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Article

Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes

  • Authors:
    • Guangrong Hu
    • Lingbo Ma
    • Fei Dong
    • Xiao Hu
    • Sida Liu
    • Hui Sun
  • View Affiliations / Copyright

    Affiliations: Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
  • Pages: 3379-3387
    |
    Published online on: August 6, 2019
       https://doi.org/10.3892/mmr.2019.10565
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Abstract

The aims of the present study were to investigate the roles and underlying mechanisms of microRNA‑124‑3p (miR‑124‑3p) in the progression of acute myocardial infarction (AMI). The expression of miR‑124‑3p was determined via reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). TargetScan analysis and a luciferase reporter assay were conducted to reveal the association between miR‑124‑3p and nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) repressing factor (NKRF). To investigate the role of miR‑124‑3p in AMI, a cell model of myocardial hypoxic/ischemic injury was established by subjecting H9c2 cardiac cells to hypoxia for 48 h. The viability of cells was determined using an MTT assay, and cell apoptosis was analyzed by flow cytometry. Additionally, the expression levels of inflammatory factors [tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6] were measured via ELISA. Furthermore, gene and protein expression levels were determined by performing RT‑qPCR and western blot analyses, respectively. It was revealed that the expression of miR‑124‑3p was significantly increased in the blood of patients with AMI and hypoxia‑treated H9c2 cells. Additionally, it was demonstrated that NKRF was a direct target of miR‑124‑3p. The hypoxia‑induced decrease in the viability of H9c2 cells and increase in cell apoptosis were eliminated by the downregulation of miR‑124‑3p. Furthermore, hypoxia significantly increased the levels of TNF‑α, IL‑1β and IL‑6, whereas miR‑124‑3p downregulation eliminated these effects. Downregulated expression of B‑cell lymphoma 2, pro‑caspase 3 and pro‑caspase 9 protein, and upregulated expression of cleaved caspases 3 and 9 was observed in hypoxic H9c2 cells; the altered expression of these proteins was suppressed by miR‑124‑3p inhibitor. Additionally, miR‑124‑3p inhibitor suppressed the hypoxia‑induced activation of the NF‑κB signaling pathway in H9c2 cells. Furthermore, it was demonstrated that the various effects of miR‑124‑3p inhibitor on H9c2 cells were eliminated by the small interfering RNA‑mediated downregulation of NKRF. In conclusion, the results of the present study indicated that miR‑124‑3p downregulation protected against AMI via inhibition of inflammatory responses and the apoptosis of cardiomyocytes by regulating the NKRF/NF‑κB pathway.
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1 

Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al: Executive summary: Heart disease and stroke statistics-2012 update: A report from the American Heart Association. Circulation. 125:188–197. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Reed GW, Rossi JE and Cannon CP: Acute myocardial infarction. Lancet. 389:197–210. 2017. View Article : Google Scholar : PubMed/NCBI

3 

White HD, Thygesen K, Alpert JS and Jaffe AS: Clinical implications of the third universal definition of myocardial infarction. Heart. 100:424–432. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Schüssler-Lenz M, Beuneu C, Menezes-Ferreira M, Jekerle V, Bartunek J, Chamuleau S, Celis P, Doevendans P, O'Donovan M, Hill J, et al: Cell-based therapies for cardiac repair: A meeting report on scientific observations crud European regulatory viewpoints. Eur J Heart Fail. 18:133–141. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Frangogiannis NG: Regulation of the inflammatory response in cardiac repair. Circ Res. 110:159–173. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Feng Y, Zhao J, Hou H, Zhang H, Jiao Y, Wang J, Wang Y and Sun Y: WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation. Acta Biochim Biophys Sin (Shanghai). 48:1075–1084. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Swynghedauw B: Molecular mechanisms of myocardial remodeling. Physiol Rev. 79:215–262. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Minicucci MF, Azevedo PS, Polegato BF, Paiva SA and Zornoff LA: Heart failure after myocardial infarction: Clinical implications and treatment. Clin Cardiol. 34:410–414. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Whelan RS, Kaplinskiy V and Kitsis RN: Cell death in the pathogenesis of heart disease: Mechanisms and significance. Annu Rev Physiol. 72:19–44. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Goretti E, Wagner DR and Devaux Y: miRNAs as biomarkers of myocardial a step forward towards personalized medicine? Trends Mol Med. 20:716–725. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Fathil MF, Md Arshad MK, Gopinath SC, Hashim U, Adzhri R, Ayub RM, Ruslinda AR, Nuzaihan MNM, Azman AH, Zaki M and Tang TH: Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers. Biosens Bioelectron. 70:209–220. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Kim J, Yao F, Xiao Z, Sun Y and Ma L: MicroRNAs and metastasis: Small RNAs play big roles. Cancer Metastasis Rev. 37:5–15. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Kozomara A and Griffiths-Jones S: miRBase: Integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39 (Database Issue). D152–D157. 2011. View Article : Google Scholar

15 

Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83–86. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Fujii T, Shimada K, Nakai T and Ohbayashi C: MicroRNAs in smoking-related carcinogenesis: Biomarkers, functions, and therapy. J Clin Med. 7(pii): E982018. View Article : Google Scholar : PubMed/NCBI

17 

Xu X and Li H: Integrated microRNA-gene analysis of coronary artery disease based on miRNA and gene expression profiles. Mol Med Rep. 13:3063–3073. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Harada M, Luo X, Murohara T, Yang B, Dobrev D and Nattel S: MicroRNA regulation and cardiac calcium signaling: Role in cardiac disease and therapeutic potential. Circ Res. 114:689–705. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Matkovich SJ and Hu Y: Regulation of cardiac microRNAs by cardiac microRNAs. Circ Res. 113:62–71. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chen Z, Li C, Lin K, Zhang Q, Chen Y and Rao L: MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers? Anatol J Cardiol. 19:140–147. 2018.PubMed/NCBI

21 

Paiva S and Agbulut O: MiRroring the multiple potentials of MicroRNAs in acute myocardial infarction. Front Cardiovasc Med. 4:732017. View Article : Google Scholar : PubMed/NCBI

22 

Guo ML, Guo LL and Weng YQ: Implication of peripheral blood miRNA-124 in predicting acute myocardial infarction. Eur Rev Med Pharmacol Sci. 21:1054–1059. 2017.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Dreikhausen U, Hiebenthal-Millow K, Bartels M, Resch K and Nourbakhsh M: NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor. Mol Cell Biol. 25:7473–7483. 2005. View Article : Google Scholar : PubMed/NCBI

25 

White HD and Chew DP: Acute myocardial infarction. Lancet. 372:570–584. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al: Heart disease and stroke statistics-2014 update: A report from the American Heart Association. Circulation. 129:e28–e292. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kulkarni S, Qi Y, O'HUigin C, Pereyra F, Ramsuran V, McLaren P, Fellay J, Nelson G, Chen H, Liao W, et al: Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Proc Natl Acad Sci USA. 110:20705–20710. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Finn NA and Searles CD: Intracellular and extracellular miRNAs in regulation of angiogenesis signaling. Curr Angiogenes. 4:299–307. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Wang YY, Li T, Liu YW, Wang Y, Hu XM, Gao WQ, Wu P, Li X, Peng WJ, Gao W, et al: Ischemic postconditioning before percutaneous coronary intervention for acute ST-segment elevation myocardial infarction reduces contrast-induced nephropathy and improves long-term prognosis. Arch Med Res. 47:483–488. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS and McManus BM: Infammation in myocardial diseases. Circ Res. 110:126–144. 2012. View Article : Google Scholar : PubMed/NCBI

31 

He Q, Zhou W, Xiong C, Tan G and Chen M: Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway. Mol Med Rep. 11:374–378. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Cheng P, Zeng W, Li L, Huo D, Zeng L, Tan J, Zhou J, Sun J, Liu G, Li Y, et al: PLGA-PNIPAM microspheres loaded with the gastrointestinal nutrient NaB ameliorate cardiac dysfunction by activating Sirt3 in acute myocardial infarction. Adv Sci (Weinh). 3:16002542016. View Article : Google Scholar : PubMed/NCBI

33 

Santana ET, Feliciano RD, Serra AJ, Brigidio E, Antonio EL, Tucci PJ, Nathanson L, Morris M and Silva JA Jr: Comparative mRNA and MicroRNA profling during acute myocardial infarction induced by coronary occlusion and ablation radio-frequency currents. Front Physiol. 7:5652016. View Article : Google Scholar : PubMed/NCBI

34 

Geng L, Liu W and Chen Y: miR-124-3p attenuates MPP+-induced neuronal injury by targeting STAT3 in SH-SY5Y cells. Exp Biol Med (Maywood). 242:1757–1764. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Yuan Q, Sun T, Ye F, Kong W and Jin H: MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA. Cancer Biomark. 19:93–101. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Kang Q, Xiang Y, Li D, Liang J, Zhang X, Zhou F, Qiao M, Nie Y, He Y, Cheng J, et al: miR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells. Oncotarget. 8:24314–24326. 2017.PubMed/NCBI

37 

Dong RF, Zhang B, Tai LW, Liu HM, Shi FK and Liu NN: The neuroprotective role of miR-124-3p in a 6-hydroxydopamine-induced cell model of parkinson's disease via the regulation of ANAX5. J Cell Biochem. 119:269–277. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Huang S, Ge X, Yu J, Han Z, Yin Z, Li Y, Chen F, Wang H, Zhang J and Lei P: Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons. FASEB J. 32:512–528. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Jiang N, Xia J, Jiang B, Xu Y and Li Y: TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells. Biomed Pharmacother. 103:1669–1677. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Nourbakhsh M and Hauser H: The transcriptional silencer protein NRF: A repressor of NF-kappa B enhancers. Immunobiology. 198:65–72. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu G, Ma L, Dong F, Hu X, Liu S and Sun H: Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes. Mol Med Rep 20: 3379-3387, 2019.
APA
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., & Sun, H. (2019). Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes. Molecular Medicine Reports, 20, 3379-3387. https://doi.org/10.3892/mmr.2019.10565
MLA
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., Sun, H."Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes". Molecular Medicine Reports 20.4 (2019): 3379-3387.
Chicago
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., Sun, H."Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes". Molecular Medicine Reports 20, no. 4 (2019): 3379-3387. https://doi.org/10.3892/mmr.2019.10565
Copy and paste a formatted citation
x
Spandidos Publications style
Hu G, Ma L, Dong F, Hu X, Liu S and Sun H: Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes. Mol Med Rep 20: 3379-3387, 2019.
APA
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., & Sun, H. (2019). Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes. Molecular Medicine Reports, 20, 3379-3387. https://doi.org/10.3892/mmr.2019.10565
MLA
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., Sun, H."Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes". Molecular Medicine Reports 20.4 (2019): 3379-3387.
Chicago
Hu, G., Ma, L., Dong, F., Hu, X., Liu, S., Sun, H."Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes". Molecular Medicine Reports 20, no. 4 (2019): 3379-3387. https://doi.org/10.3892/mmr.2019.10565
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