Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2019 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis

  • Authors:
    • Ye Feng
    • Yanbo Li
    • Lin Li
    • Xuefeng Wang
    • Zhi Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Nephrology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 693-700
    |
    Published online on: May 24, 2019
       https://doi.org/10.3892/mmr.2019.10295
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colon cancer is one of the most commonly diagnosed malignancies and is a leading cause of cancer‑associated mortality. The aim of the present study was to investigate the molecular mechanisms underlying colon cancer and identify potentially significant genes associated with the disease using weighted gene co‑expression network analysis (WGCNA). The test datasets used were downloaded from The Cancer Genome Atlas (TCGA) database. WGCNA was applied to analyze microarray data obtained from colon adenocarcinoma samples to identify significant modules and highly associated genes. A gene co‑expression network was constructed and different gene modules were selected. Functional and pathway enrichment analyses were performed to investigate the molecular mechanisms of colon cancer. In addition, highly connected hub genes associated with the most significant module were selected for further analysis. Nine specific modules associated with colon cancer were identified, of which the turquoise module was observed to exhibit the greatest association with the disease. Pathway enrichment analysis of the turquoise module suggested that genes in the turquoise module were associated with ‘RNA polymerase’ and ‘purine metabolism’. Furthermore, gene ontology enrichment analysis revealed the top 30 hub genes with a higher degree in the turquoise module, such as σ‑non‑opioid intracellular receptor 1, transmembrane protein 147  TMEM147) and carbamoyl‑phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, were predominantly enriched in the biological processes ‘translation’ and ‘gene expression’. Experimental verification demonstrated that the expression of TMEM147 in colon cancer was significantly increased compared with the control. Therefore, the results suggested that genes associated with RNA polymerase and the purine metabolic pathways may be substantially involved in the pathogenesis of colon cancer. Furthermore, TMEM147 may represent a biomarker for colon cancer.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Bertelsen CA, Neuenschwander AU, Jansen JE, Wilhelmsen M, Kirkegaard-Klitbo A, Tenma JR, Bols B, Ingeholm P, Rasmussen LA, Jepsen LV, et al: Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: A retrospective, population-based study. Lancet Oncol. 16:161–168. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tauriello DV, Calon A, Lonardo E and Batlle E: Determinants of metastatic competency in colorectal cancer. Mol Oncol. 11:97–119. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Kantara C, O'connell MR, Luthra G, Gajjar A, Sarkar S, Ullrich RL and Singh P: Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis. Lab Invest. 95:100–112. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Tie J, Wang Y, Tomasetti C, Li L, Springer S, Kinde I, Silliman N, Tacey M, Wong HL, Christie M, et al: Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci Transl Med. 8:346ra922016. View Article : Google Scholar : PubMed/NCBI

6 

Gröne J, Weber B, Staub E, Heinze M, Klaman I, Pilarsky C, Hermann K, Castanos-Velez E, Röpcke S, Mann B, et al: Differential expression of genes encoding tight junction proteins in colorectal cancer: Frequent dysregulation of claudin-1, −8 and −12. Int J Colorectal Dis. 22:651–659. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Solé X, Crous-Bou M, Cordero D, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R and Moreno V: Discovery and validation of new potential biomarkers for early detection of colon cancer. PLoS One. 9:e1067482014. View Article : Google Scholar : PubMed/NCBI

8 

Bhat A, Pope J, Smith J, Ahmad R, Chen X, Washington M, Beauchamp R, Singh A and Dhawan P: Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Oncogene. 34:4570–4580. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wang J, Yu H, Ye L, Jin L, Yu M and Lv Y: Integrated regulatory mechanisms of miRNAs and targeted genes involved in colorectal cancer. Int J Clin Exp Pathol. 8:517–529. 2015.PubMed/NCBI

10 

Dekervel J, Hompes D, van Malenstein H, Popovic D, Sagaert X, De Moor B, Van Cutsem E, D'hoore A, Verslype C and van Pelt J: Hypoxia-driven gene expression is an independent prognostic factor in stage II and III colon cancer patients. Clin Cancer Res. 20:2159–2168. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Dalerba P, Sahoo D, Paik S, Guo X, Yothers G, Song N, Wilcox-Fogel N, Forgó E, Rajendran PS, Miranda SP, et al: CDX2 as a prognostic biomarker in stage II and stage III colon cancer. N Engl J Med. 374:211–222. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Qiu CZ, Wang MZ, Yu WS, Guo YT, Wang CX and Yang XF: Correlation of GOLPH3 gene with Wnt signaling pathway in human colon cancer cells. J Cancer. 7:928–934. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich T, Arnold GJ, Krebs S, Blum H, Hermeking H, et al: ADNP is a therapeutically inducible repressor of WNT signaling in colorectal cancer. Clin Cancer Res. 23:2769–2780. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, et al: The RNA-binding protein ESRP1 promotes human colorectal cancer progression. Oncotarget. 8:10007–10024. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Gao B, Shao Q, Choudhry H, Marcus V, Dong K, Ragoussis J and Gao ZH: Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. Int J Oncol. 49:1108–1118. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Liu J, Jing L and Tu X: Weighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery disease. BMC Cardiovasc Disord. 16:542016. View Article : Google Scholar : PubMed/NCBI

17 

Jha M, Malhotra AG, Singh S and Pandey KM: Gene co-expression network analysis reveals common system-level properties of genes involved in tuberculosis across independent gene expression studies. Netw Model Anal Health Inform Bioinforma. 5:242016. View Article : Google Scholar

18 

Tomczak K, Czerwinska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

19 

Sun D, Chen J, Liu L, Zhao G, Dong P, Wu B, Wang J and Dong L: Establishment of a 12-gene expression signature to predict colon cancer prognosis. PeerJ. 6:e49422018. View Article : Google Scholar : PubMed/NCBI

20 

Chen XY, Zhang J, Hou LD, Zhang R, Chen W, Fan HN, Huang YX, Liu H and Zhu JS: Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma. Int J Immunopathol Pharmacol. 32:20587384187903182018. View Article : Google Scholar : PubMed/NCBI

21 

Johnson WE, Li C and Rabinovic A: Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 8:118–127. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

23 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

24 

Horvath S and Dong J: Geometric interpretation of gene coexpression network analysis. PLoS Comput Biol. 4:e10001172008. View Article : Google Scholar : PubMed/NCBI

25 

Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID bioinformatics resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Ma C, Lv Q, Teng S, Yu Y, Niu K and Yi C: Identifying key genes in rheumatoid arthritis by weighted gene co-expression network analysis. Int J Rheum Dis. 20:971–979. 2017. View Article : Google Scholar : PubMed/NCBI

28 

White RJ: RNA polymerase III transcription and cancer. Oncogene. 23:3208–3216. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Bellido F, Sowada N, Mur P, Lázaro C, Pons T, Valdés-Mas R, Pineda M, Aiza G, Iglesias S, Soto JL, et al: Association between germline mutations in BRF1, a subunit of the RNA polymerase III transcription complex, and hereditary colorectal cancer. Gastroenterology. 154:181–194. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Ozturk HS, Karaayvaz M, Kacmaz M, Kavutcu M, Akgül H and Durak I: Activities of the enzymes participating in purine and free-radical metabolism in cancerous human colorectal tissues. Cancer Biochem Biophys. 16:157–168. 1998.PubMed/NCBI

31 

Parker WB: Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev. 109:2880–2893. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Belzil VV, Daoud H, Camu W, Strong MJ, Dion PA and Rouleau GA: Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia. Eur J Hum Genet. 21:237–239. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Bernard-Marissal N, Médard JJ, Azzedine H and Chrast R: Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration. Brain. 138:875–890. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Gueguinou M, Crottès D, Chantôme A, Rapetti-Mauss R, Potier-Cartereau M, Clarysse L, Girault A, Fourbon Y, Jézéquel P, Guérin-Charbonnel C, et al: The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis. Oncogene. 36:3640–3647. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Sun B, Kawahara M, Ehata S and Nagamune T: AAG8 promotes carcinogenesis by activating STAT3. Cell Signal. 26:1863–1869. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Crottès D, Rapetti-Mauss R, Alcaraz-Perez F, Tichet M, Gariano G, Martial S, Guizouarn H, Pellissier B, Loubat A, Popa A, et al: SigmaR1 regulates membrane electrical activity in response to extracellular matrix stimulation to drive cancer cell invasiveness. Cancer Res. 76:607–618. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Yu F, Ng SS, Chow BK, Sze J, Lu G, Poon WS, Kung HF and Lin MC: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J Neurooncol. 103:187–195. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Rosemond E, Rossi M, McMillin SM, Scarselli M, Donaldson JG and Wess J: Regulation of M3 muscarinic receptor expression and function by transmembrane protein 147. Mol Pharmacol. 79:251–261. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Khan S, Abdelrahim M, Samudio I and Safe S: Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. Endocrinology. 144:2325–2335. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Wilkinson MF and Shyu AB: Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm. Bioessays. 23:775–787. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Löffler M, Fairbanks LD, Zameitat E, Marinaki AM and Simmonds HA: Pyrimidine pathways in health and disease. Trends Mol Med. 11:430–437. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Evans ME, Jones DP and Ziegler TR: Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. Am J Physiol Gastrointest Liver Physiol. 289:G388–G396. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Li Y, Li L, Wang X and Chen Z: Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis. Mol Med Rep 20: 693-700, 2019.
APA
Feng, Y., Li, Y., Li, L., Wang, X., & Chen, Z. (2019). Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis. Molecular Medicine Reports, 20, 693-700. https://doi.org/10.3892/mmr.2019.10295
MLA
Feng, Y., Li, Y., Li, L., Wang, X., Chen, Z."Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis". Molecular Medicine Reports 20.1 (2019): 693-700.
Chicago
Feng, Y., Li, Y., Li, L., Wang, X., Chen, Z."Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis". Molecular Medicine Reports 20, no. 1 (2019): 693-700. https://doi.org/10.3892/mmr.2019.10295
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Li Y, Li L, Wang X and Chen Z: Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis. Mol Med Rep 20: 693-700, 2019.
APA
Feng, Y., Li, Y., Li, L., Wang, X., & Chen, Z. (2019). Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis. Molecular Medicine Reports, 20, 693-700. https://doi.org/10.3892/mmr.2019.10295
MLA
Feng, Y., Li, Y., Li, L., Wang, X., Chen, Z."Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis". Molecular Medicine Reports 20.1 (2019): 693-700.
Chicago
Feng, Y., Li, Y., Li, L., Wang, X., Chen, Z."Identification of specific modules and significant genes associated with colon cancer by weighted gene co‑expression network analysis". Molecular Medicine Reports 20, no. 1 (2019): 693-700. https://doi.org/10.3892/mmr.2019.10295
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team