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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2020 Volume 21 Issue 1

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Molecular basis of degenerative spinal disorders from a proteomic perspective (Review)

Chang Liu, Minghui Yang, Libangxi Liu, Yang Zhang, Qi Zhu, Cong Huang, Hongwei Wang, Yaqing Zhang, Haiyin Li, Changqing Li, Bo Huang, Chencheng Feng, Yue Zhou
Pages: 9-19
Published online on: 12 November 2019

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Article Open Access

Aspirin metabolites 2,3‑DHBA and 2,5‑DHBA inhibit cancer cell growth: Implications in colorectal cancer prevention

Ranjini Sankaranarayanan, Chaitanya K. Valiveti, Rakesh Dachineni, D. Ramesh Kumar, Tana Lick, G. Jayarama Bhat
Pages: 20-34
Published online on: 18 November 2019

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Article Open Access

MicroRNA‑542‑3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells

Jun Sun, Yong Deng, Jin Shi, Wengang Yang
Pages: 35-42
Published online on: 20 November 2019

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Article Open Access

miR‑204 inhibits the osteogenic differentiation of mesenchymal stem cells by targeting bone morphogenetic protein 2

Xiaofeng Jiang, Zuofu Zhang, Tao Peng, Guangda Wang, Qiang Xu, Guangrun Li
Pages: 43-50
Published online on: 05 November 2019

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Article Open Access

Exploratory study on application of MALDI‑TOF‑MS to detect serum and urine peptides related to small cell lung carcinoma

Panpan Lv, Zeyuan Liu, Bin Xu, Chuanhao Tang, Xiaoyan Li, Haifeng Qin, Shaoxing Yang, Hongjun Gao, Kun He, Xiaoqing Liu
Pages: 51-60
Published online on: 05 November 2019

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Article Open Access

KR‑12‑a6 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via BMP/SMAD signaling

Lanqing Fu, Peicheng Jin, Yajun Hu, Hougen Lu, Linlin Su
Pages: 61-68
Published online on: 22 November 2019

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Article Open Access

Silencing of RBP‑JK promotes the differentiation of bone marrow mesenchymal stem cells into vascular endothelial cells

Zhengliang Luo, Yong Dai, Min Chen, Chen Zhu, Kerong Wu, Guoyuan Li, Xifu Shang
Pages: 69-76
Published online on: 06 November 2019

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Article Open Access

Anti‑Nogo‑A antibody promotes brain function recovery after cardiopulmonary resuscitation in rats by reducing apoptosis

Qinqin Wu, Haihong Zhang, Hu Nie, Zhi Zeng
Pages: 77-88
Published online on: 20 November 2019

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Article Open Access

The inhibition of miR‑101a‑3p alleviates H/R injury in H9C2 cells by regulating the JAK2/STAT3 pathway

Jingying Liu, Juanjuan Wang, Yuzhen Ning, Fengying Chen
Pages: 89-96
Published online on: 05 November 2019

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Article Open Access

Disorders of sex development: Genetic characterization of a patient cohort

Mary García-Acero, Olga Moreno-Niño, Fernando Suárez-Obando, Mónica Molina, María Carolina Manotas, Juan Carlos Prieto, Catalina Forero, Camila Céspedes, Jaime Pérez, Nicolas Fernandez, Adriana Rojas
Pages: 97-106
Published online on: 12 November 2019

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Article Open Access

Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia

Joon Ha Park, Ji Hyeon Ahn, Dae Won Kim, Tae‑Kyeong Lee, Cheol Woo Park, Young Eun Park, Jae‑Chul Lee, Hyang‑Ah Lee, Go Eun Yang, Moo‑Ho Won, Choong‑Hyun Lee
Pages: 107-114
Published online on: 20 November 2019

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Article Open Access

Neuroprotective effect of CPCGI on Alzheimer's disease and its mechanism

Xiaopeng Wang, Jing Zhao
Pages: 115-122
Published online on: 20 November 2019

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Article Open Access

Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia‑reperfusion rats Retraction in /10.3892/mmr.2025.13656

Cun‑Xian Shi, Jin Jin, Xue‑Qin Wang, Teng Song, Guang‑Hong Li, Ke‑Zhong Li, Jia‑Hai Ma
Pages: 123-130
Published online on: 20 November 2019

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Article Open Access

Iridoid glycosides from Radix Scrophulariae attenuates focal cerebral ischemia‑reperfusion injury via inhibiting endoplasmic reticulum stress‑mediated neuronal apoptosis in rats

Yanyue Chen, Lei Zhang, Xueyuan Gong, Hengpei Gong, Rubin Cheng, Fengmei Qiu, Xiaoming Zhong, Zhen Huang
Pages: 131-140
Published online on: 20 November 2019

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Article Open Access

Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma

Chuanyu Ma, Jie Qin, Junpeng Zhang, Xingli Wang, Dongjun Wu, Xiunan Li
Pages: 141-150
Published online on: 11 November 2019

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Article Open Access

Interleukin‑37 is increased in peripheral blood mononuclear cells of coronary heart disease patients and inhibits the inflammatory reaction

Huimin Li, Chen Shen, Bingni Chen, Jing Du, Bin Peng, Wei Wang, Fanwu Chi, Xiaoqiang Dong, Zhong Huang, Chao Yang
Pages: 151-160
Published online on: 06 November 2019

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Article Open Access

Roxatidine inhibits fibrosis by inhibiting NF‑κB and MAPK signaling in macrophages sensing breast implant surface materials

Litong Ji, Tie Wang, Lining Tian, Hongjiang Song, Meizhuo Gao
Pages: 161-172
Published online on: 12 November 2019

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Article Open Access

Endoplasmic reticulum stress regulates epithelial‑mesenchymal transition in human lens epithelial cells

Sheng Zhou, Jing Yang, Mingwei Wang, Danying Zheng, Yizhi Liu
Pages: 173-180
Published online on: 12 November 2019

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Article Open Access

Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells

Qin Yu, Xiaoqin Xiong, Lei Zhao, Tingting Xu, Qianhua Wang
Pages: 181-190
Published online on: 20 November 2019

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Article Open Access

The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament

Peng Wang, Ze Teng, Xiaoguang Liu, Xiao Liu, Chao Kong, Shibao Lu
Pages: 191-200
Published online on: 22 November 2019

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Article Open Access

Mitochondrial tRNAAla 5601C>T variant may affect the clinical expression of the LHON‑related ND4 11778G>A mutation in a family

Yu Ding, Yu‑Feng Ye, Mei‑Ya Li, Bo‑Hou Xia, Jian‑Hang Leng
Pages: 201-208
Published online on: 22 November 2019

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Article Open Access

miR‑218 functions as a tumor suppressor gene in cervical cancer Retraction in /10.3892/mmr.2024.13326

Zhen Liu, Lin Mao, Linlin Wang, Hong Zhang, Xiaoxia Hu
Pages: 209-219
Published online on: 11 November 2019

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Article Open Access

Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway

Baocheng Zhao, Zhenjun Wang, Jiagang Han, Guanghui Wei, Bingqiang Yi, Zhulin Li
Pages: 220-228
Published online on: 20 November 2019

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Article Open Access

Extraction and isolation of the active ingredients of dandelion and its antifungal activity against Candida albicans

Yinku Liang, Hongbo Duan, Ping Zhang, Hao Han, Feixiong Gao, Yunxiang Li, Zhongyang Xu
Pages: 229-239
Published online on: 06 November 2019

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Article Open Access

A novel GPR143 mutation in a Chinese family with X‑linked ocular albinism type 1

Xuhui Gao, Tiecheng Liu, Xuan Cheng, Aiai Dai, Wei Liu, Runpu Li, Maonian Zhang
Pages: 240-248
Published online on: 12 November 2019

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Article Open Access

Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells

Yifan Wu, Yiyang Zhao, Xuanhong He, Zhiqiang He, Tian Wang, Linxi Wan, Lai Chen, Nianlong Yan
Pages: 249-257
Published online on: 06 November 2019

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Article Open Access

Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway

Dong‑Gu Kim, Ji‑Won Choi, Il‑Joo Jo, Myoung‑Jin Kim, Ho‑Sub Lee, Seung‑Heon Hong, Ho‑Joon Song, Gi‑Sang Bae, Sung‑Joo Park
Pages: 258-266
Published online on: 19 November 2019

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Article Open Access

Prognostic and predictive roles of microRNA‑411 and its target STK17A in evaluating radiotherapy efficacy and their effects on cell migration and invasion via the p53 signaling pathway in cervical cancer Retraction in /10.3892/mmr.2026.13886

Wei Wei, Cun Liu
Pages: 267-281
Published online on: 20 November 2019

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Article Open Access

Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats

Yang Jiao, Yang Yu, Bo Li, Xiyan Gu, Keliang Xie, Guolin Wang, Yonghao Yu
Pages: 282-290
Published online on: 05 November 2019

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Article Open Access

LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models

Jianping Wu, Chuanguang Wang, Haiyang Ding
Pages: 291-303
Published online on: 20 November 2019

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Article Open Access

Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK

Ying Li, Yong Li, Te Yang, Ming Wang
Pages: 304-310
Published online on: 06 November 2019

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Article Open Access

Screening and identification of key biomarkers in prostate cancer using bioinformatics

Song Li, Junqing Hou, Weibo Xu
Pages: 311-319
Published online on: 06 November 2019

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Article Open Access

Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008

Min Lu, Tao Yi, Yong Xiong, Qian Wang, Nina Yin
Pages: 320-328
Published online on: 21 November 2019

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Article Open Access

CARD10 promotes the progression of renal cell carcinoma by regulating the NF‑κB signaling pathway

Longfei Peng, Ke He, Zhangjun Cao, Liangkuan Bi, Dexin Yu, Qi Wang, Jinyou Wang
Pages: 329-337
Published online on: 21 November 2019

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Article Open Access

Increased mitochondrial DNA copy number protects hair cells and HEI‑OC1 cells against drug‑induced apoptosis

Honglin Mei, Dongmei Mei, Huiqian Yu, Shan Sun, Yan Chen, Yanping Zhang, Renjie Chai, Huawei Li
Pages: 338-346
Published online on: 20 November 2019

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Article Open Access

A 21‑gene Support Vector Machine classifier and a 10‑gene risk score system constructed for patients with gastric cancer

Hui Jiang, Jiming Gu, Jun Du, Xiaowei Qi, Chengjia Qian, Bojian Fei
Pages: 347-359
Published online on: 21 November 2019

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Article Open Access

Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma

Jie Wei, Zhijie Xu, Xi Chen, Xiang Wang, Shuangshuang Zeng, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong, Yuanliang Yan
Pages: 360-370
Published online on: 20 November 2019

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Article

IL‑37 expression is decreased in patients with hyperhomocysteinemia and protects cells from inflammatory injury by homocysteine

Sen Wang, Zhen Huang, Wenrui Li, Suhui He, Hongmei Wu, Jiandong Zhu, Rumeng Li, Zhuangyan Liang, Zhangquan Chen
Pages: 371-378
Published online on: 06 November 2019

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Article

Retinal proteomic evaluation of rats following streptozotocin‑injection using shotgun proteomics

Hiroko Otake, Tetushi Yamamoto, Saori Deguchi, Atushi Taga, Noriaki Nagai
Pages: 379-386
Published online on: 06 November 2019

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Article

A novel ATRX mutation causes Smith‑Fineman‑Myers syndrome in a Chinese family

Liangshan Li, Jing Yu, Xiao Zhang, Mengmeng Han, Wenmiao Liu, Hui Li, Shiguo Liu
Pages: 387-392
Published online on: 12 November 2019

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Article

Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin

Ying Zhang, Shaobo Wang, Yinghui Huang, Ke Yang, Yong Liu, Xianjin Bi, Chi Liu, Jiachuan Xiong, Bo Zhang, Jinghong Zhao, Ling Nie
Pages: 393-404
Published online on: 11 November 2019

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Article

Histone 3 lysine 9 acetylation of BRG1 in the medial prefrontal cortex is associated with heroin self‑administration in rats

Qingxiao Hong, Jing Liu, Zi Lin, Dingding Zhuang, Wenjin Xu, Zemin Xu, Miaojun Lai, Huaqiang Zhu, Wenhua Zhou, Huifen Liu
Pages: 405-412
Published online on: 22 November 2019

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Article

LncRNA ANCR downregulates hypoxia‑inducible factor 1α and inhibits the growth of HPV‑negative cervical squamous cell carcinoma under hypoxic conditions

Weiwei Ta, Yao Zhang, Shangdi Zhang, Pengfei Sun
Pages: 413-419
Published online on: 05 November 2019

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Article

Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals

Huahui Zhang, Tao Xie, Yongjie Shui, Yiying Qi
Pages: 420-428
Published online on: 06 November 2019

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Article

Lipoxin A4 attenuates hyperoxia‑induced lung epithelial cell injury via the upregulation of heme oxygenase‑1 and inhibition of proinflammatory cytokines

Yan‑Yan Luo, Sheng‑Hua Wu, Hong‑Yan Lu, Bing‑Jie Li, Shu‑Jun Li, Zhong‑Yi Sun, Rui Jin, Xiao‑Qing Chen
Pages: 429-437
Published online on: 15 November 2019

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Article

Identification of a novel pathogenic mutation of the MYH3 gene in a family with distal arthrogryposis type 2B

Wen‑Bo Wang, Ling‑Chi Kong, Rong‑Tai Zuo, Qing‑Lin Kang
Pages: 438-444
Published online on: 15 November 2019

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Article

IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion

Meng Liu, Ziyang Li, Weirong Yao, Xiaoping Zeng, Lingyun Wang, Jiao Cheng, Bingyu Ma, Ruiqian Zhang, Weiping Min, Hongmei Wang
Pages: 445-453
Published online on: 12 November 2019

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Article

Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice

Weiqing Hu, Wenyue Wang, Qing Ma, Tao Liu, Jiefeng Zhang, Jicun Zhang
Pages: 454-462
Published online on: 06 November 2019

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Article

Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats

Xue He, Yulin Song, Li Wang, Jianming Xu
Pages: 463-469
Published online on: 12 November 2019

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Article

Mechanical stress promotes biological functions of C2C12 myoblasts by activating PI3K/AKT/mTOR signaling pathway

Yu Da, Yongbin Mou, Mengjia Wang, Xiao Yuan, Fuhua Yan, Weidong Lan, Fang Zhang
Pages: 470-477
Published online on: 11 November 2019

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Article

rhBMP‑7 suppresses TGF‑β1‑induced endothelial to mesenchymal transition in circulating endothelial cells by regulating Smad5

Weili Ge, Yafei Mi, Shasha Xu, Tao Li, Yifei Lu, Jianjun Jiang
Pages: 478-484
Published online on: 21 November 2019

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Article

Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells

Xing‑Chen Huo, Hui‑Wen Yang, Li‑Hua Huang, Fan Zhang, Zi‑Ye Pan, Qin Liao
Pages: 485-492
Published online on: 05 November 2019

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Article

Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression

Hwan Lee, Wonmin Ko, Anisuzzaman Chowdhury, Bin Li, Sam Cheol Kim, Hyuncheol Oh, Youn‑Chul Kim, Eun‑Rhan Woo, Nam‑In Baek, Dong‑Sung Lee
Pages: 493-500
Published online on: 19 November 2019

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Article

Differentiation potential and functional properties of a CD34‑CD133+ subpopulation of endothelial progenitor cells

Katrin Bachelier, Carolin Bergholz, Erik B. Friedrich
Pages: 501-507
Published online on: 20 November 2019

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Article

Kai‑Xin‑San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression

Yuan Hu, Xianzhe Dong, Tianyi Zhang, Hongming Ma, Wenshan Yang, Yichen Wang, Ping Liu, Yibang Chen
Pages: 508-516
Published online on: 06 November 2019

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Article Open Access

A novel gross deletion and breakpoint junction sequence analysis of ATP7B in a Chinese family with Wilson disease using next‑generation sequencing and Sanger sequencing

Wei‑Liang Liu, Fang Li, Lu Liu, Wei Chen, Zhi‑Xu He, Hao Gu, Rong Ai
Pages: 517-523
Published online on: 20 November 2019

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Research on the role and mechanism of SLC7A5 in idiopathic pulmonary fibrosis

Menghan Wang, Yao Yu, Zhaoyu Liu, Dandan Xu, Yupeng Li, Xing Zou, Ning Shan, Xining Liu, Ce Shi, Hong Chen
Article Number: 323
Published online on: 01 October 2026

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Electroencephalography research in neuropathic pain (Review)

Lanling Zhou, Nianshun Liao, Hongmei Wang, Jiaxi Zhao, Haijun Jiang, Shihua Dang, Sixun Yu, Haifeng Shu, Xin Chen
Article Number: 322
Published online on: 25 September 2026

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BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review)

Yu Liang, Tingjin Chen, Xuemei Wen, Dan Liu, Zhongjian Zhang, Weiqing Li, Hengdi Zhang
Article Number: 321
Published online on: 24 September 2026

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Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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Retraction Open Access

[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Review Open Access

Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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Retraction Open Access

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Review Open Access

Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Review Open Access

Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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December-2026 Volume 34 Issue 6

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and therapeutic horizons (Review)

Jiayuan Chen, Haoran Zhong, Jing Li, Hao Chen, Wenguang Fu
Article Number: 344
Published online on: 29 October 2026

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Role of glucagon‑like peptide‑1 receptor in cancer: Mechanisms and pharmacologic intervention (Review)

Feng Jing, Ying Zeng, Qin-Ling Yu, Chao-Ju Fu
Article Number: 343
Published online on: 27 October 2026

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A false sense of hypoxia: Pro‑tumorigenic VHL‑HIF2α dysregulation in clear cell renal cell carcinoma (Review)

Nur Qurratu' Athirah A Rahman, Ahmad Suhail Khazali, Mohamad Aiman Mohtar, Saiful Effendi Syafruddin
Article Number: 342
Published online on: 23 October 2026

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Research progress in neural regulatory mechanisms and targeted therapy of obesity (Review)

Dejie Kang, Xia Li, Yaoyou Zhang, Yihan Sun, Yuhan Li, Zhiyan Yao, Youlei Li
Article Number: 341
Published online on: 22 October 2026

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Mechanisms of the interaction between aging of the male reproductive system and obesity, and clinical management strategies (Review)

Dandan Luo, Lulu Zhang, Xiangyu Qi, Qiangbo Guan, Feng Xu, Peng Lu, Chunxiao Yu
Article Number: 340
Published online on: 22 October 2026

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Erythropoietin beyond red blood cells: Systemic and oncological functions (Review)

Kristína Danková, Zuzana Solárová, Pavol Harvanik, Martina Šemeláková, Peter Solár
Article Number: 339
Published online on: 22 October 2026

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Liquid‑liquid phase separation and post‑transcriptional regulation intersection: A new paradigm of RNA‑binding protein condensates in hepatocellular carcinoma malignant phenotypes (Review)

Xiao Liu, Yunyi Huang
Article Number: 338
Published online on: 21 October 2026

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Research advances in the interplay between ferroptosis and T cells in the tumor microenvironment (Review)

Shihan Tang, Wenbo Xu, Yichen Li, Chuwei Liu, Weitao Liu, Ruihan Liang, Qianhui Liao, Han Sun, Zhuoyan Wang, Lingchang Shi, Qiying Liu, Huiping Liu
Article Number: 337
Published online on: 21 October 2026

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Gut‑kidney axis in chronic kidney disease: Dysbiosis, uremic metabolites and therapeutic opportunities (Review) 

Yinding Wang, Hanyu Zeng, Na Liu, Dong Yang
Article Number: 336
Published online on: 16 October 2026

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Glycyrrhizic acid attenuates corneal inflammation and pathological angiogenesis through FAK/PI3K/AKT signaling

Jinjin Yu, Huiheng Qu, Yinming Fang, Weicheng Xu, Nannan Ding, Jie Ji, Nan Wang, Wei Shi
Article Number: 335
Published online on: 15 October 2026

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Erbin deficiency exacerbates sepsis‑induced liver injury through mitochondrial ROS/NLRP3‑mediated inflammatory responses

Jing Zuo, Xing Wang, Guoqing Jing, Xiaojing Wu, Xuemin Song
Article Number: 334
Published online on: 15 October 2026

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Gut microbiota in patients receiving dialysis: Mechanisms, complications and the road to personalized microbiome‑based care (Review)

Chenxia Jin, Yanping Wang
Article Number: 333
Published online on: 15 October 2026

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Article Open Access

Epigallocatechin gallate and thermal cycling‑stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress‑induced calcium ion dysregulation and oxidative stress

Fang-Tzu Hsu, Hsu-Hsiang Liu, Yi Kung, Chieh-Jou Lin, Chih-Yu Chao
Article Number: 332
Published online on: 15 October 2026

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Article Open Access

Piezo1 knockdown alleviates high‑altitude cerebral edema by improving brain microvascular endothelial cell tight junctions via blocking the calcium influx‑mediated Calpain‑1 activity

Taijian Cao, Zhicheng Xiang, Yangyang Zhao, Drolma Gomchok, Haifeng Ma, Shiwang Li, Dahai Cao, Chunqing Yang, Qiang Zhang
Article Number: 331
Published online on: 13 October 2026

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Navigating the landscape of targeted therapies for renal cell carcinoma in the era of precision medicine (Review)

Hongguo Cui, Jingheng Song, Peisen Yang, Zhengchao Zhang, Yuanyuan Liu, Gang Zhang, Aimin Tian, Jizhong Che, Yangyang Liu, Hui Sun, Yankai Xu
Article Number: 330
Published online on: 13 October 2026

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ΔNp63α‑mediated regulation of tumor‑associated genes and pathways in hepatocellular carcinoma progression

Xiaowen Lin, Anghui Peng, Min Zhang, Xinyang Yu
Article Number: 329
Published online on: 13 October 2026

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 Leptin promotes obesity‑related osteoarthritis progression via CD44/JAK2/STAT3 axis‑mediated chondrocyte apoptosis

Hao Qiu, Chao Zeng, Cheng Chen, Xin Zhou, Yongjun Zhu, Zhongliang Deng
Article Number: 328
Published online on: 09 October 2026

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Mechanical‑immune feedback regulation in distraction osteogenesis: From mechanotransduction to immune microenvironment remodeling (Review)

Xian Wang, Yuetong Wang, Shixi He, Cheng Ma, Zhengzhong He, Xuanping Huang
Article Number: 327
Published online on: 08 October 2026

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Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review)

Heng Wang, Pei Yang, Wantao Liu
Article Number: 326
Published online on: 07 October 2026

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Retraction Open Access

[Retracted] (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway

Jia-Wen Li, Xiao-Yun Wang, Xin Zhang, Lei Gao, Li-Feng Wang, Xin-Hua Yin
Article Number: 325
Published online on: 05 October 2026

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Review Open Access

Lactylation and exercise: A molecular link to disease alleviation (Review)

Jian Wang, Lei Wu
Article Number: 324
Published online on: 02 October 2026

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