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Article

Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression

  • Authors:
    • Hwan Lee
    • Wonmin Ko
    • Anisuzzaman Chowdhury
    • Bin Li
    • Sam Cheol Kim
    • Hyuncheol Oh
    • Youn‑Chul Kim
    • Eun‑Rhan Woo
    • Nam‑In Baek
    • Dong‑Sung Lee
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Chosun University, Dong‑gu, Gwangju 61452, Republic of Korea, Department of Pharmacy, Qingdao University of Science and Technology, Qingdao, Shandong 266042, P.R. China, Department of Family Practice and Community Medicine, Chosun University College of Medicine, Dong‑gu, Gwangju 61452, Republic of Korea, College of Pharmacy, Wonkwang University, Iksan, Jeollabuk-do 54538, Republic of Korea, Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung‑Hee University, Yongin, Gyeonggi-do 17104, Republic of Korea
  • Pages: 493-500
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/mmr.2019.10824
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Abstract

Brain cell damage that results from oxidative toxicity contributes to neuronal degeneration. The transcription factor nuclear factor‑E2‑related factor 2 (Nrf2) regulates the expression of heme oxygenase (HO)‑1 and glutathione (GSH), and serves a key role in the pathogenesis of neurological diseases. Brassica rapa is a turnip that is unique to Ganghwa County, and is used mainly for making kimchi, a traditional Korean food. In the current study, brassicaphenanthrene A (BrPA) from B. rapa was demonstrated to exhibit protective effects against neurotoxicity induced by glutamate via Nrf2‑mediated HO‑1 expression. Similarly, BrPA increased the expression of cellular glutathione and glutamine‑cysteine ligase genes. Furthermore, BrPA caused the nuclear translocation of Nrf2 and increased antioxidant response element (ARE) promoter activity. Nrf2 also mediated HO‑1 induction by BrPA through the PI3K/Akt and JNK regulatory pathways. The results of the present study indicated the neuroprotective effect of BrPA, a natural food component from B. rapa.
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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Ko W, Chowdhury A, Li B, Kim SC, Oh H, Kim YC, Woo ER, Baek NI, Lee DS, Lee DS, et al: Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression. Mol Med Rep 21: 493-500, 2020.
APA
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S.C., Oh, H. ... Lee, D. (2020). Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression. Molecular Medicine Reports, 21, 493-500. https://doi.org/10.3892/mmr.2019.10824
MLA
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S. C., Oh, H., Kim, Y., Woo, E., Baek, N., Lee, D."Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression". Molecular Medicine Reports 21.1 (2020): 493-500.
Chicago
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S. C., Oh, H., Kim, Y., Woo, E., Baek, N., Lee, D."Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression". Molecular Medicine Reports 21, no. 1 (2020): 493-500. https://doi.org/10.3892/mmr.2019.10824
Copy and paste a formatted citation
x
Spandidos Publications style
Lee H, Ko W, Chowdhury A, Li B, Kim SC, Oh H, Kim YC, Woo ER, Baek NI, Lee DS, Lee DS, et al: Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression. Mol Med Rep 21: 493-500, 2020.
APA
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S.C., Oh, H. ... Lee, D. (2020). Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression. Molecular Medicine Reports, 21, 493-500. https://doi.org/10.3892/mmr.2019.10824
MLA
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S. C., Oh, H., Kim, Y., Woo, E., Baek, N., Lee, D."Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression". Molecular Medicine Reports 21.1 (2020): 493-500.
Chicago
Lee, H., Ko, W., Chowdhury, A., Li, B., Kim, S. C., Oh, H., Kim, Y., Woo, E., Baek, N., Lee, D."Brassicaphenanthrene A from Brassica rapa protects HT22 neuronal cells through the regulation of Nrf2‑mediated heme oxygenase‑1 expression". Molecular Medicine Reports 21, no. 1 (2020): 493-500. https://doi.org/10.3892/mmr.2019.10824
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