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Article Open Access

Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia

  • Authors:
    • Jin Chen
    • Hui Liu
    • Liyan Li
    • Honglei Wang
    • Yi Li
    • Yihao Wang
    • Kai Ding
    • Shanfeng Hao
    • Yuanyuan Shao
    • Lijuan Li
    • Jia Song
    • Guojin Wang
    • Zonghong Shao
    • Rong Fu
  • View Affiliations / Copyright

    Affiliations: Department of Haematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3979-3990
    |
    Published online on: September 10, 2019
       https://doi.org/10.3892/mmr.2019.10663
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Abstract

In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condition was termed immune‑related haemocytopenia (IRH). However, the quantity of T lymphocytes remained unknown. In the present study, the percentage of CD4+ T‑cell subsets and related cytokines was measured using flow cytometry and an enzyme‑linked immunosorbent assay. An abnormal number of CD4+ T cell subsets was found, including increased percentages of T helper (Th)2, Th9 and Th17 cells and a decreased number of regulatory T (Treg) cells. In addition, the results showed downregulation in the levels of interleukin (IL)‑2, transforming growth factor‑β and IL‑35, and upregulation in the levels of IL‑4, IL‑6, IL‑17, IL‑23 and interferon‑γ in patients who did not receive therapy (untreated patients). These levels were significantly associated with the number of peripheral blood cells and were recovered following treatment. In conclusion, an abnormal number of CD4+ T cell subsets and corresponding abnormal levels of regulatory cytokines resulted in the stimulation of B1 lymphocytes to produce autoantibodies in IRH, which may be considered as markers to evaluate disease prognosis and treatment strategies.
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View References

1 

Fu R, Liu H, Wang Y, Liu H, He H, Chen J, Wang H, Yu H, Ding K, Huang L, et al: Distinguishing immunorelated haemocytopenia from idiopathic cytopenia of undetermined significance (ICUS): A bone marrow abnormality mediated by autoantibodies. Clin Exp Immunol. 177:412–418. 2014. View Article : Google Scholar : PubMed/NCBI

2 

He H, Shao Z and Cao Z: Bone marrow mononuclear Coombs test. Chin J Hematol. 21:550–551. 2000.

3 

Sun J, Cao Z and Tu F: Modified direct antiglobulin test. Chin J Laborat Med. 26:12–14. 2006.

4 

Wang YH, Fu R, Dong SW, Liu H and Shao ZH: Erythroblastic islands in the bone marrow of patients with immune-related pancytopenia. PLoS One. 9:e951432014. View Article : Google Scholar : PubMed/NCBI

5 

Liu H, Fu R, Wang Y, Liu H, Li L, Wang H, Chen J, Yu H and Shao Z: Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia. Clin Dev Immunol. 2013:2976782013. View Article : Google Scholar : PubMed/NCBI

6 

Wang YH, Fu R, Shao ZH, Wang HQ, Xing LM, Liu H, Wu YH, Li LJ, Liu H, Wang J, et al: Study on quantity and function of bone marrow macrophages in patients with BMMNC-Coombs Test(+) pancytopenia. Zhonghua Xue Ye Xue Za Zhi. 30:538–542. 2009.(In Chinese). PubMed/NCBI

7 

Chen J, Fu R, Li LJ, Liu H, Wang YH, Wang HL and Shao ZH: Variation in complement level and its significance in cytopenia patients with positive BMMNC-Coombs. Zhonghua Xue Ye Xue Za Zhi. 30:454–457. 2009.(In Chinese). PubMed/NCBI

8 

Fu R, Liu H, Wang J, Li LJ, Wang HL, Wang YH and Shao ZH: Preliminary study of autoantigens on the membrane of erythropoietic cells of the patients with BMMNC-Coomb's test(+) hemocytopenia. Zhonghua Yi Xue Za Zhi. 92:2689–2693. 2012.(In Chinese). PubMed/NCBI

9 

Fu R, Shao Z, He H, Liu H, Jia H, Sun J, Zhao M, He G, Shi J, Bai J, et al: Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia. Zhonghua Xue Ye Xue Za Zhi. 23:236–238. 2002.(In Chinese). PubMed/NCBI

10 

Wang Y, Fu R, Liu H, Wang H, Zhang T, Ding S, Zhang J, Gao S, Liu C, Wang J, et al: Memory B (CD5+ CD19+ CD27+) lymphocyte in patients with immune-related pancytopenia. Zhonghua Xue Ye Xue Za Zhi. 35:719–723. 2014.(In Chinese). PubMed/NCBI

11 

Raphael I and Forsthuber TG: Stability of T-cell lineages in autoimmune diseases. Expert Rev Clin Immunol. 8:299–301. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Raphael I, Nalawade S, Eagar TN and Forsthuber TG: T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 74:5–17. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q and Dong C: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 6:1133–1141. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM and Weaver CT: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6:1123–1132. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Miyara M and Sakaguchi S: Natural regulatory T cells: Mechanisms of suppression. Trends Mol Med. 13:108–116. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Fu R, Wang HL, Chen J, Wang J, Li LJ, Liu H, Wang YH, Ren Y and Shao ZH: Study of the quantity and function of Th17 cells in the blood cytopenic patients with positive BMMNC-Coombs test. Zhonghua Xue Ye Xue Za Zhi. 31:684–687. 2010.(In Chinese). PubMed/NCBI

17 

Fu R, Chen J, Wang HL, Wang J, Li LJ, Liu H, Wang YH, Ren Y and Shao ZH: Quantity and function of regulatory T cells in hemocytopenic patients with positive BMMNC-Coombs test. Zhonghua Yi Xue Za Zhi. 90:2989–2993. 2010.(In Chinese). PubMed/NCBI

18 

Yu H, Zhang J, Fu R, Liu H, Wang H, Ding K, Wang Y, Li L, Wang H and Shao Z: Increased frequency of bone marrow T follicular helper cells in patients with immune-related pancytopenia. Clin Dev Immunol. 2013:7304502013. View Article : Google Scholar : PubMed/NCBI

19 

Zhu X, Guan J, Xu J, Wei J, Jiang L, Yin J, Zhao L and Zhang Y: Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. Blood Cells Mol Dis. 53:157–160. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Heinzel FP, Sadick MD, Holaday BJ, Coffman RL and Locksley RM: Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 169:59–72. 1989. View Article : Google Scholar : PubMed/NCBI

21 

Hori S, Nomura T and Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057–1061. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Mattozzi C, Salvi M, D'Epiro S, Giancristoforo S, Macaluso L, Luci C, Lal K, Calvieri S and Richetta AG: Importance of regulatory T cells in the pathogenesis of psoriasis: Review of the literature. Dermatology. 227:134–145. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Xu D, Liu H, Komai-Koma M, Campbell C, McSharry C, Alexander J and Liew FY: CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol. 170:394–399. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T and Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 212:8–27. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Kim HP, Kelly J and Leonard WJ: The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: Importance of two widely separated IL-2 response elements. Immunity. 15:159–172. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Setoguchi R, Hori S, Takahashi T and Sakaguchi S: Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 201:723–735. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S and Chen W: A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol. 9:632–640. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Nakamura K, Kitani A and Strober W: Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 194:629–644. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Nakano S, Morimoto S, Suzuki S, Tsushima H, Yamanaka K, Sekigawa I and Takasaki Y: Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis. Rheumatology (Oxford). 54:1498–1506. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR and Weaver CT: Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 441:231–234. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O and Andris F: Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood. 113:2426–2433. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lin FJ, Jiang GR, Shan JP, Zhu C, Zou J and Wu XR: Imbalance of regulatory T cells to Th17 cells in IgA nephropathy. Scand J Clin Lab Invest. 72:221–229. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ooi JD, Kitching AR and Holdsworth SR: Review: T helper 17 cells: Their role in glomerulonephritis. Nephrology (Carlton). 15:513–521. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Stangou M, Bantis C, Skoularopoulou M, Korelidou L, Kouloukouriotou D, Scina M, Labropoulou IT, Kouri NM, Papagianni A and Efstratiadis G: Th1, Th2 and Treg/T17 cytokines in two types of proliferative glomerulonephritis. Indian J Nephrol. 26:159–166. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ and Gurney AL: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 278:1910–1914. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Croxford AL, Mair F and Becher B: IL-23: One cytokine in control of autoimmunity. Eur J Immunol. 42:2263–2273. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Olewicz-Gawlik A, Danczak-Pazdrowska A, Kuznar-Kaminska B, Gornowicz-Porowska J, Katulska K, Trzybulska D, Batura-Gabryel H, Silny W, Poplawski D and Hrycaj P: Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis. Int J Rheum Dis. 17:664–670. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Ouyang H, Shi Y, Liu Z, Feng S, Li L, Su N, Lu Y and Kong S: Increased interleukin-9 and CD4+IL-9+ T cells in patients with systemic lupus erythematosus. Mol Med Rep. 7:1031–1037. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Masuda M, Matsumoto M, Tanaka S, Nakajima K, Yamada N, Ido N, Ohtsuka T, Nishida M, Hirano T and Utsumi H: Clinical implication of peripheral CD4+CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients. J Neuroimmunol. 225:123–131. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Ishihara K and Hirano T: IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13:357–368. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Aricha R, Mizrachi K, Fuchs S and Souroujon MC: Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis. J Autoimmun. 36:135–141. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Fu R and Shao Z: Immuno-related pancytopenia: A newly recognized disease (part 1). Chin J Med. 40:5–8. 2005.

43 

Enghard P, Humrich J, Chu VT, Grussie E, Hiepe F, Burmester GR, Radbruch A, Berek C and Riemekasten G: Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development. Eur J Immunol. 40:1809–1818. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB and Rothstein TL: Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol. 37:2400–2404. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Zhong X, Lau S, Bai C, Degauque N, Holodick NE, Steven SJ, Tumang J, Gao W and Rothstein TL: A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice. Arthritis Rheum. 60:3734–3743. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Maseda D, Candando KM, Smith SH, Kalampokis I, Weaver CT, Plevy SE, Poe JC and Tedder TF: Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice. J Immunol. 191:2780–2795. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Shao Y, Fu R, Liu H, Wang Y, Ding S, Wang H, Li L and Shao Z: IgG autoantibody subclasses altered in immuno-related hemocytopenia. Cell Immunol. 294:13–20. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Wu YY, Georg I, Díaz-Barreiro A, Varela N, Lauwerys B, Kumar R, Bagavant H, Castillo-Martín M, El Salem F, Marañón C and Alarcón-Riquelme ME: Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels. J Immunol. 194:5692–5702. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Deng J, Wang X, Chen Q, Sun X, Xiao F, Ko KH, Zhang M and Lu L: B1a cells play a pathogenic role in the development of autoimmune arthritis. Oncotarget. 7:19299–19311. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Flores-Borja F, Bosma A, Ng D, Reddy V, Ehrenstein MR, Isenberg DA and Mauri C: CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Sci Transl Med. 5:173ra232013. View Article : Google Scholar : PubMed/NCBI

51 

Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR and Mauri C: CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity. 32:129–140. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Georgin-Lavialle S, Aouba A, Mouthon L, Londono-Vallejo JA, Lepelletier Y, Gabet AS and Hermine O: The telomere/telomerase system in autoimmune and systemic immune-mediated diseases. Autoimmun Rev. 9:646–651. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Fujii H, Shao L, Colmegna I, Goronzy JJ and Weyand CM: Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci USA. 106:4360–4365. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Hoffecker BM, Raffield LM, Kamen DL and Nowling TK: Systemic lupus erythematosus and vitamin D deficiency are associated with shorter telomere length among African Americans: A case-control study. PLoS One. 8:e637252013. View Article : Google Scholar : PubMed/NCBI

55 

Wu K, Higashi N, Hansen ER, Lund M, Bang K and Thestrup-Pedersen K: Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis. J Immunol. 165:4742–4747. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Son NH, Murray S, Yanovski J, Hodes RJ and Weng N: Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol. 165:1191–1196. 2000. View Article : Google Scholar : PubMed/NCBI

57 

King C, Tangye SG and Mackay CR: T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 26:741–766. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Lüthje K, Kallies A, Shimohakamada Y, Belz GT, Light A, Tarlinton DM and Nutt SL: The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol. 13:491–498. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, Walsh D, Olson MR, Kim MH, Tepper RS, et al: Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest. 123:4641–4653. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, Cianfarani F, Odorisio T, Traidl-Hoffmann C, et al: Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 119:3573–3585. 2009.PubMed/NCBI

61 

Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE and McKenzie AN: Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 203:1105–1116. 2006. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Chen J, Liu H, Li L, Wang H, Li Y, Wang Y, Ding K, Hao S, Shao Y, Li L, Li L, et al: Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia. Mol Med Rep 20: 3979-3990, 2019.
APA
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y. ... Fu, R. (2019). Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia. Molecular Medicine Reports, 20, 3979-3990. https://doi.org/10.3892/mmr.2019.10663
MLA
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y., Ding, K., Hao, S., Shao, Y., Li, L., Song, J., Wang, G., Shao, Z., Fu, R."Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia". Molecular Medicine Reports 20.5 (2019): 3979-3990.
Chicago
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y., Ding, K., Hao, S., Shao, Y., Li, L., Song, J., Wang, G., Shao, Z., Fu, R."Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia". Molecular Medicine Reports 20, no. 5 (2019): 3979-3990. https://doi.org/10.3892/mmr.2019.10663
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Spandidos Publications style
Chen J, Liu H, Li L, Wang H, Li Y, Wang Y, Ding K, Hao S, Shao Y, Li L, Li L, et al: Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia. Mol Med Rep 20: 3979-3990, 2019.
APA
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y. ... Fu, R. (2019). Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia. Molecular Medicine Reports, 20, 3979-3990. https://doi.org/10.3892/mmr.2019.10663
MLA
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y., Ding, K., Hao, S., Shao, Y., Li, L., Song, J., Wang, G., Shao, Z., Fu, R."Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia". Molecular Medicine Reports 20.5 (2019): 3979-3990.
Chicago
Chen, J., Liu, H., Li, L., Wang, H., Li, Y., Wang, Y., Ding, K., Hao, S., Shao, Y., Li, L., Song, J., Wang, G., Shao, Z., Fu, R."Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia". Molecular Medicine Reports 20, no. 5 (2019): 3979-3990. https://doi.org/10.3892/mmr.2019.10663
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