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Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism

  • Authors:
    • Hongxia Xiao
    • Zhen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Jing Men No. 2 People's Hospital, Jingmen, Hubei 448000, P.R. China, Department of Ophthalmology, Chongqing Aier Eye Hospital, Chongqing 400020, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5125-5133
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    Published online on: October 30, 2019
       https://doi.org/10.3892/mmr.2019.10778
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Abstract

Diabetic retinopathy is a major complication of diabetes. Increasing evidence has indicated that microRNAs (miRs) serves an important role in diabetic retinopathy. However, the expression and mechanism of miR‑217 in high glucose‑induced human retinal pigment epithelial cells ARPE‑19 is still unclear. Therefore, the aim of this study was to investigate the role of miR‑217 in high glucose‑induced retinal epithelial cell damage, and further to explore the molecular mechanisms. In our study, we found that compared with control group, miR‑217 was upregulated in high glucose‑induced ARPE‑19 cells. In addition, TargetScan and a dual‑luciferase reporter gene assay showed that Sirtuin 1 (SIRT1) was a direct target of miR‑217. Then, we performed reverse transcription‑quantitative polymerase chain reaction assay and western blot assay to explore the expression of SIRT1 in high glucose‑induced ARPE‑19 cells. Our results demonstrated that SIRT1 was downregulated at the mRNA and protein levels in high glucose‑induced ARPE‑19 cells. Then, ARPE‑19 cells were transfected with inhibitor control, miR‑217 inhibitor or miR‑217 inhibitor + SIRT1‑small interfering RNA for 6 h, and then the cells were treated with 50 mM D‑glucose for 24 h. We then investigated the effects of miR‑217 inhibitor on ARPE‑19 cell viability and apoptosis. An MTT assay revealed that miR‑217 inhibitor significantly increased the viability and decreased the apoptosis of high glucose‑induced ARPE‑19 cells. ELISA indicated that miR‑217 inhibitor significantly reduced the expression of inflammatory factors, such as interleukin (IL)‑1β, tumor necrosis factor‑α, and IL‑6 in high glucose‑treated ARPE‑19 cells. Additionally, a western blot assay demonstrated that miR‑217 inhibitor suppressed the expression of p‑p65. The effects of miR‑217 inhibitor on high glucose‑treated ARPE‑19 cells were significantly reversed by the silencing the SIRT1 gene. Therefore, our findings suggested that miR‑217 inhibitor protected against retinal epithelial cell damage caused by high glucose via targeting SIRT1, thereby playing a protective role in diabetic retinopathy. Targeting miR‑217 may have therapeutic potential in the treatment of diabetic retinopathy.
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View References

1 

Stewart MW: Treatment of diabetic retinopathy: Recent advances and unresolved challenges. World J Diabetes. 7:333–341. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Klein BE: Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol. 14:179–183. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, et al: Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 35:556–564. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Wang CF, Yuan JR, Qin D, Gu JF, Zhao BJ, Zhang L, Zhao D, Chen J, Hou XF, Yang N, et al: Protection of tauroursodeoxycholic acid on high glucose-induced human retinal microvascular endothelial cells dysfunction and streptozotocin-induced diabetic retinopathy rats. J Ethnopharmacol. 185:162–170. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Siasos G, Gouliopoulos N, Moschos MM, Oikonomou E, Kollia C, Konsola T, Athanasiou D, Siasou G, Mourouzis K, Zisimos K, et al: Role of endothelial dysfunction and arterial stiffness in the development of diabetic retinopathy. Diabetes Care. 38:e9–e10. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Frank RN: Diabetic retinopathy. N Engl J Med. 350:48–58. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Mizutani M, Kern TS and Lorenzi M: Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest. 97:2883–2890. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Schroder K, Zhou R and Tschopp J: The NLRP3 inflammasome: A sensor for metabolic danger? Science. 327:296–300. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Roy S, Kern TS, Song B and Stuebe C: Mechanistic insights into pathological changes in the diabetic retina: Implications for targeting diabetic retinopathy. Am J Pathol. 187:9–19. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Curtis TM, Gardiner TA and Stitt AW: Microvascular lesions of diabetic retinopathy: Clues towards understanding pathogenesis? Eye (Lond). 23:1496–1508. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Spijkerman AM, Gall MA, Tarnow L, Twisk JW, Lauritzen E, Lund-Andersen H, Emeis J, Parving HH and Stehouwer CD: Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in type 2 diabetes. Diabet Med. 24:969–976. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Shin ES, Sorenson CM and Sheibani N: Diabetes and retinal vascular dysfunction. J Ophthalmic Vis Res. 9:362–373. 2014.PubMed/NCBI

13 

Toma L, Stancu CS, Botez GM, Sima AV and Simionescu M: Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose. Biochem Biophys Res Commun. 390:877–882. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Cunha-Vaz J, Bernardes R and Lobo C: Blood-retinal barrier. Eur J Ophthalmol. 21 (Suppl 6):S3–S9. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lorenzi M and Gerhardinger C: Early cellular and molecular changes induced by diabetes in the retina. Diabetologia. 44:791–804. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zhang P, Zhang Z and Kador PF: Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells. J Ocul Pharmacol Ther. 30:4–11. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P and Stoffel M: A pancreatic islet-specifc microRNA regulates insulin secretion. Nature. 432:226–230. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Wang Q, Liu N, Yang X, Tu L and Zhang X: Small RNA-mediated responses to low- and high-temperature stresses in cotton. Sci Rep. 6:355582016. View Article : Google Scholar : PubMed/NCBI

19 

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS and Johnson JM: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Mendell J and Olson E: MicroRNAs in stress signaling and human disease. Cell. 148:1172–1187. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wei R, Deng Z and Su J: miR-217 targeting Wnt5a in osteosarcoma functions as a potential tumor suppressor. Biomed. Pharmacother. 72:158–164. 2015. View Article : Google Scholar

23 

Yin H, Liang X, Jogasuria A, Davidson NO and You M: miR-217 regulates ethanolinduced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling. Am J Pathol. 185:1286–1296. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Azam AT, Bahador R, Hesarikia H, Shakeri M and Yeganeh A: Downregulation of microRNA-217 and microRNA-646 acts as potential predictor biomarkers in progression, metastasis, and unfavorable prognosis of human osteosarcoma. Tumour Biol. 37:5769–5773. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Popov A, Szabo A and Mandys V: Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantifcation in pancreatic cancer. BMC Cancer. 15:7742015. View Article : Google Scholar : PubMed/NCBI

26 

Yin Z and Ren W: MicroRNA-217 acts as a tumor suppressor and correlates with the chemoresistance of cervical carcinoma to cisplatin. OncoTargets and Terapy. 12:759–771. 2019. View Article : Google Scholar

27 

Guo J, Feng Z, Huang Z, Wang H and Lu W: MicroRNA-217 functions as a tumour suppressor gene and correlates with cell resistance to cisplatin in lung cancer. Mol Cells. 37:664–671. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Lin CJ, Lan YM, Ou MQ, Ji LQ and Lin SD: Expression of miR-217 and HIF-1α/VEGF pathway in patients with diabetic foot ulcer and its effect on angiogenesis of diabetic foot ulcer rats. J Endocrinol Invest. May 11–2019.doi: 10.1007/s40618-019-01053-2 (Epub ahead of print). View Article : Google Scholar

29 

Sun J, Li ZP, Zhang RQ and Zhang HM: Repression of miR-217 protects against high glucose-induced podocyte injury and insulin resistance by restoring PTEN-mediated autophagy pathway. Biochem Biophys Res Commun. 483:318–324. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Shao Y, Lv C, Wu C, Zhou Y and Wang Q: Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway. Diabetes Metab Res Rev. 32:534–543. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Shao Y, Ren H, Lv C, Ma X, Wu C and Wang Q: Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease. Endocrine. 55:130–138. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Leal EC, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, Forrester JV and Ambrósio AF: High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway. Exp Eye Res. 88:983–991. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Fan Y, Qiao Y, Huang J and Tang M: Protective effects of panax notoginseng saponins against high glucose-induced oxidativeinjury in rat retinal capillary endothelial cells. Evid Based Complement Alternat Med. 2016:53263822016. View Article : Google Scholar : PubMed/NCBI

35 

Rassi DM, De Paiva CS, Dias LC, Módulo CM, Adriano L, Fantucci MZ and Rocha EM: Review: MicroRNAS in ocular surface and dry eye diseases. Ocul Surf. 15:660–669. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Romano GL, Platania CBM, Drago F, Salomone S, Ragusa M, Barbagallo C, Di Pietro C, Purrello M, Reibaldi M, Avitabile T, et al: Retinal and circulating miRNAs in age-related macular degeneration: An in vivo animal and human study. Front Pharmacol. 8:1682017. View Article : Google Scholar : PubMed/NCBI

37 

Ma J, Wang J, Liu Y, Wang C, Duan D, Lu N, Wang K, Zhang L, Gu K, Chen S, et al: Comparisons of serum miRNA expression profiles in patients with diabetic retinopathy and type 2 diabetes mellitus. Clinics (Sao Paulo). 72:111–115. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Gong Q and Su G: Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy. Biosci Rep. 37:BSR201711572017. View Article : Google Scholar : PubMed/NCBI

39 

Jiang Y, Sang Y and Qiu Q: microRNA-383 mediates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells by repressing peroxiredoxin 3. Am J Transl Res. 9:2374–2383. 2017.PubMed/NCBI

40 

Ying H and Yan Y: MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-κB signaling. Life Sci. 207:212–218. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Zhao WG, Yu SN, Lu ZH, Ma YH, Gu YM and Chen J: The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis. 31:1726–1733. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Li H, Fan J, Yin Z, Wang F, Chen C and Wang DW: Identification of cardiac-related circulating microRNA profile in human chronic heart failure. Oncotarget. 7:33–45. 2016.PubMed/NCBI

43 

Lian B, Yang D, Liu Y, Shi G, Li J, Yan X, Jin K, Liu X, Zhao J, Shang W and Zhang R: miR-128 Targets the SIRT1/ROS/DR5 pathway to sensitize colorectal cancer to TRAIL-induced apoptosis. Cell Physiol Biochem. 49:2151–2162. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Lu Y, Tan L and Wang X: Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer's disease. Neurosci Bull. Mar 18–2019.doi: 10.1007/s12264-019-00361-0 (Epub ahead of print).

45 

Sun QR, Zhang X and Fang K: Phenotype of vascular smooth muscle cells (VSMCs) is regulated by miR-29b by targeting Sirtuin 1. Med Sci Monit. 24:6599–6607Yue. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Borji M, Nourbakhsh M, Shafiee SM, Owji AA, Abdolvahabi Z, Hesari Z, Ilbeigi D, Seiri P and Yousefi Z: Down-regulation of SIRT1 expression by mir-23b contributes to lipid accumulation in HepG2 Cells. Biochem Genet. 57:507–521. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Karbasforooshan H and Karimi G: The role of SIRT1 in diabetic retinopathy. Biomed Pharmacother. 97:190–194. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Mishra M, Duraisamy AJ and Kowluru RA: Sirt1: A guardian of the development of diabetic retinopathy. Diabetes. 67:745–754. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Wang W, Zhang Y, Jin W, Xing Y and Yang A: Catechin weakens diabetic retinopathy by inhibiting the expression of NF-κB signaling pathway-mediated inflammatory factors. Ann Clin Lab Sci. 48:594–600. 2018.PubMed/NCBI

50 

Yin Y, Chen F, Wang W, Wang H and Zhang X: Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway. Mol Vis. 23:242–250. 2017.PubMed/NCBI

51 

Kim SJ, Yoo WS, Choi M, Chung I, Yoo JM and Choi W: Increased O-GlcNAcylation of NF-κB enhances retinal ganglion cell death in streptozotocin-induced diabetic retinopathy. Curr Eye Res. 41:249–257. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Tey SK, Tse EYT, Mao X, Ko FCF, Wong AST, Lo RC, Ng IO and Yam JWP: Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway. Cancer Lett. 411:150–161. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao H and Liu Z: Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism. Mol Med Rep 20: 5125-5133, 2019.
APA
Xiao, H., & Liu, Z. (2019). Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism. Molecular Medicine Reports, 20, 5125-5133. https://doi.org/10.3892/mmr.2019.10778
MLA
Xiao, H., Liu, Z."Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism". Molecular Medicine Reports 20.6 (2019): 5125-5133.
Chicago
Xiao, H., Liu, Z."Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism". Molecular Medicine Reports 20, no. 6 (2019): 5125-5133. https://doi.org/10.3892/mmr.2019.10778
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao H and Liu Z: Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism. Mol Med Rep 20: 5125-5133, 2019.
APA
Xiao, H., & Liu, Z. (2019). Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism. Molecular Medicine Reports, 20, 5125-5133. https://doi.org/10.3892/mmr.2019.10778
MLA
Xiao, H., Liu, Z."Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism". Molecular Medicine Reports 20.6 (2019): 5125-5133.
Chicago
Xiao, H., Liu, Z."Effects of microRNA‑217 on high glucose‑induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE‑19) and its underlying mechanism". Molecular Medicine Reports 20, no. 6 (2019): 5125-5133. https://doi.org/10.3892/mmr.2019.10778
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