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Article

Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction

  • Authors:
    • Mayra Azat
    • Xiaokelaiti Huojiahemaiti
    • Ranran Gao
    • Peng Peng
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830054, P.R. China
  • Pages: 5216-5222
    |
    Published online on: October 23, 2019
       https://doi.org/10.3892/mmr.2019.10768
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Abstract

The long noncoding RNA myocardial infarction associated transcript (MIAT) has been shown to be a risk allele for myocardial infarction in a previous study. However, there is still controversy about whether MIAT can be used as a biomarker for acute myocardial infarction (AMI). Peripheral blood from patients with AMI and non‑AMI patients was collected to detect the expression levels of MIAT by reverse transcription‑quantitative PCR. Correlation analysis and receiver operating characteristic (ROC) curve analysis were performed to calculate the diagnostic value of MIAT. A rat AMI model was established to detect the expression of MIAT in plasma and cardiac samples. Neonatal rat cardiomyocytes were isolated and exposed to hypoxia, and MIAT small interfering RNAs were transfected into cells to test the expression levels of MIAT and to perform apoptosis‑related assays. The results showed that the plasma levels of MIAT were significantly increased in patients with AMI compared with non‑AMI patients. Correlation analysis showed that MIAT was positively associated with creatine kinase‑MB and cardiac troponin T (cTnT). ROC analysis indicated that MIAT had the same diagnostic value as cTnT. In addition, MIAT was expressed at low levels in the normal rat heart and was highly expressed in AMI hearts. Knockdown of MIAT significantly inhibited cardiomyocyte apoptosis. The present study demonstrated that MIAT may act as a novel potential biomarker for the diagnosis of AMI.
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Copy and paste a formatted citation
Spandidos Publications style
Azat M, Huojiahemaiti X, Gao R and Peng P: Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction. Mol Med Rep 20: 5216-5222, 2019.
APA
Azat, M., Huojiahemaiti, X., Gao, R., & Peng, P. (2019). Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction. Molecular Medicine Reports, 20, 5216-5222. https://doi.org/10.3892/mmr.2019.10768
MLA
Azat, M., Huojiahemaiti, X., Gao, R., Peng, P."Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction". Molecular Medicine Reports 20.6 (2019): 5216-5222.
Chicago
Azat, M., Huojiahemaiti, X., Gao, R., Peng, P."Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction". Molecular Medicine Reports 20, no. 6 (2019): 5216-5222. https://doi.org/10.3892/mmr.2019.10768
Copy and paste a formatted citation
x
Spandidos Publications style
Azat M, Huojiahemaiti X, Gao R and Peng P: Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction. Mol Med Rep 20: 5216-5222, 2019.
APA
Azat, M., Huojiahemaiti, X., Gao, R., & Peng, P. (2019). Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction. Molecular Medicine Reports, 20, 5216-5222. https://doi.org/10.3892/mmr.2019.10768
MLA
Azat, M., Huojiahemaiti, X., Gao, R., Peng, P."Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction". Molecular Medicine Reports 20.6 (2019): 5216-5222.
Chicago
Azat, M., Huojiahemaiti, X., Gao, R., Peng, P."Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction". Molecular Medicine Reports 20, no. 6 (2019): 5216-5222. https://doi.org/10.3892/mmr.2019.10768
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