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Article Open Access

miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1

  • Authors:
    • Ye Xiao
    • Qi Guo
    • Tie‑Jian Jiang
    • Ying Yuan
    • Li Yang
    • Guang‑Wei Wang
    • Wen‑Feng Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Endocrinology Research Center, Central South University, Changsha, Hunan 410008, P.R. China, Department of Medicine, Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China, Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4558-4566
    |
    Published online on: September 24, 2019
       https://doi.org/10.3892/mmr.2019.10700
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Abstract

Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is regulated by a variety of intracellular regulatory factors including osterix, runt‑related transcription factor 2 (RUNX2), bone morphogenetic proteins and transforming growth factorβ. Recent studies have shown that microRNAs (miRs) serve a crucial role in this process. In the present study, miR‑483‑3p levels were significantly increased during osteogenic differentiation of mouse and human BMSCs. Overexpression of miR‑483‑3p promoted osteogenic differentiation, whereas inhibition of miR‑483‑3p reversed these effects. miR‑483‑3p regulated osteogenic differentiation of BMSCs by targeting STAT1, and thus enhancing RUNX2 transcriptional activity and RUNX2 nuclear translocation. In vivo, overexpression of miR‑483‑3p using a BMSC‑specific aptamer delivery system stimulated bone formation in aged mice. Therefore, the present study suggested that miR‑483‑3p promoted osteogenic differentiation of BMSCs by targeting STAT1, and miR‑483‑3 prepresent a potential therapeutic target for age‑related bone loss.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao Y, Guo Q, Jiang TJ, Yuan Y, Yang L, Wang GW and Xiao WF: miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Mol Med Rep 20: 4558-4566, 2019.
APA
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., & Xiao, W. (2019). miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Molecular Medicine Reports, 20, 4558-4566. https://doi.org/10.3892/mmr.2019.10700
MLA
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., Xiao, W."miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1". Molecular Medicine Reports 20.5 (2019): 4558-4566.
Chicago
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., Xiao, W."miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1". Molecular Medicine Reports 20, no. 5 (2019): 4558-4566. https://doi.org/10.3892/mmr.2019.10700
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Y, Guo Q, Jiang TJ, Yuan Y, Yang L, Wang GW and Xiao WF: miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Mol Med Rep 20: 4558-4566, 2019.
APA
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., & Xiao, W. (2019). miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Molecular Medicine Reports, 20, 4558-4566. https://doi.org/10.3892/mmr.2019.10700
MLA
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., Xiao, W."miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1". Molecular Medicine Reports 20.5 (2019): 4558-4566.
Chicago
Xiao, Y., Guo, Q., Jiang, T., Yuan, Y., Yang, L., Wang, G., Xiao, W."miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1". Molecular Medicine Reports 20, no. 5 (2019): 4558-4566. https://doi.org/10.3892/mmr.2019.10700
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