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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2019 Volume 20 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

HIV‑1 integrase inhibitors targeting various DDE transposases: Retroviral integration versus RAG‑mediated recombination (Review)

Mihaela Georgiana Mușat, George Mihai Nițulescu, Marius Surleac, Aristidis Tsatsakis, Demetrios A. Spandidos, Denisa Margină
Pages: 4749-4762
Published online on: 30 October 2019

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Review Open Access

Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review)

Kaixi Zhu, Qingqi Meng, Zhi Zhang, Tao Yi, Yuan He, Jing Zheng, Wei Lei
Pages: 4763-4773
Published online on: 16 October 2019

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Review Open Access

Role of endoplasmic reticulum stress in depression (Review)

Jiaxin Mao, Yanran Hu, Liemin Ruan, Yunxin Ji, Zhongze Lou
Pages: 4774-4780
Published online on: 31 October 2019

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Article Open Access

miR‑455 targets FABP4 to protect human endometrial stromal cells from cytotoxicity induced by hydrogen peroxide

Wenbo Tang, Oujing Chen, Fengxiang Yao, Lining Cui
Pages: 4781-4790
Published online on: 04 October 2019

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Article Open Access

CXCR4 and CXCR3 are two distinct prognostic biomarkers in breast cancer: Database mining for CXCR family members

Kaibo Guo, Guan Feng, Qingying Yan, Leitao Sun, Kai Zhang, Fengfei Shen, Minhe Shen, Shanming Ruan
Pages: 4791-4802
Published online on: 30 October 2019

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Article Open Access

MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer

Ling Li, Dongqing Wang
Pages: 4803-4810
Published online on: 08 October 2019

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Article Open Access

Effects of D‑Ala2, D‑Leu5‑Enkephalin pre‑ and post‑conditioning in a rabbit model of spinal cord ischemia and reperfusion injury

Danyun Fu, Haitong Liu, Hua Liu, Junyan Yao
Pages: 4811-4820
Published online on: 07 October 2019

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Article Open Access

Curcumin attenuates hypoxia/reoxygenation‑induced myocardial injury

Wenjuan Wei, Jun Peng, Jian Li
Pages: 4821-4830
Published online on: 15 October 2019

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Article Open Access

CP-25 exerts anti-angiogenic effects on a rat model of adjuvant-induced arthritis by promoting GRK2-induced downregulation of CXCR4-ERK1/2 signaling in endothelial cells

Min Zhang, Mei Gao, Jinyu Chen, Lihua Song, Wei Wei
Pages: 4831-4842
Published online on: 23 October 2019

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Article Open Access

miR‑760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b

Xujun Tang, Jiuxia Wang, Shuhong Zhou, Jing Zhou, Guyou Jia, Han Wang, Chunlei Xin, Guoning Fu, Jiahong Zhang
Pages: 4843-4854
Published online on: 29 October 2019

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Article Open Access

Chloroquine promotes gefitinib‑induced apoptosis by inhibiting protective autophagy in cutaneous squamous cell carcinoma

Chengshan Ou, Hongxia Liu, Zhenhua Ding, Liang Zhou
Pages: 4855-4866
Published online on: 09 October 2019

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Article Open Access

Placental growth factor gene silencing mitigates the epithelial‑to‑mesenchymal transition via the p38 MAPK pathway in rats with hyperoxia‑induced lung injury

Shuang Zhao, Gang Luo, Hongmin Wu, Liang Zhang
Pages: 4867-4874
Published online on: 30 October 2019

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Article Open Access

miR‑222 induces apoptosis in human intervertebral disc nucleus pulposus cells by targeting Bcl‑2

Wei Wang, Jian Wang, Jiayi Zhang, Wei Taq, Zhenxing Zhang
Pages: 4875-4882
Published online on: 09 October 2019

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Article Open Access

The JAK inhibitor tofacitinib ameliorates immune‑mediated liver injury in mice

Han Wang, Xinxia Feng, Ping Han, Yu Lei, Yujia Xia, Dean Tian, Wei Yan
Pages: 4883-4892
Published online on: 16 October 2019

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Article Open Access

Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress

Ronggang Li, Xin Li, Haibing Wu, Zhikun Yang, Li Fei, Jianhong Zhu
Pages: 4893-4904
Published online on: 17 October 2019

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Article Open Access

Whole‑exome sequencing in Russian children with non‑type 1 diabetes mellitus reveals a wide spectrum of genetic variants in MODY‑related and unrelated genes

Oleg S. Glotov, Elena A. Serebryakova, Mariia E. Turkunova, Olga A. Efimova, Andrey S. Glotov, Yury A. Barbitoff, Yulia A. Nasykhova, Alexander V. Predeus, Dmitrii E. Polev, Mikhail A. Fedyakov, Irina V. Polyakova, Tatyana E. Ivashchenko, Natalia Y. Shved, Elena S. Shabanova, Alena V. Tiselko, Olga V. Romanova, Andrey M. Sarana, Anna A. Pendina, Sergey G. Scherbak, Ekaterina V. Musina, Anastasiia V. Petrovskaia‑Kaminskaia, Liubov R. Lonishin, Liliya V. Ditkovskaya, Liudmila А. Zhelenina, Ludmila V. Tyrtova, Olga S. Berseneva, Rostislav K. Skitchenko, Evgenii N. Suspitsin, Elena B. Bashnina, Vladislav S. Baranov
Pages: 4905-4914
Published online on: 16 October 2019

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Article Open Access

Clinical and molecular characterization of four patients with NTCP deficiency from two unrelated families harboring the novel SLC10A1 variant c.595A>C (p.Ser199Arg)

Hua Li, Mei Deng, Li Guo, Jian‑Wu Qiu, Gui‑Zhi Lin, Xiao‑Ling Long, Xiao‑Min Xiao, Yuan‑Zong Song
Pages: 4915-4924
Published online on: 23 October 2019

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Article Open Access

Der p2‑A20 DNA vaccine attenuates allergic inflammation in mice with allergic rhinitis

Wenhui Hu, Li Ma, Gui Yang, Xianhai Zeng, Jiangqi Liu, Baohui Cheng, Tianyong Hu, Hailiang Zhao, Zhiqiang Liu
Pages: 4925-4932
Published online on: 21 October 2019

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Article Open Access

Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair

Banglian Deng, Wenzhong Zhu, Yansheng Duan, Yuqian Hu, Xuefeng Chen, Shuang Song, Zian Yi, Yingliang Song
Pages: 4933-4942
Published online on: 23 October 2019

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Article Open Access

Exopolysaccharide from Paecilomyces lilacinus modulates macrophage activities through the TLR4/NF‑κB/MAPK pathway

Chao He, Hai‑Yan Lin, Cai‑Chun Wang, Ming Zhang, Ying‑Ying Lin, Feng‑Ying Huang, Ying‑Zi Lin, Guang‑Hong Tan
Pages: 4943-4952
Published online on: 15 October 2019

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Article Open Access

miR‑21‑5p ameliorates hyperoxic acute lung injury and decreases apoptosis of AEC II cells via PTEN/AKT signaling in rats

Song Qin, Hongliang Wang, Guoyue Liu, Hong Mei, Miao Chen
Pages: 4953-4962
Published online on: 30 October 2019

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Article Open Access

Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet

Qian Yu, Zhengyun Xia, Emily Chiu Liong, George Lim Tipoe
Pages: 4963-4972
Published online on: 31 October 2019

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Article Open Access

MicroRNA‑4500 suppresses tumor progression in non‑small cell lung cancer by regulating STAT3

Zhi‑Ying Li, Zi‑Zhou Zhang, Hui Bi, Qiu‑Di Zhang, Su‑Juan Zhang, Lin Zhou, Xiao‑Qin Zhu, Jun Zhou
Pages: 4973-4983
Published online on: 11 October 2019

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Article Open Access

Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats

Changhong Cai, Yijia Xiang, Yonghui Wu, Ning Zhu, Huan Zhao, Jian Xu, Wensheng Lin, Chunlai Zeng
Pages: 4984-4992
Published online on: 30 October 2019

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Article Open Access

IL‑1β increases the expression of inflammatory factors in synovial fluid‑derived fibroblast‑like synoviocytes via activation of the NF‑κB‑mediated ERK‑STAT1 signaling pathway

Jie Yang, Junhu Wang, Xiaojun Liang, Hongmou Zhao, Jun Lu, Qiang Ma, Bingfei Jing, Feng Tian
Pages: 4993-5001
Published online on: 21 October 2019

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Article Open Access

Upregulation of miR‑132‑3p in cholangiocarcinoma tissues: A study based on RT‑qPCR, The Cancer Genome Atlas miRNA sequencing, Gene Expression Omnibus microarray data and bioinformatics analyses

Hua‑Yu Wu, Shuang Xia, An‑Gui Liu, Min‑Da Wei, Zhong‑Biao Chen, Yu‑Xin Li, Yu He, Min‑Jun Liao, Qi‑Ping Hu, Shang‑Ling Pan
Pages: 5002-5020
Published online on: 07 October 2019

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Article Open Access

SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma

Jing Xu, Jing Zhang, Fenglian Shan, Jie Wen, Yue Wang
Pages: 5021-5031
Published online on: 11 October 2019

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Article Open Access

Curcumin relieves paraquat‑induced lung injury through inhibiting the thioredoxin interacting protein/NLR pyrin domain containing 3‑mediated inflammatory pathway

Yi Ren, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Xin Chen, Shinan Nie
Pages: 5032-5040
Published online on: 23 August 2019

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Article Open Access

Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a Retraction in /10.3892/mmr.2025.13747

Rui Li, Lianxin Wang
Pages: 5041-5049
Published online on: 15 October 2019

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Article Open Access

Effects of β‑hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor

Xiaolin Hu, Li You, Changhua Hu, Juan Wu, Min Ai, Xiaoyan He, Wenjie Huang, Zonghui Wu
Pages: 5050-5058
Published online on: 11 October 2019

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Article Open Access

Novel compound heterozygous PKHD1 mutations cause autosomal recessive polycystic kidney disease in a Han Chinese family

Jin Wang, Dandan Qi, Jialiang Yang, Dingding Zhang, Qingwei Wang, Xueming Ju, Xiang Zhong
Pages: 5059-5063
Published online on: 11 October 2019

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Article Open Access

Antitumor effects and mechanisms of 1,25(OH)2D3 in the Pfeiffer diffuse large B lymphoma cell line

Jing Han, Yonghong Tang, Meizuo Zhong, Wenlin Wu
Pages: 5064-5074
Published online on: 17 October 2019

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Article Open Access

Identification of dysregulated serum miR-508-3p and miR-885-5p as potential diagnostic biomarkers of clear cell renal carcinoma

Siming Liu, Xiaojun Deng, Jiong Zhang
Pages: 5075-5083
Published online on: 22 October 2019

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Article Open Access

High glucose inhibits osteogenic differentiation and proliferation of MC3T3‑E1 cells by regulating P2X7

Jinsan Yang, Cao Ma, Maoshu Zhang
Pages: 5084-5090
Published online on: 31 October 2019

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Article Open Access

C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling

Da‑Zhi Ding, Ya‑Nan Jia, Bo Zhang, Cheng‑Ming Guan, Shuai Zhou, Xiang Li, Xun Cui
Pages: 5091-5099
Published online on: 15 October 2019

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Article Open Access

Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord

Yanting Mao, Yulin Huang, Ying Zhang, Chenchen Wang, Hao Wu, Xinyu Tian, Yue Liu, Bailing Hou, Ying Liang, Hui Rong, Xiaoping Gu, Zhengliang Ma
Pages: 5100-5110
Published online on: 25 October 2019

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Article Open Access

Identification of whirlin domains interacting with espin: A study of the mechanism of Usher syndrome type II

Le Wang, Bo Wei, Xueqi Fu, Yuchen Wang, Yuan Sui, Junfeng Ma, Xianhui Gong, Jilong Hao, Shu Xing
Pages: 5111-5117
Published online on: 07 October 2019

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Case Report Open Access

Idiopathic renal hypouricemia: A case report and literature review

Cuiyu Wang, Jin Wang, Song Liu, Xinhua Liang, Yifan Song, Ling Feng, Lanxin Zhong, Xiaohua Guo
Pages: 5118-5124
Published online on: 04 October 2019

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Article Open Access

Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism

Hongxia Xiao, Zhen Liu
Pages: 5125-5133
Published online on: 30 October 2019

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Article Open Access

Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury

Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yanwu You
Pages: 5134-5144
Published online on: 09 October 2019

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Article Open Access

Early‑onset epilepsy and microcephaly‑capillary malformation syndrome caused by a novel STAMBP mutation in a Chinese boy

Fangrui Wu, Ying Dai, Juan Wang, Min Cheng, Yanqin Wang, Xiujuan Li, Ping Yuan, Shuang Liao, Li Jiang, Jin Chen, Lisi Yan, Min Zhong
Pages: 5145-5151
Published online on: 17 October 2019

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Article Open Access

Effect of electrical stimulation combined with diet therapy on insulin resistance via mTOR signaling

Siqin Huang, Nianzhen Tang, Hongdi Zhao, Cheng‑Lin Tang
Pages: 5152-5162
Published online on: 30 October 2019

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Article Open Access

Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models

Sanli Xing, Yiran Hu, Xujiao Huang, Dingzhu Shen, Chuan Chen
Pages: 5163-5171
Published online on: 30 October 2019

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Article Open Access

miR‑593 inhibits proliferation and invasion and promotes apoptosis in non‑small cell lung cancer cells by targeting SLUG‑associated signaling pathways Corrigendum in /10.3892/mmr.2021.12555 Retraction in /10.3892/mmr.2025.13490

Fang Wei, Mofei Wang, Zhen Li, Yong Wang, Yong Zhou
Pages: 5172-5182
Published online on: 29 October 2019

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Article Open Access

Dexmedetomidine improves cardiac function and protects against maladaptive remodeling following myocardial infarction

Hui Han, Daopeng Dai, Jinquan Hu, Jinzhou Zhu, Lin Lu, Guorong Tao, Ruiyan Zhang
Pages: 5183-5189
Published online on: 29 October 2019

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Article Open Access

Promotion of microglial phagocytosis by tuftsin stimulates remyelination in experimental autoimmune encephalomyelitis Corrigendum in /10.3892/mmr.2020.11042

Zheng Bao, Jinqi Hao, Yuhong Li, Fumin Feng
Pages: 5190-5196
Published online on: 31 October 2019

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Article Open Access

Kaempferol promotes bone formation in part via the mTOR signaling pathway

Jing Zhao, Jue Wu, Binwu Xu, Zhen Yuan, Yu Leng, Jun Min, Xiaoyong Lan, Jun Luo
Pages: 5197-5207
Published online on: 16 October 2019

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Article

miR‑486 acts as an oncogene and potential prognostic biomarker in renal cell carcinoma

Chengwen Sun, Caihong Sun, Yibin Zhou, Ganglong Yang, Guang Li, Congming Xiang, Xiqi Ding, Jian Sun
Pages: 5208-5215
Published online on: 25 October 2019

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Article

Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction

Mayra Azat, Xiaokelaiti Huojiahemaiti, Ranran Gao, Peng Peng
Pages: 5216-5222
Published online on: 23 October 2019

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Article

Oxyntomodulin attenuates TNF‑α induced neuropathic pain by inhibiting the activation of the NF‑κB pathway

Yu Zhang, Liyong Yuan, Yuebo Chen, Chunyan Lin, Guangyao Ye
Pages: 5223-5228
Published online on: 25 October 2019

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Article Open Access

Genetic analysis of monoallelic double MYH7 mutations responsible for familial hypertrophic cardiomyopathy

Bo Wang, Jing Wang, Li‑Feng Wang, Fan Yang, Lei Xu, Wen‑Xia Li, Yang He, Lei Zuo, Qian‑Li Yang, Hong Shao, Dan Hu, Li‑Wen Liu
Pages: 5229-5238
Published online on: 16 October 2019

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Article

Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9

Quanrongzi Wang, Xisheng Liu, Jie Zhang, Ling Lu, Min Feng, Jie Wang
Pages: 5239-5248
Published online on: 11 October 2019

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Article

Gallotannin attenuates 2‑deoxy‑D‑glucose‑induced dedifferentiation and endoplasmic reticulum stress through inhibition of inositol‑requiring enzyme 1 downstream p38 kinase pathway in chondrocytes

Su Min Kim, Yohan Han, Seon‑Mi Yu, Song Ja Kim
Pages: 5249-5256
Published online on: 25 October 2019

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Article

A simple, efficient and economical method for isolating and culturing human umbilical cord blood‑derived mesenchymal stromal cells

Junhe Zhang, Junli Zhao, Qinwen Mao, Haibin Xia
Pages: 5257-5264
Published online on: 23 October 2019

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Article

BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D‑deficient mice

Huifeng Yang, Haocong Zhang, Yu Li, Liangbi Xiang, Jun Liu
Pages: 5265-5271
Published online on: 30 October 2019

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Article

Downregulation of miR‑138‑5p promotes non‑small cell lung cancer progression by regulating CDK8

Shigang Xing, Qinghua Xu, Xinlei Fan, Shanxia Wu, Feng Tian
Pages: 5272-5278
Published online on: 15 October 2019

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Article

Effect of ethanol extracts of Hericium erinaceus mycelium on morphine‑induced microglial migration

Chung‑Hsin Yeh, Li‑Wei Sun, Chang‑Mei Lai, Tzu‑Pei Yeh, Jong‑Ni Lin, Shiow‑Luan Tsay, Chin‑Chu Chen, Wan‑Ping Chen, Chien‑Min Chen, Ru‑Yin Tsai
Pages: 5279-5285
Published online on: 15 October 2019

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Article

ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress

Lei Mi, Yuepeng Zhou, Dan Wu, Qing Tao, Xuefeng Wang, Haitao Zhu, Xingyu Gao, Jingzhi Wang, Rui Ling, Jing Deng, Chaoming Mao, Deyu Chen
Pages: 5286-5296
Published online on: 09 October 2019

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Article Open Access

Gene expression profiling analysis reveals that the long non‑coding RNA uc.412 is involved in mesangial cell proliferation

Minyi Yu, Zheng Guan, Shanwen Li, Xianli Wen, Huimin Shi, Gaoting Qu, Xiaoyu Lu, Xianyi Zhu, Bin Wang, Qihua Feng, Weihua Gan, Aiqing Zhang
Pages: 5297-5303
Published online on: 16 October 2019

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Prognostic implications of aberrantly expressed methylation‑driven genes in hepatocellular carcinoma: A study based on The Cancer Genome Atlas

Jinzhong Li, Ning Chen, Xiaobing Gong
Pages: 5304-5314
Published online on: 25 October 2019

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Dendritic cell exosome‑shuttled miRNA146a regulates exosome‑induced endothelial cell inflammation by inhibiting IRAK‑1: A feedback control mechanism

Xin Zhong, Wei Gao, Runda Wu, Haibo Liu, Junbo Ge
Pages: 5315-5323
Published online on: 16 October 2019

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Gene synthesizing, expression and immunogenicity characterization of recombinant translation elongation factor 2 from Dermatophagoides farinae

Desheng Chen, Qinghui Fu, Jianli Lin, Chengshen Hu, Nana Huang, Ke Xin Chang, Baoqing Sun, Zhigang Liu
Pages: 5324-5334
Published online on: 31 October 2019

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Gene targets of sulforaphane in head and neck squamous cell carcinoma

Lanlin Hu, Hua Li, Eliot D. Lee, Jennifer R. Grandis, Julie E. Bauman, Daniel E. Johnson
Pages: 5335-5344
Published online on: 23 October 2019

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Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway

Liang Chen, Zhenshe Liu
Pages: 5345-5352
Published online on: 16 October 2019

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Potential function of microRNAs in thoracic aortic aneurysm and thoracic aortic dissection pathogenesis

Tugce Senturk, Arzu Antal, Tuba Gunel
Pages: 5353-5362
Published online on: 22 October 2019

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[Corrigendum] Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats

Jiangtao Zhou, Yina Zhao, Guangwen Wu, Bingbing Lin, Zuanfang Li, Xianxiang Liu
Pages: 5363-5363
Published online on: 18 October 2019

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

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SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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