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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2019 Volume 20 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia

Jin Chen, Hui Liu, Liyan Li, Honglei Wang, Yi Li, Yihao Wang, Kai Ding, Shanfeng Hao, Yuanyuan Shao, Lijuan Li, Jia Song, Guojin Wang, Zonghong Shao, Rong Fu
Pages: 3979-3990
Published online on: 10 September 2019

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Article Open Access

Plasma extracellular vesicle‑packaged microRNAs as candidate diagnostic biomarkers for early‑stage breast cancer

Chen Yan, Jintao Hu, Yipeng Yang, Hong Hu, Dongxian Zhou, Min Ma, Nan Xu
Pages: 3991-4002
Published online on: 10 September 2019

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Article

Suppression of microRNA‑27a protects against liver ischemia/reperfusion injury by targeting PPARγ and inhibiting endoplasmic reticulum stress

Xiaobin Chi, Yi Jiang, Yongbiao Chen, Fang Yang, Qiucheng Cai, Fan Pan, Lizhi Lv, Xiaojin Zhang
Pages: 4003-4012
Published online on: 03 September 2019

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Article Open Access

Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis

Kai Wang, Yun Chen, Zhihong Zhao, Meiying Feng, Shouquan Zhang
Pages: 4013-4022
Published online on: 16 September 2019

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Article Open Access

MicroRNA‑195 inhibits epithelial‑mesenchymal transition by targeting G protein‑coupled estrogen receptor 1 in endometrial carcinoma

Junfeng Deng, Weihua Wang, Guangyu Yu, Xiuzhen Ma
Pages: 4023-4032
Published online on: 06 September 2019

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Article Open Access

Aldosterone promotes renal interstitial fibrosis via the AIF‑1/AKT/mTOR signaling pathway

Xueying Yuan, Xingzhi Wang, Yushu Li, Xin Li, Shuyu Zhang, Lirong Hao
Pages: 4033-4044
Published online on: 13 September 2019

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Article Open Access

Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway

Liu Yang, Qi Hong, Si‑Guang Xu, Xia‑Ying Kuang, Gen‑Hong Di, Guang‑Yu Liu, Jiong Wu, Zhi‑Ming Shao, San‑Jian Yu
Pages: 4045-4258
Published online on: 03 September 2019

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Article Open Access

PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway

Shen Liu, Jun Jia, Hengxing Zhou, Chi Zhang, Lu Liu, Jun Liu, Lu Lu, Xueying Li, Yi Kang, Yongfu Lou, Zhiwei Cai, Yiming Ren, Xiaohong Kong, Shiqing Feng
Pages: 4059-4066
Published online on: 10 September 2019

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Article Open Access

Dihydroartemisinin inhibits multiplication of Brucella suis vaccine strain 2 in murine microglia BV2 cells via stimulation of caspase‑dependent apoptosis

Juan Yang, Haining Li, Zhao Wang, Liming Yu, Qiang Liu, Xiaoyan Niu, Ting Xu, Zhenhai Wang
Pages: 4067-4072
Published online on: 11 September 2019

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Article Open Access

BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44

Lei Gao, Hansong Liu, Ningwei Yin, Shanshan Zuo, Guangli Jin, Yangxi Hu, Desheng Hu, Ying Li, Qiong Song, Xuejie Fei
Pages: 4073-4080
Published online on: 02 September 2019

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Article Open Access

Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress

Yao Wang, Qian Chen, Chunxia Shi, Fangzhou Jiao, Zuojiong Gong
Pages: 4081-4090
Published online on: 10 September 2019

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Article Open Access

Reconstruction and analysis of competitive endogenous RNA network reveals regulatory role of long non‑coding RNAs in hepatic fibrosis

Hui Jiang, Furong Wu, Nannan Jiang, Jiarong Gao, Jiafu Zhang
Pages: 4091-4100
Published online on: 13 September 2019

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Article Open Access

Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats

Chengguo Su, Yuzhou Chen, Yunfei Chen, Yin Zhou, Lianbo Li, Qunwen Lu, Huahui Liu, Xiaochao Luo, Jun Zhu
Pages: 4101-4110
Published online on: 11 September 2019

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Article Open Access

D‑galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence

Jingang Hou, Yeejin Yun, Jianjie Xue, Mengqi Sun, Sunchang Kim
Pages: 4111-4118
Published online on: 12 September 2019

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Article Open Access

Hydrogen sulfide protects against high glucose‑induced lipid metabolic disturbances in 3T3‑L1 adipocytes via the AMPK signaling pathway

Zhe Pan, Jue Wang, Min Xu, Shihong Chen, Xiaobo Li, Aili Sun, Nengjun Lou, Yihong Ni
Pages: 4119-4124
Published online on: 16 September 2019

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Article Open Access

Comprehensive expression profiles and bioinformatics analysis reveal special circular RNA expression and potential predictability in the peripheral blood of humans with idiopathic membranous nephropathy

Xuefeng Jin, Bi Deng, Kun Ye, Dongmei Ye, Yiyun Huang, Xiaoyu Chen, Zhousheng Yang, Ying Chen
Pages: 4125-4139
Published online on: 10 September 2019

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Article Open Access

miR‑92a‑3p regulates trypsinogen activation via Egr1 in AR42J cells

Xueming Zhang, Bo Gao, Yang Huang, Yong Zhang, Zhituo Li, Dali Zhao, Biao Ma, Dongbo Xue, Weihui Zhang
Pages: 4140-4150
Published online on: 11 September 2019

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Article Open Access

miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke

Qini Zhao, Huan Sun, Liquan Yin, Libo Wang
Pages: 4151-4167
Published online on: 12 September 2019

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Article Open Access

lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA‑101

Wenjun Yu, Zhenni Sun, Ling Yang, Yafei Han, Lu Yue, Lihua Deng, Ruyong Yao
Pages: 4168-4174
Published online on: 03 September 2019

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Article Open Access

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Si Lei, Yanling She, Jie Zeng, Rui Chen, Shanyao Zhou, Huacai Shi
Pages: 4175-4185
Published online on: 10 September 2019

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Article Open Access

Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury

Zhongsheng Zhang, Shuangfeng Liu, Sichun Huang
Pages: 4186-4192
Published online on: 13 September 2019

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Article Open Access

LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells

Yuan‑Ming Geng, Cheng‑Xia Liu, Wei‑Ying Lu, Ping Liu, Pei‑Yan Yuan, Wei‑Long Liu, Ping‑Ping Xu, Xiao‑Qing Shen
Pages: 4193-4201
Published online on: 16 September 2019

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Article Open Access

Microarray‑based analysis of COL11A1 and TWIST1 as important differentially‑expressed pathogenic genes between left and right‑sided colon cancer

Chen Su, Jiabao Zhao, Xinya Hong, Sijiu Yang, Ying Jiang, Jingjing Hou
Pages: 4202-4214
Published online on: 10 September 2019

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Article Open Access

Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway

Shoudan Zhang, Wenshi Guo
Pages: 4215-4225
Published online on: 10 September 2019

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Article Open Access

High‑fat treatment prevents postoperative cognitive dysfunction in a hyperlipidemia model by protecting the blood‑brain barrier via Mfsd2a‑related signaling

Xiao‑Ping Zhang, Yu‑Ru Liu, Mei Chai, Hai‑Tao Yang, Guan Wang, Mei Han, Dong‑Bai Li
Pages: 4226-4234
Published online on: 12 September 2019

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Article Open Access

Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2

Zhuo Sun, Jinqi Lu, Muyu Wu, Mingyan Li, Lu Bai, Zhenduo Shi, Lin Hao, Yongping Wu
Pages: 4235-4243
Published online on: 10 September 2019

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Article Open Access

CTHRC1 and PD‑1/PD‑L1 expression predicts tumor recurrence in prostate cancer

Qing Zhou, Wei Xiong, Xing Zhou, Rui‑Song Gao, Qun‑Fang Lin, Hui‑Ying Liu, Juan‑Ni Li, Xue‑Fei Tian
Pages: 4244-4252
Published online on: 19 September 2019

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Article Open Access

Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats

Minhua Gu, Peikun He, Chenfei Lyu, Xiaoyu Liu, Yuling Xu, Saibo Cheng, Yong Gu, Yuhua Jia
Pages: 4253-4261
Published online on: 16 September 2019

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Article

GDF15 promotes osteosarcoma cell migration and invasion by regulating the TGF‑β signaling pathway

Guangfu Chen, Min Wang, Xiang Liu
Pages: 4262-4270
Published online on: 10 September 2019

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Article

MicroRNA‑20a negatively regulates the growth and osteoclastogenesis of THP‑1 cells by downregulating PPARγ

Huining Wang, Yuqin Shen
Pages: 4271-4276
Published online on: 12 September 2019

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Article

Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation

Haiying Hu, Dandan Shao, Leilei Wang, Fang He, Xiaoxu Huang, Yanyu Lu, Xiaona Xiang, Susu Zhu, Pianhong Zhang, Jianru Li, Jingsen Chen
Pages: 4277-4284
Published online on: 09 September 2019

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Article

Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion

Feng‑Chen Zhu, Dian‑Ming Jiang, Ming‑Hua Zhang, Bo Zhao, Chao He, Jian Yang
Pages: 4285-4292
Published online on: 16 September 2019

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Article

miRNA‑101‑3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway

Shuifang Chen, Zeying Zhang, Lina Chen, Jianli Zhang
Pages: 4293-4302
Published online on: 09 September 2019

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Article

MicroRNA‑30a controls the instability of inducible CD4+ Tregs through SOCS1

Ya Zhou, Yongju Li, Jia Lu, Xiaowu Hong, Lin Xu
Pages: 4303-4314
Published online on: 10 September 2019

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Article

Effects of hypoxia‑inducible factor‑1α on the proliferation and apoptosis of human synovial mesenchymal stem cells

Weiwei Zheng, Xueping Gu, Xingwei Sun, Dan Hu
Pages: 4315-4322
Published online on: 09 September 2019

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Article

Heat shock transcription factor 1 affects kidney tubular cell migration by regulating the TGF‑β1‑Smad2/3 signaling pathway

Qiang Lou, Yuanyuan Li, Beibei Hou, Yonglian Liu, Yan Zhang, Jielu Hao, Yuanfang Ma
Pages: 4323-4330
Published online on: 16 September 2019

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Article

Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro

Miho Ueta, Kazuki Takaoka, Michiyo Yamamura, Hanako Maeda, Joji Tamaoka, Yoshioro Nakano, Kazuma Noguchi, Hiromitsu Kishimoto
Pages: 4331-4339
Published online on: 10 September 2019

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Article

A novel seven‑miRNA prognostic model to predict overall survival in head and neck squamous cell carcinoma patients

Le Lu, Yufan Wu, Min Feng, Xiaofeng Xue, Yuan Fan
Pages: 4340-4348
Published online on: 10 September 2019

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Article

N‑acetyl cysteine protects HUVECs against lipopolysaccharide‑mediated inflammatory reaction by blocking the NF‑κB signaling pathway

Zhenzhen Zhang, Ting Xiong, Rui Zheng, Jialin Huang, Ling Guo
Pages: 4349-4357
Published online on: 12 September 2019

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Article

Availability of NK cell expansion agent combined with recombinant IL‑2 and IL‑15 stimulation on the expansion and high‑purity of NK cells in patients with immune‑related pancytopenia in vitro

Yang Li, Bingnan Liu, Shaoxue Ding, Chunyan Liu, Tong Chen, Lijuan Li, Zonghong Shao, Rong Fu
Pages: 4358-4366
Published online on: 09 September 2019

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Article Open Access

Delay in hepatocyte proliferation and prostaglandin D2 synthase expression for cholestasis due to endotoxin during partial hepatectomy in rats

Yusuke Wakasa, Norihisa Kimura, Toshiyuki Yamada, Takeshi Shimizu, Kenichi Hakamada, Shigeki Tsuchida
Pages: 4367-4375
Published online on: 13 September 2019

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Article

MicroRNA‑381 regulates the growth of gastric cancer cell by targeting TWIST1

Yongling Yin, Xiaoyun Li, Zongquan Guo, Fuxiang Zhou
Pages: 4376-4382
Published online on: 06 September 2019

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Article

Effects of isoflurane on complex II‑associated mitochondrial respiration and reactive oxygen species production: Roles of nitric oxide and mitochondrial KATP channels

Junan Wang, Jie Sun, Shigang Qiao, Hua Li, Tuanjie Che, Chen Wang, Jianzhong An
Pages: 4383-4390
Published online on: 09 September 2019

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Correction Open Access

[Corrigendum] Effects of the Tangningtongluo formula as an alternative strategy for diabetics via upregulation of insulin receptor substrate-1

Long Cheng, Junmei Song, Geng Li, Yue Liu, Yuming Wang, Xiangbao Meng, Guibo Sun, Xiaobo Sun
Pages: 4391-4392
Published online on: 04 September 2019

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Correction Open Access

[Corrigendum] The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease

Hui Zhu, Xinyue Qi, Yuehe Liu, Wei Liao, Xiangshui Sun, Yuping Tang
Pages: 4393-4393
Published online on: 04 September 2019

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Article Open Access

Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach Corrigendum in /10.3892/mmr.2021.12308

Maciej Brązert, Wiesława Kranc, Piotr Celichowski, Katarzyna Ożegowska, Joanna Budna‑Tukan, Michal Jeseta, Leszek Pawelczyk, Małgorzata Bruska, Maciej Zabel, Michał Nowicki, Bartosz Kempisty
Pages: 4403-4414
Published online on: 26 September 2019

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Article Open Access

Bioinformatics analysis of gene expression profile data to screen key genes involved in intracranial aneurysms

Tie Guo, Dan Hou, Dan Yu
Pages: 4415-4424
Published online on: 23 September 2019

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Article Open Access

Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats

Yi Li, Yongcheng Du, Aizhen Zhang, Rui Jiang, Xin Nie, Xue Xiong
Pages: 4425-4432
Published online on: 20 September 2019

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Article Open Access

CaSR participates in the regulation of vascular tension in the mesentery of hypertensive rats via the PLC‑IP3/AC‑V/cAMP/RAS pathway

Wenwen Zhang, Ruixia Sun, Hua Zhong, Na Tang, Yongmin Liu, Yongli Zhao, Tian Zhang, Fang He
Pages: 4433-4448
Published online on: 27 August 2019

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Article Open Access

MicroRNA‑195 suppresses rectal cancer growth and metastasis via regulation of the PI3K/AKT signaling pathway Retraction in /10.3892/mmr.2025.13543

Yeli Wang, Linsong Mu, Miaoling Huang
Pages: 4449-4458
Published online on: 01 October 2019

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Article Open Access

UCP2 silencing aggravates mitochondrial dysfunction in astrocytes under septic conditions

Wanwan Peng, Jinda Huang, Yijun Zheng, Yue Ding, Sitao Li, Junliang Zhang, Juanjuan Lyu, Qiyi Zeng
Pages: 4459-4466
Published online on: 02 October 2019

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Article Open Access

Tissue-specific transcriptional regulation of epithelial/endothelial and mesenchymal markers during renovascular hypertension

Leandro Ricardo Ferraz, Bianca Caruso Moreira, Gabriela de Souza Rodrigues de Queiroz, Regiane de Freitas Formigari, Marcelo Augusto Marreto Esquisatto, Maira Felonato, Armindo Antonio Alves, Bruna Fontana Thomazini, Camila Andréa de Oliveira
Pages: 4467-4476
Published online on: 02 October 2019

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Article Open Access

TAFA5 promotes proliferation and migration in gastric cancer

Zhiqing Hu, Gengming Niu, Jun Ren, Xin Wang, Liang Chen, Runqi Hong, Chongwei Ke
Pages: 4477-4488
Published online on: 02 October 2019

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Article Open Access

Expression of HIF‑1α in cycling stretch‑induced osteogenic differentiation of bone mesenchymal stem cells

Haibo Yu, Wenyi Yu, Ying Liu, Xiao Yuan, Rongtao Yuan, Qingyuan Guo
Pages: 4489-4498
Published online on: 30 September 2019

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Article Open Access

ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

Xian Zhang, Xinying Yang, Ming Chen, Shaolie Zheng, Jinyuan Li, Shaoqiang Lin, Xiaoyu Wang
Pages: 4499-4506
Published online on: 26 September 2019

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Article Open Access

MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells

Zhongzeng Liang, Qunwen Pan, Zhi Zhang, Chaosheng Huang, Zeming Yan, Yuanqi Zhang, Jianwen Li
Pages: 4507-4514
Published online on: 24 September 2019

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Article Open Access

Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway

Yonghui Wang, Yana Sui, Yinggang Tao
Pages: 4515-4522
Published online on: 23 September 2019

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Article Open Access

Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats

Di Zhang, Yan‑Juan Yu, Feng‑Sen Xu, Jun‑Hua Yuan, Rui Wang, Cai‑Shun Zhang, Liu‑Xin Wang, Yuan Liu, Li‑Min Song, Jun‑Li Liu, Jing Dong
Pages: 4523-4532
Published online on: 01 October 2019

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Article Open Access

Downregulation of LINC01638 lncRNA inhibits migration and invasion of pancreatic ductal adenocarcinoma cells by reducing TGF‑β signaling

Huimin Lu, Jun Ye, Ling Zhang, Mao Li, Shan Lu, Dujiang Yang, Weiming Hu
Pages: 4533-4539
Published online on: 24 September 2019

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Article Open Access

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II‑induced arthritis

Zhe‑Yong Li, Jing‑Jing Zhou, Chun‑Lei Luo, Le‑Meng Zhang
Pages: 4540-4550
Published online on: 26 September 2019

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Published online on: 25 September 2019

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miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1

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Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

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Published online on: 24 September 2019

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Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells

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MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis

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Published online on: 26 September 2019

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Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats

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Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism

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Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models

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KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells

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MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis

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Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats

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House dust mite induces Sonic hedgehog signaling that mediates epithelial‑mesenchymal transition in human bronchial epithelial cells

Yimin Zou, Wenjuan Song, Lingxiao Zhou, Yanxiong Mao, Wei Hong
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Jue Wang, Haihong Lv
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Shankargouda Patil, Clinton D'Souza, Prakash Patil, Vidya Patil, Mridula Prabhu, Anil Bargale, Vishwas Kaveeshwar, Sarath Kumar, Praveenkumar Shetty
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Yan‑Ming Tian, Si‑Yu Tian, Dong Wang, Fang Cui, Xiang‑Jian Zhang, Yi Zhang
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Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins

Bo Zhang, Ge Zhan, Qing Fang, Fang Wang, Yang Li, Yuhao Zhang, Lei Zhao, Guocui Zhang, Baoxin Li
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Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts

Fange Kong, Xueying Cai, Siyu Zhai, Ruochen Wang, Xiaoyi Zheng, Yue Ma, Hui Bi, Di Wang
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Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Pages: 4731-4740
Published online on: 01 October 2019

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

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Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
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Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Published online on: 31 October 2025

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Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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