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Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK

  • Authors:
    • Ying Li
    • Yong Li
    • Te Yang
    • Ming Wang
  • View Affiliations / Copyright

    Affiliations: Cardiovascular Department, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 304-310
    |
    Published online on: November 6, 2019
       https://doi.org/10.3892/mmr.2019.10806
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Abstract

Dioscin has been shown to affect the regulation of metabolic diseases, including diabetes; however, the mechanism of action is still unclear. Under high glucose (HG) conditions, the expression of scavenger receptors and the uptake of oxidized low‑density lipoprotein (oxLDL) are upregulated in dendritic cells (DCs), which are critical steps in atherogenesis and inflammation. In this study, the focus was on the impact of dioscin on the function of DCs. Immature DCs were cultured with: 5.5 mM glucose medium (control group); 30 mM glucose medium (HG group); HG + 10 mM dioscin; HG + 20 mM dioscin; HG + 30 mM dioscin; and HG + 40 mM dioscin. For subsequent experiments, 30 mM dioscin was used as the experimental concentration. Dichlorodihydrofluorescein fluorescence was used to measure the intracellular production of reactive oxygen species (ROS) in DCs. The expression levels of the scavenger receptors, including class A scavenger receptors (SR‑A), CD36 and lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1) were determined via quantitative PCR. The protein expression of p38 mitogen‑activated protein kinase (MAPK) was determined by western blotting. Furthermore, ELISA was used to detect the levels of interleukin (IL)‑6, IL‑10 and IL‑12. Finally, DCs were incubated with diOlistic (Dil)‑labeled oxLDL, and flow cytometry analysis was used to investigate the Dil‑oxLDL‑incorporated fraction. The incubation of DCs with dioscin inhibited the induction of ROS production, in a dose‑dependent manner, under HG conditions. The upregulation of SR‑A, CD36 and LOX‑1 genes was partially abolished by dioscin, which also partially reversed p38 MAPK protein upregulation. Furthermore, increased secretion of IL‑6 and IL‑12, and decreased secretion of IL‑10 in DCs, induced by HG, was also reversed by dioscin. To conclude, dioscin could attenuate the production of ROS, inflammatory cytokine secretion and oxLDL uptake by DCs in HG conditions by preventing the expression of scavenger receptors and p38 MAPK, thus playing a positive role in preventing atherogenesis.
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1 

Abraham TM, Pencina KM, Pencina MJ and Fox CS: Trends in diabetes incidence: the Framingham heart study. Diabetes Care. 38:482–487. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Geiss LS, Wang J, Cheng YJ, Thompson TJ, Barker L, Li Y, Albright AL and Gregg EW: Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980–2012. JAMA. 312:1218–1226. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kosiborod M, Gomes MB, Nicolucci A, Pocock S, Rathmann W, Shestakova MV, Watada H, Shimomura I, Chen H, Cid-Ruzafa J, et al: Vascular complications in patients with type 2 diabetes: Prevalence and associated factors in 38 countries (the DISCOVER study program). Cardiovasc Diabetol. 17:1502018. View Article : Google Scholar : PubMed/NCBI

4 

Suzuki LA, Poot M, Gerrity RG and Bornfeldt KE: Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: Lack of direct growth-promoting effects of high glucose levels. Diabetes. 50:851–860. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Gilardini Montani MS, Granato M, Cuomo L, Valia S, Di Renzo L, D'Orazi G, Faggioni A and Cirone M: High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK. Biochim Biophys Acta. 1862:805–813. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: Recommendations for a Public Health Approach. 2nd. Geneva: 2016

7 

Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352:1685–1695. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Lu H, Yao K, Huang D, Sun A, Zou Y, Qian J and Ge J: High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells. Cardiovasc Diabetol. 12:802013. View Article : Google Scholar : PubMed/NCBI

9 

Ptak W, Klimek M, Bryniarski K, Ptak M and Majcher P: Macrophage function in alloxan diabetic mice: Expression of adhesion molecules, generation of monokines and oxygen and NO radicals. Clin Exp Immunol. 114:13–18. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Beauloye C, Marsin AS, Bertrand L, Krause U, Hardie DG, Vanoverschelde JL and Hue L: Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides. FEBS Lett. 505:348–352. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Lu H, Huang D, Yao K, Li C, Chang S, Dai Y, Sun A, Zou Y, Qian J and Ge J: Insulin enhances dendritic cell maturation and scavenger receptor-mediated uptake of oxidised low-density lipoprotein. J Diabetes Complications. 29:465–471. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Huang D, Lu H, Liu H, Yao K, Sun A, Zou Y and Ge J: Losartan attenuates human monocyte-derived dendritic cell immune maturation via downregulation of lectin-like oxidized low-density lipoprotein receptor-1. J Cardiovasc Pharmacol. 60:133–139. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Tao X, Yin L, Xu L and Peng J: Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections. Pharmacol Res. 137:259–269. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K and Peng J: Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage. Br J Pharmacol. 176:919–937. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Hu Y, Mao Z, Xu L, Yin L, Tao X, Tang Z, Qi Y, Sun P and Peng J: Protective effect of dioscin against intestinal ischemia/reperfusion injury via adjusting miR-351-5p-mediated oxidative stress. Pharmacol Res. 137:56–63. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K and Peng J: Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 97:481–488. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Yao H, Tao X, Xu L, Qi Y, Yin L, Han X, Xu Y, Zheng L and Peng J: Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway. Pharmacol Res. 131:51–60. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C and Peng J: Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway. Int Immunopharmacol. 36:132–141. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, et al: Protective effects of dioscin against lipopolysaccharide-induced acute lung injury through inhibition of oxidative stress and inflammation. Front Pharmacol. 8:1202017. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Y, Tao X, Yin L, Xu L, Xu Y, Qi Y, Han X, Song S, Zhao Y, Lin Y, et al: Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway. Br J Pharmacol. 174:2512–2527. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zheng L, Han X, Hu Y, Zhao X, Yin L, Xu L, Qi Y, Xu Y, Han X, Liu K and Peng J: Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis. Pharmacol Res. 139:431–439. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Tao X, Xu L, Yin L, Han X, Qi Y, Xu Y, Song S, Zhao Y and Peng J: Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β. Cell Death Dis. 8:e29892017. View Article : Google Scholar : PubMed/NCBI

23 

Si L, Xu L, Yin L, Qi Y, Han X, Xu Y, Zhao Y, Liu K and Peng J: Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of the Akt1 signalling pathway. Br J Pharmacol. 174:553–568. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zhao L, Tao X, Qi Y, Xu L, Yin L and Peng J: Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol. 16:189–198. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Wu S, Xu H, Peng J, Wang C, Jin Y, Liu K, Sun H and Qin J: Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway. Biochimie. 110:62–72. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, et al: Potent effects of dioscin against obesity in mice. Sci Rep. 5:79732015. View Article : Google Scholar : PubMed/NCBI

27 

Tao X, Qi Y, Xu L, Yin L, Han X, Xu Y, Wang C, Sun H and Peng J: Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis. Pharmacol Res. 108:90–101. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Coventry BJ, Austyn JM, Chryssidis S, Hankins D and Harris A: Identification and isolation of CD1a positive putative tumour infiltrating dendritic cells in human breast cancer. Adv Exp Med Biol. 417:571–577. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Zhang LF, Okuma K, Tanaka R, Kodama A, Kondo K, Ansari AA and Tanaka Y: Generation of mature dendritic cells with unique phenotype and function by in vitro short-term culture of human monocytes in the presence of interleukin-4 and interferon-beta. Exp Biol Med (Maywood). 233:721–731. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Pan CH and Luo RC: Tumor necrosis factor-alpha pretreatment for in vitro culture of mature dendritic cells. Di Yi Jun Yi Da Xue Xue Bao. 23:114–117. 2003.(In Chinese). PubMed/NCBI

32 

Fernandez Pujol B, Lucibello FC, Zuzarte M, Lütjens P, Müller R and Havemann K: Dendritic cells derived from peripheral monocytes express endothelial markers and in the presence of angiogenic growth factors differentiate into endothelial-like cells. Eur J Cell Biol. 80:99–110. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Kurosaki E and Ogasawara H: Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data. Pharmacol Ther. 139:51–59. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Xu L, Li Y, Dai Y and Peng J: Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms. Pharmacol Res. 130:451–465. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Zhu S, Tang S and Su F: Dioscin inhibits ischemic stroke-induced inflammation through inhibition of the TLR4/MyD88/NF-κB signaling pathway in a rat model. Mol Med Rep. 17:660–666. 2018.PubMed/NCBI

36 

Li S, Cheng B, Hou L, Huang L, Cui Y, Xu D, Shen X and Li S: Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. Anticancer Drugs. 29:234–242. 2018.PubMed/NCBI

37 

Qin J, Kang Y, Xu Z, Zang C, Fang B and Liu X: Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 64:47–52. 2014.PubMed/NCBI

38 

Yu H, Zheng L, Xu L, Yin L, Lin Y, Li H, Liu K and Peng J: Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats. Phytother Res. 29:228–240. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Wei Q, Zhu T, Xiao X, Sun L, Zhang Z and Huang T: Dioscin attenuates myocardial damages in diabetic rats maybe by regulating NO-sGC-cGMP-PKG pathway. Ann Clin Lab Sci. 49:97–104. 2019.PubMed/NCBI

40 

Li H, Yu L and Zhao C: Dioscin attenuates high-fat diet-induced insulin resistance of adipose tissue through the IRS-1/PI3K/Akt signaling pathway. Mol Med Rep. 19:1230–1237. 2019.PubMed/NCBI

41 

Fang Z, Deng Q, Hu H, Wang X, Sun X, Ge X and Wang P: Characteristics of immunogenic and tolerogenic dendritic cells within the arterial wall in atherosclerosis and in vitro. Int J Clin Exp Med. 7:4846–4856. 2014.PubMed/NCBI

42 

Gil-Pulido J and Zernecke A: Antigen-presenting dendritic cells in atherosclerosis. Eur J Pharmacol. 816:25–31. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Zernecke A: Dendritic cells in atherosclerosis: Evidence in mice and humans. Arterioscler Thromb Vasc Biol. 35:763–770. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Gu L, Tao X, Xu Y, Han X, Qi Y, Xu L, Yin L and Peng J: Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway. Toxicol Appl Pharmacol. 292:19–29. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W and Haegeman G: p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem. 273:3285–3290. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Nishizawa T and Bornfeldt KE: Diabetic vascular disease and the potential role of macrophage glucose metabolism. Ann Med. 44:555–563. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K and Peng J: Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 284:37–45. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Zhang Y, Xu Y, Qi Y, Xu L, Song S, Yin L, Tao X, Zhen Y, Han X, Ma X, et al: Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation. Toxicology. 378:53–64. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y, Qi Y, Han X and Peng J: Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme. Food Chem Toxicol. 59:657–669. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Zhao X, Xu L, Zheng L, Yin L, Qi Y, Han X, Xu Y and Peng J: Potent effects of dioscin against gastric cancer in vitro and in vivo. Phytomedicine. 23:274–282. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Maier W, Altwegg LA, Corti R, Gay S, Hersberger M, Maly FE, Sütsch G, Roffi M, Neidhart M, Eberli FR, et al: Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: Locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation. 111:1355–1361. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Zhang X, Niessner A, Nakajima T, Ma-Krupa W, Kopecky SL, Frye RL, Goronzy JJ and Weyand CM: Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque. Circ Res. 98:524–531. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Yin Y, Liu W, Ji G and Dai Y: The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 in regulating endothelial cell apoptosis. Eur J Cell Biol. 92:150–159. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li Y, Yang T and Wang M: Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. Mol Med Rep 21: 304-310, 2020.
APA
Li, Y., Li, Y., Yang, T., & Wang, M. (2020). Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. Molecular Medicine Reports, 21, 304-310. https://doi.org/10.3892/mmr.2019.10806
MLA
Li, Y., Li, Y., Yang, T., Wang, M."Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK". Molecular Medicine Reports 21.1 (2020): 304-310.
Chicago
Li, Y., Li, Y., Yang, T., Wang, M."Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK". Molecular Medicine Reports 21, no. 1 (2020): 304-310. https://doi.org/10.3892/mmr.2019.10806
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li Y, Yang T and Wang M: Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. Mol Med Rep 21: 304-310, 2020.
APA
Li, Y., Li, Y., Yang, T., & Wang, M. (2020). Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. Molecular Medicine Reports, 21, 304-310. https://doi.org/10.3892/mmr.2019.10806
MLA
Li, Y., Li, Y., Yang, T., Wang, M."Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK". Molecular Medicine Reports 21.1 (2020): 304-310.
Chicago
Li, Y., Li, Y., Yang, T., Wang, M."Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK". Molecular Medicine Reports 21, no. 1 (2020): 304-310. https://doi.org/10.3892/mmr.2019.10806
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