Open Access

Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models

  • Authors:
    • Shaopeng Li
    • Lanzhou Li
    • Han Yan
    • Xue Jiang
    • Weiwei Hu
    • Ning Han
    • Di Wang
  • View Affiliations

  • Published online on: September 26, 2019     https://doi.org/10.3892/mmr.2019.10708
  • Pages: 4623-4633
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gout is a type of serious arthritis that is caused by hyperuricemia. Celery is an umbelliferous plant that was shown to exhibit anti‑inflammatory activity in rodent. The present study aimed to investigate the effects and potential preliminary mechanisms of celery seed aqueous extract (CSAE) and celery seed oil extract (CSOL) for gout treatment. The components of CSAE and CSOL were systematically analyzed. In mice with hyperuricemia induced by potassium oxonate and yeast extract, CSAE and CSOL treatment reduced the serum levels of uric acid and xanthine oxidase. In addition, CSAE and CSOL reduced the levels of reactive oxygen species and increased the serum levels of superoxide dismutase and glutathione peroxidase in mouse serum. In rats with acute gouty arthritis induced by intra‑articular injection of monosodium urate crystals, CSAE and CSOL treatment alleviated the swelling of the ankle joints and reduced inflammatory cell infiltration around the ankle joints. In addition, CSAE and CSOL reduced the levels of interleukin (IL)‑1β and tumor necrosis factor α and increased the levels of IL‑10. The results of the present study suggested that celery seed extracts may have anti‑gout properties, partially through anti‑inflammatory and antioxidative effects.
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November-2019
Volume 20 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li S, Li L, Yan H, Jiang X, Hu W, Han N and Wang D: Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep 20: 4623-4633, 2019
APA
Li, S., Li, L., Yan, H., Jiang, X., Hu, W., Han, N., & Wang, D. (2019). Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models. Molecular Medicine Reports, 20, 4623-4633. https://doi.org/10.3892/mmr.2019.10708
MLA
Li, S., Li, L., Yan, H., Jiang, X., Hu, W., Han, N., Wang, D."Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models". Molecular Medicine Reports 20.5 (2019): 4623-4633.
Chicago
Li, S., Li, L., Yan, H., Jiang, X., Hu, W., Han, N., Wang, D."Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models". Molecular Medicine Reports 20, no. 5 (2019): 4623-4633. https://doi.org/10.3892/mmr.2019.10708