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DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma

  • Authors:
    • Zuohong Ma
    • Yefu Liu
    • Zhiqiang Hao
    • Xiangdong Hua
    • Wenxin Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2519-2532
    |
    Published online on: July 11, 2019
       https://doi.org/10.3892/mmr.2019.10487
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Abstract

Changes in the methylation levels of tumor suppressor genes or proto‑oncogenes are involved in the pathogenesis of hepatitis C virus (HCV) infection‑induced hepatocellular carcinoma (HCC). The aim of the present study was to identify novel aberrantly methylated differentially expressed genes by integrating mRNA expression profile (GSE19665 and GSE62232) and methylation profile (GSE60753) microarrays downloaded from the Gene Expression Omnibus database. Functional enrichment analysis of screened genes was performed using the DAVID software and BinGO database. Protein‑protein interaction (PPI) networks were constructed using the STRING database, followed by module analysis with MCODE software. The transcriptional and translational expression levels of crucial genes were confirmed using The Cancer Genome Atlas (TCGA) datasets and Human Protein Atlas database (HPA). A total of 122 downregulated/hypermethylated genes and 63 upregulated/hypomethylated genes were identified. These genes were enriched in the Gene Ontology biological processes terms of ‘inflammatory response’ [Fos proto‑oncogene, AP‑1 transcription factor subunit (FOS)] and ‘cell cycle process’ [aurora kinase A (AURKA), cyclin dependent kinase inhibitor 3 (CDKN3) and ubiquitin conjugating enzyme E2 C (UBE2C)]. PPI network and module analysis indicated that human oncogenes FOS, AURKA, CDKN3 and UBE2C may be hub genes. mRNA, protein expression and methylation levels of AURKA and FOS were validated by TCGA and HPA data. In conclusion, aberrantly methylated AURKA and FOS may be potential therapeutic targets for HCV‑positive HCC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Jing L, Huang L, Yan J, Qiu M and Yan Y: Liver resection for hepatocellular carcinoma: Personal experiences in a series of 1330 consecutive cases in China. ANZ J Surg. 88:E713–E717. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Petruzziello A: Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) related hepatocellular carcinoma. Open Virol J. 12:26–32. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Moore MS, Bocour A, Tran OC, Qiao B, Schymura MJ, Laraque F and Winters A: Effect of hepatocellular carcinoma on mortality among individuals with Hepatitis B or Hepatitis C infection in New York City, 2001–2012. Open Forum Infect Dis. 5:ofy1442018. View Article : Google Scholar : PubMed/NCBI

5 

Kiran M, Chawla YK and Kaur J: Methylation profiling of tumor suppressor genes and oncogenes in hepatitis virus-related hepatocellular carcinoma in northern India. Cancer Genet Cytogenet. 195:112–119. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Zekri AR, Bahnasy AA, Shoeab FE, Mohamed WS, El-Dahshan DH, Ali FT, Sabry GM, Dasgupta N and Daoud SS: Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma. J Adv Res. 5:27–40. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ramadan RA, Zaki MA, Awad AM and El-Ghalid LA: Aberrant methylation of promoter region of SPINT2/HAI-2 gene: An epigenetic mechanism in hepatitis C virus-induced hepatocarcinogenesis. Genet Test Mol Biomarkers. 19:399–404. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Takagi K, Fujiwara K, Takayama T, Mamiya T, Soma M and Nagase H: DNA hypermethylation of zygote arrest 1 (ZAR1) in hepatitis C virus positive related hepatocellular carcinoma. Springerplus. 2:1502013. View Article : Google Scholar : PubMed/NCBI

9 

Tsunedomi R, Iizuka N, Yoshimura K, Iida M, Tsutsui M, Hashimoto N, Kanekiyo S, Sakamoto K, Tamesa T and Oka M: ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma. Int J Oncol. 42:1551–1559. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mileo AM, Mattarocci S, Matarrese P, Anticoli S, Abbruzzese C, Catone S, Sacco R, Paggi MG and Ruggieri A: Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation. J Exp Clin Cancer Res. 34:1402015. View Article : Google Scholar : PubMed/NCBI

11 

Quan H, Zhou F, Nie D, Chen Q, Cai X, Shan X, Zhou Z, Chen K, Huang A, Li S and Tang N: Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. Oncogene. 33:2826–2835. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H and Kaneda A: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci. 101:1501–1510. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Yang Y, Chen L, Gu J, Zhang H, Yuan J, Lian Q, Lv G, Wang S, Wu Y, Yang YC, et al: Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 8:144212017. View Article : Google Scholar : PubMed/NCBI

14 

Hlady RA, Tiedemann RL, Puszyk W, Zendejas I, Roberts LR, Choi JH, Liu C and Robertson KD: Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. Oncotarget. 5:9425–9443. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

16 

Szekely GJ and Rizzo ML: Hierarchical clustering via Joint between-within distances: Extending Ward's minimum variance method. J Classification. 22:151–183. 2005. View Article : Google Scholar

17 

Liu Y, Sun J and Zhao M: ONGene: A literature-based database for human oncogenes. J Genet Genomics. 44:119–121. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43 (Database Issue). D447–D452. 2015. View Article : Google Scholar

19 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Tang Y, Li M, Wang J, Pan Y and Wu FX: CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems. 127:67–72. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

22 

Huang DW, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Maere S, Heymans K and Kuiper M: BiNGO: A Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks. Bioinformatics. 21:3448–3449. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Pontén F, Jirström K and Uhlen M: The human protein atlas-a tool for pathology. J Pathol. 216:387–393. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Irshad M, Gupta P and Irshad K: Molecular basis of hepatocellular carcinoma induced by hepatitis C virus infection. World J Hepatol. 9:1305–1314. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Moustafa S, Karakasiliotis I and Mavromara P: Hepatitis C virus core+1/ARF protein modulates Cyclin D1/pRb pathway and promotes carcinogenesis. J Virol. 92(pii): e02036–17. 2018.PubMed/NCBI

27 

Bassiouny AEE, Nosseir MM, Zoheiry MK, Ameen NA, Abdelhadi AM, Ibrahim IM, Zada S, El-Deen AH and El-Bassiouni NE: Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma. World J Hepatol. 2:32–41. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P and Nigg EA: Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 158:617–623. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Benten D, Keller G, Quaas A, Schrader J, Gontarewicz A, Balabanov S, Braig M, Wege H, Moll J, Lohse AW and Brummendorf TH: Aurora kinase inhibitor PHA-739358 suppresses growth of hepatocellular carcinoma in vitro and in a xenograft mouse model. Neoplasia. 11:934–944. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao X, Wang H, Sen S, Hung MC, Mills GB, et al: Aurora Kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 16:3171–3181. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Zhou N, Singh K, Mir MC, Parker Y, Lindner D, Dreicer R, Ecsedy JA, Zhang Z, The BT, Almasan A and Hansel DE: The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res. 19:1717–1728. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Dong W, Qiu JX and Zhou SF: The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. Drug Des Devel Ther. 9:1627–1652. 2015.PubMed/NCBI

33 

Zhu Q, Yu X, Zhou ZW, Zhou C, Chen XW and Zhou SF: Inhibition of Aurora A Kinase by alisertib induces autophagy and cell cycle arrest and increases chemosensitivity in human hepatocellular carcinoma HepG2 cells. Curr Cancer Drug Targets. 17:386–401. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Zhu Q, Yu X, Zhou ZW, Luo M, Zhou C, He ZX, Chen Y and Zhou SF: A quantitative proteomic response of hepatocellular carcinoma Hep3B cells to danusertib, a pan-Aurora kinase inhibitor. J Cancer. 9:2061–2071. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Chen C, Song G, Xiang J, Zhang H, Zhao S and Zhan Y: AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. Biochem Biophys Res Commun. 486:514–520. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Mohiuddin MK, Chava S, Upendrum P, Latha M, Zubeda S, Kumar A, Ahuja YR, Hasan Q and Mohan V: Role of Human papilloma virus infection and altered methylation of specific genes in esophageal cancer. Asian Pac J Cancer Prev. 14:4187–4193. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Watanabe T, Hiasa Y, Tokumoto Y, Hirooka M, Abe M, Ikeda Y, Matsuura B, Chung RT and Onji M: Protein Kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with Hepatitis C virus infection. PLoS One. 8:e677502013. View Article : Google Scholar : PubMed/NCBI

38 

Oliveiraferrer L, Rößler K, Haustein V, Schröder C, Wicklein D, Maltseva D, Khaustova N, Samatov T, Tonevitsky A, Mahner S, et al: c-FOS suppresses ovarian cancer progression by changing adhesion. Br J Cancer. 110:753–763. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Guo JC, Li J, Zhao YP, Zhou L, Cui QC, Zhou WX, Zhang TP and You L: Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer. PLoS One. 10:e01203322015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma Z, Liu Y, Hao Z, Hua X and Li W: DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma. Mol Med Rep 20: 2519-2532, 2019.
APA
Ma, Z., Liu, Y., Hao, Z., Hua, X., & Li, W. (2019). DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma. Molecular Medicine Reports, 20, 2519-2532. https://doi.org/10.3892/mmr.2019.10487
MLA
Ma, Z., Liu, Y., Hao, Z., Hua, X., Li, W."DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma". Molecular Medicine Reports 20.3 (2019): 2519-2532.
Chicago
Ma, Z., Liu, Y., Hao, Z., Hua, X., Li, W."DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma". Molecular Medicine Reports 20, no. 3 (2019): 2519-2532. https://doi.org/10.3892/mmr.2019.10487
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Z, Liu Y, Hao Z, Hua X and Li W: DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma. Mol Med Rep 20: 2519-2532, 2019.
APA
Ma, Z., Liu, Y., Hao, Z., Hua, X., & Li, W. (2019). DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma. Molecular Medicine Reports, 20, 2519-2532. https://doi.org/10.3892/mmr.2019.10487
MLA
Ma, Z., Liu, Y., Hao, Z., Hua, X., Li, W."DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma". Molecular Medicine Reports 20.3 (2019): 2519-2532.
Chicago
Ma, Z., Liu, Y., Hao, Z., Hua, X., Li, W."DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma". Molecular Medicine Reports 20, no. 3 (2019): 2519-2532. https://doi.org/10.3892/mmr.2019.10487
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