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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-2019 Volume 20 Issue 1

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Advances in nanomaterials for use in photothermal and photodynamic therapeutics (Review)

Zhizhou Yang, Zhaorui Sun, Yi Ren, Xin Chen, Wei Zhang, Xuhui Zhu, Zongwan Mao, Jianliang Shen, Shinan Nie
Pages: 5-15
Published online on: 09 May 2019

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Article

Association between quasispecies variants of hepatitis B virus, as detected by high‑throughput sequencing, and progression of advanced liver disease in Indonesian patients

Wahyu Aristyaning Putri, Yoshihiko Yano, Laura Navika Yamani, Yujiao Liang, Yan Mardian, Takako Utsumi, Soetjipto Soetjipto, Maria Inge Lusida, Yoshitake Hayashi
Pages: 16-24
Published online on: 16 May 2019

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Article

Administration of live, but not inactivated, Faecalibacterium prausnitzii has a preventive effect on dextran sodium sulfate‑induced colitis in mice

Yujiro Kawade, Misaki Sakai, Mariko Okamori, Mayuko Morita, Katsura Mizushima, Tomohiro Ueda, Tomohisa Takagi, Yuji Naito, Yoshito Itoh, Takashi Shimada
Pages: 25-32
Published online on: 14 May 2019

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Article Open Access

miR‑338‑3p inhibits A549 lung cancer cell proliferation and invasion by targeting AKT and β‑catenin signaling pathways

Jia Liu, Linggai Cao, Na Zhao, Yue Feng, Ze Yu, Yuhua Li, Chunbo Teng, Jifan Hu, Tao Li
Pages: 33-40
Published online on: 09 May 2019

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Article Open Access

Neuregulin‑1 impacting bone marrow mesenchymal stem cell migration is conducive to functional recovery following spinal cord injury

Xi‑Meng Yi, Yi Chen, Guan‑Jun Tu
Pages: 41-48
Published online on: 09 May 2019

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Article

The protective effect of the TUG1/miR‑197/MAPK1 axis on lipopolysaccharide‑induced podocyte injury

Dong Zhao, Zheng Liu, Heng Zhang
Pages: 49-56
Published online on: 09 May 2019

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Article Open Access

MicroRNA‑34a inhibits cell growth and migration in human glioma cells via MMP‑9

Xuepeng Wang, Xi Chen, Lin Sun, Xiaoli Bi, Haitao He, Lei Chen, Jinfeng Pang
Pages: 57-64
Published online on: 13 May 2019

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Article

A novel mutation associated with Type III Bartter syndrome: A report of five cases

Yanhan Li, Chengcheng Wu, Jie Gu, Dong Li, Yanling Yang
Pages: 65-72
Published online on: 16 May 2019

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Article

Bryonia dioica aqueous extract induces apoptosis and G2/M cell cycle arrest in MDA‑MB 231 breast cancer cells

Bachir Benarba, Almahy Elmallah, Atanasio Pandiella
Pages: 73-80
Published online on: 09 May 2019

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Article Open Access

miRNA‑30a‑3p inhibits metastasis and enhances radiosensitivity in esophageal carcinoma by targeting insulin‑like growth factor 1 receptor Retraction in /10.3892/mmr.2026.13822

Yanxin Fan, Xiuhua Bian, Pudong Qian, Jing Wen, Pengwei Yan, Yanhong Luo, Jing Wu, Qian Zhang
Pages: 81-94
Published online on: 09 May 2019

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Article Open Access

Possibility of early diagnosis in a fetus affected by Prader‑Willi syndrome with maternal hetero‑UPD15: A lesson to be learned

Yanling Dong, Shu Liu, Junnan Li, Jian Li, Qian Chen, Jianyun Luo, Chunlei Li, Huifan Li, Hongbo Qi, Rong Li
Pages: 95-102
Published online on: 15 May 2019

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Article

Contribution of sex‑based immunological differences to the enhanced immune response in female mice following vaccination with hepatitis B vaccine

Meng Li, Yuwei Zhao, Xue Chen, Xuemei Fu, Wen Li, Humin Liu, Yufang Dong, Chuanyao Liu, Xiao Zhang, Li Shen, Bing Li, Yaomei Tian
Pages: 103-110
Published online on: 10 May 2019

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Article Open Access

Role of FN1 and GREB1 gene polymorphisms in endometriosis

Charoula Matalliotaki, Michail Matalliotakis, Nilufer Rahmioglu, George Mavromatidis, Ioannis Matalliotakis, George Koumantakis, Krina Zondervan, Demetrios A. Spandidos, George N. Goulielmos, Maria I. Zervou
Pages: 111-116
Published online on: 15 May 2019

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Article

Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass‑associated inflammatory lung injury in juvenile rats

Xiang Kong, Yi Zuo, Yu'ang Huang, Jianjun Ge
Pages: 117-124
Published online on: 14 May 2019

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Article Open Access

ILF3 promotes gastric cancer proliferation and may be used as a prognostic marker

Yü Liu, Yong Li, Yijie Zhao, Yang Liu, Liqiao Fan, Nan Jia, Qun Zhao
Pages: 125-134
Published online on: 09 May 2019

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Article Open Access

Toosendanin induces the apoptosis of human Ewing's sarcoma cells via the mitochondrial apoptotic pathway

Tian Gao, An Xie, Xuqiang Liu, Haibo Zhan, Jin Zeng, Min Dai, Bin Zhang
Pages: 135-140
Published online on: 09 May 2019

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Article Open Access

Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis

Xiaobing Yao, Fan Cheng, Weiming Yu, Ting Rao, Wei Li, Sheng Zhao, Xiangjun Zhou, Jinzhuo Ning
Pages: 141-150
Published online on: 09 May 2019

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Article Open Access

ΜicroRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway

Huagang Liang, Chao Wang, Kun Gao, Jian Li, Rui Jia
Pages: 151-161
Published online on: 09 May 2019

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Article Open Access

FGF signaling contributes to atherosclerosis by enhancing the inflammatory response in vascular smooth muscle cells

Ming Qi, Shijie Xin
Pages: 162-170
Published online on: 16 May 2019

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Article Open Access

miR‑10b‑3p, miR‑8112 and let‑7j as potential biomarkers for autoimmune inner ear diseases

Juhong Zhang, Na Wang, Anting Xu
Pages: 171-181
Published online on: 16 May 2019

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Article Open Access

Long non‑coding RNA FER1L4 inhibits cell proliferation and metastasis through regulation of the PI3K/AKT signaling pathway in lung cancer cells

Xuejin Gao, Nianchang Wang, Shanshan Wu, Hongmei Cui, Xue An, Yuping Yang
Pages: 182-190
Published online on: 09 May 2019

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Article

Regulatory effects of Ningdong granule on dopaminergic and serotonergic neurotransmission in a rat model of Tourette syndrome assessed by PET

Yuan Wang, Anyuan Li
Pages: 191-197
Published online on: 15 May 2019

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Article Open Access

Striatisporolide A, a butenolide metabolite from Athyrium multidentatum (Doll.) Ching, as a potential antibacterial agent

Ji‑Wen Sheng, Dong‑Mei Liu, Liang Jing, Gui‑Xue Xia, Wei‑Fen Zhang, Jing‑Ru Jiang, Jin‑Bao Tang
Pages: 198-204
Published online on: 15 May 2019

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Article Open Access

Thermal pretreatment promotes the protective effect of HSP70 against tendon adhesion in tendon healing by increasing HSP70 expression

Xiao‑Ming Tang, Jian Dai, Hai‑Lang Sun
Pages: 205-215
Published online on: 15 May 2019

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Article

Identification of pathogenic genes and transcription factors in glaucoma

Jie Feng, Jing Xu
Pages: 216-224
Published online on: 14 May 2019

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Article Open Access

Integrated bioinformatic analysis of differentially expressed genes and signaling pathways in plaque psoriasis

Yu‑Jing Zhang, Yu‑Zhe Sun, Xing‑Hua Gao, Rui‑Qun Qi
Pages: 225-235
Published online on: 15 May 2019

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Article Open Access

MicroRNA‑30a‑5p promotes proliferation and inhibits apoptosis of human pulmonary artery endothelial cells under hypoxia by targeting YKL‑40

Hong Tan, Hua Yao, Zhenbang Lie, Guo Chen, Shuguang Lin, Ying Zhang
Pages: 236-244
Published online on: 16 May 2019

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Article Open Access

Transcriptomics analysis of sirolimus treatment in lupus nephritis

Dongdong Wang, Xiao Chen, Meng Fu, Zhiping Li
Pages: 245-251
Published online on: 14 May 2019

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Article Open Access

miR‑342 inhibits glioma cell proliferation by targeting GPRC5A

Jianjiao Wang, Yan Yang, Yuandong Cao, Xinyu Tang
Pages: 252-260
Published online on: 15 May 2019

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Article

ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer

Zheng Dong, Bingchun Li, Xiaojuan Wang
Pages: 261-269
Published online on: 15 May 2019

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Article Open Access

miR‑144 promotes the proliferation and differentiation of bone mesenchymal stem cells by downregulating the expression of SFRP1

Ling Tang, Wenjun Lu, Jian Huang, Xu Tang, Huiyun Zhang, Shujiao Liu
Pages: 270-280
Published online on: 16 May 2019

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Article Open Access

Bioinformatics identification of microRNAs involved in polycystic ovary syndrome based on microarray data

Yan Hou, Yaoqin Wang, Suming Xu, Gaimei Qi, Xueqing Wu
Pages: 281-291
Published online on: 16 May 2019

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Article Open Access

Downregulation of the long non‑coding RNA FOXD2‑AS1 inhibits cell proliferation, migration and invasion in osteosarcoma

Haomeng Zhang, Yao Lu, Jun Wang, Tian Zhang, Chuan Dong, Xiaoxiang Li, Xinli Wang, Qiong Ma, Tongtao Yang, Yong Zhou
Pages: 292-302
Published online on: 16 May 2019

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Article

Bioinformatics‑based identification of key pathways and candidate genes for estrogen‑induced intrahepatic cholestasis using DNA microarray analysis

Dong Xiang, Yanjiao Xu, Wenxi He, Jinyu Yang, Chengliang Zhang, Dong Liu
Pages: 303-311
Published online on: 16 May 2019

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Article Open Access

Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF‑κB and Wnt/β‑catenin signaling pathways

Yuzhe He, Safwat Adel Abdo Moqbel, Langhai Xu, Jisheng Ran, Chiyuan Ma, Kai Xu, Jiapeng Bao, Lifeng Jiang, Weiping Chen, Yan Xiong, Lidong Wu
Pages: 312-322
Published online on: 14 May 2019

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Article Open Access

TFAP2E methylation promotes 5‑fluorouracil resistance via exosomal miR‑106a‑5p and miR‑421 in gastric cancer MGC‑803 cells

Sun Jingyue, Wang Xiao, Zha Juanmin, Li Wei, Li Daoming, Xu Hong
Pages: 323-331
Published online on: 14 May 2019

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Article

Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus

Lina Liu, Jing Yan, Fei Ge, Xiangtao Xu, Jun Lu, Huilian Shi, Shuihong Li, Yue Zhao, Changzheng Zhang
Pages: 332-340
Published online on: 10 May 2019

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Article Open Access

Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway

Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Song
Pages: 341-349
Published online on: 09 May 2019

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Article Open Access

Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes

Gaopeng Guan, Lei Yang, Wenyin Huang, Jun Zhang, Puhua Zhang, Huan Yu, Shengyuan Liu, Xiang Gu
Pages: 350-358
Published online on: 09 May 2019

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Article Open Access

Fr‑HMGB1 and ds‑HMGB1 activate the kynurenine pathway via different mechanisms in association with depressive‑like behavior

Bo Wang, Yong‑Jie Lian, Wen‑Jun Su, Lin‑Lin Liu, Jia‑Mei Li, Chun‑Lei Jiang, Yun‑Xia Wang
Pages: 359-367
Published online on: 09 May 2019

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Article

Downregulation of syndecan‑1 expression induces activation of hepatic stellate cells via the TGF‑β1/Smad3 signaling pathway

Min Deng, Longsheng Xu, Xinsheng Xie, Xiong Sheng, Zhuolin Zou, Ming Yao
Pages: 368-374
Published online on: 09 May 2019

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Article Open Access

Identification and integrative analysis of microRNAs and mRNAs involved in proliferation and invasion of pressure‑treated human liver cancer cell lines

Si Shen, Xu Luo, Kewei Gao, Yunchen Sun, Dingkang Yao, Liang Zhu
Pages: 375-387
Published online on: 09 May 2019

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Article Open Access

Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma

Shu Zhou, Xue Piao, Chengyan Wang, Rui Wang, Zhimin Song
Pages: 393-400
Published online on: 22 May 2019

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Article Open Access

Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca2+‑mediated mitochondrial pathway Retraction in /10.3892/mmr.2025.13561

Zhigang Nie, Shuang Deng, Lei Zhang, Sen Chen, Qiang Lu, Hao Peng
Pages: 401-408
Published online on: 22 May 2019

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Article Open Access

Amyloid β precursor protein silencing attenuates epithelial‑mesenchymal transition of nasopharyngeal carcinoma cells via inhibition of the MAPK pathway

Jin Xu, Yin Ying, Gaoyun Xiong, Liqin Lai, Qingliang Wang, Yue Yang
Pages: 409-416
Published online on: 24 May 2019

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Article Open Access

Bioinformatics analysis of a long non‑coding RNA and mRNA regulation network in rats with middle cerebral artery occlusion based on RNA sequencing

Xianchun Duan, Lan Han, Daiyin Peng, Can Peng, Ling Xiao, Qiuyu Bao, Huasheng Peng
Pages: 417-432
Published online on: 27 May 2019

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Article Open Access

De novo transcriptome analysis of gene responses to pest feeding in leaves of Panax ginseng C. A. Meyer

Guangsheng Xi, Yanling Wang, Le Yin, Yunjia Wang, Shengxue Zhou
Pages: 433-444
Published online on: 22 May 2019

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Article Open Access

High developmental pluripotency‑associated 4 expression promotes cell proliferation and glycolysis, and predicts poor prognosis in non‑small‑cell lung cancer

Longfei Li, Yufeng Wang, Qiang Wang, Jingming Qu, Xiangju Wei, Jilei Xu, Yuanjin Wang, Feng Suo, Yangjie Zhang
Pages: 445-454
Published online on: 22 May 2019

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Article Open Access

Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice

Wu‑Wei Li, Tao‑Yuan Wang, Bo Cao, Bin Liu, Yu‑Mei Rong, Juan‑Juan Wang, Fei Wei, Lu‑Qing Wei, Hong Chen, Yan‑Xia Liu
Pages: 455-462
Published online on: 22 May 2019

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Article Open Access

Resveratrol alleviates inflammatory injury and enhances the apoptosis of fibroblast‑like synoviocytes via mitochondrial dysfunction and ER stress in rats with adjuvant arthritis

Jinsen Lu, Yongshun Zheng, Jiazhao Yang, Junqiang Zhang, Wei Cao, Xiaoyu Chen, Shiyuan Fang
Pages: 463-472
Published online on: 22 May 2019

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Article Open Access

Paneth cell ablation increases the small intestinal injury during acute necrotizing pancreatitis in rats

Liyan Liu, Yuecheng Guo, Junyuan Zheng, Yingying Lu, Yucui Shen, Chunlan Huang, Yue Zeng, Xingpeng Wang
Pages: 473-484
Published online on: 22 May 2019

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Article Open Access

Identification of a lncRNA‑associated competing endogenous RNA‑regulated network in clear cell renal cell carcinoma

Beibei Liu, Tantu Ma, Qingwen Li, Sheng Wang, Wei Sun, Wenyong Li, Jianmin Liu, Yuanyuan Guo
Pages: 485-494
Published online on: 23 May 2019

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Article Open Access

Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models Retraction in /10.3892/mmr.2026.13925

Yong Liu, Yan Zhang, Ming Hu, Yu‑Hu Li, Xing‑Hua Cao
Pages: 495-504
Published online on: 27 May 2019

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Article Open Access

Novel de novo frameshift variant in the ASXL3 gene in a child with microcephaly and global developmental delay

Marketa Wayhelova, Jan Oppelt, Jan Smetana, Eva Hladilkova, Hana Filkova, Eva Makaturova, Petra Nikolova, Rastislav Beharka, Renata Gaillyova, Petr Kuglik
Pages: 505-512
Published online on: 27 May 2019

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Article Open Access

Comprehensive analysis of differentially expressed profiles of non‑coding RNAs in peripheral blood and ceRNA regulatory networks in non‑syndromic orofacial clefts

Yuwei Gao, Qiguang Zang, Hongquan Song, Songbin Fu, Wenjing Sun, Wei Zhang, Xiaotong Wang, Yong Li, Xiaohui Jiao
Pages: 513-528
Published online on: 22 May 2019

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Article Open Access

Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling

Shasha Chen, Feng Cai, Jirong Wang, Zhouxin Yang, Chi Gu, Guofu Wang, Genxiang Mao, Jing Yan
Pages: 529-538
Published online on: 23 May 2019

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Article Open Access

Combination of targeting CD24 and inhibiting autophagy suppresses the proliferation and enhances the apoptosis of colorectal cancer cells

Jingwei Zhuo, Xinying Wang
Pages: 539-548
Published online on: 23 May 2019

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Article Open Access

Bioinformatics analysis of the regulatory lncRNA‑miRNA‑mRNA network and drug prediction in patients with hypertrophic cardiomyopathy

Jiajianghui Li, Zining Wu, Deqiang Zheng, Yue Sun, Sisi Wang, Yuxiang Yan
Pages: 549-558
Published online on: 23 May 2019

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Article Open Access

Expression of transforming growth factor β and matrix metalloproteinases in the aqueous humor of patients with congenital ectopia lentis

Qianzhong Cao, Bing Xiao, Guangming Jin, Jianqiang Lin, Yiyao Wang, Charlotte Aimee Young, Junxiong Lin, Yijing Zhou, Bo Zhang, Mingzhe Cao, Kaili Wu, Danying Zheng
Pages: 559-566
Published online on: 23 May 2019

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Article Open Access

β‑catenin signalling inhibits cartilage endplate chondrocyte homeostasis in vitro

Lei Ding, Zengxin Jiang, Jingping Wu, Defang Li, Houlei Wang, Wei Lu, Qingmin Zeng, Guoxiong Xu
Pages: 567-572
Published online on: 27 May 2019

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Article Open Access

A 9‑lncRNA risk score system for predicting the prognosis of patients with hepatitis B virus‑positive hepatocellular carcinoma

Honghong Liu, Ping Zhao, Xueyuan Jin, Yanling Zhao, Yongqian Chen, Tao Yan, Jianjun Wang, Liang Wu, Yongqiang Sun
Pages: 573-583
Published online on: 22 May 2019

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Article Open Access

iTRAQ‑based proteomic analysis of endotoxin tolerance induced by lipopolysaccharide

Qian Zhang, Yingchun Hu, Jing Zhang, Cunliang Deng
Pages: 584-592
Published online on: 22 May 2019

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Evaluation of EGFR mutations in NSCLC with highly sensitive droplet digital PCR assays

Xi‑Wen Jiang, Wei Liu, Xiao‑Ya Zhu, Xiao‑Xie Xu
Pages: 593-603
Published online on: 21 May 2019

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miR‑221‑3p promotes the cell growth of non‑small cell lung cancer by targeting p27

Guoqing Yin, Bo Zhang, Jia Li
Pages: 604-612
Published online on: 23 May 2019

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Silencing of heat shock protein 27 increases the radiosensitivity of non‑small cell lung carcinoma cells

Liping Xu, Xuemei Lin, Yihua Zheng, Hua Zhou
Pages: 613-621
Published online on: 22 May 2019

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Characterization of a prognostic four‑gene methylation signature associated with radiotherapy for head and neck squamous cell carcinoma

Jiabao Ma, Rui Li, Jie Wang
Pages: 622-632
Published online on: 24 May 2019

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Comparison of biological characteristics of mesenchymal stem cells derived from the human umbilical cord and decidua parietalis

Yu‑Tao Guan, Yong Xie, Dong‑Sheng Li, Yu‑Yuan Zhu, Xiao‑Lu Zhang, Ying‑Lin Feng, Yang‑Ping Chen, Li‑Jiang Xu, Pin‑Fu Liao, Gang Wang
Pages: 633-639
Published online on: 23 May 2019

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Long intergenic non‑coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression

Xianghai Wang, Hongbing Liu, Kaikai Shen, Xianhui Pan, Yuqing Wei, Tangfeng Lv, Yong Song
Pages: 640-654
Published online on: 23 May 2019

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Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway

Lili Gao, Yi Fan, Xiuli Zhang, Lina Yang, Wenyu Huang, Tianyu Hang, Mingyang Li, Shuyan Du, Jianfei Ma
Pages: 655-663
Published online on: 22 May 2019

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Substance P enhances BMSC osteogenic differentiation via autophagic activation

Wen Geng, Huimin Shi, Ximin Zhang, Wei Tan, Yuan Cao, Rongcheng Mei
Pages: 664-670
Published online on: 21 May 2019

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Construction and function of a fusion protein consisting of a single‑chain variable fragment and RBP4

Hongxia Li, Guangming Cao, Tong Lou, Zhenyu Zhang, Chongdong Liu
Pages: 671-677
Published online on: 22 May 2019

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Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab treatment

Paolo Fagone, Emanuela Mazzon, Santa Mammana, Roberto Di Marco, Flaminia Spinasanta, Maria Sofia Basile, Maria Cristina Petralia, Placido Bramanti, Ferdinando Nicoletti, Katia Mangano
Pages: 678-684
Published online on: 23 May 2019

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The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease Corrigendum in /10.3892/mmr.2019.10648

Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tang
Pages: 685-692
Published online on: 22 May 2019

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Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis

Ye Feng, Yanbo Li, Lin Li, Xuefeng Wang, Zhi Chen
Pages: 693-700
Published online on: 24 May 2019

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LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet

Tao Hao, Hongying Chen, Sisi Wu, Haoming Tian
Pages: 701-708
Published online on: 28 May 2019

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Baicalin inhibits C2C12 myoblast apoptosis and prevents against skeletal muscle injury

Yutao Pan, Dongli Song, Weiyan Zhou, Xiuhong Lu, Haiyan Wang, Zengchun Li
Pages: 709-718
Published online on: 27 May 2019

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MicroRNA‑21 contributes to the puerarin‑induced cardioprotection via suppression of apoptosis and oxidative stress in a cell model of ischemia/reperfusion injury

Hai‑Xiang Xu, Wen Pan, Jian‑Feng Qian, Feng Liu, Hai‑Qi Dong, Qing‑Jun Liu
Pages: 719-727
Published online on: 22 May 2019

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Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway

Qiongyu Li, Lihui Wei, Shan Lin, Youqin Chen, Jiumao Lin, Jun Peng
Pages: 728-734
Published online on: 27 May 2019

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MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways

Huixiao Dong, Benliang Cui, Xiuzhen Hao
Pages: 735-744
Published online on: 22 May 2019

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RNA‑seq analyses of antibiotic resistance mechanisms in Serratia marcescens

Zhaodong Li, Meihua Xu, Hui Wei, Lili Wang, Min Deng
Pages: 745-754
Published online on: 22 May 2019

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c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?

Yuyuan Liu, Ping Shen, Yongmei Zhou, Li Tang, Huaqi Chai
Pages: 755-762
Published online on: 22 May 2019

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Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes

Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, Youngwan Seo, Chang‑Suk Kong
Pages: 763-770
Published online on: 21 May 2019

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Effect of copper nanoparticles on brain cytochrome P450 enzymes in rats

Yanyan Wang, Huaqiao Tang, Min Xu, Jie Luo, Ling Zhao, Fei Shi, Gang Ye, Cheng Lv, Yinglun Li
Pages: 771-778
Published online on: 27 May 2019

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Reductions in gut microbiota‑derived metabolite trimethylamine N‑oxide in the circulation may ameliorate myocardial infarction‑induced heart failure in rats, possibly by inhibiting interleukin‑8 secretion

Xiaoyan Li, Yongcun Sun, Xinru Zhang, Jing Wang
Pages: 779-786
Published online on: 27 May 2019

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Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting

Magdy El‑Salhy, Odd Helge Gilja, Jan Gunnar Hatlebakk
Pages: 787-794
Published online on: 23 May 2019

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miR‑148a modulates the viability, migration and invasion of oral squamous cell carcinoma cells by regulating HLA‑G expression

Yuying Zhang, Xin Jin, Jie Wang
Pages: 795-801
Published online on: 22 May 2019

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Callistephin enhances the protective effects of isoflurane on microglial injury through downregulation of inflammation and apoptosis

Lili Zhao, Shibiao Chen, Tianyin Liu, Xiuhong Wang, Haijin Huang, Weicheng Liu
Pages: 802-812
Published online on: 22 May 2019

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Effect of passaging on the stemness of infrapatellar fat pad‑derived stem cells and potential role of nucleostemin as a prognostic marker of impaired stemness

Subathra Radhakrishnan, Omana Anna Trentz, Catherine Ann Martin, Mettu Srinivas Reddy, Mohamed Rela, Marimuthu Chinnarasu, Narayana Kalkura, Shanmugaapriya Sellathamby
Pages: 813-829
Published online on: 22 May 2019

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Effect of macrophage migration inhibitory factor on inflammatory cytokines and fibrogenic gene expression in human RPE cells

Dong Qin, Yanrong Jiang, Xuemin Jin
Pages: 830-836
Published online on: 22 May 2019

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Bupivacaine at clinically relevant concentrations induces toxicity in human intervertebral disc cells via the induction of autophagy in vitro

Ge Yang, Zhuoyang Li, Haibo Mei, Weihua Ye, Shengxiang Huang, Kun Liu, Qian Tan
Pages: 837-843
Published online on: 22 May 2019

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August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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