       https://doi.org/10.3892/mmr.2019.10232
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Abstract

Saikosaponin‑D (SSD), which is the main bioactive component in the traditional Chinese medicine Chai Hu (Bupleurum falcatum L), possesses estrogen‑like properties and is widely used in treating estrogen‑related neurological disorders. The current study aimed to investigate the protective effects of SSD on the fear memory deficit in ovariectomized (OVX) rats and the potential underlying mechanism. SSD treatment significantly prolonged freezing time in OVX rats in a manner similar to that of estradiol (E2), whereas this effect was markedly suppressed by co‑administration of ICI182780, a non‑selective estrogen receptor (ER) inhibitor. The expression of ERα in the hippocampus of OVX rats was significantly elevated by SSD; however, Erβ expression and E2 synthesis were not markedly affected by SSD treatment. Collectively, this study demonstrated that SSD‑mediated fear memory improvement in OVX rats may be attributed not to E2 levels or ERβ activity, but to ERα activation in the hippocampus.
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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Yan J, Ge F, Xu X, Lu J, Shi H, Li S, Zhao Y and Zhang C: Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Mol Med Rep 20: 332-340, 2019.
APA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H. ... Zhang, C. (2019). Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Molecular Medicine Reports, 20, 332-340. https://doi.org/10.3892/mmr.2019.10232
MLA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20.1 (2019): 332-340.
Chicago
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20, no. 1 (2019): 332-340. https://doi.org/10.3892/mmr.2019.10232
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Yan J, Ge F, Xu X, Lu J, Shi H, Li S, Zhao Y and Zhang C: Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Mol Med Rep 20: 332-340, 2019.
APA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H. ... Zhang, C. (2019). Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Molecular Medicine Reports, 20, 332-340. https://doi.org/10.3892/mmr.2019.10232
MLA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20.1 (2019): 332-340.
Chicago
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20, no. 1 (2019): 332-340. https://doi.org/10.3892/mmr.2019.10232
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