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Role of FN1 and GREB1 gene polymorphisms in endometriosis

  • Authors:
    • Charoula Matalliotaki
    • Michail Matalliotakis
    • Nilufer Rahmioglu
    • George Mavromatidis
    • Ioannis Matalliotakis
    • George Koumantakis
    • Krina Zondervan
    • Demetrios A. Spandidos
    • George N. Goulielmos
    • Maria I. Zervou
  • View Affiliations / Copyright

    Affiliations: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Wellcome Trust Centre for Human Genetics, Nuffield Department of Women's and Reproductive Health, John Radcliffe Hospital, University of Oxford, OX3 7BN Oxford, UK, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Department of Obstetrics and Gynecology, Venizeleio and Pananio General Hospital of Heraklion, 71409 Heraklion, Greece, Genesis Athens Clinic, 152 32 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Matalliotaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 111-116
    |
    Published online on: May 15, 2019
       https://doi.org/10.3892/mmr.2019.10247
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Abstract

Endometriosis is a complex gynecological disorder, affecting up to 10% of women of childbearing age, characterized by the presence of functional endometrial tissue at ectopic positions generally within the peritoneum. It is a heritable condition influenced by multiple genetic, epigenetic and environmental factors, with an overall heritability estimated at approximately 50%. The aim of the present study was to evaluate the association of rs1250248 and rs11674184 single nucleotide polymorphisms (SNPs), mapping to fibronectin 1 (FN1) and growth regulation by estrogen in breast cancer 1 (GREB1) genetic loci, respectively, with the risk of endometriosis. A total of 166 women with endometriosis (stages I-IV) who were hospitalized for the condition, diagnosed by laparoscopic intervention and histologically confirmed, and 168 normal controls were recruited and genotyped. Genotyping of the rs1250248 and rs11674184 SNPs was performed with TaqMan primer/probe sets. A significant association was detected with the A allele, as well as the AA and AG genotypes of rs1250248 (FN1) in patients with endometriosis, as well as in patients with stage I and II of the disease only. The rs11674184 SNP of the GREB1 gene was not found to be associated with an increased susceptibility to endometriosis either for all patients (stages I-IV) or for subgroups of stage I and II or III and IV of the disease only. Our results demonstrated a genetic association between the rs1250248 (FN1) SNP and endometriosis at both the genotypic and allelic level. However, although rs11674184 of GREB1 constitutes one of the most consistently associated SNPs with endometriosis in European ancestry populations, it was not found to be associated with endometriosis in this study.
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Copy and paste a formatted citation
Spandidos Publications style
Matalliotaki C, Matalliotakis M, Rahmioglu N, Mavromatidis G, Matalliotakis I, Koumantakis G, Zondervan K, Spandidos DA, Goulielmos GN, Zervou MI, Zervou MI, et al: Role of FN1 and GREB1 gene polymorphisms in endometriosis. Mol Med Rep 20: 111-116, 2019.
APA
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G. ... Zervou, M.I. (2019). Role of FN1 and GREB1 gene polymorphisms in endometriosis. Molecular Medicine Reports, 20, 111-116. https://doi.org/10.3892/mmr.2019.10247
MLA
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G., Zondervan, K., Spandidos, D. A., Goulielmos, G. N., Zervou, M. I."Role of FN1 and GREB1 gene polymorphisms in endometriosis". Molecular Medicine Reports 20.1 (2019): 111-116.
Chicago
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G., Zondervan, K., Spandidos, D. A., Goulielmos, G. N., Zervou, M. I."Role of FN1 and GREB1 gene polymorphisms in endometriosis". Molecular Medicine Reports 20, no. 1 (2019): 111-116. https://doi.org/10.3892/mmr.2019.10247
Copy and paste a formatted citation
x
Spandidos Publications style
Matalliotaki C, Matalliotakis M, Rahmioglu N, Mavromatidis G, Matalliotakis I, Koumantakis G, Zondervan K, Spandidos DA, Goulielmos GN, Zervou MI, Zervou MI, et al: Role of FN1 and GREB1 gene polymorphisms in endometriosis. Mol Med Rep 20: 111-116, 2019.
APA
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G. ... Zervou, M.I. (2019). Role of FN1 and GREB1 gene polymorphisms in endometriosis. Molecular Medicine Reports, 20, 111-116. https://doi.org/10.3892/mmr.2019.10247
MLA
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G., Zondervan, K., Spandidos, D. A., Goulielmos, G. N., Zervou, M. I."Role of FN1 and GREB1 gene polymorphisms in endometriosis". Molecular Medicine Reports 20.1 (2019): 111-116.
Chicago
Matalliotaki, C., Matalliotakis, M., Rahmioglu, N., Mavromatidis, G., Matalliotakis, I., Koumantakis, G., Zondervan, K., Spandidos, D. A., Goulielmos, G. N., Zervou, M. I."Role of FN1 and GREB1 gene polymorphisms in endometriosis". Molecular Medicine Reports 20, no. 1 (2019): 111-116. https://doi.org/10.3892/mmr.2019.10247
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