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Article

LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet

  • Authors:
    • Tao Hao
    • Hongying Chen
    • Sisi Wu
    • Haoming Tian
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Core Facility, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 701-708
    |
    Published online on: May 28, 2019
       https://doi.org/10.3892/mmr.2019.10304
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Abstract

The pathogenesis of nonalcoholic fatty liver disease non‑alcoholic steatohepatitis (NASH) has not been fully elucidated, and there are currently no effective treatments for NASH. The aim of the present study was to explore the therapeutic effects of the glucagon‑like peptide‑1 (GLP‑1) receptor agonist liraglutide (LRG) on NASH and the underlying mechanisms. C57BL6J mice were fed a high‑fat diet (HFD) for 8 weeks to induce hepatic steatosis, and then LRG was injected subcutaneously for 4 weeks. The expression of sterol regulatory element‑binding protein 1 (SREBP1) and adenosine monophosphate‑activated protein kinase (AMPK) as well as the phosphorylation of mechanistic target of rapamycin (mTOR) and p70 ribosomal S6 kinase (p70S6K) were determined by western blot analysis. The intracellular distribution of SREBP1 was assessed by immunofluorescence staining. The results revealed that LRG treatment ameliorated HFD‑induced hepatic lipid accumulation and inhibited body weight gain. In addition, LRG treatment significantly suppressed the expression of hepatic SREBP1 as well as the phosphorylation of mTOR and p70S6K; it also increased the phosphorylation of AMPK and acetyl coenzyme A carboxylase. Furthermore, LRG treatment inhibited the hepatic nuclear translocation of SREBP1. It was suggested that the GLP‑1 receptor agonist LRG may have ameliorated hepatic steatosis by activating the AMPK/mTOR/SREBP1 signaling pathway as opposed to inhibiting body weight gain.
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1 

Vernon G, Baranova A and Younossi ZM: Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 34:274–285. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL and Friedman JE: Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 63:2702–2713. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Chackelevicius CM, Gambaro SE, Tiribelli C and Rosso N: Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis. World J Gastroenterol. 22:9096–9103. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Clarke JD, Dzierlenga AL, Nelson NR, Li H, Werts S, Goedken MJ and Cherrington NJ: Mechanism of altered metformin distribution in nonalcoholic steatohepatitis. Diabetes. 64:3305–3313. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Little TJ, Doran S, Meyer JH, Smout AJ, O'Donovan DG, Wu KL, Jones KL, Wishart J, Rayner CK, Horowitz M and Feinle-Bisset C: The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab. 291:E647–E655. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kitade H, Chen G, Ni Y and Ota T: nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments. Nutrients. 9(pii): E3872017. View Article : Google Scholar : PubMed/NCBI

7 

Byrne CD and Targher G: NAFLD: A multisystem disease. J Hepatol. 62 (Suppl):S47–S64. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Yamazaki S, Satoh H and Watanabe T: Liraglutide enhances insulin sensitivity by activating AMP-activated protein kinase in male Wistar rats. Endocrinology. 155:3288–3301. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Bakan I and Laplante M: Connecting mTORC1 signaling to SREBP-1 activation. Curr Opin Lipidol. 23:226–234. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Li S, Ogawa W, Emi A, Hayashi K, Senga Y, Nomura K, Hara K, Yu D and Kasuga M: Role of S6K1 in regulation of SREBP1c expression in the liver. Biochem Biophys Res Commun. 412:197–202. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Kim LC, Cook RS and Chen J: mTORC1 and mTORC2 in cancer and the tumor microenvironment. Oncogene. 36:2191–2201. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Song YM, Lee YH, Kim JW, Ham DS, Kang ES, Cha BS, Lee HC and Lee BW: Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy. 11:46–59. 2015. View Article : Google Scholar : PubMed/NCBI

13 

He Q, Sha S, Sun L, Zhang J and Dong M: GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway. Biochem Biophys Res Commun. 476:196–203. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Soliman GA: The integral role of mTOR in lipid metabolism. Cell Cycle. 10:861–862. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Quan HY, Kim DY, Kim SJ, Jo HK, Kim GW and Chung SH: Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. Biochem Pharmacol. 85:1330–1340. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Wang S, Li X, Guo H, Yuan Z, Wang T, Zhang L and Jiang Z: Emodin alleviates hepatic steatosis by inhibiting SREBP1 activity via the CaMKK-AMPK-mTOR-p70S6K signaling pathway: Emodin alleviates NAFLD by CaMKK-AMPK-mTOR-SREBP1. Hepatol Res. 47:2016.

17 

Jones B, Bloom SR, Buenaventura T, Tomas A and Rutter GA: Control of insulin secretion by GLP-1. Peptides. 100:75–84. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH and Drucker DJ: The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Endocrinology. 150:1155–1164. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Lee J, Hong SW, Rhee EJ and Lee WY: GLP-1 receptor agonist and non-alcoholic fatty liver disease. Diabetes Metab J. 36:262–267. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Butler PC: Glucagon-like peptide 1 drugs as second-line therapy for type 2 diabetes. JAMA Intern Med. 176:1–3. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wang XC, Gusdon AM, Liu H and Qu S: Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation. World J Gastroenterol. 20:14821–14830. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Dong Y, Lv Q, Li S, Wu Y, Li L, Li J, Zhang F, Sun X and Tong N: Efficacy and safety of glucagon-like peptide-1 receptor agonists in non-alcoholic fatty liver disease: A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 41:284–295. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hansen BC, Gografe S, Pritt S, Jen KC, McWhirter CA, Barman SM, Comuzzie A, Greene M, McNulty JA, Michele DE, et al: Ensuring due process in the IACUC and animal welfare setting: Considerations in developing noncompliance policies and procedures for institutional animal care and use committees and institutional officials. FASEB J. 31:4216–4225. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Cheluvappa R, Scowen P and Eri R: Ethics of animal research in human disease remediation, its institutional teaching; and alternatives to animal experimentation. Pharmacol Res Perspect. 5:2017. View Article : Google Scholar : PubMed/NCBI

25 

Liu J, Wang G, Jia Y and Xu Y: GLP-1 receptor agonists: Effects on the progression of non-alcoholic fatty liver disease. Diabetes Metab Res Rev. 31:329–335. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN and Sabatini DM: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146:408–420. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R and Shore D: Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell. 33:704–716. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Gowans GJ, Hawley SA, Ross FA and Hardie DG: AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab. 18:556–566. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Bojic LA, Telford DE, Fullerton MD, Ford RJ, Sutherland BG, Edwards JY, Sawyez CG, Gros R, Kemp BE, Steinberg GR and Huff MW: PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. J Lipid Res. 55:1254–1266. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Laplante M and Sabatini DM: An emerging role of mTOR in lipid biosynthesis. Curr Biol. 19:R1046–R1052. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Melnik BC: Linking diet to acne metabolomics, inflammation, and comedogenesis: An update. Clin Cosmet Investig Dermatol. 8:371–388. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Carling D and Viollet B: Beyond energy homeostasis: The expanding role of AMP-activated protein kinase in regulating metabolism. Cell Metab. 21:799–804. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Jeong KJ, Kim GW and Chung SH: AMP-activated protein kinase: An emerging target for ginseng. J Ginseng Res. 38:83–88. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Horton JD, Goldstein JL and Brown MS: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 109:1125–1131. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, et al: Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 39:171–183. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ and Jefferson LS: The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab. 304:E229–E236. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ricoult SJ, Yecies JL, Ben-Sahra I and Manning BD: Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 35:1250–1260. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Laplante M and Sabatini DM: Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci. 126:1713–1719. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Katsurada K and Yada T: Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist. J Diabetes Investig. 7 (Suppl 1):S64–S69. 2016. View Article : Google Scholar

40 

Cariou B: Pleiotropic effects of insulin and GLP-1 receptor agonists: Potential benefits of the association. Diabetes Metab 41 (6 Suppl 1). 6S28–6S35. 2015. View Article : Google Scholar

41 

Seufert J and Gallwitz B: The extra-pancreatic effects of GLP-1 receptor agonists: A focus on the cardiovascular, gastrointestinal and central nervous systems. Diabetes Obes Metab. 16:673–688. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hao T, Chen H, Wu S and Tian H: LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. Mol Med Rep 20: 701-708, 2019.
APA
Hao, T., Chen, H., Wu, S., & Tian, H. (2019). LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. Molecular Medicine Reports, 20, 701-708. https://doi.org/10.3892/mmr.2019.10304
MLA
Hao, T., Chen, H., Wu, S., Tian, H."LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet". Molecular Medicine Reports 20.1 (2019): 701-708.
Chicago
Hao, T., Chen, H., Wu, S., Tian, H."LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet". Molecular Medicine Reports 20, no. 1 (2019): 701-708. https://doi.org/10.3892/mmr.2019.10304
Copy and paste a formatted citation
x
Spandidos Publications style
Hao T, Chen H, Wu S and Tian H: LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. Mol Med Rep 20: 701-708, 2019.
APA
Hao, T., Chen, H., Wu, S., & Tian, H. (2019). LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. Molecular Medicine Reports, 20, 701-708. https://doi.org/10.3892/mmr.2019.10304
MLA
Hao, T., Chen, H., Wu, S., Tian, H."LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet". Molecular Medicine Reports 20.1 (2019): 701-708.
Chicago
Hao, T., Chen, H., Wu, S., Tian, H."LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet". Molecular Medicine Reports 20, no. 1 (2019): 701-708. https://doi.org/10.3892/mmr.2019.10304
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