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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October-2019 Volume 20 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Targeting heterotopic ossification by inhibiting activin receptor‑like kinase 2 function (Review)

Fuli Shi, Jiayu Gao, Junrong Zou, Ying Ying, Hui Lin
Pages: 2979-2989
Published online on: 06 August 2019

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Article Open Access

An 8‑gene signature predicts the prognosis of cervical cancer following radiotherapy

Fei Xie, Dan Dong, Na Du, Liang Guo, Weihua Ni, Hongyan Yuan, Nannan Zhang, Jiang Jie, Guomu Liu, Guixiang Tai
Pages: 2990-3002
Published online on: 29 July 2019

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Article Open Access

SREBP2 is upregulated in esophageal squamous cell carcinoma and co‑operates with c‑Myc to regulate HMGCR expression

Chenxi Zhong, Limin Fan, Zhigang Li, Feng Yao, Heng Zhao
Pages: 3003-3010
Published online on: 09 August 2019

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Article Open Access

MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data

Hongshi Cao, Yu Zhang, Zhe Chu, Bolun Zhao, Haiyan Wang, Libin An
Pages: 3011-3018
Published online on: 30 July 2019

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Article Open Access

Effect of estradiol on high glucose‑induced osteoblast injury

Guangrun Li, Xiaofeng Jiang, Liping Liu, Xiaoyang Liu, Hongtao Liu, Zuofu Zhang
Pages: 3019-3026
Published online on: 06 August 2019

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Article Open Access

Curcumin protects the pancreas from acute pancreatitis via the mitogen‑activated protein kinase signaling pathway

Yingjie Wang, Chanyuan Bu, Kangkang Wu, Rui Wang, Jiayong Wang
Pages: 3027-3034
Published online on: 01 August 2019

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Article Open Access

Role of osteoprotegerin in the regulation of dental epithelial‑mesenchymal signaling during tooth development

Xin Gao, Junming Zheng, Shaoqin Tu, Bin Cai, Rongsheng Zeng, Lusai Xiang
Pages: 3035-3042
Published online on: 07 August 2019

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Article Open Access

MicroRNA‑451 relieves inflammation in cerebral ischemia‑reperfusion via the Toll‑like receptor 4/MyD88/NF‑κB signaling pathway

Wenyan Li, Minghao Dong, Liangzhao Chu, Luqian Feng, Xiaochuan Sun
Pages: 3043-3054
Published online on: 12 August 2019

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Article Open Access

STC1 regulates glioblastoma migration and invasion via the TGF‑β/SMAD4 signaling pathway

Yan Xiong, Qibai Wang
Pages: 3055-3064
Published online on: 09 August 2019

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Article Open Access

Therapeutic effect of transplantation of human bone marrow‑derived mesenchymal stem cells on neuron regeneration in a rat model of middle cerebral artery occlusion

Ping Xie, Ming Deng, Qin‑Guo Sun, Yong‑Gang Ma, Yan Zhou, Jiang‑Hua Ming, Qing Chen, Shi‑Qing Liu, Jun‑Qi Liu, Jun Cai, Fei Wu
Pages: 3065-3074
Published online on: 30 July 2019

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Article Open Access

Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray

Junkui Sun, Hongen Xu, Muge Qi, Chi Zhang, Jianxiang Shi
Pages: 3075-3084
Published online on: 31 July 2019

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Article Open Access

Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway

Yan Li, Lidan Liu, Yue Tian, Jin Zhang
Pages: 3085-3094
Published online on: 31 July 2019

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Article Open Access

Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways

Chun‑Yang Han, Tao‑Tao Sun, Guang‑Pei Xv, Si‑Si Wang, Jin‑Gang Gu, Cui‑Yan Liu
Pages: 3095-3102
Published online on: 06 August 2019

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Article Open Access

COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer

Xiaoxia Jiang, Mengjie Wu, Xin Xu, Liwei Zhang, Yingying Huang, Zhenzhen Xu, Kuifeng He, Haiyong Wang, Haohao Wang, Lisong Teng
Pages: 3103-3112
Published online on: 01 August 2019

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Article Open Access

Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway

Hai‑Jin Zhang, Yi‑Na Zhang, Zong‑Yan Teng
Pages: 3113-3122
Published online on: 07 August 2019

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Article Open Access

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production

Chun Fan, Qiuxia Ji, Chunyang Zhang, Shuo Xu, Hui Sun, Zhiyuan Li
Pages: 3123-3130
Published online on: 09 August 2019

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Article Open Access

Halofuginone protects against advanced glycation end products‑induced injury of H9C2 cells via alleviating endoplasmic reticulum stress‑associated apoptosis and inducing autophagy

Yu‑Hui Li, Wei‑Li Zhang, Hao‑Ying Zhou, Da‑Wei Yu, Xiao‑Ning Sun, Qin Hu
Pages: 3131-3139
Published online on: 06 August 2019

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Article Open Access

MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer

Li Liu, Wuzhang Wang, Song Gao, Xiuwen Wang
Pages: 3140-3148
Published online on: 31 July 2019

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Article Open Access

Upregulated microRNA‑671‑3p promotes tumor progression by suppressing forkhead box P2 expression in non‑small‑cell lung cancer Retraction in /10.3892/mmr.2026.13829

Zhi‑Ying Li, Zi‑Zhou Zhang, Hui Bi, Qiu‑Di Zhang, Su‑Juan Zhang, Lin Zhou, Xiao‑Qin Zhu, Jun Zhou
Pages: 3149-3159
Published online on: 06 August 2019

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Article Open Access

lncRNA/circRNA‑miRNA‑mRNA ceRNA network in lumbar intervertebral disc degeneration

Jinwen Zhu, Xinliang Zhang, Wenjie Gao, Huimin Hu, Xiaodong Wang, Dingjun Hao
Pages: 3160-3174
Published online on: 07 August 2019

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Article Open Access

Ginsenoside Rb1 prevents steroid‑induced avascular necrosis of the femoral head through the bone morphogenetic protein‑2 and vascular endothelial growth factor pathway

Junwu Ye, Daiqin Wei, Lin Peng, Tianmin Chang
Pages: 3175-3181
Published online on: 06 August 2019

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Article Open Access

MicroRNA‑217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1

Liyun Zhang, Juan Chen, Qin He, Ze Chao, Xuyong Li, Manhua Chen
Pages: 3182-3190
Published online on: 09 August 2019

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Article Open Access

Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins

Chong Yu, Xiang Wang, Yi Hong, Guojun Chen, Jin  Ge, Hao Cao, Bin Zhou
Pages: 3191-3201
Published online on: 01 August 2019

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Article Open Access

PPWD1 is associated with the occurrence of postmenopausal osteoporosis as determined by weighted gene co‑expression network analysis

Guo‑Feng Qian, Lu‑Shun Yuan, Min Chen, Dan Ye, Guo‑Ping Chen, Zhe Zhang, Cheng‑Jiang Li, Vijith Vijayan, Yu Xiao
Pages: 3202-3214
Published online on: 07 August 2019

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Article Open Access

Allium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma mouse model

So‑Hyeon Bok, Ji‑Hye Seo, Chun‑Sik Bae, Bossng Kang, Seung Sik Cho, Dae‑Hun Park
Pages: 3215-3223
Published online on: 06 August 2019

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Article Open Access

Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice

Youlin Wang, Pan Yang, Bo Zhang, Yao Ding, Shun  Lei, Yuning Hou, Xiaoqing Guan, Qingwang Li
Pages: 3224-3232
Published online on: 01 August 2019

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Article Open Access

Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX

Jingjing Wu, Bin Wei, Yuye Shi, Xueying Lu, Yihan Ding, Chunling Wang, Yufeng Li
Pages: 3233-3239
Published online on: 31 July 2019

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Article Open Access

Krüppel‑like factor 4 ameliorates diabetic kidney disease by activating autophagy via the mTOR pathway

Jianguang Gong, Huifang Zhan, Yiwen Li, Wei Zhang, Juan Jin, Qiang He
Pages: 3240-3248
Published online on: 09 August 2019

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Article Open Access

Proapoptotic effects of 2,5‑hexanedione on pheochromocytoma cells via oxidative injury

Baoning Qi, Shouzhu Xu, Yuan Liang, Jiaxin Wang, Zhigang Zhang, Juan Li, Jing Zhou
Pages: 3249-3255
Published online on: 01 August 2019

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Article Open Access

miR‑320a upregulation contributes to the development of preeclampsia by inhibiting the growth and invasion of trophoblast cells by targeting interleukin 4

Ning Xie, Zhi Jia, Li Li
Pages: 3256-3264
Published online on: 08 August 2019

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Article Open Access

Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling

Zhu‑Ling Jiang, Han Jin, Zhong‑Shuang Liu, Ming‑Yue Liu, Xiao‑Fang Cao, Yang‑Yang Jiang, Hong‑Dan Bai, Bin Zhang, Ying Li
Pages: 3265-3275
Published online on: 31 July 2019

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Article Open Access

Impact of SLC20A1 on the Wnt/β‑catenin signaling pathway in somatotroph adenomas

Jianhua Li, Wei Dong, Zhenye Li, Hongyun Wang, Hua Gao, Yazhuo Zhang
Pages: 3276-3284
Published online on: 06 August 2019

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Article Open Access

Niacin regulates apolipoprotein M expression via liver X receptor‑α

Liu Yang, Tie Li, Shuiping Zhao, Saidan Zhang
Pages: 3285-3291
Published online on: 06 August 2019

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Article Open Access

Impaired intestinal barrier function in a mouse model of hyperuricemia

Yingjie Guo, Hailong Li, Zhen Liu, Changgui Li, Yunqing Chen, Chen Jiang, Yanan Yu, Zibin Tian
Pages: 3292-3300
Published online on: 12 August 2019

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Article Open Access

Upregulation of Myc promotes the evasion of NK cell‑mediated immunity through suppression of NKG2D ligands in K562 cells

Young‑Shin Lee, Woong Heo, Cheol‑Hun Son, Chi‑Dug Kang, You‑Soo Park, Jaeho Bae
Pages: 3301-3307
Published online on: 09 August 2019

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Article Open Access

Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level

Heng Liu, Zhuoyang Li, Yongping Cao, Yunpeng Cui, Xin Yang, Zhichao Meng, Rui Wang
Pages: 3308-3316
Published online on: 06 August 2019

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Article Open Access

Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huh‑7 cells by regulating the ERK‑VEGF/MMP9 signaling pathway

Yafei Chen, Xin Chen, Xiaojun Ding, Yingwei Wang
Pages: 3317-3325
Published online on: 06 August 2019

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Article Open Access

Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone

Yue Xing, Wancong Zhang, Hanxing Zhao, Zhiwei Shen, Weijie Liang, Jianda Zhou, Lungang Shi, Jiasheng Chen, Xiaoping Zhong, Shijie Tang
Pages: 3326-3336
Published online on: 06 August 2019

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Article

Role of prostaglandin E2 receptor 4 in the modulation of apoptosis and mitophagy during ischemia/reperfusion injury in the kidney

Chenguang Ding, Feng Han, Heli Xiang, Yuxiang Wang, Meng Dou, Xinxin Xia, Yang Li, Jin Zheng, Xiaoming Ding, Wujun Xue, Puxun Tian
Pages: 3337-3346
Published online on: 08 August 2019

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Article

Ulinastatin ameliorates LPS‑induced pulmonary inflammation and injury by blocking the MAPK/NF‑κB signaling pathways in rats

Minjie Ju, Hongyu He, Song Chen, Yimei Liu, Yujing Liu, Simeng Pan, Yijun Zheng, Lizhen Xuan, Duming Zhu, Zhe Luo
Pages: 3347-3354
Published online on: 06 August 2019

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Article Open Access

Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth

Ning Xie, Yuan‑Rong Liu, Yan‑Mei Li, Ya‑Nan Yang, Li Pan, Yu‑Bo Wei, Ping‑Yu Wang, You‑Jie Li, Shu‑Yang Xie
Pages: 3355-3362
Published online on: 06 August 2019

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Article

Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats

Yuexia Ding, Airong Kang, Qiling Tang, Ying Zhao
Pages: 3363-3370
Published online on: 08 August 2019

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Article

Long non‑coding RNA TP73 antisense RNA 1 facilitates the proliferation and migration of cervical cancer cells via regulating microRNA‑607/cyclin D2

Hongmei Zhang, Bing Xue, Shuyuan Wang, Xiaoxia Li, Tingting Fan
Pages: 3371-3378
Published online on: 08 August 2019

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Article

Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes

Guangrong Hu, Lingbo Ma, Fei Dong, Xiao Hu, Sida Liu, Hui Sun
Pages: 3379-3387
Published online on: 06 August 2019

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Article

Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Pages: 3388-3394
Published online on: 08 August 2019

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Article

ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage

Lihe Li, Baoyang Liu
Pages: 3395-3405
Published online on: 09 August 2019

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Article

Overexpression of the medium‑conductance calcium‑activated potassium channel (SK4) and the HCN2 channel to generate a biological pacemaker

Hongyi Zhao, Mei Yang, Fengyuan Wang, Ankang Yang, Qingyan Zhao, Xi Wang, Yanhong Tang, Teng Wang, Congxin Huang
Pages: 3406-3414
Published online on: 20 August 2019

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Article

RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin‑1β pathway

Pengrong Lou, Shitao Zou, Zengfu Shang, Chao He, Aidi Gao, Shunyu Hou, Jundong Zhou
Pages: 3415-3423
Published online on: 06 August 2019

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Article

HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury

Jun‑Jun Huang, Jie Xia, Li‑Li Huang, Ya‑Chun Li
Pages: 3424-3432
Published online on: 08 August 2019

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Article

Neuroprotective role of icariin in experimental spinal cord injury via its antioxidant, anti‑neuroinflammatory and anti‑apoptotic properties

Guizhi Jia, Yuqiang Zhang, Weihong Li, Hongliang Dai
Pages: 3433-3439
Published online on: 30 July 2019

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Article

MicroRNA‑330 is downregulated in retinoblastoma and suppresses cell viability and invasion by directly targeting ROCK1

Ling Wang, Lina Wang, Lin Li, Hong Zhang, Xueman Lyu
Pages: 3440-3447
Published online on: 01 August 2019

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Article

Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment in mice

Hae Jin Lee, Sung‑Kwon Lee, Dong‑Ryung Lee, Bong‑Keun Choi, Bao Le, Seung Hwan Yang
Pages: 3448-3455
Published online on: 09 August 2019

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Review Open Access

Circular RNAs: A novel target among non‑coding RNAs with potential roles in malignant tumors (Review)

Weisong Zhao, Man Dong, Jinru Pan, Yajie Wang, Jingyi Zhou, Jianjun Ma, Shaoyang Liu
Pages: 3463-3474
Published online on: 02 September 2019

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Article Open Access

Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma

Jiangtao Liu, Yulin Li
Pages: 3475-3486
Published online on: 20 August 2019

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Article Open Access

Rsf‑1 regulates malignant melanoma cell viability and chemoresistance via NF‑κB/Bcl‑2 signaling

Jiani He, Lin Fu, Qingchang Li
Pages: 3487-3498
Published online on: 23 August 2019

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Article Open Access

Silencing of MALAT1 inhibits migration and invasion by sponging miR‑1‑3p in prostate cancer cells

Xiaofan Dai, Zuowen Liang, Lingyun Liu, Kaimin Guo, Shengqi Xu, Hongliang Wang
Pages: 3499-3508
Published online on: 22 August 2019

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Article Open Access

Overexpressed circPVT1 in oral squamous cell carcinoma promotes proliferation by serving as a miRNA sponge

Tianpeng He, Xin Li, Dongmei Xie, Lili Tian
Pages: 3509-3518
Published online on: 26 August 2019

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Article Open Access

MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2

Yanli Wang, Fengcai Li, Dandan Ma, Yuhua Gao, Runpu Li, Yingjie Gao
Pages: 3519-3526
Published online on: 26 August 2019

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Article Open Access

Overexpression of microRNA‑155 alleviates palmitate‑induced vascular endothelial cell injury in human umbilical vein endothelial cells by negatively regulating the Wnt signaling pathway Retraction in /10.3892/mmr.2025.13559

Yanping Zhao, Wenquan Rao, Yanna Wan, Xinglong Yang, Guorong Wang, Jun Deng, Min Dai, Qiang Liu
Pages: 3527-3534
Published online on: 27 August 2019

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Article Open Access

Antiproliferative and pro‑apoptotic effects of Cyclocarya paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Yongjun Jin, Zhezhu Jin, Sanya Jiang
Pages: 3535-3542
Published online on: 02 September 2019

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Article Open Access

Crosstalk between microRNAs, the putative target genes and the lncRNA network in metabolic diseases

Taís Silveira Assmann, Fermín I. Milagro, José Alfredo Martínez
Pages: 3543-3554
Published online on: 21 August 2019

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Article Open Access

Strontium‑containing α‑calcium sulfate hemihydrate promotes bone repair via the TGF‑β/Smad signaling pathway

Zhi Liu, Zewei Yu, Hong Chang, Yu Wang, Haibo Xiang, Xianrong Zhang, Bin Yu
Pages: 3555-3564
Published online on: 20 August 2019

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Article Open Access

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

Jun Zhang, Rongming Xu, Lei Wu, Jihong Jiang
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Published online on: 02 September 2019

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Microtubule‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis

Lei‑Lei Gao, Fei Xu, Zhen Jin, Xiao‑Yan Ying, Jin‑Wei Liu
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Published online on: 22 August 2019

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The identification of CRNDE, H19, UCA1 and HOTAIR as the key lncRNAs involved in oxaliplatin or irinotecan resistance in the chemotherapy of colorectal cancer based on integrative bioinformatics analysis

Fangfang Sun, Weiwei Liang, Jing Qian
Pages: 3583-3596
Published online on: 14 August 2019

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Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis

Agnieszka Kaufman‑Szymczyk, Katarzyna Majda, Agata Szuławska‑Mroczek, Krystyna Fabianowska‑Majewska, Katarzyna Lubecka
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DNA‑PKcs PARylation regulates DNA‑PK kinase activity in the DNA damage response

Yang Han, Feng Jin, Ying Xie, Yike Liu, Sai Hu, Xiao‑Dan Liu, Hua Guan, Yongqing Gu, Teng Ma, Ping‑Kun Zhou
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MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo

Mingfen Lv, Zhengjun Li, Jingjing Liu, Fan Lin, Qianwen Zhang, Zhiming Li, Yi Wang, Keyu Wang, Yunsheng Xu
Pages: 3617-3624
Published online on: 23 August 2019

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Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo

Qingjun Liu, Leibo Wang, David Li, Jingxia Zhao, Shen Chen, Jialin Li
Pages: 3625-3632
Published online on: 21 August 2019

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MicroRNA‑212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells

Zhi Chen, Yuzhen Liu, Bo Qi, Chengwei Gu, Xiufeng Wei, Ling Guo, Wenjian Yao, Baosheng Zhao
Pages: 3633-3641
Published online on: 03 September 2019

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CFHR1 is a potentially downregulated gene in lung adenocarcinoma

Geting Wu, Yuanliang Yan, Xiang Wang, Xinxin Ren, Xi Chen, Shuangshuang Zeng, Jie Wei, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong, Jianhua Zhou, Zhijie Xu
Pages: 3642-3648
Published online on: 03 September 2019

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Integrative genomics analysis of hub genes and their relationship with prognosis and signaling pathways in esophageal squamous cell carcinoma

Fang‑Fang Chen, Shi‑Rong Zhang, Hao Peng, Yun‑Zhao Chen, Xiao‑Bin Cui
Pages: 3649-3660
Published online on: 23 August 2019

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CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis

Yi Cao, Jianbo Xiong, Zhengrong Li, Guoyang Zhang, Yi Tu, Lizhen Wang, Zhigang Jie
Pages: 3661-3670
Published online on: 29 August 2019

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Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration Retraction in /10.3892/mmr.2022.12770

Kun Wang, Tie‑Nian Zhu, Rui‑Jing Zhao
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Published online on: 27 August 2019

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Screening of key genes associated with R‑CHOP immunochemotherapy and construction of a prognostic risk model in diffuse large B‑cell lymphoma

Ran Liu, Zhi Chen, Shujun Wang, Gang Zhao, Yan Gu, Qi Han, Baoan Chen
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Published online on: 29 August 2019

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Methylophiopogonanone B of Radix Ophiopogonis protects cells from H2O2‑induced apoptosis through the NADPH oxidase pathway in HUVECs

Liling Wang, Yifeng Zhou, Yuchuan Qin, Yanbin Wang, Bentong Liu, Ru Fang, Minge Bai
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Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives

Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K. Alegakis, Evangelia Sarandi, Maria Thanasoula, Demetrios A. Spandidos, Aristidis Tsatsakis, Mayya Petrovna Razgonova, Daniela Calina
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Piperine ameliorates the severity of fibrosis via inhibition of TGF‑β/SMAD signaling in a mouse model of chronic pancreatitis

Ji‑Won Choi, Sung‑Kon Lee, Myoung‑Jin Kim, Dong‑Gu Kim, Joon‑Yeon Shin, Ziqi Zhou, Il‑Joo Jo, Ho‑Joon Song, Gi‑Sang Bae, Sung‑Joo Park
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Accumulation of advanced glycation end products potentiate human retinal capillary endothelial cells mediated diabetic retinopathy

Dan Tao, Ninghua Ni, Tiesong Zhang, Chao Li, Qing Sun, Ling Wang, Yan Mei
Pages: 3719-3727
Published online on: 20 August 2019

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Sam68 mediates high glucose‑induced podocyte apoptosis through modulation of Bax/Bcl‑2

Yuyu Chen, Li Zhang, Shuangxin Liu, Binfeng Yao, Hong Zhang, Shun Liang, Jianchao Ma, Xinling Liang, Wei Shi
Pages: 3728-3734
Published online on: 21 August 2019

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Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transition

Zhenlv Lin, Lin Zhang, Junfeng Zhou, Jiantao Zheng
Pages: 3735-3745
Published online on: 21 August 2019

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miR‑488 negatively regulates osteogenic differentiation of bone marrow mesenchymal stem cells induced by psoralen by targeting Runx2

Yongquan Huang, Qiuke Hou, Haitao Su, Dongfeng Chen, Yiwen Luo, Tao Jiang
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Published online on: 23 August 2019

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MicroRNA‑301a‑3p overexpression promotes cell invasion and proliferation by targeting runt‑related transcription factor 3 in prostate cancer

Li Fan, Yao Wang, Wei Huo, Wei‑Hua Wang
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Published online on: 05 September 2019

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Proteinase‑activated receptor 2 deficiency is a protective factor against cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury

Min Wang, Yiwen Ma, Tiantian Zhang, Lin Gao, Shan Zhang, Qizhi Chen
Pages: 3764-3772
Published online on: 26 August 2019

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Expression of TIGIT/CD155 and correlations with clinical pathological features in human hepatocellular carcinoma

Xiangguo Duan, Juanxi Liu, Jianjian Cui, Bin Ma, Qiunan Zhou, Xiaojuan Yang, Zhenhui Lu, Yong Du, Chunxia Su
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Published online on: 02 September 2019

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lncRNA ROR promotes the progression of renal cell carcinoma through the miR‑206/VEGF axis Retraction in /10.3892/mmr.2024.13229

Jianguo Shi, Datian Zhang, Zhenhai Zhong, Wen Zhang
Pages: 3782-3792
Published online on: 02 September 2019

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Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism

Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao Fu
Pages: 3793-3801
Published online on: 26 August 2019

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Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells

Bo Xu, Xiang Wei, Minjian Chen, Kaipeng Xie, Yuqing Zhang, Zhenyao Huang, Tianyu Dong, Weiyue Hu, Kun Zhou, Xiumei Han, Xin Wu, Yankai Xia
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COX‑2 promotes epithelial‑mesenchymal transition and migration in osteosarcoma MG‑63 cells via PI3K/AKT/NF‑κB signaling

Xueliang Zhang, Peng Qu, Hui Zhao, Tong Zhao, Nong Cao
Pages: 3811-3819
Published online on: 21 August 2019

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hNTCP‑expressing primary pig hepatocytes are a valuable tool for investigating hepatitis B virus infection and antiviral drugs

Ming Zhou, Bo Qin, Xue‑Song Deng, Xiao‑Li Zeng, Ying Lu, Zi‑Gang Huang, Chun‑Chen Wu, Li‑Sha Mou
Pages: 3820-3828
Published online on: 29 August 2019

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Effect of astragaloside IV and the role of nuclear receptor RXRα in human peritoneal mesothelial cells in high glucose‑based peritoneal dialysis fluids

Weiwei Zhu, Xin Zhang, Kun Gao, Xufang Wang
Pages: 3829-3839
Published online on: 22 August 2019

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p27kip1 haploinsufficiency preserves myocardial function in the early stages of myocardial infarction via Atg5‑mediated autophagy flux restoration

Ningtian Zhou, Qiong Huang, Weili Cheng, Yingbin Ge, Dianfu Li, Junhong Wang
Pages: 3840-3848
Published online on: 02 September 2019

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Upregulation of lncRNA RMRP promotes the activation of cardiac fibroblasts by regulating miR‑613

Shuang‑Yin Zhang, Sheng‑Hui Huang, Shi‑Xiong Gao, Ying‑Bin Wang, Ping Jin, Feng‑Jiao Lu
Pages: 3849-3857
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Identification of key miRNA‑mRNA pairs in septic mice by bioinformatics analysis

Jianxin Chen, Min Lin, Sen Zhang
Pages: 3858-3866
Published online on: 20 August 2019

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lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes

Xiaoliang Mei, Jian Tong, Wei Zhu, Yongliang Zhu
Pages: 3867-3873
Published online on: 02 September 2019

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MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a

Ying Ye, Lijun Zhang, Yanan Song, Juhua Zhuang, Guoyu Wang, Jing Ni, Suiliang Zhang, Wei Xia
Pages: 3874-3882
Published online on: 21 August 2019

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Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy

Feifei Wang, Zhewen Zhang, Wing Ting Leung, Jing Chen, Juan Yi, Chunmei Ying, Minmin Yuan, Mingyan Wang, Na Zhang, Xuemin Qiu, Ling Wang, Hulai Wei
Pages: 3883-3892
Published online on: 27 August 2019

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Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro

Rong Sun, Yang Yang, Zheng Gu, Xinye Tang, Cheng Zhang, Wei Kou, Ping Wei
Pages: 3893-3900
Published online on: 02 September 2019

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miR‑519d‑3p promotes TGFβ/Smad mediated postoperative epidural scar formation via suppression of BAMBI

Longbiao Yang, Qingyuan Gao, Feng Lv, Min Guo, Dong Zhao
Pages: 3901-3909
Published online on: 30 August 2019

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Willed‑movement training reduces middle cerebral artery occlusion‑induced motor deficits and improves angiogenesis and survival of cerebral endothelial cells via upregulating hypoxia‑inducible factor‑1α

Zhiwen Zhou, Xiang Ren, Wensheng Zhou, Lijun Zheng
Pages: 3910-3916
Published online on: 09 August 2019

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Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Rongyan Guan, Wei Wang, Bin Fu, Yujun Pang, Ye Lou, Hong Li
Pages: 3917-3923
Published online on: 22 August 2019

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Effects of vascular endothelial growth factor and insulin growth factor‑1 on proliferation, migration, osteogenesis and vascularization of human carious dental pulp stem cells

Wanyu Lu, Wenan Xu, Jianjia Li, Yan Chen, Yuhua Pan, Buling Wu
Pages: 3924-3932
Published online on: 23 August 2019

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Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism

Daeun Moon, Jinu Kim, Sang‑Pil Yoon
Pages: 3933-3941
Published online on: 20 August 2019

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Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1

Dazhi Wang, Zhi Huang, Lei Li, Yingnan Yuan, Lei Xiang, Xiaowen Wu, Caifang Ni, Wenfeng Yu
Pages: 3942-3950
Published online on: 21 August 2019

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Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression

Jialuo Cai, Yilin Zhu, Yajie Zuo, Qiaozhen Tong, Zhiguo Zhang, Lei Yang, Xiaoping Li, Gangqiang Yi
Pages: 3951-3958
Published online on: 29 August 2019

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miR‑497 inhibits the proliferation and migration of A549 non‑small‑cell lung cancer cells by targeting FGFR1

Qibin Huang, Hongtao Li, Xiaofeng Dai, Di Zhao, Bingfeng Guan, Wen Xia
Pages: 3959-3967
Published online on: 23 August 2019

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Correction Open Access

[Corrigendum] Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury

Peiyan Huang, Jun Gu, Junguo Wu, Lei Geng, Yang Hong, Siqun Wang, Minghai Wang
Pages: 3968-3968
Published online on: 30 August 2019

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May-2026 Volume 33 Issue 5

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CiteScore: 8.5

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Article Open Access

Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization

Yifan Cai, Yucheng Zhong, Honglin Wang, Shuang Zhu, Fang Huang, Qiuyue Zhang, Shaobo Hu
Article Number: 156
Published online on: 30 March 2026

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Advances in the mechanisms of extracellular vesicles and circulating tumor cells in hepatocellular carcinoma metastasis (Review)

Sitong Yi, Wenxin Liu, Zhaohui Wang
Article Number: 155
Published online on: 30 March 2026

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Diagnostic importance of serum markers in lung cancer

Qichen Liang, Jianmei Song, Haixiang Wei, Lu Ning, Baoyu He, Ziteng Zhang
Article Number: 154
Published online on: 30 March 2026

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VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway

Xing Yang, Wenjuan Fang, Rui Chang, Linlin Ma, Xiaoyan Chen, Yanfei Li
Article Number: 153
Published online on: 30 March 2026

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Stabilin‑1: An immunoregulatory scavenger receptor in inflammation and tissue homeostasis (Review)

Xiao-Lei Xiang, Xin-Tong Ye, Yu-Tong Wu, Chen Chen, Chu-Ying Yu, Su-Ting Qian, Dan-Li Cai
Article Number: 152
Published online on: 26 March 2026

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Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)

Hong Wang, Hongyuan Lv, Xiaolin Zhang, Meifang Liu, Liyuan Wang
Article Number: 151
Published online on: 26 March 2026

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Tonsil‑derived mesenchymal stem cell‑derived extracellular vesicles suppress MAPK‑NF‑κB signaling and restore osteogenic differentiation in LPS‑stimulated periodontal ligament fibroblasts

Won-Jung Bae, Su Kang Kim, Han-Soo Kim, Sang Wook Kang, Ju Yeon Ban
Article Number: 150
Published online on: 26 March 2026

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Succinylation modification in diabetes and diabetic complications: Mechanisms and functions (Review)

Yeteng Xiong, Fei Luo, Bingnan Li, Qinfeng Yang
Article Number: 149
Published online on: 26 March 2026

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Polyphyllin II regulates ROS levels and promotes ferroptosis in bladder cancer cells

Quanlai Qiao, Ruifang Guo, Zhonghua Sun, Yaxin Shi, Yuning Xie, Zhiyong Liu
Article Number: 148
Published online on: 26 March 2026

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Veronicastrum sibiricum (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restoration

Eunhye Lee, Minjeong Kwon, Ju-Ock Nam
Article Number: 147
Published online on: 26 March 2026

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Role and clinical importance of lactylation in tumors (Review)

Chaowei Zhang, Xinyu Tang, Yuxuan Han, Weiyi Yao, Qing Hong, Yanan Zhu, Na Chen
Article Number: 146
Published online on: 26 March 2026

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Photodynamic therapy: A paradigm shift in overcoming drug‑resistant tuberculosis (Review)

Shuhao Cheng, Yuqing Wang, Jie Yao, Guodong Cheng, Gengzhi Ye, Fapeng Shi, Xiaolei Ma
Article Number: 145
Published online on: 26 March 2026

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Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review)

Yiyu Qin, Yang Zhou
Article Number: 144
Published online on: 26 March 2026

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[Retracted] Na+/K+‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways

Huilin Gong, Pengbiao Lü, Jiangwei Zhang, Dandong Li, Jin Zheng, Jinning Song
Article Number: 143
Published online on: 23 March 2026

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Multi‑omics and their integration in psoriasis research (Review)

Hengyan Zhang, Danping Li, Lijuan Zhu, Heguo Yan, Licong Yang, Xuesong Yang, Ye Zhou
Article Number: 142
Published online on: 23 March 2026

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LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming

Beibei Dai, Lili Yang, Yu Zhang, Aiyong Yu
Article Number: 141
Published online on: 23 March 2026

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Mechanism of BRCC36 affecting cardiac rupture after acute infarction through the Wnt‑JNK signaling pathway

Yongzhe Guo, Linyan Chen, Shumei Li, Xintao Zhang, Huizhong Lin
Article Number: 140
Published online on: 20 March 2026

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[Corrigendum] Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway

Ping Niu, Yuxuan Sun, Shiyi Wang, Guang Li, Xiaomin Tang, Jiaqiang Sun, Chunchen Pan, Jingwu Sun
Article Number: 139
Published online on: 19 March 2026

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Role of liver X receptors in the pathogenesis and treatment of chronic liver disease (Review)

Honghui You, Xiangjun Tang, Xiaoyan Fu, Jiaqi Zhou, Liyuan Wang, Hongxia Zhang, Xianhong Du, Shujuan Liang, Meifang Liu
Article Number: 138
Published online on: 19 March 2026

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Mechanistic insights and therapeutic potential of sphingosine‑1‑phosphate in the development of pulmonary fibrosis (Review)

Yanling Qin, Chenqi Tang, Sen Tan, Guangnan Liu
Article Number: 137
Published online on: 18 March 2026

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Advances in the biological functions of miR‑205 in various diseases (Review)

Dandan Chai, Hua Du, Yingxu Shi
Article Number: 136
Published online on: 18 March 2026

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[Retracted] MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim

Zhifang Zhao, Jie Zheng, Youchen Ye, Kefeng Zhao, Ruozhang Wang, Ran Wang
Article Number: 135
Published online on: 16 March 2026

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Precision medicine approach to coronary artery disease: Haptoglobin phenotype‑guided risk assessment

Zhengxin He, Hong Liu, Keran Jia, Daxin Lei, Liyun An, Jia Wang, Fukun Wang
Article Number: 134
Published online on: 12 March 2026

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[Expression of Concern] Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Article Number: 133
Published online on: 11 March 2026

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Glucose‑driven TRIB3 enhances the tumorigenic potential of colon cancer via the PI3K/AKT pathway

Yunting Bai, Xuying Huang, Guangyu An, Yang Ge, Rui Yan, Dan Yu
Article Number: 132
Published online on: 10 March 2026

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[Retracted] miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

Yan-Yan Bai, Jun-Zhi Niu
Article Number: 131
Published online on: 09 March 2026

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Dexmedetomidine protects against myocardial ischemia reperfusion injury by inhibiting the TLR2‑NF‑κB pathway in diabetic mice

Zhengjie Chen, Liangyu Zheng, Gang Chen
Article Number: 130
Published online on: 06 March 2026

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Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis

Yu Han, Siqi Yang, Jing Zhang, Yaoguang Wang, Xi Zhao, Huan Liu
Article Number: 129
Published online on: 05 March 2026

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[Retracted] Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

Fen Chen, Haiyang Xie, Haiwei Bao, Laurencia Violetta, Shusen Zheng
Article Number: 128
Published online on: 05 March 2026

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Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review)

Teng Ma, Siwei Zhang, Miaomiao Xiao, Zhijian Ma, Junhong Guan
Article Number: 127
Published online on: 04 March 2026

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Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)

Jinjin Yu, Huiheng Qu, Weicheng Xu, Yiming Fang, Nan Wang, Wei Shi
Article Number: 126
Published online on: 04 March 2026

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Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review)

Ze Li, Qiuli Ming, Tianyu Yang, Mengna Liu, Linpeng Fu, Jingshuang Yang, Zhaofeng Lu
Article Number: 125
Published online on: 04 March 2026

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Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer

Qi Chen, Hui Chen, Hui Yang, Yin Tao, Xiaolan Zhu
Article Number: 124
Published online on: 04 March 2026

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[Corrigendum] Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury 

Guo-Qian He, Yan Chen, Hui-Juan Liao, Wen-Ming Xu, Wei Zhang, Guo-Lin He
Article Number: 123
Published online on: 26 February 2026

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June-2026 Volume 33 Issue 6

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Potential for anti‑angiogenic therapy targeting the receptor for advanced glycation end products/VEGF axis in ulcerative colitis (Review)

Chen Xu, Yuting Li, Yahua Hong, Dayong Zhou, Kun He, Lianghui Wang, Feng Hong
Article Number: 166
Published online on: 09 April 2026

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[Retracted] Molecular mechanisms underlying mangiferin‑induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells

Wei Shi, Jiagang Deng, Rongsheng Tong, Yong Yang, Xia He, Jianzhen Lv, Hailian Wang, Shaoping Deng, Ping Qi, Dingding Zhang, Yi Wang
Article Number: 165
Published online on: 07 April 2026

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Mechanism of and research progress on alterations in the RET gene in thyroid cancer (Review)

Meng Wei, Rui Wang, Jincan Qian, Qiang Fang, Jun Tao
Article Number: 164
Published online on: 02 April 2026

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Current research progress on extracellular vesicles derived from mesenchymal stem cells in tuberculosis treatment (Review)

Dejun Fan, Yan Yang, Li Yang
Article Number: 163
Published online on: 01 April 2026

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Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling

Shao-Jung Li, Tzu-Yu Cheng, Yu-Hsun Kao, Wei-Yu Chen, Cheng-Chih Chung, Nguyen Ngoc Trang, Pao-Huan Chen, Yi-Jen Chen
Article Number: 162
Published online on: 01 April 2026

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Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)

Zhonglei Wang, Wenjue Guo, Haojia He, Yi Zhang, Na Li
Article Number: 161
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 160
Published online on: 01 April 2026

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Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)

Beomwoo Lee, Changgyu Son, Sunho Eom, Yuwen Li, Seon-Hwan Kim, Jongsun Park
Article Number: 159
Published online on: 30 March 2026

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Combining bioinformatics prediction with experimental validation to explore the ameliorative effect of Psoralea corylifolia on vitiligo

Chen Zhang, Zhanhong Cao, Mengyang Wei, Xuanxuan Zhu, Yan Yan, Zhenhua Wang, Meng Zhang
Article Number: 158
Published online on: 30 March 2026

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[Retracted] All‑trans‑retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by down­regulating p53 expression

Tao-Gen Zhang, Xue-Dong Li, Guo-Yong Yu, Peng Xie, Yun-Guo Wang, Zhao-Yong Liu, Quan Hong, De-Zhong Liu, Shi-Xin Du
Article Number: 157
Published online on: 30 March 2026

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