1
|
Simonneau G, Gatzoulis MA, Adatia I,
Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Kumar RK,
Landzberg M, Machado RF, et al: Updated clinical classification of
pulmonary hypertension. Turk Kardiyol Dern Arsivi (Turkish). 42
(Suppl):S45–S54. 2014.
|
2
|
D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky
EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM,
Kernis JT, et al: Survival in patients with primary pulmonary
hypertension. Results from a national prospective registry. Ann
Intern Med. 115:343–349. 1991. View Article : Google Scholar : PubMed/NCBI
|
3
|
McLaughlin VV, Sitbon O, Badesch DB, Barst
RJ, Black C, Galiè N, Rainisio M, Simonneau G and Rubin LJ:
Survival with first-line bosentan in patients with primary
pulmonary hypertension. Eur Respir J. 25:244–249. 2005. View Article : Google Scholar : PubMed/NCBI
|
4
|
Chan SY and Loscalzo J: Pathogenic
mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol.
44:14–30. 2008. View Article : Google Scholar : PubMed/NCBI
|
5
|
Tang H, Desai AA and Yuan JX: Genetic
insights into pulmonary arterial hypertension. Application of
whole-exome sequencing to the study of pathogenic mechanisms. Am J
Respir Crit Care Med. 194:393–397. 2016. View Article : Google Scholar : PubMed/NCBI
|
6
|
Zhou W, Negash S, Liu J and Raj JU:
Modulation of pulmonary vascular smooth muscle cell phenotype in
hypoxia: Role of cGMP-dependent protein kinase and myocardin. Am J
Physiol Lung Cell Mol Physiol. 296:L780–L789. 2009. View Article : Google Scholar : PubMed/NCBI
|
7
|
Bartel DP: MicroRNAs: Genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Bushati N and Cohen SM: microRNA
functions. Annu Rev Cell Dev Biol. 23:175–205. 2007. View Article : Google Scholar : PubMed/NCBI
|
9
|
Krol J, Loedige I and Filipowicz W: The
widespread regulation of microRNA biogenesis, function and decay.
Nat Rev Genet. 11:597–610. 2010. View
Article : Google Scholar : PubMed/NCBI
|
10
|
Bertero T, Lu Y, Annis S, Hale A, Bhat B,
Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, et al:
Systems-level regulation of microRNA networks by miR-130/301
promotes pulmonary hypertension. J Clin Invest. 124:3514–3528.
2014. View
Article : Google Scholar : PubMed/NCBI
|
11
|
Caruso P, Dempsie Y, Stevens HC, McDonald
RA, Long L, Lu R, White K, Mair KM, McClure JD, Southwood M, et al:
A role for miR-145 in pulmonary arterial hypertension: Evidence
from mouse models and patient samples. Circ Res. 111:290–300. 2012.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Potus F, Graydon C, Provencher S and
Bonnet S: Vascular remodeling process in pulmonary arterial
hypertension, with focus on miR-204 and miR-126 (2013 Grover
Conference series). Pulm Circ. 4:175–184. 2014. View Article : Google Scholar : PubMed/NCBI
|
13
|
Gore B, Izikki M, Mercier O, Dewachter L,
Fadel E, Humbert M, Dartevelle P, Simonneau G, Naeije R, Lebrin F
and Eddahibi S: Key role of the endothelial TGF-beta/ALK1/endoglin
signaling pathway in humans and rodents pulmonary hypertension.
PLoS One. 9:e1003102014. View Article : Google Scholar : PubMed/NCBI
|
14
|
Savage-Dunn C: TGF-beta signaling.
WormBook. 9:1–12. 2005.
|
15
|
Yan Y, Wang XJ, Li SQ, Yang SH, Lv ZC,
Wang LT, He YY, Jiang X, Wang Y and Jing ZC: Elevated levels of
plasma transforming growth factor-β1 in idiopathic and heritable
pulmonary arterial hypertension. Int J Cardiol. 222:368–374. 2016.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Massague J: TGF-beta signal transduction.
Ann Rev Biochem. 67:753–791. 1998. View Article : Google Scholar : PubMed/NCBI
|
17
|
Oh SP, Seki T, Goss KA, Imamura T, Yi Y,
Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S and Li E: Activin
receptor-like kinase 1 modulates transforming growth factor-beta 1
signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S
A. 97:2626–2631. 2000. View Article : Google Scholar : PubMed/NCBI
|
18
|
Uznanska-Loch B, Wiklo K,
Kulczycka-Wojdala D, Szymańska B, Chrzanowski Ł, Wierzbowska-Drabik
K, Trzos E, Kasprzak JD and Kurpesa M: Genetic variants in a Polish
population of patients with pulmonary arterial hypertension:
Sequencing of BMPR2, ALK1, and ENG genes. Kardiol Pol. 76:852–859.
2018. View Article : Google Scholar : PubMed/NCBI
|
19
|
Chida A, Shintani M, Yagi H, Fujiwara M,
Kojima Y, Sato H, Imamura S, Yokozawa M, Onodera N, Horigome H, et
al: Outcomes of childhood pulmonary arterial hypertension in BMPR2
and ALK1 mutation carriers. Am J Cardiol. 110:586–593. 2012.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Zhang H, Du L, Zhong Y, Flanders KC and
Roberts JD Jr: Transforming growth factor-β stimulates Smad1/5
signaling in pulmonary artery smooth muscle cells and fibroblasts
of the newborn mouse through ALK1. Am J Physiol Lung Cell Mol
Physiol. 313:L615–L627. 2017. View Article : Google Scholar : PubMed/NCBI
|
21
|
Zhu D, Mackenzie NC, Shanahan CM, Shroff
RC, Farquharson C and MacRae VE: BMP-9 regulates the osteoblastic
differentiation and calcification of vascular smooth muscle cells
through an ALK1 mediated pathway. J Cell Mol Med. 19:165–174. 2015.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Li L, Shi JY, Zhu GQ and Shi B: MiR-17-92
cluster regulates cell proliferation and collagen synthesis by
targeting TGFB pathway in mouse palatal mesenchymal cells. J Cell
Biochem. 113:1235–1244. 2012. View Article : Google Scholar : PubMed/NCBI
|
23
|
Wang X, Yan C, Xu X, Dong L, Su H, Hu Y,
Zhang R and Ying K: Long noncoding RNA expression profiles of
hypoxic pulmonary hypertension rat model. Gene. 579:23–28. 2016.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Krek A, Grun D, Poy MN, Wolf R, Rosenberg
L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M
and Rajewsky N: Combinatorial microRNA target predictions. Nat
Genet. 37:495–500. 2005. View
Article : Google Scholar : PubMed/NCBI
|
25
|
Lewis BP, Shih IH, Jones-Rhoades MW,
Bartel DP and Burge CB: Prediction of mammalian microRNA targets.
Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI
|
26
|
Zhou S, Sun L, Cao C, Wu P, Li M, Sun G,
Fei G, Ding X and Wang R: Hypoxia-induced microRNA-26b inhibition
contributes to hypoxic pulmonary hypertension via CTGF. J Cell
Biochem. 119:1942–1952. 2018. View Article : Google Scholar : PubMed/NCBI
|
27
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee
DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al:
Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic
Acids Res. 33:e1792005. View Article : Google Scholar : PubMed/NCBI
|
29
|
Wang X: A PCR-based platform for microRNA
expression profiling studies. RNA. 15:716–723. 2009. View Article : Google Scholar : PubMed/NCBI
|
30
|
Song Y, Jones JE, Beppu H, Keaney JF Jr,
Loscalzo J and Zhang YY: Increased susceptibility to pulmonary
hypertension in heterozygous BMPR2-mutant mice. Circulation.
112:553–562. 2005. View Article : Google Scholar : PubMed/NCBI
|
31
|
Fischer AH, Jacobson KA, Rose J and Zeller
R: Hematoxylin and eosin staining of tissue and cell sections. CSH
Protoc 2008: pdb prot4986. 2008.
|
32
|
Xu X, Hu H, Wang X, Ye W, Su H, Hu Y, Dong
L, Zhang R and Ying K: Involvement of CapG in proliferation and
apoptosis of pulmonary arterial smooth muscle cells and in
hypoxia-induced pulmonary hypertension rat model. Exp Lung Res.
42:142–153. 2016. View Article : Google Scholar : PubMed/NCBI
|
33
|
Thum T, Galuppo P, Wolf C, Fiedler J,
Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J,
Haverich A, et al: MicroRNAs in the human heart: A clue to fetal
gene reprogramming in heart failure. Circulation. 116:258–267.
2007. View Article : Google Scholar : PubMed/NCBI
|
34
|
Mann DL: MicroRNAs and the failing heart.
N Eng J Med. 356:2644–2645. 2007. View Article : Google Scholar
|
35
|
Sarkar J, Gou D, Turaka P, Viktorova E,
Ramchandran R and Raj JU: MicroRNA-21 plays a role in
hypoxia-mediated pulmonary artery smooth muscle cell proliferation
and migration. Am J Physiol Lung Cell Mol Physiol. 299:L861–L871.
2010. View Article : Google Scholar : PubMed/NCBI
|
36
|
Courboulin A, Paulin R, Giguère NJ,
Saksouk N, Perreault T, Meloche J, Paquet ER, Biardel S, Provencher
S, Côté J, et al: Role for miR-204 in human pulmonary arterial
hypertension. J Exp Med. 208:535–548. 2011. View Article : Google Scholar : PubMed/NCBI
|
37
|
Guo L, Qiu Z, Wei L, Yu X, Gao X, Jiang S,
Tian H, Jiang C and Zhu D: The microRNA-328 regulates hypoxic
pulmonary hypertension by targeting at insulin growth factor 1
receptor and L-type calcium channel-α1C. Hypertension.
59:1006–1013. 2012. View Article : Google Scholar : PubMed/NCBI
|
38
|
Siragam V, Rutnam ZJ, Yang W, Fang L, Luo
L, Yang X, Li M, Deng Z, Qian J, Peng C and Yang BB: MicroRNA
miR-98 inhibits tumor angiogenesis and invasion by targeting
activin receptor-like kinase-4 and matrix metalloproteinase-11.
Oncotarget. 3:1370–1385. 2012. View Article : Google Scholar : PubMed/NCBI
|
39
|
Trembath RC: Mutations in the TGF-beta
type 1 receptor, ALK1, in combined primary pulmonary hypertension
and hereditary haemorrhagic telangiectasia, implies pathway
specificity. J Heart Lung Transplant. 20:1752001. View Article : Google Scholar : PubMed/NCBI
|
40
|
Fujiwara M, Yagi H, Matsuoka R, Akimoto K,
Furutani M, Imamura S, Uehara R, Nakayama T, Takao A, Nakazawa M
and Saji T: Implications of mutations of activin receptor-like
kinase 1 gene (ALK1) in addition to bone morphogenetic protein
receptor II gene (BMPR2) in children with pulmonary arterial
hypertension. Circ J. 72:127–133. 2008. View Article : Google Scholar : PubMed/NCBI
|
41
|
Jerkic M, Kabir MG, Davies A, Yu LX,
McIntyre BA, Husain NW, Enomoto M, Sotov V, Husain M, Henkelman M,
et al: Pulmonary hypertension in adult Alk1 heterozygous mice due
to oxidative stress. Cardiovasc Res. 92:375–384. 2011. View Article : Google Scholar : PubMed/NCBI
|
42
|
Soubrier F, Chung WK, Machado R, Grünig E,
Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH and
Humbert M: Genetics and genomics of pulmonary arterial
hypertension. J Am Coll Cardiol. 62:D13–D21. 2013. View Article : Google Scholar : PubMed/NCBI
|