Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2020 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway

  • Authors:
    • Dong‑Gu Kim
    • Ji‑Won Choi
    • Il‑Joo Jo
    • Myoung‑Jin Kim
    • Ho‑Sub Lee
    • Seung‑Heon Hong
    • Ho‑Joon Song
    • Gi‑Sang Bae
    • Sung‑Joo Park
  • View Affiliations / Copyright

    Affiliations: Hanbang Cardio‑Renal Syndrome Research Center, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea, Division of Beauty Sciences, School of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea, Department of Herbology, School of Korean Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 258-266
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/mmr.2019.10823
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition to the major role, it also participates in the protection of renal and systemic inflammation. Although IMCD cells could take part in renal and systemic inflammation, investigations on renal inflammation in IMCD cells have rarely been reported. Although berberine (BBR) has been reported to show diverse pharmacological effects, its anti‑inflammatory and protective effects on IMCD cells have not been studied. Therefore, in the present study, we examined the anti‑inflammatory and protective effects of BBR in mouse IMCD‑3 (mIMCD‑3) cells against lipopolysaccharide (LPS). An MTT assay was carried out to investigate the toxicity of BBR on mIMCD‑3 cells. Reverse transcription quantitative‑PCR and western blotting were performed to analysis pro‑inflammatory molecules and cytokines. Mechanisms of BBR were examined by western blotting and immunocytochemistry. According to previous studies, pro‑inflammatory molecules, such as inducible nitric oxide synthase and cyclooxygenase‑2, and pro‑inflammatory cytokines, such as interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α are increased in LPS‑exposed mIMCD‑3 cells. However, the production of these pro‑inflammatory molecules is significantly inhibited by treatment with BBR. In addition, BBR inhibited translocation of nuclear factor (NF)‑κB p65 from the cytosol to the nucleus, and degradation of inhibitory κ‑Bα in LPS‑exposed mIMCD‑3 cells. In conclusion, BBR could inhibit renal inflammatory responses via inhibition of NF‑κB signaling and ultimately contribute to amelioration of renal injury during systemic inflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Tchapyjnikov D, Li Y, Pisitkun T, Hoffert JD, Yu MJ and Knepper MA: Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS. Physiol Genomics. 40:167–183. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Kim DG, Bae GS, Jo IJ, Choi SB, Kim MJ, Jeong JH, Kang DG, Lee HS, Song HJ and Park SJ: Guggulsterone attenuated lipopolysaccharide-induced inflammatory responses in mouse inner medullary collecting Duct-3 cells. Inflammation. 39:87–95. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Welch AK, Jeanette Lynch I, Gumz ML, Cain BD and Wingo CS: Aldosterone alters the chromatin structure of the murine endothelin-1 gene. Life Sci. 159:121–126. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Mohaupt MG, Schwöbel J, Elzie JL, Kannan GS and Kone BC: Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells. Am J Physiol. 268:F770–F777. 1995.PubMed/NCBI

5 

Chassin C, Vimont S, Cluzeaud F, Bens M, Goujon JM, Fernandez B, Hertig A, Rondeau E, Arlet G, Hornef MW and Vandewalle A: TLR4 facilitates translocation of bacteria across renal collecting duct cells. J Am Soc Nephrol. 19:2364–2374. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguénec C, Buzoni-Gatel D and Vandewalle A: Renal collecting duct epithelial cells react to pyelonephritis-associated escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol. 177:4773–4784. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Choi JY, Nam SA, Jin DC, Kim J and Cha JH: Expression and cellular localization of inducible nitric oxide synthase in lipopolysaccharide-treated rat kidneys. J Histochem Cytochem. 60:301–315. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Küper C, Beck FX and Neuhofer W: Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells. Am J Physiol Renal Physiol. 302:F38–F46. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Sun SF, Zhao TT, Zhang HJ, Huang XR, Zhang WK, Zhang L, Yan MH, Dong X, Wang H, Wen YM, et al: Renoprotective effect of berberine on type 2 diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 42:662–670. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Linn YC, Lu J, Lim LC, Sun H, Sun J, Zhou Y and Ng HS: Berberine-induced haemolysis revisited: Safety of Rhizoma coptidis and cortex phellodendri in chronic haematological diseases. Phytother Res. 26:682–686. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Dong Y, Chen YT, Yang YX, Zhou XJ, Dai SJ, Tong JF, Shou D and Li C: Metabolomics study of type 2 diabetes mellitus and the antidiabetic effect of berberine in zucker diabetic fatty rats using Uplc-ESI-Hdms. Phytother Res. 30:823–828. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang J, Peng Y, Liu Y, Yang J, Ding N and Tan W: Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth. BMC Cancer. 15:5952015. View Article : Google Scholar : PubMed/NCBI

13 

Pietra D, Borghini A and Bianucci AM: In vitro studies of antifibrotic and cytoprotective effects elicited by proto-berberine alkaloids in human dermal fibroblasts. Pharmacol Rep. 67:1081–1089. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Peng L, Kang S, Yin Z, Jia R, Song X, Li L, Li Z, Zou Y, Liang X, Li L, et al: Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Int J Clin Exp Pathol. 8:5217–5223. 2015.PubMed/NCBI

15 

Kwon OJ, Kim MY, Shin SH, Lee AR, Lee JY, Seo BI, Shin MR, Choi HG, Kim JA, Min BS, et al: Antioxidant and anti-inflammatory effects of Rhei rhizoma and coptidis rhizoma mixture on reflux esophagitis in rats. Evid Based Complement Altern Med. 2016:20521802016. View Article : Google Scholar

16 

Wang B, Xu X, He X, Wang Z and Yang M: Berberine improved aldo-induced podocyte injury via inhibiting oxidative stress and endoplasmic reticulum stress pathways both in vivo and in vitro. Cell Physiol Biochem. 39:217–228. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS and Bodhankar SL: Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 38:996–1006. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Chen X, Zhang Y, Zhu Z, Liu H, Guo H, Xiong C, Xie K, Zhang X and Su S: Protective effect of berberine on doxorubicin-induced acute hepatorenal toxicity in rats. Mol Med Rep. 13:3953–3960. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Jiang Q, Liu P, Wu X, Liu W, Shen X, Lan T, Xu S, Peng J, Xie X and Huang H: Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway. Mol Cell Endocrinol. 331:34–40. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Yokozawa T, Ishida A, Kashiwada Y, Cho EJ, Kim HY and Ikeshiro Y: Coptidis Rhizoma: Protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components. J Pharm Pharmacol. 56:547–556. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Pålsson-McDermott EM and O'Neill LA: Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology. 113:153–162. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Zhu L, Gu P and Shen H: Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats. Int Immunopharmacol. 68:242–251. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Rezaee R, Monemi A, SadeghiBonjar MA and Hashemzaei M: Berberine alleviates paclitaxel-induced neuropathy. J Pharmacopuncture. 22:90–94. 2019.PubMed/NCBI

25 

Domitrović R, Cvijanović O, Pernjak-Pugel E, Skoda M, Mikelić L and Crnčević-Orlić Ž: Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol. 62:397–406. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Zhu L, Han J, Yuan R, Xue L and Pang W: Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway. Biol Res. 51:92018. View Article : Google Scholar : PubMed/NCBI

27 

Li ZY, Liu B, Zhuang XJ, Shen YD, Tian HR, Ji Y, Li LX and Liu F: Effects of berberine on the serum cystatin C levels and urine albumin/creatine ratio in patients with type 2 diabetes mellitus. Zhonghua Yi Xue Za Zhi. 98:3756–3761. 2018.(In Chinese). PubMed/NCBI

28 

Hu Y, Ehli EA, Kittelsrud J, Ronan PJ, Munger K, Downey T, Bohlen K, Callahan L, Munson V, Jahnke M, et al: Lipid-lowering effect of berberine in human subjects and rats. Phytomedicine. 19:861–867. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Yin J, Xing H and Ye J: Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 57:712–717. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Flores-Mireles AL, Walker JN, Caparon M and Hultgren SJ: Urinary tract infections: Epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 13:269–284. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Stone SC, Mallon WK, Childs JM and Docherty SD: Emphysematous pyelonephritis: Clues to rapid diagnosis in the Emergency Department. J Emerg Med. 28:315–319. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Kim JE, Jung HJ, Lee YJ and Kwon TH: Vasopressin-regulated miRNAs and AQP2-targeting miRNAs in kidney collecting duct cells. Am J Physiol Renal Physiol. 308:F749–F764. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Gao M, Cao R, Du S, Jia X, Zheng S, Huang S, Han Q, Liu J, Zhang X, Miao Y, et al: Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts. Proc Natl Acad Sci USA. 112:8397–8402. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Kishore BK, Nelson RD, Miller RL, Carlson NG and Kohan DE: P2Y(2) receptors and water transport in the kidney. Purinergic Signal. 5:491–499. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Li YX, Huang Y, Liu S, Mao Y, Yuan CY, Yang X and Yao LJ: Glycogen synthase kinase-3 modulates hyperosmotic-induced urea transporter A1 relocation in the inner medullary collecting duct cells. Nephron. 133:71–79. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M and Pollock JS: High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am J Physiol Regul Integr Comp Physiol. 311:R263–R271. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Pandit MM, Gao Y, van Hoek A and Kohan DE: Osmolar regulation of endothelin-1 production by the inner medullary collecting duct. Life Sci. 159:135–139. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Fuson AL, Komlosi P, Unlap TM, Bell PD and Peti-Peterdi J: Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney. Am J Physiol Renal Physiol. 285:F558–F564. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Gueutin V, Vallet M, Jayat M, Peti-Peterdi J, Cornière N, Leviel F, Sohet F, Wagner CA, Eladari D and Chambrey R: Renal β-intercalated cells maintain body fluid and electrolyte balance. J Clin Invest. 123:4219–4231. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Huo TL, Grenader A, Blandina P and Healy DP: Prostaglandin E2 production in rat IMCD cells. II. Possible role for locally formed dopamine. Am J Physiol. 261:F655–F662. 1991.PubMed/NCBI

41 

Chen M, Cai H, Klein JD, Laur O and Chen G: Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions. Front Physiol. 6:3102015. View Article : Google Scholar : PubMed/NCBI

42 

Ranieri M, Tamma G, Di Mise A, Russo A, Centrone M, Svelto M, Calamita G and Valenti G: Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2. J Cell Sci. 128:2350–2360. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Zheng P, Lin Y, Wang F, Luo R, Zhang T, Hu S, Feng P, Liang X, Li C and Wang W: 4-PBA improves lithium-induced nephrogenic diabetes insipidus by attenuating ER stress. Am J Physiol Renal Physiol. 311:F763–F776. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Hyndman KA, Boesen EI, Elmarakby AA, Brands MW, Huang P, Kohan DE, Pollock DM and Pollock JS: Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure. Hypertension. 62:91–98. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Anders HJ and Muruve DA: The inflammasomes in kidney disease. J Am Soc Nephrol. 22:1007–1018. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Hijiya N, Miyake K, Akashi S, Matsuura K, Higuchi Y and Yamamoto S: Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology. 70:18–25. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassalo J, Curi R, Velloso LA and Saad MJ: Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes. 56:1986–1998. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Nicola JP, Vélez ML, Lucero AM, Fozzatti L, Pellizas CG and Masini-Repiso AM: Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells. Endocrinology. 150:500–5008. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Hirata T, Osuga Y, Hirota Y, Koga K, Yoshino O, Harada M, Morimoto C, Yano T, Nishii O, Tsutsumi O and Taketani Y: Evidence for the presence of toll-like receptor 4 system in the human endometrium. J Clin Endocrinol Metab. 90:548–556. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Wolf G, Bohlender J, Bondeva T, Roger T, Thaiss F and Wenzel UO: Angiotensin II upregulates toll-like receptor 4 on mesangial cells. J Am Soc Nephrol. 17:1585–1593. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J and Gokce N: Inducible toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring). 16:932–937. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Hayden MS and Ghosh S: NF-κB, the first quarter-century: Remarkable progress and outstanding questions. Genes Dev. 26:203–234. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Vallabhapurapu S and Karin M: Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27:693–733. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Karin M and Greten FR: NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Li Q and Verma IM: NF-kappaB regulation in the immune system. Nat Rev Immunol. 2:725–734. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Ghosh S, May MJ and Kopp EB: NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 16:225–260. 1998. View Article : Google Scholar : PubMed/NCBI

57 

Caamaño J and Hunter CA: NF-kappaB family of transcription factors: Central regulators of innate and adaptive immune functions. Clin Microbiol Rev. 15:414–429. 2002. View Article : Google Scholar : PubMed/NCBI

58 

May MJ and Ghosh S: Signal transduction through NF-kappa B. Immunol Today. 19:80–88. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Oka S, Kamata H, Kamata K, Yagisawa H and Hirata H: N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases. FEBS Lett. 472:196–202. 2000. View Article : Google Scholar : PubMed/NCBI

60 

Gupta SC, Sundaram C, Reuter S and Aggarwal BB: Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 1799:775–787. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Strickson S, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N and Cohen P: The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 451:427–437. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Ghashghaeinia M, Toulany M, Saki M, Bobbala D, Fehrenbacher B, Rupec R, Rodemann HP, Ghoreschi K, Röcken M, Schaller M, et al: The NFĸB pathway inhibitors bay 11-7082 and parthenolide induce programmed cell death in anucleated erythrocytes. Cell Physiol Biochem. 27:45–54. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Zhao C, Wang Y, Yuan X, Sun G, Shen B, Xu F, Fan G, Jin M, Li X and Liu G: Berberine inhibits lipopolysaccharide-induced expression of inflammatory cytokines by suppressing TLR4-mediated NF-ĸB and MAPK signaling pathways in rumen epithelial cells of Holstein calves. J Dairy Res. 86:171–176. 2019. View Article : Google Scholar : PubMed/NCBI

64 

Zhang H, Shan Y, Wu Y, Xu C, Yu X, Zhao J, Yan J and Shang W: Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells. Int Immunopharmacol. 52:93–100. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Gao MY, Chen L, Yang L, Yu X, Kou JP and Yu BY: Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells. Pharmacol Rep. 66:480–484. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Wang X, Feng S, Ding N, He Y, Li C, Li M, Ding X, Ding H, Li J, Wu J and Li Y: Anti-inflammatory effects of berberine hydrochloride in an LPS-induced murine model of mastitis. Evid Based Complement Alternat Med. 2018:51643142018.PubMed/NCBI

67 

Lee IA, Hyun YJ and Kim DH: Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation. Eur J Pharmacol. 648:162–170. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim DG, Choi JW, Jo IJ, Kim MJ, Lee HS, Hong SH, Song HJ, Bae GS and Park SJ: Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Mol Med Rep 21: 258-266, 2020.
APA
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S. ... Park, S. (2020). Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Molecular Medicine Reports, 21, 258-266. https://doi.org/10.3892/mmr.2019.10823
MLA
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S., Song, H., Bae, G., Park, S."Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway". Molecular Medicine Reports 21.1 (2020): 258-266.
Chicago
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S., Song, H., Bae, G., Park, S."Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway". Molecular Medicine Reports 21, no. 1 (2020): 258-266. https://doi.org/10.3892/mmr.2019.10823
Copy and paste a formatted citation
x
Spandidos Publications style
Kim DG, Choi JW, Jo IJ, Kim MJ, Lee HS, Hong SH, Song HJ, Bae GS and Park SJ: Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Mol Med Rep 21: 258-266, 2020.
APA
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S. ... Park, S. (2020). Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Molecular Medicine Reports, 21, 258-266. https://doi.org/10.3892/mmr.2019.10823
MLA
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S., Song, H., Bae, G., Park, S."Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway". Molecular Medicine Reports 21.1 (2020): 258-266.
Chicago
Kim, D., Choi, J., Jo, I., Kim, M., Lee, H., Hong, S., Song, H., Bae, G., Park, S."Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway". Molecular Medicine Reports 21, no. 1 (2020): 258-266. https://doi.org/10.3892/mmr.2019.10823
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team