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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October-2019 Volume 20 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Targeting heterotopic ossification by inhibiting activin receptor‑like kinase 2 function (Review)

Fuli Shi, Jiayu Gao, Junrong Zou, Ying Ying, Hui Lin
Pages: 2979-2989
Published online on: 06 August 2019

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Article Open Access

An 8‑gene signature predicts the prognosis of cervical cancer following radiotherapy

Fei Xie, Dan Dong, Na Du, Liang Guo, Weihua Ni, Hongyan Yuan, Nannan Zhang, Jiang Jie, Guomu Liu, Guixiang Tai
Pages: 2990-3002
Published online on: 29 July 2019

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Article Open Access

SREBP2 is upregulated in esophageal squamous cell carcinoma and co‑operates with c‑Myc to regulate HMGCR expression

Chenxi Zhong, Limin Fan, Zhigang Li, Feng Yao, Heng Zhao
Pages: 3003-3010
Published online on: 09 August 2019

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Article Open Access

MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data

Hongshi Cao, Yu Zhang, Zhe Chu, Bolun Zhao, Haiyan Wang, Libin An
Pages: 3011-3018
Published online on: 30 July 2019

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Article Open Access

Effect of estradiol on high glucose‑induced osteoblast injury

Guangrun Li, Xiaofeng Jiang, Liping Liu, Xiaoyang Liu, Hongtao Liu, Zuofu Zhang
Pages: 3019-3026
Published online on: 06 August 2019

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Article Open Access

Curcumin protects the pancreas from acute pancreatitis via the mitogen‑activated protein kinase signaling pathway

Yingjie Wang, Chanyuan Bu, Kangkang Wu, Rui Wang, Jiayong Wang
Pages: 3027-3034
Published online on: 01 August 2019

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Article Open Access

Role of osteoprotegerin in the regulation of dental epithelial‑mesenchymal signaling during tooth development

Xin Gao, Junming Zheng, Shaoqin Tu, Bin Cai, Rongsheng Zeng, Lusai Xiang
Pages: 3035-3042
Published online on: 07 August 2019

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Article Open Access

MicroRNA‑451 relieves inflammation in cerebral ischemia‑reperfusion via the Toll‑like receptor 4/MyD88/NF‑κB signaling pathway

Wenyan Li, Minghao Dong, Liangzhao Chu, Luqian Feng, Xiaochuan Sun
Pages: 3043-3054
Published online on: 12 August 2019

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Article Open Access

STC1 regulates glioblastoma migration and invasion via the TGF‑β/SMAD4 signaling pathway

Yan Xiong, Qibai Wang
Pages: 3055-3064
Published online on: 09 August 2019

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Article Open Access

Therapeutic effect of transplantation of human bone marrow‑derived mesenchymal stem cells on neuron regeneration in a rat model of middle cerebral artery occlusion

Ping Xie, Ming Deng, Qin‑Guo Sun, Yong‑Gang Ma, Yan Zhou, Jiang‑Hua Ming, Qing Chen, Shi‑Qing Liu, Jun‑Qi Liu, Jun Cai, Fei Wu
Pages: 3065-3074
Published online on: 30 July 2019

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Article Open Access

Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray

Junkui Sun, Hongen Xu, Muge Qi, Chi Zhang, Jianxiang Shi
Pages: 3075-3084
Published online on: 31 July 2019

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Article Open Access

Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway

Yan Li, Lidan Liu, Yue Tian, Jin Zhang
Pages: 3085-3094
Published online on: 31 July 2019

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Article Open Access

Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways

Chun‑Yang Han, Tao‑Tao Sun, Guang‑Pei Xv, Si‑Si Wang, Jin‑Gang Gu, Cui‑Yan Liu
Pages: 3095-3102
Published online on: 06 August 2019

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Article Open Access

COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer

Xiaoxia Jiang, Mengjie Wu, Xin Xu, Liwei Zhang, Yingying Huang, Zhenzhen Xu, Kuifeng He, Haiyong Wang, Haohao Wang, Lisong Teng
Pages: 3103-3112
Published online on: 01 August 2019

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Article Open Access

Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway

Hai‑Jin Zhang, Yi‑Na Zhang, Zong‑Yan Teng
Pages: 3113-3122
Published online on: 07 August 2019

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Article Open Access

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production

Chun Fan, Qiuxia Ji, Chunyang Zhang, Shuo Xu, Hui Sun, Zhiyuan Li
Pages: 3123-3130
Published online on: 09 August 2019

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Article Open Access

Halofuginone protects against advanced glycation end products‑induced injury of H9C2 cells via alleviating endoplasmic reticulum stress‑associated apoptosis and inducing autophagy

Yu‑Hui Li, Wei‑Li Zhang, Hao‑Ying Zhou, Da‑Wei Yu, Xiao‑Ning Sun, Qin Hu
Pages: 3131-3139
Published online on: 06 August 2019

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Article Open Access

MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer

Li Liu, Wuzhang Wang, Song Gao, Xiuwen Wang
Pages: 3140-3148
Published online on: 31 July 2019

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Article Open Access

Upregulated microRNA‑671‑3p promotes tumor progression by suppressing forkhead box P2 expression in non‑small‑cell lung cancer

Zhi‑Ying Li, Zi‑Zhou Zhang, Hui Bi, Qiu‑Di Zhang, Su‑Juan Zhang, Lin Zhou, Xiao‑Qin Zhu, Jun Zhou
Pages: 3149-3159
Published online on: 06 August 2019

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Article Open Access

lncRNA/circRNA‑miRNA‑mRNA ceRNA network in lumbar intervertebral disc degeneration

Jinwen Zhu, Xinliang Zhang, Wenjie Gao, Huimin Hu, Xiaodong Wang, Dingjun Hao
Pages: 3160-3174
Published online on: 07 August 2019

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Article Open Access

Ginsenoside Rb1 prevents steroid‑induced avascular necrosis of the femoral head through the bone morphogenetic protein‑2 and vascular endothelial growth factor pathway

Junwu Ye, Daiqin Wei, Lin Peng, Tianmin Chang
Pages: 3175-3181
Published online on: 06 August 2019

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Article Open Access

MicroRNA‑217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1

Liyun Zhang, Juan Chen, Qin He, Ze Chao, Xuyong Li, Manhua Chen
Pages: 3182-3190
Published online on: 09 August 2019

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Article Open Access

Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins

Chong Yu, Xiang Wang, Yi Hong, Guojun Chen, Jin  Ge, Hao Cao, Bin Zhou
Pages: 3191-3201
Published online on: 01 August 2019

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Article Open Access

PPWD1 is associated with the occurrence of postmenopausal osteoporosis as determined by weighted gene co‑expression network analysis

Guo‑Feng Qian, Lu‑Shun Yuan, Min Chen, Dan Ye, Guo‑Ping Chen, Zhe Zhang, Cheng‑Jiang Li, Vijith Vijayan, Yu Xiao
Pages: 3202-3214
Published online on: 07 August 2019

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Article Open Access

Allium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma mouse model

So‑Hyeon Bok, Ji‑Hye Seo, Chun‑Sik Bae, Bossng Kang, Seung Sik Cho, Dae‑Hun Park
Pages: 3215-3223
Published online on: 06 August 2019

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Article Open Access

Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice

Youlin Wang, Pan Yang, Bo Zhang, Yao Ding, Shun  Lei, Yuning Hou, Xiaoqing Guan, Qingwang Li
Pages: 3224-3232
Published online on: 01 August 2019

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Article Open Access

Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX

Jingjing Wu, Bin Wei, Yuye Shi, Xueying Lu, Yihan Ding, Chunling Wang, Yufeng Li
Pages: 3233-3239
Published online on: 31 July 2019

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Article Open Access

Krüppel‑like factor 4 ameliorates diabetic kidney disease by activating autophagy via the mTOR pathway

Jianguang Gong, Huifang Zhan, Yiwen Li, Wei Zhang, Juan Jin, Qiang He
Pages: 3240-3248
Published online on: 09 August 2019

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Article Open Access

Proapoptotic effects of 2,5‑hexanedione on pheochromocytoma cells via oxidative injury

Baoning Qi, Shouzhu Xu, Yuan Liang, Jiaxin Wang, Zhigang Zhang, Juan Li, Jing Zhou
Pages: 3249-3255
Published online on: 01 August 2019

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Article Open Access

miR‑320a upregulation contributes to the development of preeclampsia by inhibiting the growth and invasion of trophoblast cells by targeting interleukin 4

Ning Xie, Zhi Jia, Li Li
Pages: 3256-3264
Published online on: 08 August 2019

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Article Open Access

Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling

Zhu‑Ling Jiang, Han Jin, Zhong‑Shuang Liu, Ming‑Yue Liu, Xiao‑Fang Cao, Yang‑Yang Jiang, Hong‑Dan Bai, Bin Zhang, Ying Li
Pages: 3265-3275
Published online on: 31 July 2019

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Article Open Access

Impact of SLC20A1 on the Wnt/β‑catenin signaling pathway in somatotroph adenomas

Jianhua Li, Wei Dong, Zhenye Li, Hongyun Wang, Hua Gao, Yazhuo Zhang
Pages: 3276-3284
Published online on: 06 August 2019

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Article Open Access

Niacin regulates apolipoprotein M expression via liver X receptor‑α

Liu Yang, Tie Li, Shuiping Zhao, Saidan Zhang
Pages: 3285-3291
Published online on: 06 August 2019

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Article Open Access

Impaired intestinal barrier function in a mouse model of hyperuricemia

Yingjie Guo, Hailong Li, Zhen Liu, Changgui Li, Yunqing Chen, Chen Jiang, Yanan Yu, Zibin Tian
Pages: 3292-3300
Published online on: 12 August 2019

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Article Open Access

Upregulation of Myc promotes the evasion of NK cell‑mediated immunity through suppression of NKG2D ligands in K562 cells

Young‑Shin Lee, Woong Heo, Cheol‑Hun Son, Chi‑Dug Kang, You‑Soo Park, Jaeho Bae
Pages: 3301-3307
Published online on: 09 August 2019

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Article Open Access

Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level

Heng Liu, Zhuoyang Li, Yongping Cao, Yunpeng Cui, Xin Yang, Zhichao Meng, Rui Wang
Pages: 3308-3316
Published online on: 06 August 2019

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Article Open Access

Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huh‑7 cells by regulating the ERK‑VEGF/MMP9 signaling pathway

Yafei Chen, Xin Chen, Xiaojun Ding, Yingwei Wang
Pages: 3317-3325
Published online on: 06 August 2019

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Article Open Access

Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone

Yue Xing, Wancong Zhang, Hanxing Zhao, Zhiwei Shen, Weijie Liang, Jianda Zhou, Lungang Shi, Jiasheng Chen, Xiaoping Zhong, Shijie Tang
Pages: 3326-3336
Published online on: 06 August 2019

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Article

Role of prostaglandin E2 receptor 4 in the modulation of apoptosis and mitophagy during ischemia/reperfusion injury in the kidney

Chenguang Ding, Feng Han, Heli Xiang, Yuxiang Wang, Meng Dou, Xinxin Xia, Yang Li, Jin Zheng, Xiaoming Ding, Wujun Xue, Puxun Tian
Pages: 3337-3346
Published online on: 08 August 2019

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Article

Ulinastatin ameliorates LPS‑induced pulmonary inflammation and injury by blocking the MAPK/NF‑κB signaling pathways in rats

Minjie Ju, Hongyu He, Song Chen, Yimei Liu, Yujing Liu, Simeng Pan, Yijun Zheng, Lizhen Xuan, Duming Zhu, Zhe Luo
Pages: 3347-3354
Published online on: 06 August 2019

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Article Open Access

Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth

Ning Xie, Yuan‑Rong Liu, Yan‑Mei Li, Ya‑Nan Yang, Li Pan, Yu‑Bo Wei, Ping‑Yu Wang, You‑Jie Li, Shu‑Yang Xie
Pages: 3355-3362
Published online on: 06 August 2019

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Article

Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats

Yuexia Ding, Airong Kang, Qiling Tang, Ying Zhao
Pages: 3363-3370
Published online on: 08 August 2019

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Article

Long non‑coding RNA TP73 antisense RNA 1 facilitates the proliferation and migration of cervical cancer cells via regulating microRNA‑607/cyclin D2

Hongmei Zhang, Bing Xue, Shuyuan Wang, Xiaoxia Li, Tingting Fan
Pages: 3371-3378
Published online on: 08 August 2019

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Article

Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes

Guangrong Hu, Lingbo Ma, Fei Dong, Xiao Hu, Sida Liu, Hui Sun
Pages: 3379-3387
Published online on: 06 August 2019

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Article

Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Pages: 3388-3394
Published online on: 08 August 2019

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Article

ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage

Lihe Li, Baoyang Liu
Pages: 3395-3405
Published online on: 09 August 2019

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Article

Overexpression of the medium‑conductance calcium‑activated potassium channel (SK4) and the HCN2 channel to generate a biological pacemaker

Hongyi Zhao, Mei Yang, Fengyuan Wang, Ankang Yang, Qingyan Zhao, Xi Wang, Yanhong Tang, Teng Wang, Congxin Huang
Pages: 3406-3414
Published online on: 20 August 2019

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Article

RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin‑1β pathway

Pengrong Lou, Shitao Zou, Zengfu Shang, Chao He, Aidi Gao, Shunyu Hou, Jundong Zhou
Pages: 3415-3423
Published online on: 06 August 2019

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Article

HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury

Jun‑Jun Huang, Jie Xia, Li‑Li Huang, Ya‑Chun Li
Pages: 3424-3432
Published online on: 08 August 2019

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Article

Neuroprotective role of icariin in experimental spinal cord injury via its antioxidant, anti‑neuroinflammatory and anti‑apoptotic properties

Guizhi Jia, Yuqiang Zhang, Weihong Li, Hongliang Dai
Pages: 3433-3439
Published online on: 30 July 2019

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Article

MicroRNA‑330 is downregulated in retinoblastoma and suppresses cell viability and invasion by directly targeting ROCK1

Ling Wang, Lina Wang, Lin Li, Hong Zhang, Xueman Lyu
Pages: 3440-3447
Published online on: 01 August 2019

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Article

Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment in mice

Hae Jin Lee, Sung‑Kwon Lee, Dong‑Ryung Lee, Bong‑Keun Choi, Bao Le, Seung Hwan Yang
Pages: 3448-3455
Published online on: 09 August 2019

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Review Open Access

Circular RNAs: A novel target among non‑coding RNAs with potential roles in malignant tumors (Review)

Weisong Zhao, Man Dong, Jinru Pan, Yajie Wang, Jingyi Zhou, Jianjun Ma, Shaoyang Liu
Pages: 3463-3474
Published online on: 02 September 2019

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Article Open Access

Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma

Jiangtao Liu, Yulin Li
Pages: 3475-3486
Published online on: 20 August 2019

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Article Open Access

Rsf‑1 regulates malignant melanoma cell viability and chemoresistance via NF‑κB/Bcl‑2 signaling

Jiani He, Lin Fu, Qingchang Li
Pages: 3487-3498
Published online on: 23 August 2019

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Article Open Access

Silencing of MALAT1 inhibits migration and invasion by sponging miR‑1‑3p in prostate cancer cells

Xiaofan Dai, Zuowen Liang, Lingyun Liu, Kaimin Guo, Shengqi Xu, Hongliang Wang
Pages: 3499-3508
Published online on: 22 August 2019

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Article Open Access

Overexpressed circPVT1 in oral squamous cell carcinoma promotes proliferation by serving as a miRNA sponge

Tianpeng He, Xin Li, Dongmei Xie, Lili Tian
Pages: 3509-3518
Published online on: 26 August 2019

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Article Open Access

MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2

Yanli Wang, Fengcai Li, Dandan Ma, Yuhua Gao, Runpu Li, Yingjie Gao
Pages: 3519-3526
Published online on: 26 August 2019

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Article Open Access

Overexpression of microRNA‑155 alleviates palmitate‑induced vascular endothelial cell injury in human umbilical vein endothelial cells by negatively regulating the Wnt signaling pathway Retraction in /10.3892/mmr.2025.13559

Yanping Zhao, Wenquan Rao, Yanna Wan, Xinglong Yang, Guorong Wang, Jun Deng, Min Dai, Qiang Liu
Pages: 3527-3534
Published online on: 27 August 2019

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Article Open Access

Antiproliferative and pro‑apoptotic effects of Cyclocarya paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Yongjun Jin, Zhezhu Jin, Sanya Jiang
Pages: 3535-3542
Published online on: 02 September 2019

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Article Open Access

Crosstalk between microRNAs, the putative target genes and the lncRNA network in metabolic diseases

Taís Silveira Assmann, Fermín I. Milagro, José Alfredo Martínez
Pages: 3543-3554
Published online on: 21 August 2019

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Article Open Access

Strontium‑containing α‑calcium sulfate hemihydrate promotes bone repair via the TGF‑β/Smad signaling pathway

Zhi Liu, Zewei Yu, Hong Chang, Yu Wang, Haibo Xiang, Xianrong Zhang, Bin Yu
Pages: 3555-3564
Published online on: 20 August 2019

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Article Open Access

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

Jun Zhang, Rongming Xu, Lei Wu, Jihong Jiang
Pages: 3565-3572
Published online on: 02 September 2019

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Microtubule‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis

Lei‑Lei Gao, Fei Xu, Zhen Jin, Xiao‑Yan Ying, Jin‑Wei Liu
Pages: 3573-3582
Published online on: 22 August 2019

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The identification of CRNDE, H19, UCA1 and HOTAIR as the key lncRNAs involved in oxaliplatin or irinotecan resistance in the chemotherapy of colorectal cancer based on integrative bioinformatics analysis

Fangfang Sun, Weiwei Liang, Jing Qian
Pages: 3583-3596
Published online on: 14 August 2019

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Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis

Agnieszka Kaufman‑Szymczyk, Katarzyna Majda, Agata Szuławska‑Mroczek, Krystyna Fabianowska‑Majewska, Katarzyna Lubecka
Pages: 3597-3608
Published online on: 27 August 2019

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DNA‑PKcs PARylation regulates DNA‑PK kinase activity in the DNA damage response

Yang Han, Feng Jin, Ying Xie, Yike Liu, Sai Hu, Xiao‑Dan Liu, Hua Guan, Yongqing Gu, Teng Ma, Ping‑Kun Zhou
Pages: 3609-3616
Published online on: 02 September 2019

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MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo

Mingfen Lv, Zhengjun Li, Jingjing Liu, Fan Lin, Qianwen Zhang, Zhiming Li, Yi Wang, Keyu Wang, Yunsheng Xu
Pages: 3617-3624
Published online on: 23 August 2019

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Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo

Qingjun Liu, Leibo Wang, David Li, Jingxia Zhao, Shen Chen, Jialin Li
Pages: 3625-3632
Published online on: 21 August 2019

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MicroRNA‑212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells

Zhi Chen, Yuzhen Liu, Bo Qi, Chengwei Gu, Xiufeng Wei, Ling Guo, Wenjian Yao, Baosheng Zhao
Pages: 3633-3641
Published online on: 03 September 2019

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CFHR1 is a potentially downregulated gene in lung adenocarcinoma

Geting Wu, Yuanliang Yan, Xiang Wang, Xinxin Ren, Xi Chen, Shuangshuang Zeng, Jie Wei, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong, Jianhua Zhou, Zhijie Xu
Pages: 3642-3648
Published online on: 03 September 2019

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Integrative genomics analysis of hub genes and their relationship with prognosis and signaling pathways in esophageal squamous cell carcinoma

Fang‑Fang Chen, Shi‑Rong Zhang, Hao Peng, Yun‑Zhao Chen, Xiao‑Bin Cui
Pages: 3649-3660
Published online on: 23 August 2019

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CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis

Yi Cao, Jianbo Xiong, Zhengrong Li, Guoyang Zhang, Yi Tu, Lizhen Wang, Zhigang Jie
Pages: 3661-3670
Published online on: 29 August 2019

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Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration Retraction in /10.3892/mmr.2022.12770

Kun Wang, Tie‑Nian Zhu, Rui‑Jing Zhao
Pages: 3671-3678
Published online on: 27 August 2019

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Screening of key genes associated with R‑CHOP immunochemotherapy and construction of a prognostic risk model in diffuse large B‑cell lymphoma

Ran Liu, Zhi Chen, Shujun Wang, Gang Zhao, Yan Gu, Qi Han, Baoan Chen
Pages: 3679-3690
Published online on: 29 August 2019

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Methylophiopogonanone B of Radix Ophiopogonis protects cells from H2O2‑induced apoptosis through the NADPH oxidase pathway in HUVECs

Liling Wang, Yifeng Zhou, Yuchuan Qin, Yanbin Wang, Bentong Liu, Ru Fang, Minge Bai
Pages: 3691-3700
Published online on: 29 August 2019

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Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives

Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K. Alegakis, Evangelia Sarandi, Maria Thanasoula, Demetrios A. Spandidos, Aristidis Tsatsakis, Mayya Petrovna Razgonova, Daniela Calina
Pages: 3701-3708
Published online on: 23 August 2019

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Piperine ameliorates the severity of fibrosis via inhibition of TGF‑β/SMAD signaling in a mouse model of chronic pancreatitis

Ji‑Won Choi, Sung‑Kon Lee, Myoung‑Jin Kim, Dong‑Gu Kim, Joon‑Yeon Shin, Ziqi Zhou, Il‑Joo Jo, Ho‑Joon Song, Gi‑Sang Bae, Sung‑Joo Park
Pages: 3709-3718
Published online on: 02 September 2019

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Accumulation of advanced glycation end products potentiate human retinal capillary endothelial cells mediated diabetic retinopathy

Dan Tao, Ninghua Ni, Tiesong Zhang, Chao Li, Qing Sun, Ling Wang, Yan Mei
Pages: 3719-3727
Published online on: 20 August 2019

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Sam68 mediates high glucose‑induced podocyte apoptosis through modulation of Bax/Bcl‑2

Yuyu Chen, Li Zhang, Shuangxin Liu, Binfeng Yao, Hong Zhang, Shun Liang, Jianchao Ma, Xinling Liang, Wei Shi
Pages: 3728-3734
Published online on: 21 August 2019

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Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transition

Zhenlv Lin, Lin Zhang, Junfeng Zhou, Jiantao Zheng
Pages: 3735-3745
Published online on: 21 August 2019

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miR‑488 negatively regulates osteogenic differentiation of bone marrow mesenchymal stem cells induced by psoralen by targeting Runx2

Yongquan Huang, Qiuke Hou, Haitao Su, Dongfeng Chen, Yiwen Luo, Tao Jiang
Pages: 3746-3754
Published online on: 23 August 2019

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Article

MicroRNA‑301a‑3p overexpression promotes cell invasion and proliferation by targeting runt‑related transcription factor 3 in prostate cancer

Li Fan, Yao Wang, Wei Huo, Wei‑Hua Wang
Pages: 3755-3763
Published online on: 05 September 2019

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Proteinase‑activated receptor 2 deficiency is a protective factor against cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury

Min Wang, Yiwen Ma, Tiantian Zhang, Lin Gao, Shan Zhang, Qizhi Chen
Pages: 3764-3772
Published online on: 26 August 2019

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Expression of TIGIT/CD155 and correlations with clinical pathological features in human hepatocellular carcinoma

Xiangguo Duan, Juanxi Liu, Jianjian Cui, Bin Ma, Qiunan Zhou, Xiaojuan Yang, Zhenhui Lu, Yong Du, Chunxia Su
Pages: 3773-3781
Published online on: 02 September 2019

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lncRNA ROR promotes the progression of renal cell carcinoma through the miR‑206/VEGF axis Retraction in /10.3892/mmr.2024.13229

Jianguo Shi, Datian Zhang, Zhenhai Zhong, Wen Zhang
Pages: 3782-3792
Published online on: 02 September 2019

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Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism

Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao Fu
Pages: 3793-3801
Published online on: 26 August 2019

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Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells

Bo Xu, Xiang Wei, Minjian Chen, Kaipeng Xie, Yuqing Zhang, Zhenyao Huang, Tianyu Dong, Weiyue Hu, Kun Zhou, Xiumei Han, Xin Wu, Yankai Xia
Pages: 3802-3810
Published online on: 23 August 2019

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COX‑2 promotes epithelial‑mesenchymal transition and migration in osteosarcoma MG‑63 cells via PI3K/AKT/NF‑κB signaling

Xueliang Zhang, Peng Qu, Hui Zhao, Tong Zhao, Nong Cao
Pages: 3811-3819
Published online on: 21 August 2019

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hNTCP‑expressing primary pig hepatocytes are a valuable tool for investigating hepatitis B virus infection and antiviral drugs

Ming Zhou, Bo Qin, Xue‑Song Deng, Xiao‑Li Zeng, Ying Lu, Zi‑Gang Huang, Chun‑Chen Wu, Li‑Sha Mou
Pages: 3820-3828
Published online on: 29 August 2019

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Effect of astragaloside IV and the role of nuclear receptor RXRα in human peritoneal mesothelial cells in high glucose‑based peritoneal dialysis fluids

Weiwei Zhu, Xin Zhang, Kun Gao, Xufang Wang
Pages: 3829-3839
Published online on: 22 August 2019

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p27kip1 haploinsufficiency preserves myocardial function in the early stages of myocardial infarction via Atg5‑mediated autophagy flux restoration

Ningtian Zhou, Qiong Huang, Weili Cheng, Yingbin Ge, Dianfu Li, Junhong Wang
Pages: 3840-3848
Published online on: 02 September 2019

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Upregulation of lncRNA RMRP promotes the activation of cardiac fibroblasts by regulating miR‑613

Shuang‑Yin Zhang, Sheng‑Hui Huang, Shi‑Xiong Gao, Ying‑Bin Wang, Ping Jin, Feng‑Jiao Lu
Pages: 3849-3857
Published online on: 02 September 2019

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Identification of key miRNA‑mRNA pairs in septic mice by bioinformatics analysis

Jianxin Chen, Min Lin, Sen Zhang
Pages: 3858-3866
Published online on: 20 August 2019

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lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes

Xiaoliang Mei, Jian Tong, Wei Zhu, Yongliang Zhu
Pages: 3867-3873
Published online on: 02 September 2019

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Article

MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a

Ying Ye, Lijun Zhang, Yanan Song, Juhua Zhuang, Guoyu Wang, Jing Ni, Suiliang Zhang, Wei Xia
Pages: 3874-3882
Published online on: 21 August 2019

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Article

Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy

Feifei Wang, Zhewen Zhang, Wing Ting Leung, Jing Chen, Juan Yi, Chunmei Ying, Minmin Yuan, Mingyan Wang, Na Zhang, Xuemin Qiu, Ling Wang, Hulai Wei
Pages: 3883-3892
Published online on: 27 August 2019

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Article

Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro

Rong Sun, Yang Yang, Zheng Gu, Xinye Tang, Cheng Zhang, Wei Kou, Ping Wei
Pages: 3893-3900
Published online on: 02 September 2019

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Article

miR‑519d‑3p promotes TGFβ/Smad mediated postoperative epidural scar formation via suppression of BAMBI

Longbiao Yang, Qingyuan Gao, Feng Lv, Min Guo, Dong Zhao
Pages: 3901-3909
Published online on: 30 August 2019

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Article

Willed‑movement training reduces middle cerebral artery occlusion‑induced motor deficits and improves angiogenesis and survival of cerebral endothelial cells via upregulating hypoxia‑inducible factor‑1α

Zhiwen Zhou, Xiang Ren, Wensheng Zhou, Lijun Zheng
Pages: 3910-3916
Published online on: 09 August 2019

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Article

Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Rongyan Guan, Wei Wang, Bin Fu, Yujun Pang, Ye Lou, Hong Li
Pages: 3917-3923
Published online on: 22 August 2019

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Article

Effects of vascular endothelial growth factor and insulin growth factor‑1 on proliferation, migration, osteogenesis and vascularization of human carious dental pulp stem cells

Wanyu Lu, Wenan Xu, Jianjia Li, Yan Chen, Yuhua Pan, Buling Wu
Pages: 3924-3932
Published online on: 23 August 2019

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Article

Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism

Daeun Moon, Jinu Kim, Sang‑Pil Yoon
Pages: 3933-3941
Published online on: 20 August 2019

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Article

Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1

Dazhi Wang, Zhi Huang, Lei Li, Yingnan Yuan, Lei Xiang, Xiaowen Wu, Caifang Ni, Wenfeng Yu
Pages: 3942-3950
Published online on: 21 August 2019

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Article

Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression

Jialuo Cai, Yilin Zhu, Yajie Zuo, Qiaozhen Tong, Zhiguo Zhang, Lei Yang, Xiaoping Li, Gangqiang Yi
Pages: 3951-3958
Published online on: 29 August 2019

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Article

miR‑497 inhibits the proliferation and migration of A549 non‑small‑cell lung cancer cells by targeting FGFR1

Qibin Huang, Hongtao Li, Xiaofeng Dai, Di Zhao, Bingfeng Guan, Wen Xia
Pages: 3959-3967
Published online on: 23 August 2019

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Correction Open Access

[Corrigendum] Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury

Peiyan Huang, Jun Gu, Junguo Wu, Lei Geng, Yang Hong, Siqun Wang, Minghai Wang
Pages: 3968-3968
Published online on: 30 August 2019

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
Article Number: 101
Published online on: 27 January 2026

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PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity

Hevna Dhulkifle, Lubna Therachiyil, Maram H. Hasan, Shahd M. Younis, Nizar A. Al‑Shar'i, Huseyin C. Yalcin, Zaid H. Maayah
Article Number: 100
Published online on: 27 January 2026

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[Retracted] miR‑367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression

Jianwen Long, Jing Luo, Xuwen Yin
Article Number: 99
Published online on: 26 January 2026

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Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 33 Issue 4

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Integrative bioinformatics and experimental analysis reveals FRA1 as a key mediator of tubulointerstitial inflammation in lupus nephritis

Wenpeng Ni, Jialin He, Zhouyu Zeng, Jialong Ke, Runpei Lin, Jianming Peng, Kunyi Deng, Lijuan Wen, Yanhui Chen, Chilun Zhang, Yanfen Li, Guanghong Gu
Article Number: 103
Published online on: 28 January 2026

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[Corrigendum] Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway

Hong-Yu Meng, De-Cheng Shao, Han Li, Xiao-Dan Huang, Guang Yang, Bing Xu, Hai-Yun Niu
Article Number: 102
Published online on: 28 January 2026

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