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Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway

  • Authors:
    • Shoudan Zhang
    • Wenshi Guo
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4215-4225
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    Published online on: September 10, 2019
       https://doi.org/10.3892/mmr.2019.10659
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Abstract

Glioma is one of the most common types of tumor of the central nervous system with high mobility and mortality. The prognosis of patients with high‑grade glioma is poor. Therefore, it is urgent to develop the therapeutic strategies for the treatment of glioma. Long non‑coding RNAs (lncRNAs) have been reported as potential inducers or suppressors of numerous types of tumors including glioma. Previous studies have revealed that lncRNA maternally expressed gene 3 (MEG3) is involved in the initiation and progression of cancer; however, the underlying mechanisms remain unclear. In the present study, MEG3 was downregulated in glioma tissue. In addition, downregulation of MEG3 was observed in human glioma cell lines compared with normal astrocyte cells. Furthermore, overexpressed MEG3 inhibited the proliferation, migration and invasion of glioma cells. Additionally, microRNA‑96‑5p (miR‑96‑5p) was a promising target of MEG3, and the promoting effects of miR‑96‑5p on cell growth and metastasis could be reversed by upregulated MEG3. Metastasis suppressor 1 (MTSS1) was predicted as the putative target of miR‑96‑5p, and its expression was restored by MEG3. In summary, the present data provided novel insight into the roles of MEG3 in glioma, and MEG3/miR‑96‑5p/MTSS1 signaling could be a promising therapeutic target for the treatment of patients with glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S and Guo W: Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway . Mol Med Rep 20: 4215-4225, 2019.
APA
Zhang, S., & Guo, W. (2019). Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway . Molecular Medicine Reports, 20, 4215-4225. https://doi.org/10.3892/mmr.2019.10659
MLA
Zhang, S., Guo, W."Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway ". Molecular Medicine Reports 20.5 (2019): 4215-4225.
Chicago
Zhang, S., Guo, W."Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway ". Molecular Medicine Reports 20, no. 5 (2019): 4215-4225. https://doi.org/10.3892/mmr.2019.10659
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S and Guo W: Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway . Mol Med Rep 20: 4215-4225, 2019.
APA
Zhang, S., & Guo, W. (2019). Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway . Molecular Medicine Reports, 20, 4215-4225. https://doi.org/10.3892/mmr.2019.10659
MLA
Zhang, S., Guo, W."Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway ". Molecular Medicine Reports 20.5 (2019): 4215-4225.
Chicago
Zhang, S., Guo, W."Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway ". Molecular Medicine Reports 20, no. 5 (2019): 4215-4225. https://doi.org/10.3892/mmr.2019.10659
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