Open Access

Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair

  • Authors:
    • Banglian Deng
    • Wenzhong Zhu
    • Yansheng Duan
    • Yuqian Hu
    • Xuefeng Chen
    • Shuang Song
    • Zian Yi
    • Yingliang Song
  • View Affiliations

  • Published online on: October 23, 2019     https://doi.org/10.3892/mmr.2019.10764
  • Pages: 4933-4942
  • Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammation‑related bone defects pose a heavy burden on patients and orthopedic surgeons. Although stem‑cell‑based bone repair has developed rapidly, it is of great significance to characterize bio‑active molecules that facilitate bone regeneration. It is reported that a glucagon‑like peptide 1 receptor agonist, exendin‑4, promoted bone regeneration mediated by the transplantation of adipose‑derived stem cells in a metaphyseal defect mouse model of femur injury. However, the underlying mechanism is unclear. Bone imaging, immunohistochemistry real‑time PCR and western blot analysis were used in the present study, and the results revealed that exendin‑4 increased the transcription of the osteogenic differentiation‑related genes and induced osteogenic differentiation in situ. Furthermore, the present data obtained from sorted adipose‑derived stem cells revealed that exendin‑4 promoted osteogenic differentiation and inhibited adipogenic differentiation in vitro. These findings indicated that exendin‑4 facilitates osteogenic differentiation of transplanted adipose‑derived stem cells for bone repair and illuminated clinical prospects of both adipose‑derived stem cells and exendin‑4 in stem‑cell‑based bone defect repair.
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December-2019
Volume 20 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Deng B, Zhu W, Duan Y, Hu Y, Chen X, Song S, Yi Z and Song Y: Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair. Mol Med Rep 20: 4933-4942, 2019
APA
Deng, B., Zhu, W., Duan, Y., Hu, Y., Chen, X., Song, S. ... Song, Y. (2019). Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair. Molecular Medicine Reports, 20, 4933-4942. https://doi.org/10.3892/mmr.2019.10764
MLA
Deng, B., Zhu, W., Duan, Y., Hu, Y., Chen, X., Song, S., Yi, Z., Song, Y."Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair". Molecular Medicine Reports 20.6 (2019): 4933-4942.
Chicago
Deng, B., Zhu, W., Duan, Y., Hu, Y., Chen, X., Song, S., Yi, Z., Song, Y."Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair". Molecular Medicine Reports 20, no. 6 (2019): 4933-4942. https://doi.org/10.3892/mmr.2019.10764