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Article

Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice

  • Authors:
    • Weiqing Hu
    • Wenyue Wang
    • Qing Ma
    • Tao Liu
    • Jiefeng Zhang
    • Jicun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The People' Hospital of Weifang City, Weifang, Shandong 261000, P.R. China, Department of Obstetrics and Gynecology, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, P.R. China, Department of Pharmacy, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, P.R. China
  • Pages: 454-462
    |
    Published online on: November 6, 2019
       https://doi.org/10.3892/mmr.2019.10800
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Abstract

Blueberry anthocyanin‑enriched extract (BAE) has been demonstrated to protect against cardiovascular diseases by activating multiple target genes. The present study investigated the effects of BAE on transverse aortic constriction (TAC)‑induced myocardial dysfunction in mice and explored its possible molecular mechanisms. A total of 30 male mice were divided randomly into control, TAC and TAC + BAE groups. Mice in the TAC + BAE groups were administered BAE by oral gavage for 6 consecutive weeks. Myocardial dysfunction was assessed using echocardiogram, histopathology, TUNEL assay, immunofluorescence staining, reverse transcription‑quantitative PCR and western blot analysis. The results demonstrated that BAE treatment significantly ameliorated heart weight, left ventricular weight, myocardial dysfunction, left ventricular hypertrophy and fibrosis. In addition, BAE treatment alleviated TAC‑induced inflammation, oxidative stress and apoptosis. Notably, BAE treatment markedly reduced asymmetric dimethylarginine (ADMA) concentration and significantly increased dimethylarginine dimethylaminohydrolase 1 (DDAH1) expression and nitric oxide (NO) production. The present data indicated that BAE treatment ameliorated TAC‑induced myocardial dysfunction, oxidative stress, inflammatory response and apoptosis via the DDAH1/ADMA/NO signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Hu W, Wang W, Ma Q, Liu T, Zhang J and Zhang J: Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Mol Med Rep 21: 454-462, 2020.
APA
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., & Zhang, J. (2020). Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Molecular Medicine Reports, 21, 454-462. https://doi.org/10.3892/mmr.2019.10800
MLA
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., Zhang, J."Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice". Molecular Medicine Reports 21.1 (2020): 454-462.
Chicago
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., Zhang, J."Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice". Molecular Medicine Reports 21, no. 1 (2020): 454-462. https://doi.org/10.3892/mmr.2019.10800
Copy and paste a formatted citation
x
Spandidos Publications style
Hu W, Wang W, Ma Q, Liu T, Zhang J and Zhang J: Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Mol Med Rep 21: 454-462, 2020.
APA
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., & Zhang, J. (2020). Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Molecular Medicine Reports, 21, 454-462. https://doi.org/10.3892/mmr.2019.10800
MLA
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., Zhang, J."Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice". Molecular Medicine Reports 21.1 (2020): 454-462.
Chicago
Hu, W., Wang, W., Ma, Q., Liu, T., Zhang, J., Zhang, J."Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice". Molecular Medicine Reports 21, no. 1 (2020): 454-462. https://doi.org/10.3892/mmr.2019.10800
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