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Article Open Access

TAFA5 promotes proliferation and migration in gastric cancer

  • Authors:
    • Zhiqing Hu
    • Gengming Niu
    • Jun Ren
    • Xin Wang
    • Liang Chen
    • Runqi Hong
    • Chongwei Ke
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4477-4488
    |
    Published online on: October 2, 2019
       https://doi.org/10.3892/mmr.2019.10724
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Abstract

TAFA chemokine like family member 5 (TAFA5), a TAFA family member that encodes small secreted proteins in the central nervous system, has been demonstrated to have increased expression in human malignancies. However, the expression and function of TAFA5 in gastric cancer (GC) remains unclear. In the present study, public datasets and human GC samples were used to determine the TAFA5 expression levels. The results revealed that TAFA5 was upregulated in GC when compared with adjacent normal tissues. Overexpression of TAFA5 in GC was associated with poor differentiation, and worse tumor, nodal and metastasis stages. In addition, high TAFA5 expression was correlated with unfavorable patient prognoses. In vitro experiments indicated that downregulation of TAFA5 inhibited the proliferation and migration of GC cell lines. Finally, the results from gene set enrichment analysis using data from The Cancer Genome Atlas revealed that TAFA5 expression was significantly correlated with genes associated with epithelial‑mesenchymal transition, which was further confirmed by western blot analysis. In conclusion, the results of the present study suggested that TAFA5 had significant effects on GC progression, suggesting that it may serve as a potential therapeutic target for GC therapy.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Malvezzi M, Bonifazi M, Bertuccio P, Levi F, La Vecchia C, Decarli A and Negri E: An age-period-cohort analysis of gastric cancer mortality from 1950 to 2007 in Europe. Ann Epidemol. 20:898–905. 2010. View Article : Google Scholar

4 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Van Cutsem E, Sagaert X, Topal B, Haustermans K and Prenen H: Gastric cancer. Lancet. 388:2654–2664. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE and Rupp F: TAFA: A novel secreted family with conserved cysteine residues and restricted expression in the brain. Genomics. 83:727–734. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Paulsen SJ, Christensen MT, Vrang N and Larsen LK: The putative neuropeptide TAFA5 is expressed in the hypothalamic paraventricular nucleus and is regulated by dehydration. Brain Res. 1199:1–9. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Pan X, Karner CM and Carroll TJ: Myc cooperates with beta-catenin to drive gene expression in nephron progenitor cells. Development. 144:4173–4182. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G and Carroll TJ: Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development. 138:1247–1257. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Park MY, Kim HS, Lee M, Park B, Lee HY, Cho EB, Seong JY and Bae YS: FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Sci Rep. 7:155752017. View Article : Google Scholar : PubMed/NCBI

11 

Janvilisri T, Leelawat K, Roytrakul S, Paemanee A and Tohtong R: Novel serum biomarkers to differentiate cholangiocarcinoma from benign biliary tract diseases using a proteomic approach. Dis Markers. 2015:1053582015. View Article : Google Scholar : PubMed/NCBI

12 

Diaz de Stahl T, Hartmann C, de Bustos C, Piotrowski A, Benetkiewicz M, Mantripragada KK, Tykwinski T, von Deimling A and Dumanski JP: Chromosome 22 tiling-path array-CGH analysis identifies germ-line- and tumor-specific aberrations in patients with glioblastoma multiforme. Genes Chromosomes Cancer. 44:161–169. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, et al: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 44:62–66. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Howitt BE, Sun HH, Roemer MG, Kelley A, Chapuy B, Aviki E, Pak C, Connelly C, Gjini E, Shi Y, et al: Genetic basis for PD-L1 expression in squamous cell carcinomas of the cervix and vulva. JAMA Oncol. 2:518–522. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Shi JY, Ma LJ, Zhang JW, Duan M, Ding ZB, Yang LX, Cao Y, Zhou J, Fan J, Zhang X, et al: FOXP3 is a HCC suppressor gene and Acts through regulating the TGF-beta/Smad2/3 signaling pathway. BMC Cancer. 17:6482017. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Zhao S, Zhou L, Niu G, Li Y, Zhao D and Zeng H: Differential regulation of orphan nuclear receptor TR3 transcript variants by novel vascular growth factor signaling pathways. FASEB J. 28:4524–4533. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Hu HM, Chen Y, Liu L, Zhang CG, Wang W, Gong K, Huang Z, Guo MX, Li WX and Li W: C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. Faseb J. 27:163–173. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, et al: Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4. Faseb J. 29:131–140. 2015. View Article : Google Scholar : PubMed/NCBI

20 

D'Errico M, de Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, et al: Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur J Cancer. 45:461–469. 2009. View Article : Google Scholar

21 

Cho JY, Lim JY, Cheong JH, Park YY, Yoon SL, Kim SM, Kim SB, Kim H, Hong SW, Park YN, et al: Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res. 17:1850–1857. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, et al: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 34:2672003. View Article : Google Scholar : PubMed/NCBI

24 

Zheng C, Chen D, Zhang Y, Bai Y, Huang S, Zheng D, Liang W, She S, Peng X, Wang P, et al: FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and Differentiation. Faseb J fj201800020RRR. 2018. View Article : Google Scholar

25 

Wang X, Shen C, Chen X, Wang J, Cui X, Wang Y, Zhang H, Tang L, Lu S, Fei J and Wang Z: Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice. Acta Biochim Biophys Sin (Shanghai). 50:984–995. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Kambrun C, Roca-Lapirot O, Salio C, Landry M, Moqrich A and Le Feuvre Y: TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction. Cell Rep. 22:2886–2897. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Shao Y, Deng T, Zhang T, Li P and Wang Y: FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. FEBS Lett. 589:467–475. 2015. View Article : Google Scholar : PubMed/NCBI

28 

da Silva JM, Moreira Dos Santos TP, Sobral LM, Queiroz-Junior CM, Rachid MA, Proudfoot AEI, Garlet GP, Batista AC, Teixeira MM, Leopoldino AM, et al: Relevance of CCL3/CCR5 axis in oral carcinogenesis. Oncotarget. 8:51024–51036. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Naito T, Baba T, Takeda K, Sasaki S, Nakamoto Y and Mukaida N: High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites. Cancer Lett. 366:93–99. 2015. View Article : Google Scholar : PubMed/NCBI

30 

De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 13:97–110. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, et al: Novel Adipokine, FAM19A5, inhibits neointima formation after injury through sphingosine-1-phosphate receptor 2. Circulation. 138:48–63. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu Z, Niu G, Ren J, Wang X, Chen L, Hong R and Ke C: TAFA5 promotes proliferation and migration in gastric cancer . Mol Med Rep 20: 4477-4488, 2019.
APA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., & Ke, C. (2019). TAFA5 promotes proliferation and migration in gastric cancer . Molecular Medicine Reports, 20, 4477-4488. https://doi.org/10.3892/mmr.2019.10724
MLA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20.5 (2019): 4477-4488.
Chicago
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20, no. 5 (2019): 4477-4488. https://doi.org/10.3892/mmr.2019.10724
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Z, Niu G, Ren J, Wang X, Chen L, Hong R and Ke C: TAFA5 promotes proliferation and migration in gastric cancer . Mol Med Rep 20: 4477-4488, 2019.
APA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., & Ke, C. (2019). TAFA5 promotes proliferation and migration in gastric cancer . Molecular Medicine Reports, 20, 4477-4488. https://doi.org/10.3892/mmr.2019.10724
MLA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20.5 (2019): 4477-4488.
Chicago
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20, no. 5 (2019): 4477-4488. https://doi.org/10.3892/mmr.2019.10724
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