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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2019 Volume 20 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia

Jin Chen, Hui Liu, Liyan Li, Honglei Wang, Yi Li, Yihao Wang, Kai Ding, Shanfeng Hao, Yuanyuan Shao, Lijuan Li, Jia Song, Guojin Wang, Zonghong Shao, Rong Fu
Pages: 3979-3990
Published online on: 10 September 2019

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Article Open Access

Plasma extracellular vesicle‑packaged microRNAs as candidate diagnostic biomarkers for early‑stage breast cancer

Chen Yan, Jintao Hu, Yipeng Yang, Hong Hu, Dongxian Zhou, Min Ma, Nan Xu
Pages: 3991-4002
Published online on: 10 September 2019

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Article

Suppression of microRNA‑27a protects against liver ischemia/reperfusion injury by targeting PPARγ and inhibiting endoplasmic reticulum stress

Xiaobin Chi, Yi Jiang, Yongbiao Chen, Fang Yang, Qiucheng Cai, Fan Pan, Lizhi Lv, Xiaojin Zhang
Pages: 4003-4012
Published online on: 03 September 2019

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Article Open Access

Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis

Kai Wang, Yun Chen, Zhihong Zhao, Meiying Feng, Shouquan Zhang
Pages: 4013-4022
Published online on: 16 September 2019

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Article Open Access

MicroRNA‑195 inhibits epithelial‑mesenchymal transition by targeting G protein‑coupled estrogen receptor 1 in endometrial carcinoma

Junfeng Deng, Weihua Wang, Guangyu Yu, Xiuzhen Ma
Pages: 4023-4032
Published online on: 06 September 2019

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Article Open Access

Aldosterone promotes renal interstitial fibrosis via the AIF‑1/AKT/mTOR signaling pathway

Xueying Yuan, Xingzhi Wang, Yushu Li, Xin Li, Shuyu Zhang, Lirong Hao
Pages: 4033-4044
Published online on: 13 September 2019

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Article Open Access

Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway

Liu Yang, Qi Hong, Si‑Guang Xu, Xia‑Ying Kuang, Gen‑Hong Di, Guang‑Yu Liu, Jiong Wu, Zhi‑Ming Shao, San‑Jian Yu
Pages: 4045-4258
Published online on: 03 September 2019

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Article Open Access

PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway

Shen Liu, Jun Jia, Hengxing Zhou, Chi Zhang, Lu Liu, Jun Liu, Lu Lu, Xueying Li, Yi Kang, Yongfu Lou, Zhiwei Cai, Yiming Ren, Xiaohong Kong, Shiqing Feng
Pages: 4059-4066
Published online on: 10 September 2019

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Article Open Access

Dihydroartemisinin inhibits multiplication of Brucella suis vaccine strain 2 in murine microglia BV2 cells via stimulation of caspase‑dependent apoptosis

Juan Yang, Haining Li, Zhao Wang, Liming Yu, Qiang Liu, Xiaoyan Niu, Ting Xu, Zhenhai Wang
Pages: 4067-4072
Published online on: 11 September 2019

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Article Open Access

BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44

Lei Gao, Hansong Liu, Ningwei Yin, Shanshan Zuo, Guangli Jin, Yangxi Hu, Desheng Hu, Ying Li, Qiong Song, Xuejie Fei
Pages: 4073-4080
Published online on: 02 September 2019

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Article Open Access

Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress

Yao Wang, Qian Chen, Chunxia Shi, Fangzhou Jiao, Zuojiong Gong
Pages: 4081-4090
Published online on: 10 September 2019

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Article Open Access

Reconstruction and analysis of competitive endogenous RNA network reveals regulatory role of long non‑coding RNAs in hepatic fibrosis

Hui Jiang, Furong Wu, Nannan Jiang, Jiarong Gao, Jiafu Zhang
Pages: 4091-4100
Published online on: 13 September 2019

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Article Open Access

Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats

Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zhu
Pages: 4101-4110
Published online on: 11 September 2019

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Article Open Access

D‑galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence

Jingang Hou, Yeejin Yun, Jianjie Xue, Mengqi Sun, Sunchang Kim
Pages: 4111-4118
Published online on: 12 September 2019

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Article Open Access

Hydrogen sulfide protects against high glucose‑induced lipid metabolic disturbances in 3T3‑L1 adipocytes via the AMPK signaling pathway

Zhe Pan, Jue Wang, Min Xu, Shihong Chen, Xiaobo Li, Aili Sun, Nengjun Lou, Yihong Ni
Pages: 4119-4124
Published online on: 16 September 2019

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Article Open Access

Comprehensive expression profiles and bioinformatics analysis reveal special circular RNA expression and potential predictability in the peripheral blood of humans with idiopathic membranous nephropathy

Xuefeng Jin, Bi Deng, Kun Ye, Dongmei Ye, Yiyun Huang, Xiaoyu Chen, Zhousheng Yang, Ying Chen
Pages: 4125-4139
Published online on: 10 September 2019

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Article Open Access

miR‑92a‑3p regulates trypsinogen activation via Egr1 in AR42J cells

Xueming Zhang, Bo Gao, Yang Huang, Yong Zhang, Zhituo Li, Dali Zhao, Biao Ma, Dongbo Xue, Weihui Zhang
Pages: 4140-4150
Published online on: 11 September 2019

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Article Open Access

miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke

Qini Zhao, Huan Sun, Liquan Yin, Libo Wang
Pages: 4151-4167
Published online on: 12 September 2019

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Article Open Access

lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA‑101

Wenjun Yu, Zhenni Sun, Ling Yang, Yafei Han, Lu Yue, Lihua Deng, Ruyong Yao
Pages: 4168-4174
Published online on: 03 September 2019

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Article Open Access

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Si Lei, Yanling She, Jie Zeng, Rui Chen, Shanyao Zhou, Huacai Shi
Pages: 4175-4185
Published online on: 10 September 2019

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Article Open Access

Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury

Zhongsheng Zhang, Shuangfeng Liu, Sichun Huang
Pages: 4186-4192
Published online on: 13 September 2019

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Article Open Access

LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells

Yuan‑Ming Geng, Cheng‑Xia Liu, Wei‑Ying Lu, Ping Liu, Pei‑Yan Yuan, Wei‑Long Liu, Ping‑Ping Xu, Xiao‑Qing Shen
Pages: 4193-4201
Published online on: 16 September 2019

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Article Open Access

Microarray‑based analysis of COL11A1 and TWIST1 as important differentially‑expressed pathogenic genes between left and right‑sided colon cancer

Chen Su, Jiabao Zhao, Xinya Hong, Sijiu Yang, Ying Jiang, Jingjing Hou
Pages: 4202-4214
Published online on: 10 September 2019

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Article Open Access

Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway

Shoudan Zhang, Wenshi Guo
Pages: 4215-4225
Published online on: 10 September 2019

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Article Open Access

High‑fat treatment prevents postoperative cognitive dysfunction in a hyperlipidemia model by protecting the blood‑brain barrier via Mfsd2a‑related signaling

Xiao‑Ping Zhang, Yu‑Ru Liu, Mei Chai, Hai‑Tao Yang, Guan Wang, Mei Han, Dong‑Bai Li
Pages: 4226-4234
Published online on: 12 September 2019

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Article Open Access

Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2

Zhuo Sun, Jinqi Lu, Muyu Wu, Mingyan Li, Lu Bai, Zhenduo Shi, Lin Hao, Yongping Wu
Pages: 4235-4243
Published online on: 10 September 2019

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Article Open Access

CTHRC1 and PD‑1/PD‑L1 expression predicts tumor recurrence in prostate cancer

Qing Zhou, Wei Xiong, Xing Zhou, Rui‑Song Gao, Qun‑Fang Lin, Hui‑Ying Liu, Juan‑Ni Li, Xue‑Fei Tian
Pages: 4244-4252
Published online on: 19 September 2019

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Article Open Access

Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats

Minhua Gu, Peikun He, Chenfei Lyu, Xiaoyu Liu, Yuling Xu, Saibo Cheng, Yong Gu, Yuhua Jia
Pages: 4253-4261
Published online on: 16 September 2019

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Article

GDF15 promotes osteosarcoma cell migration and invasion by regulating the TGF‑β signaling pathway

Guangfu Chen, Min Wang, Xiang Liu
Pages: 4262-4270
Published online on: 10 September 2019

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Article

MicroRNA‑20a negatively regulates the growth and osteoclastogenesis of THP‑1 cells by downregulating PPARγ

Huining Wang, Yuqin Shen
Pages: 4271-4276
Published online on: 12 September 2019

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Article

Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation

Haiying Hu, Dandan Shao, Leilei Wang, Fang He, Xiaoxu Huang, Yanyu Lu, Xiaona Xiang, Susu Zhu, Pianhong Zhang, Jianru Li, Jingsen Chen
Pages: 4277-4284
Published online on: 09 September 2019

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Article

Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion

Feng‑Chen Zhu, Dian‑Ming Jiang, Ming‑Hua Zhang, Bo Zhao, Chao He, Jian Yang
Pages: 4285-4292
Published online on: 16 September 2019

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Article

miRNA‑101‑3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway

Shuifang Chen, Zeying Zhang, Lina Chen, Jianli Zhang
Pages: 4293-4302
Published online on: 09 September 2019

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Article

MicroRNA‑30a controls the instability of inducible CD4+ Tregs through SOCS1

Ya Zhou, Yongju Li, Jia Lu, Xiaowu Hong, Lin Xu
Pages: 4303-4314
Published online on: 10 September 2019

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Article

Effects of hypoxia‑inducible factor‑1α on the proliferation and apoptosis of human synovial mesenchymal stem cells

Weiwei Zheng, Xueping Gu, Xingwei Sun, Dan Hu
Pages: 4315-4322
Published online on: 09 September 2019

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Article

Heat shock transcription factor 1 affects kidney tubular cell migration by regulating the TGF‑β1‑Smad2/3 signaling pathway

Qiang Lou, Yuanyuan Li, Beibei Hou, Yonglian Liu, Yan Zhang, Jielu Hao, Yuanfang Ma
Pages: 4323-4330
Published online on: 16 September 2019

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Article

Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro

Miho Ueta, Kazuki Takaoka, Michiyo Yamamura, Hanako Maeda, Joji Tamaoka, Yoshioro Nakano, Kazuma Noguchi, Hiromitsu Kishimoto
Pages: 4331-4339
Published online on: 10 September 2019

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Article

A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients

Le Lu, Yufan Wu, Min Feng, Xiaofeng Xue, Yuan Fan
Pages: 4340-4348
Published online on: 10 September 2019

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Article

N‑acetyl cysteine protects HUVECs against lipopolysaccharide‑mediated inflammatory reaction by blocking the NF‑κB signaling pathway

Zhenzhen Zhang, Ting Xiong, Rui Zheng, Jialin Huang, Ling Guo
Pages: 4349-4357
Published online on: 12 September 2019

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Article

Availability of NK cell expansion agent combined with recombinant IL‑2 and IL‑15 stimulation on the expansion and high‑purity of NK cells in patients with immune‑related pancytopenia in vitro

Yang Li, Bingnan Liu, Shaoxue Ding, Chunyan Liu, Tong Chen, Lijuan Li, Zonghong Shao, Rong Fu
Pages: 4358-4366
Published online on: 09 September 2019

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Article Open Access

Delay in hepatocyte proliferation and prostaglandin D2 synthase expression for cholestasis due to endotoxin during partial hepatectomy in rats

Yusuke Wakasa, Norihisa Kimura, Toshiyuki Yamada, Takeshi Shimizu, Kenichi Hakamada, Shigeki Tsuchida
Pages: 4367-4375
Published online on: 13 September 2019

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Article

MicroRNA‑381 regulates the growth of gastric cancer cell by targeting TWIST1

Yongling Yin, Xiaoyun Li, Zongquan Guo, Fuxiang Zhou
Pages: 4376-4382
Published online on: 06 September 2019

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Article

Effects of isoflurane on complex II‑associated mitochondrial respiration and reactive oxygen species production: Roles of nitric oxide and mitochondrial KATP channels

Junan Wang, Jie Sun, Shigang Qiao, Hua Li, Tuanjie Che, Chen Wang, Jianzhong An
Pages: 4383-4390
Published online on: 09 September 2019

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Correction Open Access

[Corrigendum] Effects of the Tangningtongluo formula as an alternative strategy for diabetics via upregulation of insulin receptor substrate-1

Long Cheng, Junmei Song, Geng Li, Yue Liu, Yuming Wang, Xiangbao Meng, Guibo Sun, Xiaobo Sun
Pages: 4391-4392
Published online on: 04 September 2019

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Correction Open Access

[Corrigendum] The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease

Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tang
Pages: 4393-4393
Published online on: 04 September 2019

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Article Open Access

Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach Corrigendum in /10.3892/mmr.2021.12308

Maciej Brązert, Wiesława Kranc, Piotr Celichowski, Katarzyna Ożegowska, Joanna Budna‑Tukan, Michal Jeseta, Leszek Pawelczyk, Małgorzata Bruska, Maciej Zabel, Michał Nowicki, Bartosz Kempisty
Pages: 4403-4414
Published online on: 26 September 2019

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Article Open Access

Bioinformatics analysis of gene expression profile data to screen key genes involved in intracranial aneurysms

Tie Guo, Dan Hou, Dan Yu
Pages: 4415-4424
Published online on: 23 September 2019

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Article Open Access

Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats

Yi Li, Yongcheng Du, Aizhen Zhang, Rui Jiang, Xin Nie, Xue Xiong
Pages: 4425-4432
Published online on: 20 September 2019

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Article Open Access

CaSR participates in the regulation of vascular tension in the mesentery of hypertensive rats via the PLC‑IP3/AC‑V/cAMP/RAS pathway

Wenwen Zhang, Ruixia Sun, Hua Zhong, Na Tang, Yongmin Liu, Yongli Zhao, Tian Zhang, Fang He
Pages: 4433-4448
Published online on: 27 August 2019

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Article Open Access

MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway Retraction in /10.3892/mmr.2025.13543

Yeli Wang, Linsong Mu, Miaoling Huang
Pages: 4449-4458
Published online on: 01 October 2019

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Article Open Access

UCP2 silencing aggravates mitochondrial dysfunction in astrocytes under septic conditions

Wanwan Peng, Jinda Huang, Yijun Zheng, Yue Ding, Sitao Li, Junliang Zhang, Juanjuan Lyu, Qiyi Zeng
Pages: 4459-4466
Published online on: 02 October 2019

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Article Open Access

Tissue-specific transcriptional regulation of epithelial/endothelial and mesenchymal markers during renovascular hypertension

Leandro Ricardo Ferraz, Bianca Caruso Moreira, Gabriela de Souza Rodrigues de Queiroz, Regiane de Freitas Formigari, Marcelo Augusto Marreto Esquisatto, Maira Felonato, Armindo Antonio Alves, Bruna Fontana Thomazini, Camila Andréa de Oliveira
Pages: 4467-4476
Published online on: 02 October 2019

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Article Open Access

TAFA5 promotes proliferation and migration in gastric cancer

Zhiqing Hu, Gengming Niu, Jun Ren, Xin Wang, Liang Chen, Runqi Hong, Chongwei Ke
Pages: 4477-4488
Published online on: 02 October 2019

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Article Open Access

Expression of HIF‑1α in cycling stretch‑induced osteogenic differentiation of bone mesenchymal stem cells

Haibo Yu, Wenyi Yu, Ying Liu, Xiao Yuan, Rongtao Yuan, Qingyuan Guo
Pages: 4489-4498
Published online on: 30 September 2019

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Article Open Access

ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

Xian Zhang, Xinying Yang, Ming Chen, Shaolie Zheng, Jinyuan Li, Shaoqiang Lin, Xiaoyu Wang
Pages: 4499-4506
Published online on: 26 September 2019

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Article Open Access

MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells

Zhongzeng Liang, Qunwen Pan, Zhi Zhang, Chaosheng Huang, Zeming Yan, Yuanqi Zhang, Jianwen Li
Pages: 4507-4514
Published online on: 24 September 2019

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Article Open Access

Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway

Yonghui Wang, Yana Sui, Yinggang Tao
Pages: 4515-4522
Published online on: 23 September 2019

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Article Open Access

Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats

Di Zhang, Yan‑Juan Yu, Feng‑Sen Xu, Jun‑Hua Yuan, Rui Wang, Cai‑Shun Zhang, Liu‑Xin Wang, Yuan Liu, Li‑Min Song, Jun‑Li Liu, Jing Dong
Pages: 4523-4532
Published online on: 01 October 2019

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Article Open Access

Downregulation of LINC01638 lncRNA inhibits migration and invasion of pancreatic ductal adenocarcinoma cells by reducing TGF‑β signaling

Huimin Lu, Jun Ye, Ling Zhang, Mao Li, Shan Lu, Dujiang Yang, Weiming Hu
Pages: 4533-4539
Published online on: 24 September 2019

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Article Open Access

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II‑induced arthritis

Zhe‑Yong Li, Jing‑Jing Zhou, Chun‑Lei Luo, Le‑Meng Zhang
Pages: 4540-4550
Published online on: 26 September 2019

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Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway

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miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1

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Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

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Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells

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Effects of resveratrol on learning and memory in rats with vascular dementia

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MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis

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Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats

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Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism

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Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models

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KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells

Madhura Patankar, Sinikka Eskelinen, Anne Tuomisto, Markus J. Mäkinen, Tuomo J. Karttunen
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MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis

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Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation

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Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats

Min Chen, Zhaoming Huang, Hong Bi, Xinghua Pan, Jian He, Lewei He, Xu He, Junyi Du, Kaihua Zhou, Liyan Wang, Qing Wang, Xiang Guo, Zhixian Jin
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House dust mite induces Sonic hedgehog signaling that mediates epithelial‑mesenchymal transition in human bronchial epithelial cells

Yimin Zou, Wenjuan Song, Lingxiao Zhou, Yanxiong Mao, Wei Hong
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Jue Wang, Haihong Lv
Pages: 4683-4687
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Culture and characterization of human dental pulp‑derived stem cells as limbal stem cells for corneal damage repair

Shankargouda Patil, Clinton D'Souza, Prakash Patil, Vidya Patil, Mridula Prabhu, Anil Bargale, Vishwas Kaveeshwar, Sarath Kumar, Praveenkumar Shetty
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Phosphoproteomic profiling of oxycodone‑treated spinal cord of rats with cancer‑induced bone pain

Hou‑Sheng Deng, Long‑Sheng Xu, Hua‑Dong Ni, Yun‑Gong Wang, Hong‑Bo Li, Qiu‑Li He, Miao Xu, Ming Yao
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Elevated expression of the leptin receptor ob‑R may contribute to inflammation in patients with ulcerative colitis

Yan‑Ming Tian, Si‑Yu Tian, Dong Wang, Fang Cui, Xiang‑Jian Zhang, Yi Zhang
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Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins

Bo Zhang, Ge Zhan, Qing Fang, Fang Wang, Yang Li, Yuhao Zhang, Lei Zhao, Guocui Zhang, Baoxin Li
Pages: 4713-4722
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Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts

Fange Kong, Xueying Cai, Siyu Zhai, Ruochen Wang, Xiaoyi Zheng, Yue Ma, Hui Bi, Di Wang
Pages: 4723-4730
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Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Pages: 4731-4740
Published online on: 01 October 2019

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

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[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

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Article Number: 75
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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

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Article Number: 73
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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
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[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

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Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
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[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
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[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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