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Article

Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy

  • Authors:
    • Feifei Wang
    • Zhewen Zhang
    • Wing Ting Leung
    • Jing Chen
    • Juan Yi
    • Chunmei Ying
    • Minmin Yuan
    • Mingyan Wang
    • Na Zhang
    • Xuemin Qiu
    • Ling Wang
    • Hulai Wei
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. China, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3883-3892
    |
    Published online on: August 27, 2019
       https://doi.org/10.3892/mmr.2019.10621
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Abstract

Autophagy is an essential metabolic pathway mediated by lysosomal degradation, which is involved in scavenging and recycling senescent or damaged organelles and biological macromolecules in eukaryotic cells. The present study explored the association between the autophagic activity and chemotherapy resistance of leukaemia cells, and the possibility of using autophagy inhibitors to combat leukemic drug resistance. It was found that the levels of basic autophagy in multidrug‑resistant leukaemia cells (K562/ADM) were significantly higher compared with sensitive cells (K562), and that Adriamycin (ADM) was capable of inducing autophagic activity in K562 and K562/ADM cells. K562 and K562/ADM cells were treated with a series of hydroxychloroquine (HCQ) concentrations to inhibit cellular autophagy and detect cell sensitivity to ADM. The results demonstrated that the sensitivity of K562 cells to ADM was mildly enhanced by HCQ, and that the sensitivity of K562/ADM cells to ADM was markedly strengthened by HCQ. In addition, more typical morphological changes associated with apoptosis emerged, and the ratio of Bax/Bcl‑2 and activity of caspase‑3 were markedly increased in K562/ADM cells treated with HCQ. Notably, the expression of mdr1 mRNA and P‑glycoprotein (P‑gp) in drug‑resistant K562/ADM cells was upregulated along with increasing autophagic activity induced by ADM. Furthermore, HCQ significantly reduced the increase in P‑gp expression by inhibiting autophagic activity. Collectively, these findings indicated that the inhibition of autophagy significantly promoted the sensitivity of K562/ADM cells to ADM by facilitating apoptosis. Furthermore, inhibition of autophagy attenuated the expression of P‑gp; therefore, P‑gp may be involved in autophagic regulation in drug‑resistant cells.
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1 

Wouters BJ and Delwel R: Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia. Blood. 127:42–52. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Burnett A, Wetzler M and Lowenberg B: Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 29:487–494. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Gao W and Estey E: Moving toward targeted therapies in acute myeloid leukemia. Clin Adv Hematol Oncol. 13:748–754. 2015.PubMed/NCBI

4 

Ramos P and Bentires-Alj M: Mechanism-based cancer therapy: Resistance to therapy, therapy for resistance. Oncogene. 34:3617–3626. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Jones PM and George AM: The ABC transporter structure and mechanism: Perspectives on recent research. Cell Mol Life Sci. 61:682–699. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Borst P, Evers R, Kool M and Wijnholds J: A family of drug transporters: The multidrug resistance-associated proteins. J Natl Cancer Inst. 92:1295–1302. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Bodor M, Kelly EJ and Ho RJ: Characterization of the human MDR1 gene. AAPS J. 7:E1–E5. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I and Gottesman MM: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 39:361–398. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Abraham J, Salama NN and Azab AK: The role of P-glycoprotein in drug resistance in multiple myeloma. Leuk Lymphoma. 56:26–33. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Danial NN and Korsmeyer SJ: Cell death: Critical control points. Cell. 116:205–219. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Delbridge AR and Strasser A: The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell Death Differ. 22:1071–1080. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Zheng JH, Viacava Follis A, Kriwacki RW and Moldoveanu T: Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J. 283:2690–2700. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Kroemer G, Galluzzi L and Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev. 87:99–163. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ghibelli L and Diederich M: Multistep and multitask bax activation. Mitochondrion. 10:604–613. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kvansakul M and Hinds MG: The Bcl-2 family: Structures, interactions and targets for drug discovery. Apoptosis. 20:136–150. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Indran IR, Tufo G, Pervaiz S and Brenner C: Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochim Biophys Acta. 1807:735–745. View Article : Google Scholar : PubMed/NCBI

17 

Zhi X, Feng W, Rong Y and Liu R: Anatomy of autophagy: From the beginning to the end. Cell Mol Life Sci. 75:815–831. 2017. View Article : Google Scholar : PubMed/NCBI

18 

He C and Klionsky DJ: Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 43:67–93. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Budini M, Buratti E, Morselli E and Criollo A: Autophagy and its impact on neurodegenerative diseases: New roles for TDP-43 and C9orf72. Front Mol Neurosci. 10:1702017. View Article : Google Scholar : PubMed/NCBI

21 

Morandi E, Jagessar SA, t Hart BA and Gran B: EBV infection empowers human b cells for autoimmunity: Role of autophagy and relevance to multiple sclerosis. J Immunol. 199:435–448. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, et al: Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat Commun. 8:982017. View Article : Google Scholar : PubMed/NCBI

23 

Fulda S: Autophagy in cancer therapy. Front Oncol. 7:1282017. View Article : Google Scholar : PubMed/NCBI

24 

Gewirtz DA: The four faces of autophagy: Implications for cancer therapy. Cancer Res. 74:647–651. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S and Auberger P: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res. 70:1042–1052. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Wang F, Chen J, Zhang Z, Yi J, Yuan M, Wang M, Zhang N, Qiu X, Wei H and Wang L: Differences of basic and induced autophagic activity between K562 and K562/ADM cells. Intractable Rare Dis Res. 6:281–290. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Liu K, Liu PC, Liu R and Wu X: Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry. Med Sci Monit Basic Res. 21:15–20. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Daver N, Cortes J, Kantarjian H and Ravandi F: Acute myeloid leukemia: Advancing clinical trials and promising therapeutics. Expert Rev Hematol. 9:433–445. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Plasschaert SL, de Bont ES, Boezen M, vander Kolk DM, Daenen SM, Faber KN, Kamps WA, de Vries EG and Vellenga E: Expression of multidrug resistance-associated proteins predicts prognosis in childhood and adult acute lymphoblastic leukemia. Clin Cancer Res. 11:8661–8668. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Chen J, Wei H, Xie B, Wang B and Cheng J and Cheng J: Endoplasmic reticulum stress contributes to arsenic trioxide-induced apoptosis in drug-sensitive and -resistant leukemia cells. Leuk Res. 36:1526–1535. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Li CL, Wei HL, Chen J, Wang B, Xie B, Fan LL and Li LJ: Arsenic trioxide induces autophagy and antitumor effects in burkitt's lymphoma raji cells. Oncol Rep. 32:1557–1563. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Han W, Sun J, Feng L, Wang K, Li D, Pan Q, Chen Y, Jin W, Wang X, Pan H and Jin H: Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One. 6:e284912011. View Article : Google Scholar : PubMed/NCBI

35 

Riz I, Hawley TS and Hawley RG: KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget. 6:14814–14831. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Sun Q, Liu T, Yuan Y, Guo Z, Xie G, Du S, Lin X, Xu Z, Liu M, Wang W, et al: MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1. Int J Cancer. 136:1003–1012. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Zhang H, Tang J, Li C, Kong J, Wang J, Wu Y, Xu E and Lai M: MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells. Cancer Lett. 356:781–790. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Kim SH, Kim KY, Yu SN, Park SK, Choi HD, Ji JH and Ahn SC: Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 468:151–156. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Li CL, Wei HL, Chen J, Wang B, Xie B, Fan LL and Li LJ: Ebb-and-flow of macroautophagy and chaperone-mediated autophagy in raji cells induced by starvation and arsenic trioxide. Asian Pac J Cancer Prev. 15:5715–5719. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Caminal-Montero L and Suárez-Díaz S: Hydroxychloroquine and antimalarials. J Rheumatol. 15:jrheum.190559. 2019.

41 

Zhang H, Han D, Lv T, Liu K, Yang Y, Xu X and Chen Y: Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway. Drug Des Devel Ther. 13:2153–2167. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, He C and Pan H: P38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 344:174–179. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Oral O, Akkoc Y, Bayraktar O and Gozuacik D: Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis. Histol Histopathol. 31:479–498. 2016.PubMed/NCBI

44 

Zhou Y, Sun K, Ma Y, Yang H, Zhang Y, Kong X and Wei L: Autophagy inhibits chemotherapy-induced apoptosis through downregulating bad and bim in hepatocellular carcinoma cells. Sci Rep. 4:53822014. View Article : Google Scholar : PubMed/NCBI

45 

Yuan N, Song L, Zhang S, Lin W, Cao Y, Xu F, Fang Y, Wang Z, Zhang H, Li X, et al: Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 100:345–356. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Rees DC, Johnson E and Lewinson O: ABC transporters: The power to change. Nat Rev Mol Cell Biol. 10:218–227. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Breier A, Gibalova L, Seres M, Barancik M and Sulova Z: New insight into p-glycoprotein as a drug target. Anticancer Agents Med Chem. 13:159–170. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Silva R, Vilas-Boas V, Carmo H, Dinis-Oliveira RJ, Carvalho F, de Lourdes Bastos M and Remiao F: Modulation of P-glycoprotein efflux pump: Induction and activation as a therapeutic strategy. Pharmacol Ther. 149:1–123. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Zhang LH, Yang AJ, Wang M, Liu W, Wang CY, Xie XF, Chen X, Dong JF and Li M: Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells. Apoptosis. 21:473–488. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Sun WL, Lan D, Gan TQ and Cai ZW: Autophagy facilitates multidrug resistance development through inhibition of apoptosis in breast cancer cells. Neoplasma. 62:199–208. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Liu W, Meng Q, Sun Y, Wang C, Huo X, Liu Z, Sun P, Sun H, Ma X and Liu K: Targeting P-Glycoprotein: Nelfinavir reverses adriamycin resistance in K562/ADR cells. Cell Physiol Biochem. 51:1616–1631. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Zhang Z, Leung WT, Chen J, Yi J, Ying C, Yuan M, Wang M, Zhang N, Qiu X, Qiu X, et al: Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy. Mol Med Rep 20: 3883-3892, 2019.
APA
Wang, F., Zhang, Z., Leung, W.T., Chen, J., Yi, J., Ying, C. ... Wei, H. (2019). Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy. Molecular Medicine Reports, 20, 3883-3892. https://doi.org/10.3892/mmr.2019.10621
MLA
Wang, F., Zhang, Z., Leung, W. T., Chen, J., Yi, J., Ying, C., Yuan, M., Wang, M., Zhang, N., Qiu, X., Wang, L., Wei, H."Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy". Molecular Medicine Reports 20.4 (2019): 3883-3892.
Chicago
Wang, F., Zhang, Z., Leung, W. T., Chen, J., Yi, J., Ying, C., Yuan, M., Wang, M., Zhang, N., Qiu, X., Wang, L., Wei, H."Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy". Molecular Medicine Reports 20, no. 4 (2019): 3883-3892. https://doi.org/10.3892/mmr.2019.10621
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Zhang Z, Leung WT, Chen J, Yi J, Ying C, Yuan M, Wang M, Zhang N, Qiu X, Qiu X, et al: Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy. Mol Med Rep 20: 3883-3892, 2019.
APA
Wang, F., Zhang, Z., Leung, W.T., Chen, J., Yi, J., Ying, C. ... Wei, H. (2019). Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy. Molecular Medicine Reports, 20, 3883-3892. https://doi.org/10.3892/mmr.2019.10621
MLA
Wang, F., Zhang, Z., Leung, W. T., Chen, J., Yi, J., Ying, C., Yuan, M., Wang, M., Zhang, N., Qiu, X., Wang, L., Wei, H."Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy". Molecular Medicine Reports 20.4 (2019): 3883-3892.
Chicago
Wang, F., Zhang, Z., Leung, W. T., Chen, J., Yi, J., Ying, C., Yuan, M., Wang, M., Zhang, N., Qiu, X., Wang, L., Wei, H."Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy". Molecular Medicine Reports 20, no. 4 (2019): 3883-3892. https://doi.org/10.3892/mmr.2019.10621
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