Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2019 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling

  • Authors:
    • Da‑Zhi Ding
    • Ya‑Nan Jia
    • Bo Zhang
    • Cheng‑Ming Guan
    • Shuai Zhou
    • Xiang Li
    • Xun Cui
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Institute of Clinical Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China, Department of Physiology, College of Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5091-5099
    |
    Published online on: October 15, 2019
       https://doi.org/10.3892/mmr.2019.10744
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

C‑type natriuretic peptide (CNP), from the family of natriuretic peptides (NPs), has been shown to induce antihypertrophic and antifibrotic effects in cardiomyocytes. However, the roles of CNP in the atrial dysregulation of connexin (Cx)40 and Cx43 remain to be elucidated. The present study aimed to investigate the effects of CNP on angiotensin (Ang) II‑induced Cx40 and Cx43 dysregulation in isolated perfused beating rat left atria. A rat isolated perfused beating atrial model was used and the protein levels were determined via western blotting. Ang II significantly upregulated NF‑κB, activator protein‑1, transforming growth factor‑β1 (TGF‑β1), collagen I and matrix metalloproteinase 2, leading to atrial fibrosis, and downregulated expression of Cx40 and Cx43. The changes in Cx40 and Cx43 induced by Ang II were abolished by CNP through upregulation of phosphorylated AMP‑activated kinase a1 (AMPK) and downregulation of TGF‑β1. The effects of CNP on AMPK and TGF‑β1 levels were inhibited by KT5823 and pertussis toxin, inhibitors of protein kinase G (PKG) and NP receptor type C (NPR‑C), respectively. Thus, CNP can prevent Ang II‑induced dysregulation of Cx40 and Cx43 through activation of AMPK via the CNP‑PKG and CNP‑NPR‑C pathways in isolated beating rat atria. The present findings suggested that CNP may be therapeutically useful for clinical conditions involving cardiac dysregulation of Cx expression‑related diseases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Sudoh T, Minamino N, Kangawa K and Matsuo H: C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun. 168:863–870. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Abassi Z, Karram T, Ellaham S, Winaver J and Hoffman A: Implications of the natriuretic peptide system in the pathogenesis of heart failure: Diagnostic and therapeutic importance. Pharm Ther. 102:223–241. 2004. View Article : Google Scholar

3 

Scotland RS, Ahluwalia A and Hobbs AJ: C-type natriuretic peptide in vascular physiology and disease. Pharm Ther. 105:85–93. 2005. View Article : Google Scholar

4 

Del Ry S, Cabiati M, Vozzi F, Battolla B, Caselli C, Forini F, Segnani C, Prescimone T, Giannessi D and Mattii L: Expression of C-type natriuretic peptide and its receptor NPR-B in cardiomyocytes. Peptides. 32:1713–1718. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Del Ry S, Maltinti M, Piacenti M, Passino C, Emdin M and Giannessi D: Cardiac production of C-type natriuretic peptide in heart failure. J Cardiovasc Med (Hagerstown). 7:397–399. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kalra PR, Clague JR, Bolger AP, Anker SD, Poole-Wilson PA, Struthers AD and Coats AJ: Myocardial production of C-type natriuretic peptide in chronic heart failure. Circulation. 107:571–573. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS and Hobbs AJ: C-type natriuretic peptide co-ordinates cardiac structure and function. Eur Heart J. (pii): ehz093Mar 21–2019.(Epub ahead of print). PubMed/NCBI

8 

Calvieri C, Rubattu S and Volpe M: Molecular mechanisms underlying cardiac anti-hypertrophic and antifibrotic effects of natriuretic peptides. J Mol Med (Berl). 90:5–13. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, de Waard MC, Sterner-Kock A, Stepan H, Schultheiss HP, Duncker DJ and Walther T: Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice. Eur J Heart Fail. 9:548–557. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Soeki T, Kishimoto I, Okumura H, Tokudome T, Horio T, Mori K and Kangawa K: C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. J Am Coll Cardiol. 45:608–616. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Dhein S: Gap junction channels in the cardiovascular system: Pharmacological and physiological modulation. Trends Pharmacol Sci. 19:229–241. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Davis LM, Kanter HL, Beyer EC and Saffitz JE: Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol. 24:1124–1132. 1994. View Article : Google Scholar : PubMed/NCBI

13 

Davis LM, Rodefeld ME, Green K, Beyer EC and Saffitz JE: Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol. 6:813–822. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Severs NJ, Coppen SR, Dupont E, Yeh HI, Ko YS and Matsushita T: Gap junction alterations in human cardiac disease. Cardiovasc Res. 62:368–377. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Tanaka H, Matsuyama TA and Takamatsu T: Towards an integrated understanding of cardiac arrhythmogenesis-growing roles of experimental pathology. Pathol Int. 67:8–16. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Kim S and Iwao H: Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev. 52:11–34. 2000.PubMed/NCBI

17 

Zhang B, Cui X, Jin HH, Hong L, Liu X, Li X, Zhang QG and Liu LP: Ginsenoside Re prevents angiotensin II-induced gap-junction remodeling by activation of PPARγ in isolated beating rat atria. Life Sci. 190:36–45. 2017. View Article : Google Scholar : PubMed/NCBI

18 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals8th. National Academies Press (US); Washington, DC: 2011

19 

Qi H, Liu Y, Li S, Chen Y, Li L, Cao Y, E M, Shi P, Song C, Li B and Sun H: Activation of AMPK attenuated cardiac fibrosis by inhibiting CDK2 via p21/p27 and miR-29 family pathways in ratsnd. Mol Ther Nucleic Acids. 8:277–290. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Liu X, Zhang Y, Hong L, Han CJ, Zhang B, Zhou S, Wu CZ, Liu LP and Cui X: Gallic acid increases atrial natriuretic peptide secretion and mechanical dynamics through activation of PKC. Life Sci. 181:45–52. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Gu X, Fang T, Kang P, Hu J, Yu Y, Li Z, Cheng X and Gao Q: Effect of ALDH2 on high glucose-induced cardiac fibroblast oxidative stress, apoptosis, and fibrosis. Oxid Med Cell Longev. Oct 9–2017.(Epub ahead of print). View Article : Google Scholar

22 

Horio T, Tokudome T, Maki T, Yoshihara F, Suga S, Nishikimi T, Kojima M, Kawano Y and Kangawa K: Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Endocrinology. 144:2279–2284. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Del Ry S: C-type natriuretic peptide: A new cardiac mediator. Peptides. 40:93–98. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Wenzel S, Taimor G, Piper HM and Schlüter KD: Redox-sensitive intermediates mediate angiotensin II-induced p38 MAP kinase activation, AP-1bindingactivity, and TGF-beta expression in adult ventricular cardiomyocytes. FASEBJ. 15:2291–2293. 2001. View Article : Google Scholar

25 

Izumiya Y, Araki S, Usuku H, Rokutanda T, Hanatani S and Ogawa H: Chronic C-type natriuretic peptide infusion attenuates angiotensin II-induced myocardial superoxide production and cardiac remodeling. Int J Vasc Med. 2012:2460582012.PubMed/NCBI

26 

Ichiki T, Boerrigter G, Huntley BK, Sangaralingham SJ, McKie PM, Harty GJ, Harders GE and Burnett JC Jr: Differential expression of the pro-natriuretic peptide convertases corin and furin in experimental heart failure and atrial fibrosis. Am J Physiol RegulIntegr Comp Physiol. 304:R102–R109. 2013. View Article : Google Scholar

27 

Mishra R, Cool BL, Laderoute KR, Foretz M, Viollet B and Simonson MS: AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation. J Biol Chem. 283:10461–10469. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Hernandez JS, Barreto-Torres G, Kuznetsov AV, Khuchua Z and Javadov S: Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: The role of mitochondria. J Cell Mol Med. 18:709–720. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Fujita K, Maeda N, Sonoda M, Ohashi K, Hibuse T, Nishizawa H, Nishida M, Hiuge A, Kurata A, Kihara S, et al: Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler Thromb Vasc Biol. 28:863–870. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding DZ, Jia YN, Zhang B, Guan CM, Zhou S, Li X and Cui X: C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Mol Med Rep 20: 5091-5099, 2019.
APA
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., & Cui, X. (2019). C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Molecular Medicine Reports, 20, 5091-5099. https://doi.org/10.3892/mmr.2019.10744
MLA
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., Cui, X."C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling". Molecular Medicine Reports 20.6 (2019): 5091-5099.
Chicago
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., Cui, X."C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling". Molecular Medicine Reports 20, no. 6 (2019): 5091-5099. https://doi.org/10.3892/mmr.2019.10744
Copy and paste a formatted citation
x
Spandidos Publications style
Ding DZ, Jia YN, Zhang B, Guan CM, Zhou S, Li X and Cui X: C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Mol Med Rep 20: 5091-5099, 2019.
APA
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., & Cui, X. (2019). C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Molecular Medicine Reports, 20, 5091-5099. https://doi.org/10.3892/mmr.2019.10744
MLA
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., Cui, X."C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling". Molecular Medicine Reports 20.6 (2019): 5091-5099.
Chicago
Ding, D., Jia, Y., Zhang, B., Guan, C., Zhou, S., Li, X., Cui, X."C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling". Molecular Medicine Reports 20, no. 6 (2019): 5091-5099. https://doi.org/10.3892/mmr.2019.10744
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team