Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9

  • Authors:
    • Quanrongzi Wang
    • Xisheng Liu
    • Jie Zhang
    • Ling Lu
    • Min Feng
    • Jie Wang
  • View Affiliations

  • Published online on: October 11, 2019     https://doi.org/10.3892/mmr.2019.10740
  • Pages: 5239-5248
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Abstract

The two‑edged effect of matrix metalloproteinase‑9 (MMP9) makes it difficult to understand its role in liver fibrogenesis and fibrosis resolution. The present study aimed to investigate the dynamic features of liver fibrogenesis and fibrosis resolution in the absence of MMP9. MMP9‑/‑ mice were used to induce liver fibrosis by thioacetamide. The degrees of liver fibrogenesis and fibrosis resolution were designated by the levels of collagen I, III and IV, which were determined via western blotting. Liver injury and the transcriptional levels of MMPs and tissue inhibitor of metalloproteinases (TIMPs) were also determined. It was revealed that, in the absence of MMP9, acute liver injury was attenuated and the expression of collagen was alleviated at the early stage of liver fibrosis, particularly in the first 3 weeks. However, their levels increased to levels as high as those in the control group by week 8. During liver fibrosis resolution, in the absence of MMP9, the ratio of (MMP9 + MMP13)/TIMP1 and the ratio of (MMP2+ MMP14)/TIMP2 were decreased, and the collagen levels were increased. The present study revealed the dynamic features of liver fibrogenesis and fibrosis resolution in the absence of MMP9. The information obtained here will improve current understanding of the effect that MMP9 has in liver fibrogenesis and fibrosis resolution.
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December-2019
Volume 20 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Q, Liu X, Zhang J, Lu L, Feng M and Wang J: Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9. Mol Med Rep 20: 5239-5248, 2019
APA
Wang, Q., Liu, X., Zhang, J., Lu, L., Feng, M., & Wang, J. (2019). Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9. Molecular Medicine Reports, 20, 5239-5248. https://doi.org/10.3892/mmr.2019.10740
MLA
Wang, Q., Liu, X., Zhang, J., Lu, L., Feng, M., Wang, J."Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9". Molecular Medicine Reports 20.6 (2019): 5239-5248.
Chicago
Wang, Q., Liu, X., Zhang, J., Lu, L., Feng, M., Wang, J."Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9". Molecular Medicine Reports 20, no. 6 (2019): 5239-5248. https://doi.org/10.3892/mmr.2019.10740