Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2020 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats

  • Authors:
    • Xue He
    • Yulin Song
    • Li Wang
    • Jianming Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
  • Pages: 463-469
    |
    Published online on: November 12, 2019
       https://doi.org/10.3892/mmr.2019.10817
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has been reported that pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF‑κB, exerts a hepatoprotective effect on acute and chronic liver damage. The aim of the present study was to explore the INH/RIF‑induced protective effects and mechanisms of PDTC on liver injury. Rats were intragastrically administered INH (50 mg/kg/day) and RIF (50 mg/kg/day) daily for 28 days. PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co‑administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF‑κB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)‑α, bile salt export pump (BSEP), and protein expression of BSEP. It was found that the inhibition of NF‑κB activation by PDTC treatment markedly alleviated liver biochemical and histological injury, decreased oxidative stress and mRNA levels of TNF‑α, and prevented decreases in BSEP mRNA and protein expression induced by the co‑administration of INH and RIF. Collectively, the present data suggested that INH/RIF‑induced liver injury is dependent on the activation of NF‑κB. PDTC exerted a therapeutic effect on INH/RIF‑induced liver injury by increasing BSEP expression, and exhibiting antioxidant and anti‑inflammatory activities.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

World Health Organization, . Global tuberculosis report 2015. World Health Organization; Geneva: 2015

2 

Yew WW and Leung CC: Antituberculosis drugs and hepatotoxicity. Respirology. 11:699–707. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Yew WW, Chang KC and Chan DP: Oxidative stress and first-line antituberculosis drug-induced hepatotoxicity. Antimicrob Agents Chemother. 62:e02637–17. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Baskaran UL and Sabina EP: Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: A review. J Integr Med. 15:27–36. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Santhosh S, Sini TK, Anandan R and Mathee PT: Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats. Eur J Pharmacol. 572:69–73. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Chowdhury A, Santra A, Bhattacharjee K, Ghatak S, Saha DR and Dhali GK: Mitochondrial oxidative stress and penneability transition in isoniaizd and Rifampicin induced liver injury in mice. J Hepatol. 45:117–126. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Nicoletti NF, Rodrigues-Junior V, Santos AA Jr, Leite CE, Dias AC, Batista EL Jr, Basso LA, Campos MM, Santos DS and Souto AA: Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. J Nat Prod. 77:2190–2195. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J and Baud V: A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem. 286:32277–32288. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bruck R, Schey R, Aeed H, Hochman A, Genina O and Pines M: A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis. Liver Int. 24:169–176. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Qin JD, Cao ZH, Li XF, Kang XL, Xue Y, Li YL, Zhang D, Liu XY and Xue YZ: Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 52:1460–1466. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Yang F, Li X, Wang LK, Wang LW, Han XQ, Zhang H and Gong ZJ: Inhibitions of NF-κB and TNF-α result in differential effects in rats with acute on chronic liver failure induced by d-Gal and LPS. Inflammation. 37:848–857. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Demirbilek S, Akin M, Gürünlüoğlu K, Aydin NE, Emre MH, Taş E, Aksoy RT and Ay S: The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats. Pediatr Surg Int. 22:655–663. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Rana SV, Pal R, Vaiphie K and Singh K: Effect of different oral doses of isoniazid-rifampicin in rats. Mol Cell Biochem. 289:39–47. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Pal R, Vaiphei K, Sikander A, Singh K and Rana SV: Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World J Gastroenterol. 12:636–639. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Matsui N, Kasajima K, Hada M, Nagata T, Senga N, Yasui Y, Fukuishi N and Akagi M: Inhibiton of NF-kappaB activation during ischemia reduces hepatic ischemia/reperfusion injury in rats. J Toxicol Sci. 30:103–110. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Heiman J, Wallin M, Gustafsson BI, Friman S and Delbro D: Pharmacological of rat liver by up-regulation of heme oxygenase 1. Transplant Proc. 38:2705–2707. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Pan M, Song YL, Xu JM and Gan HZ: Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats. J Pineal Res. 41:79–84. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Wang FS, Fan JG, Zhang Z, Gao B and Wang HY: The global burden of liver disease: The major impact of China. Hepatology. 60:2099–2108. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Işık A, Fırat D, Korkmaz S, Demiryılmaz İ and Yılmaz İ: Atipik prezente kist hidatik: Pankreas Başında Kitle. Sakarya Tıp Dergisi. 8:149–152. 2018.

20 

Işık A, Sayar İ, Gülhan B and Firat D: Fascioliasis: A rare case mimicking cholelithiasis. J Kartal TR. 27:145–146. 2016.

21 

Sodhi CP, Rana SV, Mehta SK, Vaiphei K, Attari S and Mehta S: Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats. Drug Chem Toxicol. 20:255–269. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Tian XF, Yao JH, Li YH, Gao HF, Wang ZZ, Yang CM and Zheng SS: Protective effect of pyrrolidine dithiocarbamate on liver injury induced by intestinal ischemia-reperfusion in rats. Hepatobiliary Pancreat Dis Int. 5:90–95. 2006.PubMed/NCBI

23 

Rana SV, Pal R, Vaiphei K, Ola RP and Singh K: Hepatoprotection by carotenoids in isoniazid-rifampicin induced hepatic injury in rats. Biochem Cell Biol. 88:819–834. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Narayanan A, Amaya M, Voss K, Chung M, Benedict A, Sampey G, Kehn-Hall K, Luchini A, Liotta L, Bailey C, et al: Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells. Virology. 449:270–286. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Kastl L, Sauer SW, Ruppert T, Beissbarth T, Becker MS, Süss D, Krammer PH and Gülow K: TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells. FEBS Lett. 588:175–183. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Lu JW, Wang H, Yan-Li J, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W and Xu DX: Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis. J Hepatol. 48:442–452. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Yu HX, Wang XL, Zhang LN, Zhang J and Zhao W: Involvement of the TLR4/NF-κB signaling pathway in the repair of esophageal mucosa injury in rats with gastroesophageal reflux disease. Cell Physiol Biochem. 51:1645–1657. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Borghi SM, Fattori V, Ruiz-Miyazawa KW, Bertozzi MM, Lourenco-Gonzalez Y, Tatakihara RI, Bussmann AJC, Mazzuco TL, Casagrande R and Verri WA Jr: Pyrrolidine dithiocarbamate inhibits mouse acute kidney injury induced by diclofenac by targeting oxidative damage, cytokines and NF-κB activity. Life Sci. 208:221–231. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Masson MJ, Collins LA and Pohl LR: The role of cytokines in the mechanism of adverse drug reactions. Handb Exp Pharmacol. 195–231. 2010.doi: 10.1007/978-3-642-00663-0_8. View Article : Google Scholar : PubMed/NCBI

30 

Blaser H, Dostert C, Mak TW and Brenner D: TNF and ROS crosstalk in inflammation. Trends Cell Biol. 26:249–261. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Morgan MJ and Liu ZG: Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol Cells. 30:1–12. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Moe KT, Khairunnisa K, Yin NO, Chin-Dusting J, Wong P and Wong MC: Tumor necrosis factor-α-induced nuclear factor-kappaB activation in human cardiomyocytes is mediated by NADPH oxidase. J Physiol Biochem. 70:769–779. 2014. View Article : Google Scholar : PubMed/NCBI

33 

He CY, Jiang LP, Wang CY and Zhang Y: Inhibition of NF-κB by pyrrolidine dithiocarbamate prevents the inflammatory response in a ligature-induced peri-implantitis model: A canine study. Cell Physiol Biochem. 49:610–625. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Padda MS, Sanchez M, Akhtar AJ and Boyer JL: Drug-induced cholestasis. Hepatology. 53:1377–1387. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Corsini A and Bortolini M: Drug-induced liver injury: The role of drug metabolism and transport. J Clin Pharmacol. 53:463–474. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Kubitz R, Dröge C, Kluge S, Stindt J and Häussinger D: Genetic variations of bile salt transporters. Drug Discov Today Technol. 12:e55–e67. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Kis E, Ioja E, Rajnai Z, Jani M, Méhn D, Herédi-Szabó K and Krajcsi P: BSEP inhibition: In vitro screens to assess cholestatic potential of drugs. Toxicol In Vitro. 26:1294–1299. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Stieger B: The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handb Exp Pharmacol. 205–259. 2011.doi: 10.1007/978-3-642-14541-4_5. View Article : Google Scholar : PubMed/NCBI

39 

Guo YX, Xu XF, Zhang QZ, Li C, Deng Y, Jiang P, He LY and Peng WX: The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity. Toxicol Mech Methods. 25:382–387. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Sato K, Hall C, Glaser S, Francis H, Meng F and Alpini G: Pathogenesis of kupffer cells in cholestatic liver injury. Am J Pathol. 186:2238–2247. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Le Vee M, Lecureur V, Stieger B and Fardel O: Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos. 37:685–693. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Donner MG, Schumacher S, Warskulat U, Heinemann J and Häussinger D: Obstructive cholestasis induces TNF-alpha- and IL-1-mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. Am J Physiol Gastrointest Liver Physiol. 293:G1134–G1146. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Diao L, Li N, Brayman TG, Hotz KJ and Lai Y: Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. J Biol Chem. 285:31185–31192. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Chen Y, Song X, Valanejad L, Vasilenko A, More V, Qiu X, Chen W, Lai Y, Slitt A, Stoner M, et al: Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. Hepatology. 57:1530–1541. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He X, Song Y, Wang L and Xu J: Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Mol Med Rep 21: 463-469, 2020.
APA
He, X., Song, Y., Wang, L., & Xu, J. (2020). Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Molecular Medicine Reports, 21, 463-469. https://doi.org/10.3892/mmr.2019.10817
MLA
He, X., Song, Y., Wang, L., Xu, J."Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats". Molecular Medicine Reports 21.1 (2020): 463-469.
Chicago
He, X., Song, Y., Wang, L., Xu, J."Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats". Molecular Medicine Reports 21, no. 1 (2020): 463-469. https://doi.org/10.3892/mmr.2019.10817
Copy and paste a formatted citation
x
Spandidos Publications style
He X, Song Y, Wang L and Xu J: Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Mol Med Rep 21: 463-469, 2020.
APA
He, X., Song, Y., Wang, L., & Xu, J. (2020). Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Molecular Medicine Reports, 21, 463-469. https://doi.org/10.3892/mmr.2019.10817
MLA
He, X., Song, Y., Wang, L., Xu, J."Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats". Molecular Medicine Reports 21.1 (2020): 463-469.
Chicago
He, X., Song, Y., Wang, L., Xu, J."Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats". Molecular Medicine Reports 21, no. 1 (2020): 463-469. https://doi.org/10.3892/mmr.2019.10817
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team