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Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2

  • Authors:
    • Zhuo Sun
    • Jinqi Lu
    • Muyu Wu
    • Mingyan Li
    • Lu Bai
    • Zhenduo Shi
    • Lin Hao
    • Yongping Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Urology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4235-4243
    |
    Published online on: September 10, 2019
       https://doi.org/10.3892/mmr.2019.10668
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Abstract

Proper spindle formation and accurate chromosome segregation are essential for ensuring mitotic fidelity. Phosphatase and tensin homolog (PTEN) is a multifunctional protein, which is able to maintain the stability of the genome and chromosomes. The present study described an essential role of PTEN in regulating chromosome segregation to prevent gross genomic instability via regulation of mitotic arrest deficient 2 (MAD2). PTEN knockdown induced cell cycle arrest and abnormal chromosome segregation, which manifested as the formation of anaphase bridges, lagging chromosomes and premature chromatid separation. In addition, MAD2 was identified as a potential target of PTEN. Furthermore, the present study revealed that PTEN knockdown resulted in MAD2 degradation via the ubiquitin‑proteasomal pathway, while restoration of MAD2 expression partially ameliorated the mitotic defects induced by PTEN loss. The results from the present study proposed a novel mechanism by which PTEN maintains chromosome stability.
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1 

Chalhoub N and Baker SJ: PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 4:127–150. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, et al: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 15:356–362. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Di Cristofano A and Pandolfi PP: The multiple roles of PTEN in tumor suppression. Cell. 100:387–390. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Salmena L, Carracedo A and Pandolfi PP: Tenets of PTEN tumor suppression. Cell. 133:403–414. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Yin Y and Shen WH: PTEN: A new guardian of the genome. Oncogene. 27:5443–5453. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Carracedo A and Pandolfi PP: The PTEN-PI3K pathway: Of feedbacks and cross-talks. Oncogene. 27:5527–5541. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Berger AH and Pandolfi PP: Haplo-insufficiency: A driving force in cancer. J Pathol. 223:137–146. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP and Yin Y: Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 128:157–170. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M and Pandolfi PP: Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 144:187–199. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Chen ZH, Zhu M, Yang J, Liang H, He J, He S, Wang P, Kang X, McNutt MA, Yin Y and Shen WH: PTEN interacts with histone H1 and controls chromatin condensation. Cell Rep. 8:2003–2014. 2014. View Article : Google Scholar : PubMed/NCBI

11 

He J, Kang X, Yin Y, Chao KS and Shen WH: PTEN regulates DNA replication progression and stalled fork recovery. Nat Commun. 6:76202015. View Article : Google Scholar : PubMed/NCBI

12 

Kang X, Song C, Du X, Zhang C, Liu Y, Liang L, He J, Lamb K, Shen WH and Yin Y: PTEN stabilizes TOP2A and regulates the DNA decatenation. Sci Rep. 5:178732015. View Article : Google Scholar : PubMed/NCBI

13 

Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, et al: Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 7:193–204. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Sun Z, Huang C, He J, Lamb KL, Kang X, Gu T, Shen WH and Yin Y: PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep. 6:844–854. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Schuyler SC, Wu YF and Kuan VJ: The Mad1-Mad2 balancing act-a damaged spindle checkpoint in chromosome instability and cancer. J Cell Sci. 125:4197–4206. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Musacchio A: The molecular biology of spindle assembly checkpoint signaling dynamics. Curr Biol. 25:R1002–R1018. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Shandilya J and Roberts SG: A role of WT1 in cell division and genomic stability. Cell Cycle. 14:1358–1364. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Han JS, Holland AJ, Fachinetti D, Kulukian A, Cetin B and Cleveland DW: Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell. 51:92–104. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Lau DT and Murray AW: Mad2 and Mad3 cooperate to arrest budding yeast in mitosis. Curr Biol. 22:180–190. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Burds AA, Lutum AS and Sorger PK: Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci USA. 102:11296–11301. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Rao CV, Yamada HY, Yao Y and Dai W: Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: A perspective from genetic studies in mice. Carcinogenesis. 30:1469–1474. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Schvartzman JM, Duijf PH, Sotillo R, Coker C and Benezra R: Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell. 19:701–714. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Feng J, Liang J, Li J, Li Y, Liang H, Zhao X, McNutt MA and Yin Y: PTEN controls the DNA replication process through MCM2 in response to replicative stress. Cell Rep. 13:1295–1303. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM and Sellers WR: Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA. 96:2110–2115. 1999. View Article : Google Scholar : PubMed/NCBI

25 

He J, Zhang Z, Ouyang M, Yang F, Hao H, Lamb KL, Yang J, Yin Y and Shen WH: PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nat Commun. 7:123552016. View Article : Google Scholar : PubMed/NCBI

26 

Wang LG, Liu XM, Kreis W and Budman DR: The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review. Cancer Chemother Pharmacol. 44:355–361. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Wang TH, Wang HS and Soong YK: Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer. 88:2619–2628. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Shandilya J, Toska E, Richard DJ, Medler KF and Roberts SG: WT1 interacts with MAD2 and regulates mitotic checkpoint function. Nat Commun. 5:49032014. View Article : Google Scholar : PubMed/NCBI

29 

Homer HA, McDougall A, Levasseur M, Yallop K, Murdoch AP and Herbert M: Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Genes Dev. 19:202–207. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV and Benezra R: MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 409:355–359. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, et al: Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 128:141–156. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Hernando E, Nahlé Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald W, Benezra R, et al: Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 430:797–802. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E and Pagano M: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature. 452:365–369. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Das T, Roy KS, Chakrabarti T, Mukhopadhyay S and Roychoudhury S: Withaferin A modulates the Spindle assembly checkpoint by degradation of Mad2-Cdc20 complex in colorectal cancer cell lines. Biochem Pharmacol. 91:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Osmundson EC, Ray D, Moore FE, Gao Q, Thomsen GH and Kiyokawa H: The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint. J Cell Biol. 183:267–277. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Choi YH, Kim YJ, Jeong HM, Jin YH, Yeo CY and Lee KY: Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation. FEBS J. 281:3656–3666. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Z, Hou SQ, He J, Gu T, Yin Y and Shen WH: PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle. 15:2476–2485. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C and Stenmark H: PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol. 12:362–371. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Radu A, Neubauer V, Akagi T, Hanafusa H and Georgescu MM: PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol. 23:6139–6149. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Wang L, Yang L, Lu Y, Chen Y, Liu T, Peng Y, Zhou Y, Cao Y, Bi Z, Liu T, et al: Osthole induces cell cycle arrest and inhibits migration and invasion via PTEN/Akt pathways in osteosarcoma. Cell Physiol Biochem. 38:2173–2182. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Xiong X, Ren HZ, Li MH, Mei JH, Wen JF and Zheng CL: Down-regulated miRNA-214 induces a cell cycle G1 arrest in gastric cancer cells by up-regulating the PTEN protein. Pathol Oncol Res. 17:931–937. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Bolanos-Garcia VM: Assessment of the mitotic spindle assembly checkpoint (SAC) as the target of anticancer therapies. Curr Cancer Drug Targets. 9:131–141. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Dominguez-Brauer C, Thu KL, Mason JM, Blaser H, Bray MR and Mak TW: Targeting mitosis in cancer: Emerging strategies. Mol Cell. 60:524–536. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Huang HC, Shi J, Orth JD and Mitchison TJ: Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 16:347–358. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer. 9:153–166. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Cicenas J, Kalyan K, Sorokinas A, Jatulyte A, Valiunas D, Kaupinis A and Valius M: Highlights of the latest advances in research on CDK inhibitors. Cancers (Basel). 6:2224–2242. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Z, Lu J, Wu M, Li M, Bai L, Shi Z, Hao L and Wu Y: Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Mol Med Rep 20: 4235-4243, 2019.
APA
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z. ... Wu, Y. (2019). Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Molecular Medicine Reports, 20, 4235-4243. https://doi.org/10.3892/mmr.2019.10668
MLA
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z., Hao, L., Wu, Y."Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2". Molecular Medicine Reports 20.5 (2019): 4235-4243.
Chicago
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z., Hao, L., Wu, Y."Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2". Molecular Medicine Reports 20, no. 5 (2019): 4235-4243. https://doi.org/10.3892/mmr.2019.10668
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Z, Lu J, Wu M, Li M, Bai L, Shi Z, Hao L and Wu Y: Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Mol Med Rep 20: 4235-4243, 2019.
APA
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z. ... Wu, Y. (2019). Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Molecular Medicine Reports, 20, 4235-4243. https://doi.org/10.3892/mmr.2019.10668
MLA
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z., Hao, L., Wu, Y."Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2". Molecular Medicine Reports 20.5 (2019): 4235-4243.
Chicago
Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z., Hao, L., Wu, Y."Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2". Molecular Medicine Reports 20, no. 5 (2019): 4235-4243. https://doi.org/10.3892/mmr.2019.10668
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