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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2019 Volume 20 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia

Jin Chen, Hui Liu, Liyan Li, Honglei Wang, Yi Li, Yihao Wang, Kai Ding, Shanfeng Hao, Yuanyuan Shao, Lijuan Li, Jia Song, Guojin Wang, Zonghong Shao, Rong Fu
Pages: 3979-3990
Published online on: 10 September 2019

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Article Open Access

Plasma extracellular vesicle‑packaged microRNAs as candidate diagnostic biomarkers for early‑stage breast cancer

Chen Yan, Jintao Hu, Yipeng Yang, Hong Hu, Dongxian Zhou, Min Ma, Nan Xu
Pages: 3991-4002
Published online on: 10 September 2019

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Article

Suppression of microRNA‑27a protects against liver ischemia/reperfusion injury by targeting PPARγ and inhibiting endoplasmic reticulum stress

Xiaobin Chi, Yi Jiang, Yongbiao Chen, Fang Yang, Qiucheng Cai, Fan Pan, Lizhi Lv, Xiaojin Zhang
Pages: 4003-4012
Published online on: 03 September 2019

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Article Open Access

Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis

Kai Wang, Yun Chen, Zhihong Zhao, Meiying Feng, Shouquan Zhang
Pages: 4013-4022
Published online on: 16 September 2019

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Article Open Access

MicroRNA‑195 inhibits epithelial‑mesenchymal transition by targeting G protein‑coupled estrogen receptor 1 in endometrial carcinoma

Junfeng Deng, Weihua Wang, Guangyu Yu, Xiuzhen Ma
Pages: 4023-4032
Published online on: 06 September 2019

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Article Open Access

Aldosterone promotes renal interstitial fibrosis via the AIF‑1/AKT/mTOR signaling pathway

Xueying Yuan, Xingzhi Wang, Yushu Li, Xin Li, Shuyu Zhang, Lirong Hao
Pages: 4033-4044
Published online on: 13 September 2019

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Article Open Access

Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway

Liu Yang, Qi Hong, Si‑Guang Xu, Xia‑Ying Kuang, Gen‑Hong Di, Guang‑Yu Liu, Jiong Wu, Zhi‑Ming Shao, San‑Jian Yu
Pages: 4045-4258
Published online on: 03 September 2019

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Article Open Access

PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway

Shen Liu, Jun Jia, Hengxing Zhou, Chi Zhang, Lu Liu, Jun Liu, Lu Lu, Xueying Li, Yi Kang, Yongfu Lou, Zhiwei Cai, Yiming Ren, Xiaohong Kong, Shiqing Feng
Pages: 4059-4066
Published online on: 10 September 2019

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Article Open Access

Dihydroartemisinin inhibits multiplication of Brucella suis vaccine strain 2 in murine microglia BV2 cells via stimulation of caspase‑dependent apoptosis

Juan Yang, Haining Li, Zhao Wang, Liming Yu, Qiang Liu, Xiaoyan Niu, Ting Xu, Zhenhai Wang
Pages: 4067-4072
Published online on: 11 September 2019

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Article Open Access

BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44

Lei Gao, Hansong Liu, Ningwei Yin, Shanshan Zuo, Guangli Jin, Yangxi Hu, Desheng Hu, Ying Li, Qiong Song, Xuejie Fei
Pages: 4073-4080
Published online on: 02 September 2019

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Article Open Access

Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress

Yao Wang, Qian Chen, Chunxia Shi, Fangzhou Jiao, Zuojiong Gong
Pages: 4081-4090
Published online on: 10 September 2019

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Article Open Access

Reconstruction and analysis of competitive endogenous RNA network reveals regulatory role of long non‑coding RNAs in hepatic fibrosis

Hui Jiang, Furong Wu, Nannan Jiang, Jiarong Gao, Jiafu Zhang
Pages: 4091-4100
Published online on: 13 September 2019

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Article Open Access

Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats

Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zhu
Pages: 4101-4110
Published online on: 11 September 2019

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Article Open Access

D‑galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence

Jingang Hou, Yeejin Yun, Jianjie Xue, Mengqi Sun, Sunchang Kim
Pages: 4111-4118
Published online on: 12 September 2019

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Article Open Access

Hydrogen sulfide protects against high glucose‑induced lipid metabolic disturbances in 3T3‑L1 adipocytes via the AMPK signaling pathway

Zhe Pan, Jue Wang, Min Xu, Shihong Chen, Xiaobo Li, Aili Sun, Nengjun Lou, Yihong Ni
Pages: 4119-4124
Published online on: 16 September 2019

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Article Open Access

Comprehensive expression profiles and bioinformatics analysis reveal special circular RNA expression and potential predictability in the peripheral blood of humans with idiopathic membranous nephropathy

Xuefeng Jin, Bi Deng, Kun Ye, Dongmei Ye, Yiyun Huang, Xiaoyu Chen, Zhousheng Yang, Ying Chen
Pages: 4125-4139
Published online on: 10 September 2019

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Article Open Access

miR‑92a‑3p regulates trypsinogen activation via Egr1 in AR42J cells

Xueming Zhang, Bo Gao, Yang Huang, Yong Zhang, Zhituo Li, Dali Zhao, Biao Ma, Dongbo Xue, Weihui Zhang
Pages: 4140-4150
Published online on: 11 September 2019

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Article Open Access

miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke

Qini Zhao, Huan Sun, Liquan Yin, Libo Wang
Pages: 4151-4167
Published online on: 12 September 2019

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Article Open Access

lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA‑101

Wenjun Yu, Zhenni Sun, Ling Yang, Yafei Han, Lu Yue, Lihua Deng, Ruyong Yao
Pages: 4168-4174
Published online on: 03 September 2019

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Article Open Access

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Si Lei, Yanling She, Jie Zeng, Rui Chen, Shanyao Zhou, Huacai Shi
Pages: 4175-4185
Published online on: 10 September 2019

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Article Open Access

Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury

Zhongsheng Zhang, Shuangfeng Liu, Sichun Huang
Pages: 4186-4192
Published online on: 13 September 2019

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Article Open Access

LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells

Yuan‑Ming Geng, Cheng‑Xia Liu, Wei‑Ying Lu, Ping Liu, Pei‑Yan Yuan, Wei‑Long Liu, Ping‑Ping Xu, Xiao‑Qing Shen
Pages: 4193-4201
Published online on: 16 September 2019

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Article Open Access

Microarray‑based analysis of COL11A1 and TWIST1 as important differentially‑expressed pathogenic genes between left and right‑sided colon cancer

Chen Su, Jiabao Zhao, Xinya Hong, Sijiu Yang, Ying Jiang, Jingjing Hou
Pages: 4202-4214
Published online on: 10 September 2019

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Article Open Access

Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway

Shoudan Zhang, Wenshi Guo
Pages: 4215-4225
Published online on: 10 September 2019

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Article Open Access

High‑fat treatment prevents postoperative cognitive dysfunction in a hyperlipidemia model by protecting the blood‑brain barrier via Mfsd2a‑related signaling

Xiao‑Ping Zhang, Yu‑Ru Liu, Mei Chai, Hai‑Tao Yang, Guan Wang, Mei Han, Dong‑Bai Li
Pages: 4226-4234
Published online on: 12 September 2019

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Article Open Access

Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2

Zhuo Sun, Jinqi Lu, Muyu Wu, Mingyan Li, Lu Bai, Zhenduo Shi, Lin Hao, Yongping Wu
Pages: 4235-4243
Published online on: 10 September 2019

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Article Open Access

CTHRC1 and PD‑1/PD‑L1 expression predicts tumor recurrence in prostate cancer

Qing Zhou, Wei Xiong, Xing Zhou, Rui‑Song Gao, Qun‑Fang Lin, Hui‑Ying Liu, Juan‑Ni Li, Xue‑Fei Tian
Pages: 4244-4252
Published online on: 19 September 2019

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Article Open Access

Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats

Minhua Gu, Peikun He, Chenfei Lyu, Xiaoyu Liu, Yuling Xu, Saibo Cheng, Yong Gu, Yuhua Jia
Pages: 4253-4261
Published online on: 16 September 2019

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Article

GDF15 promotes osteosarcoma cell migration and invasion by regulating the TGF‑β signaling pathway

Guangfu Chen, Min Wang, Xiang Liu
Pages: 4262-4270
Published online on: 10 September 2019

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Article

MicroRNA‑20a negatively regulates the growth and osteoclastogenesis of THP‑1 cells by downregulating PPARγ

Huining Wang, Yuqin Shen
Pages: 4271-4276
Published online on: 12 September 2019

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Article

Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation

Haiying Hu, Dandan Shao, Leilei Wang, Fang He, Xiaoxu Huang, Yanyu Lu, Xiaona Xiang, Susu Zhu, Pianhong Zhang, Jianru Li, Jingsen Chen
Pages: 4277-4284
Published online on: 09 September 2019

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Article

Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion

Feng‑Chen Zhu, Dian‑Ming Jiang, Ming‑Hua Zhang, Bo Zhao, Chao He, Jian Yang
Pages: 4285-4292
Published online on: 16 September 2019

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Article

miRNA‑101‑3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway

Shuifang Chen, Zeying Zhang, Lina Chen, Jianli Zhang
Pages: 4293-4302
Published online on: 09 September 2019

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Article

MicroRNA‑30a controls the instability of inducible CD4+ Tregs through SOCS1

Ya Zhou, Yongju Li, Jia Lu, Xiaowu Hong, Lin Xu
Pages: 4303-4314
Published online on: 10 September 2019

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Article

Effects of hypoxia‑inducible factor‑1α on the proliferation and apoptosis of human synovial mesenchymal stem cells

Weiwei Zheng, Xueping Gu, Xingwei Sun, Dan Hu
Pages: 4315-4322
Published online on: 09 September 2019

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Article

Heat shock transcription factor 1 affects kidney tubular cell migration by regulating the TGF‑β1‑Smad2/3 signaling pathway

Qiang Lou, Yuanyuan Li, Beibei Hou, Yonglian Liu, Yan Zhang, Jielu Hao, Yuanfang Ma
Pages: 4323-4330
Published online on: 16 September 2019

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Article

Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro

Miho Ueta, Kazuki Takaoka, Michiyo Yamamura, Hanako Maeda, Joji Tamaoka, Yoshioro Nakano, Kazuma Noguchi, Hiromitsu Kishimoto
Pages: 4331-4339
Published online on: 10 September 2019

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Article

A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients

Le Lu, Yufan Wu, Min Feng, Xiaofeng Xue, Yuan Fan
Pages: 4340-4348
Published online on: 10 September 2019

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Article

N‑acetyl cysteine protects HUVECs against lipopolysaccharide‑mediated inflammatory reaction by blocking the NF‑κB signaling pathway

Zhenzhen Zhang, Ting Xiong, Rui Zheng, Jialin Huang, Ling Guo
Pages: 4349-4357
Published online on: 12 September 2019

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Article

Availability of NK cell expansion agent combined with recombinant IL‑2 and IL‑15 stimulation on the expansion and high‑purity of NK cells in patients with immune‑related pancytopenia in vitro

Yang Li, Bingnan Liu, Shaoxue Ding, Chunyan Liu, Tong Chen, Lijuan Li, Zonghong Shao, Rong Fu
Pages: 4358-4366
Published online on: 09 September 2019

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Article Open Access

Delay in hepatocyte proliferation and prostaglandin D2 synthase expression for cholestasis due to endotoxin during partial hepatectomy in rats

Yusuke Wakasa, Norihisa Kimura, Toshiyuki Yamada, Takeshi Shimizu, Kenichi Hakamada, Shigeki Tsuchida
Pages: 4367-4375
Published online on: 13 September 2019

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Article

MicroRNA‑381 regulates the growth of gastric cancer cell by targeting TWIST1

Yongling Yin, Xiaoyun Li, Zongquan Guo, Fuxiang Zhou
Pages: 4376-4382
Published online on: 06 September 2019

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Article

Effects of isoflurane on complex II‑associated mitochondrial respiration and reactive oxygen species production: Roles of nitric oxide and mitochondrial KATP channels

Junan Wang, Jie Sun, Shigang Qiao, Hua Li, Tuanjie Che, Chen Wang, Jianzhong An
Pages: 4383-4390
Published online on: 09 September 2019

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Correction Open Access

[Corrigendum] Effects of the Tangningtongluo formula as an alternative strategy for diabetics via upregulation of insulin receptor substrate-1

Long Cheng, Junmei Song, Geng Li, Yue Liu, Yuming Wang, Xiangbao Meng, Guibo Sun, Xiaobo Sun
Pages: 4391-4392
Published online on: 04 September 2019

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Correction Open Access

[Corrigendum] The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease

Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tang
Pages: 4393-4393
Published online on: 04 September 2019

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Article Open Access

Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach Corrigendum in /10.3892/mmr.2021.12308

Maciej Brązert, Wiesława Kranc, Piotr Celichowski, Katarzyna Ożegowska, Joanna Budna‑Tukan, Michal Jeseta, Leszek Pawelczyk, Małgorzata Bruska, Maciej Zabel, Michał Nowicki, Bartosz Kempisty
Pages: 4403-4414
Published online on: 26 September 2019

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Article Open Access

Bioinformatics analysis of gene expression profile data to screen key genes involved in intracranial aneurysms

Tie Guo, Dan Hou, Dan Yu
Pages: 4415-4424
Published online on: 23 September 2019

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Article Open Access

Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats

Yi Li, Yongcheng Du, Aizhen Zhang, Rui Jiang, Xin Nie, Xue Xiong
Pages: 4425-4432
Published online on: 20 September 2019

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Article Open Access

CaSR participates in the regulation of vascular tension in the mesentery of hypertensive rats via the PLC‑IP3/AC‑V/cAMP/RAS pathway

Wenwen Zhang, Ruixia Sun, Hua Zhong, Na Tang, Yongmin Liu, Yongli Zhao, Tian Zhang, Fang He
Pages: 4433-4448
Published online on: 27 August 2019

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Article Open Access

MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway Retraction in /10.3892/mmr.2025.13543

Yeli Wang, Linsong Mu, Miaoling Huang
Pages: 4449-4458
Published online on: 01 October 2019

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Article Open Access

UCP2 silencing aggravates mitochondrial dysfunction in astrocytes under septic conditions

Wanwan Peng, Jinda Huang, Yijun Zheng, Yue Ding, Sitao Li, Junliang Zhang, Juanjuan Lyu, Qiyi Zeng
Pages: 4459-4466
Published online on: 02 October 2019

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Article Open Access

Tissue-specific transcriptional regulation of epithelial/endothelial and mesenchymal markers during renovascular hypertension

Leandro Ricardo Ferraz, Bianca Caruso Moreira, Gabriela de Souza Rodrigues de Queiroz, Regiane de Freitas Formigari, Marcelo Augusto Marreto Esquisatto, Maira Felonato, Armindo Antonio Alves, Bruna Fontana Thomazini, Camila Andréa de Oliveira
Pages: 4467-4476
Published online on: 02 October 2019

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Article Open Access

TAFA5 promotes proliferation and migration in gastric cancer

Zhiqing Hu, Gengming Niu, Jun Ren, Xin Wang, Liang Chen, Runqi Hong, Chongwei Ke
Pages: 4477-4488
Published online on: 02 October 2019

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Article Open Access

Expression of HIF‑1α in cycling stretch‑induced osteogenic differentiation of bone mesenchymal stem cells

Haibo Yu, Wenyi Yu, Ying Liu, Xiao Yuan, Rongtao Yuan, Qingyuan Guo
Pages: 4489-4498
Published online on: 30 September 2019

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Article Open Access

ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

Xian Zhang, Xinying Yang, Ming Chen, Shaolie Zheng, Jinyuan Li, Shaoqiang Lin, Xiaoyu Wang
Pages: 4499-4506
Published online on: 26 September 2019

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Article Open Access

MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells

Zhongzeng Liang, Qunwen Pan, Zhi Zhang, Chaosheng Huang, Zeming Yan, Yuanqi Zhang, Jianwen Li
Pages: 4507-4514
Published online on: 24 September 2019

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Article Open Access

Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway

Yonghui Wang, Yana Sui, Yinggang Tao
Pages: 4515-4522
Published online on: 23 September 2019

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Article Open Access

Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats

Di Zhang, Yan‑Juan Yu, Feng‑Sen Xu, Jun‑Hua Yuan, Rui Wang, Cai‑Shun Zhang, Liu‑Xin Wang, Yuan Liu, Li‑Min Song, Jun‑Li Liu, Jing Dong
Pages: 4523-4532
Published online on: 01 October 2019

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Article Open Access

Downregulation of LINC01638 lncRNA inhibits migration and invasion of pancreatic ductal adenocarcinoma cells by reducing TGF‑β signaling

Huimin Lu, Jun Ye, Ling Zhang, Mao Li, Shan Lu, Dujiang Yang, Weiming Hu
Pages: 4533-4539
Published online on: 24 September 2019

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Article Open Access

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II‑induced arthritis

Zhe‑Yong Li, Jing‑Jing Zhou, Chun‑Lei Luo, Le‑Meng Zhang
Pages: 4540-4550
Published online on: 26 September 2019

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Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway

Genquan Yue, Caixia Chen, Ligang Bai, Guoqiang Wang, Yong Huang, Yunbin Wang, Hongwei Cui, Yunfeng Xiao
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Published online on: 25 September 2019

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miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1

Ye Xiao, Qi Guo, Tie‑Jian Jiang, Ying Yuan, Li Yang, Guang‑Wei Wang, Wen‑Feng Xiao
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Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Yinyao Ma, Xuxia Liang, Hua Wu, Chun Zhang, Yanhua Ma
Pages: 4567-4575
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Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells

Yan‑Qing Zang, Yan‑Yu Feng, Ying‑Hua Luo, Yu‑Qing Zhai, Xue‑Ying Ju, Yu‑Chao Feng, Ya‑Nan Sheng, Jia‑Ru Wang, Chang‑Qing Yu, Cheng‑Hao Jin
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Effects of resveratrol on learning and memory in rats with vascular dementia

Yeqing Zhang, Yuwang Li, Yinxiao Wang, Gengyin Wang, Lingqun Mao, Danhong Zhang, Jinhua Wang
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MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis

Weihua Xu, Jin Li, Hongtao Tian, Ruoyu Wang, Yong Feng, Jing Tang, Jie Jia
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Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats

Hong Zhao, Xiao‑Yu Gao, Zan‑Hua Liu, Jian‑Wen Lin, Su‑Ping Wang, De‑Xin Wang, Yong‑Bo Zhang
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Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism

Zhen Zhang, Jing Wang, Yingwei Zhu, Hui Zhang, Hongxin Wang
Pages: 4612-4622
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Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models

Shaopeng Li, Lanzhou Li, Han Yan, Xue Jiang, Weiwei Hu, Ning Han, Di Wang
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KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells

Madhura Patankar, Sinikka Eskelinen, Anne Tuomisto, Markus J. Mäkinen, Tuomo J. Karttunen
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MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis

Fenggen Yan, Weiwei Meng, Siqi Ye, Xian Zhang, Xiumei Mo, Junfeng Liu, Dacan Chen, Ying Lin
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Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation

Lei Song, Yi Luo, Xinyue Wang, Mohammed M. Almutairi, Huafeng Pan, Weirong Li, Yongqiang Liu, Qi Wang, Ming Hong
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Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats

Min Chen, Zhaoming Huang, Hong Bi, Xinghua Pan, Jian He, Lewei He, Xu He, Junyi Du, Kaihua Zhou, Liyan Wang, Qing Wang, Xiang Guo, Zhixian Jin
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Published online on: 30 September 2019

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House dust mite induces Sonic hedgehog signaling that mediates epithelial‑mesenchymal transition in human bronchial epithelial cells

Yimin Zou, Wenjuan Song, Lingxiao Zhou, Yanxiong Mao, Wei Hong
Pages: 4674-4682
Published online on: 26 September 2019

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Case Report Open Access

Identification of a novel mutation in the thyroid hormone receptor β gene that causes thyroid hormone resistance syndrome: A case report

Jue Wang, Haihong Lv
Pages: 4683-4687
Published online on: 24 September 2019

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Culture and characterization of human dental pulp‑derived stem cells as limbal stem cells for corneal damage repair

Shankargouda Patil, Clinton D'Souza, Prakash Patil, Vidya Patil, Mridula Prabhu, Anil Bargale, Vishwas Kaveeshwar, Sarath Kumar, Praveenkumar Shetty
Pages: 4688-4694
Published online on: 19 September 2019

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Phosphoproteomic profiling of oxycodone‑treated spinal cord of rats with cancer‑induced bone pain

Hou‑Sheng Deng, Long‑Sheng Xu, Hua‑Dong Ni, Yun‑Gong Wang, Hong‑Bo Li, Qiu‑Li He, Miao Xu, Ming Yao
Pages: 4695-4705
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Elevated expression of the leptin receptor ob‑R may contribute to inflammation in patients with ulcerative colitis

Yan‑Ming Tian, Si‑Yu Tian, Dong Wang, Fang Cui, Xiang‑Jian Zhang, Yi Zhang
Pages: 4706-4712
Published online on: 01 October 2019

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Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins

Bo Zhang, Ge Zhan, Qing Fang, Fang Wang, Yang Li, Yuhao Zhang, Lei Zhao, Guocui Zhang, Baoxin Li
Pages: 4713-4722
Published online on: 19 September 2019

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Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts

Fange Kong, Xueying Cai, Siyu Zhai, Ruochen Wang, Xiaoyi Zheng, Yue Ma, Hui Bi, Di Wang
Pages: 4723-4730
Published online on: 25 September 2019

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Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling Expression of Concern in /10.3892/mmr.2026.13843

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Pages: 4731-4740
Published online on: 01 October 2019

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CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
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[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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November-2026 Volume 34 Issue 5

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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