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BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44

  • Authors:
    • Lei Gao
    • Hansong Liu
    • Ningwei Yin
    • Shanshan Zuo
    • Guangli Jin
    • Yangxi Hu
    • Desheng Hu
    • Ying Li
    • Qiong Song
    • Xuejie Fei
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Zhengzhou Central Hospital Affiliated with Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Department of Anesthesiology, Zhengzhou Central Hospital Affiliated with Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Department of Hospital Infections, Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 200021, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4073-4080
    |
    Published online on: September 2, 2019
       https://doi.org/10.3892/mmr.2019.10633
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Abstract

Colorectal cancer (CRC) currently leads to many deaths worldwide. The regulatory mechanism, however, remains largely unclear. In the present study, bioinformatics methods were used to identify genes associated with CRC prognosis and to detect the molecular signals regulating the cell cycle in two CRC cell lines. It was revealed that BNIPL‑2 expression was higher in CRC tissues than in adjacent tissue samples. Upregulation of BNIPL‑2 was correlated with poor prognosis and the adverse malignant stages T and M. BNIPL‑2 was also associated with signaling pathways involved in cancer cell growth. BNIPL‑2 overexpression promoted cell proliferation and increased the proportion of cells in the G2/M phase. Knockdown of BNIPL‑2 inhibited cell proliferation. CD44 was regulated by BNIPL‑2 and promoted cell proliferation. Downregulation of CD44 suppressed cell proliferation and rescued the cell proliferation promoted by BNIPL‑2. Overexpression of CD44 restored the cell proliferation suppressed by BNIPL‑2 knockdown. The present study not only suggested that BNIPL‑2 may be a potential biomarker of CRC but also indicated that BNIPL‑2 regulates CRC cancer proliferation via CD44, which could be a diagnostic and clinical treatment target.
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Copy and paste a formatted citation
Spandidos Publications style
Gao L, Liu H, Yin N, Zuo S, Jin G, Hu Y, Hu D, Li Y, Song Q, Fei X, Fei X, et al: BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Mol Med Rep 20: 4073-4080, 2019.
APA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y. ... Fei, X. (2019). BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Molecular Medicine Reports, 20, 4073-4080. https://doi.org/10.3892/mmr.2019.10633
MLA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20.5 (2019): 4073-4080.
Chicago
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20, no. 5 (2019): 4073-4080. https://doi.org/10.3892/mmr.2019.10633
Copy and paste a formatted citation
x
Spandidos Publications style
Gao L, Liu H, Yin N, Zuo S, Jin G, Hu Y, Hu D, Li Y, Song Q, Fei X, Fei X, et al: BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Mol Med Rep 20: 4073-4080, 2019.
APA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y. ... Fei, X. (2019). BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Molecular Medicine Reports, 20, 4073-4080. https://doi.org/10.3892/mmr.2019.10633
MLA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20.5 (2019): 4073-4080.
Chicago
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20, no. 5 (2019): 4073-4080. https://doi.org/10.3892/mmr.2019.10633
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