Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2019 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis

  • Authors:
    • Fenggen Yan
    • Weiwei Meng
    • Siqi Ye
    • Xian Zhang
    • Xiumei Mo
    • Junfeng Liu
    • Dacan Chen
    • Ying Lin
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China, Department of Dermatology, The Second Affiliated Hospital of Henan University of Chinese Medicine, Henan Provincial Hospital of Chinese Medicine, Henan, Zhengzhou 450000, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4645-4653
    |
    Published online on: September 20, 2019
       https://doi.org/10.3892/mmr.2019.10695
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have demonstrated that microRNA (miR)‑146a is involved in the inflammatory response of atopic dermatitis (AD). The aim of the present study was to investigate the expression of miR‑146a in the serum of patients with AD and in skin lesions of AD animal models. In addition, we aimed to predict and verify the target genes of miR‑146a. miR‑146a expression was measured in AD patient serum via reverse transcription‑quantitative PCR. T‑helper (Th)1 [CD4+; interferon (IFN)‑γ+] and Th2 [CD4+; interleukin (IL)‑4+] expression in peripheral blood mononuclear cells was evaluated using flow cytometry. Following the establishment of a 2,4‑dinitrofluorobenzene‑induced C57BL/6 mouse AD model, Th1 (CD4+IFN‑γ+) and Th2 (CD4+IL‑4+) expression was analyzed in murine spleen cells via flow cytometry. Plasmids were transfected into 293T cells and at 48 h post‑transfection, cells were analyzed using a luciferase assay system. The results revealed that the AD group had a significantly lower Th1/Th2 ratio and a significantly higher miR‑146a expression compared with the control group (P<0.05). Furthermore, a decreased Th1/Th2 ratio and a significantly increased miR‑146a expression were observed in the model group compared with the control group (P<0.01). We also conducted a dual‑luciferase assay to determine whether small ubiquitin‑related modifier 1 (SUMO1) if the target gene of miR‑146a. We observed a ~30% decrease in the relative luciferase activity in cells containing the 3'‑untranslated region of SUMO1 + miR‑146a). The results of the luciferase assay indicated that may be a direct mRNA target of miR‑146a; however, the quantification of band density of SUMO1 expression following western blotting did not significantly differ. The development of animal models in AD research is of vital importance. The results revealed that miR‑146a may be a potential regulator involved in the pathogenesis of AD. Furthermore, the current study determined that miR‑146a could be a valuable marker of AD and thus, may be applied in the development of therapeutic strategies for treating AD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Weidinger S, Beck LA, Bieber T, Kabashima K and Irvine AD: Atopic dermatitis. Nat Rev Dis Primers. 4:12018. View Article : Google Scholar : PubMed/NCBI

2 

Bieber T: Atopic dermatitis. N Engl J Med. 358:1483–1494. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Xu F, Yan S, Li F, Cai M, Chai W, Wu M, Fu C, Zhao Z, Kan H, Kang K and Xu J: Prevalence of childhood atopic dermatitis: An urban and rural community-based study in shanghai, China. PLoS One. 7:e361742012. View Article : Google Scholar : PubMed/NCBI

4 

Guo Y, Li P, Tang J, Han X, Zou X, Xu G, Xu Z, Wei F, Liu Q, Wang M, et al: Prevalence of atopic dermatitis in Chinese children aged 1–7 ys. Sci Rep. 6:297512016. View Article : Google Scholar : PubMed/NCBI

5 

Wang AX and Xu Landén N: New insights into T cells and their signature cytokines in atopic dermatitis. IUBMB Life. 67:601–610. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Li S, Liu L, Zhuang X, Yu Y, Liu X, Cui X, Ji L, Pan Z, Cao X, Mo B, et al: MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in arabidopsis. Cell. 153:562–574. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wahid F, Shehzad A, Khan T and Kim YY: MicroRNAs: Synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta. 1803:1231–1243. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Lau PW and MacRae IJ: The molecular machines that mediate microRNA maturation. J Cell Mol Med. 13:54–60. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Sonkoly E and Pivarcsi A: Advances in microRNAs: Implications for immunity and inflammatory diseases. J Cell Mol Med. 13:24–38. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yoshizawa JM and Wong DT: Salivary microRNAs and oral cancer detection. Methods Mol Biol. 936:313–324. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Tili E, Michaille JJ, Wernicke D, Alder H, Costinean S, Volinia S and Croce CM: Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. Proc Natl Acad Sci USA. 108:4908–4913. 2011. View Article : Google Scholar : PubMed/NCBI

12 

West C and McDermott MF: Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF-κB signalling pathway. Biosci Rep. 37(pii): BSR201701802017. View Article : Google Scholar : PubMed/NCBI

13 

Park H, Huang X, Lu C, Cairo MS and Zhou X: MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins. J Biol Chem. 290:2831–2841. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Lindner JM, Kayo H, Hedlund S, Fukuda Y, Fukao T and Nielsen PJ: Cutting Edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells. J Immunol. 192:4483–4486. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Wang S, Zhang X, Ju Y, Zhao B, Yan X, Hu J, Shi L, Yang L, Ma Z, Chen L, et al: MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic Hepatitis B. J Immunol. 191:293–301. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Williams AE, Perry MM, Moschos SA, Larner-Svensson HM and Lindsay MA: Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans. 36:1211–1215. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Rebane A, Runnel T, Aab A, Maslovskaja J, Rückert B, Zimmermann M, Plaas M, Kärner J, Treis A, Pihlap M, et al: MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. J Allergy Clin Immunol. 134:836–847.e11. 2014. View Article : Google Scholar : PubMed/NCBI

18 

M HJ and Georg R: Diagnostic features of atopic dermatitis. Acta Dermatovener. 60:44–47. 1980.

19 

Eichenfield LF, Lucky AW, Boguniewicz M, Langley RG, Cherill R, Marshall K, Bush C and Graeber M: Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents. J Am Acad Dermatol. 46:495–504. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Heo JC, Nam DY, Seo MS and Lee SH: Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton. Int J Mol Med. 28:733–737. 2011.PubMed/NCBI

21 

Heo JC, Son HU, Kim SL and Lee SH: A derivative of L-allo threonine alleviates 2,4-dinitrofluorobenzene-induced atopic dermatitis indications. Biosci Biotechnol Biochem. 76:2021–2025. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Nam DY, Lee JM, Heo JC and Lee SH: Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius. Int J Mol Med. 28:1013–1018. 2011.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 42015.doi: 10.7554/eLife.05005.

25 

Oh JG, Watanabe S, Lee A, Gorski PA, Lee P, Jeong D, Liang L, Liang Y, Baccarini A, Sahoo S, et al: miR-146a suppresses SUMO1 expression and induces cardiac dysfunction in maladaptive hypertrophy. Circ Res. 123:673–685. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Deleanu D and Nedelea I: Biological therapies for atopic dermatitis: An update. Exp Ther Med. 17:1061–1067. 2019.PubMed/NCBI

27 

Thomsen SF: Atopic dermatitis: Natural history, diagnosis, and treatment. ISRN Allergy. 2014:3542502014. View Article : Google Scholar : PubMed/NCBI

28 

Rożalski M, Rudnicka L and Samochocki Z: MiRNA in atopic dermatitis. Postepy Dermatol Alergol. 33:157–162. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Specjalski K and Jassem E: MicroRNAs: Potential biomarkers and targets of therapy in allergic diseases? Arch Immunol Ther Exp (Warsz). 67:213–223. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Bin L and Leung DY: Genetic and epigenetic studies of atopic dermatitis. Allergy Asthma Clin Immunol. 12:522016. View Article : Google Scholar : PubMed/NCBI

31 

Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, et al: MicroRNAs: Novel regulators involved in the pathogenesis of psoriasis? PLoS One. 2:e6102007. View Article : Google Scholar : PubMed/NCBI

32 

Bhardwaj N: MicroRNAs in atopic dermatitis: A review. J Transl Genet Genom. 1:15–22. 2017. View Article : Google Scholar

33 

Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, Xu N, Meisgen F, Wei T, Bradley M, et al: MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol. 126:581–589.e1-e20. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Auriemma M, Vianale G, Amerio P and Reale M: Cytokines and T cells in atopic dermatitis. Eur Cytokine Netw. 24:37–44. 2013.PubMed/NCBI

35 

Lipozencić J, Pastar Z, Kulisić SM and Pavić I: Immunologic aspects of atopic dermatitis. Acta Dermatovenerol Croat. 17:226–234. 2009.PubMed/NCBI

36 

Agrawal R, Wisniewski JA and Woodfolk JA: The role of regulatory T cells in atopic dermatitis. Curr Probl Dermatol. 41:112–124. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Miraglia del Giudice M, Decimo F, Leonardi S, Maioello N, Amelio R, Capasso A, Capristo C and Capristo AF: Immune dysregulation in atopic dermatitis. Allergy Asthma Proc. 27:451–455. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Grewe M, Bruijnzeel-Koomen CA, Schöpf E, Maioello N, Amelio R, Capasso A, Capristo C and Capristo AF: A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today. 19:359–361. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Li L, Chen XP and Li YJ: MicroRNA-146a and human disease. Scand J Immunol. 71:227–231. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Ammari M, Jorgensen C and Apparailly F: Impact of microRNAs on the understanding and treatment of rheumatoid arthritis. Curr Opin Rheumatol. 25:225–233. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Dai Y, Huang YS, Tang M, Lv TY, Hu CX, Tan YH, Xu ZM and Yin YB: Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus. 16:939–946. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Jiménez-Morales S, Gamboa-Becerra R, Baca V, Del Río-Navarro BE, López-Ley DY, Velázquez-Cruz R, Saldaña-Alvarez Y, Salas-Martínez G and Orozco L: MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients. Tissue Antigens. 80:317–321. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D and Rudensky AY: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 142:914–929. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, Huang X, Zhou H, de Vries N, Tak PP, et al: MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 60:1065–1075. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Kamali K, Korjan ES, Eftekhar E, Malekzadeh K and Soufi FG: The role of miR-146a on NF-κB expression level in human umbilical vein endothelial cells under hyperglycemic condition. Bratisl Lek Listy. 117:376–380. 2016.PubMed/NCBI

47 

Xie Q, Wei W, Ruan J, Ding Y, Zhuang A, Bi X, Sun H, Gu P, Wang Z and Fan X: Effects of miR-146a on the osteogenesis of adipose-derived mesenchymal stem cells and bone regeneration. Sci Rep. 7:428402017. View Article : Google Scholar : PubMed/NCBI

48 

Lyons JJ and Milner JD: Primary atopic disorders. J Exp Med. 215:1009–1022. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan F, Meng W, Ye S, Zhang X, Mo X, Liu J, Chen D and Lin Y: MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis. Mol Med Rep 20: 4645-4653, 2019.
APA
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J. ... Lin, Y. (2019). MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis. Molecular Medicine Reports, 20, 4645-4653. https://doi.org/10.3892/mmr.2019.10695
MLA
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J., Chen, D., Lin, Y."MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis". Molecular Medicine Reports 20.5 (2019): 4645-4653.
Chicago
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J., Chen, D., Lin, Y."MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis". Molecular Medicine Reports 20, no. 5 (2019): 4645-4653. https://doi.org/10.3892/mmr.2019.10695
Copy and paste a formatted citation
x
Spandidos Publications style
Yan F, Meng W, Ye S, Zhang X, Mo X, Liu J, Chen D and Lin Y: MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis. Mol Med Rep 20: 4645-4653, 2019.
APA
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J. ... Lin, Y. (2019). MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis. Molecular Medicine Reports, 20, 4645-4653. https://doi.org/10.3892/mmr.2019.10695
MLA
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J., Chen, D., Lin, Y."MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis". Molecular Medicine Reports 20.5 (2019): 4645-4653.
Chicago
Yan, F., Meng, W., Ye, S., Zhang, X., Mo, X., Liu, J., Chen, D., Lin, Y."MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis". Molecular Medicine Reports 20, no. 5 (2019): 4645-4653. https://doi.org/10.3892/mmr.2019.10695
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team