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Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1

Corrigendum in: /10.3892/mmr.2020.11008
  • Authors:
    • Min Lu
    • Tao Yi
    • Yong Xiong
    • Qian Wang
    • Nina Yin
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Department of Pathogen Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Department of Anatomy, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 320-328
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    Published online on: November 21, 2019
       https://doi.org/10.3892/mmr.2019.10839
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Abstract

Cortex Mori Radicis extract (CMR) has various pharmacological properties, such as anti‑inflammatory, anti‑allergic and anti‑hyperglycemic effects. However, the effects and mechanisms of CMR in the neuroregeneration of diabetic peripheral neuropathy (DPN) are unclear. In the present study, the effects of CMR on neurite outgrowth of dorsal root ganglia (DRG) neurons in diabetic rats were investigated and its underlying mechanisms were explored. SD rats were subjected to a high‑fat diet with low‑dose streptozotocin to induce a Type II diabetes model with peripheral neuropathy. CMR was then applied for four weeks continuously with or without injection of small interfere (si)RNA targeting the transient receptor potential canonical channel 1 (TRPC1) via the tail vein. Blood glucose levels, the number of Nissl bodies, neurite outgrowth and growth cone turning in DRG neurons were evaluated. The expression of TRPC1 protein, Ca2+ influx and activation of the PI3K/AKT signaling pathway were also investigated. The results of the present study showed that CMR significantly lowered blood glucose levels, reversed the loss of Nissl bodies, induced neurite outgrowth and restored the response of the growth cone of DRG neurons in diabetic rats. CMR exerted neurite outgrowth‑promoting effects by increasing TRPC1 expression, reducing Ca2+ influx and enhancing AKT phosphorylation. siRNA targeting TRPC1 in the CMR group abrogated its anti‑diabetic and neuroregenerative effects, suggesting the involvement of TRPC1 in the biological effects of CMR on DPN.
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View References

1 

Xiang Y, Zhou Z, Deng C and Leslie RD: Latent autoimmune diabetes in adults in Asians: Similarities and differences between east and west. J Diabetes. 5:118–126. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Becker M, Benromano T, Shahar A, Nevo Z and Pick CG: Changes in the basal membrane of dorsal root ganglia schwann cells explain the biphasic pattern of the peripheral neuropathy in streptozotocin-induced diabetic rats. J Mol Neurosci. 54:704–713. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Xu Q, Pan J, Yu J, Liu X, Liu L, Zuo X, Wu P, Deng H, Zhang J and Ji A: Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract. 101:99–105. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Gordois A, Scuffham P, Shearer A, Oglesby A and Tobian JA: The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care. 26:1790–1795. 2003. View Article : Google Scholar : PubMed/NCBI

5 

WEI ZX: Experiences in treating diabetic peripheral neuropathy with traditional Chinese medicine. Chin J Integr Med. 14:248–250. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Choi HJ, Kim NJ and Kim DH: Inhibitory effects of crude drugs on alpha-glucosidase. Arch Pharm Res. 23:261–266. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Chen F, Nakashima N, Kimura I and Kimura M: Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Yakugaku Zasshi. 115:476–482. 1995.(In Japanese). View Article : Google Scholar : PubMed/NCBI

8 

Lian J, Chen J, Yuan Y, Chen J, Daud M, Sayed M, Luo L, Zhu Y, Li S and Bu S: Cortex mori radicis extract attenuates myocardial damages in diabetic rats by regulating ERS. Biomed Pharmacother. 90:777–785. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Yin N, Hong X, Han Y, Duan Y, Zhang Y and Chen Z: Cortex mori radicis extract induces neurite outgrowth in PC12 cells activating ERK signaling pathway via inhibiting Ca(2+) influx. Int J Clin Exp Med. 8:5022–5032. 2015.PubMed/NCBI

10 

Hwang SH, Kang IJ and Lim SS: Antidiabetic effect of fresh nopal (opuntia ficus-indica) in low-dose streptozotocin-induced diabetic rats fed a high-fat diet. Evid Based Complement Alternat Med. 2017:43807212017. View Article : Google Scholar : PubMed/NCBI

11 

Lee MS, Park WS, Kim YH, Kwon SH, Jang YJ, Han D, Morita K and Her S: Antidepressant-like effects of Cortex Mori Radicis extract via bidirectional phosphorylation of glucocorticoid receptors in the hippocampus. Behav Brain Res. 236:56–61. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Yue HY, Yin C, Hou JL, Zeng X, Chen YX, Zhong W, Hu PF, Deng X, Tan YX, Zhang JP, et al: Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats. Gut. 59:236–246. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH and Ayala A: In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood. 106:2295–2301. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Taiana MM, Lombardi R, Porretta-Serapiglia C, Ciusani E, Oggioni N, Sassone J, Bianchi R and Lauria G: Neutralization of schwann cell-secreted VEGF is protective to in vitro and in vivo experimental diabetic neuropathy. PLoS One. 9:e1084032014. View Article : Google Scholar : PubMed/NCBI

15 

Gao F, Xiang HC, Li HP, Jia M, Pan XL, Pan HL and Li M: Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain. Brain Behav Immun. 67:91–100. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Gasperini R, Choi-Lundberg D, Thompson MJ, Mitchell CB and Foa L: Homer regulates calcium signaling in growth cone turning. Neural Dev. 4:292009. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Coppey LJ, Shevalye H, Obrosov A, Davidson EP and Yorek MA: Determination of peripheral neuropathy in high-fat fed low-dose streptozotocin treated female C57BI/6J mice and Sprague-Dawley rats. J Diabetes Investig. 9:1033–1040. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Schmidt RE, Parvin CA and Green KG: Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice. J Neuropathol Exp Neurol. 67:1166–1186. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Yang X, Yao W, Liu H, Gao Y, Liu R and Xu L: Tangluoning, a traditional Chinese medicine, attenuates in vivo and in vitro diabetic peripheral neuropathy through modulation of PERK/Nrf2 pathway. Sci Rep. 7:10142017. View Article : Google Scholar : PubMed/NCBI

21 

Kang TH, Moon E, Hong BN, Choi SZ, Son M, Park JH and Kim SY: Diosgenin from Dioscorea nipponica ameliorates diabetic neuropathy by inducing nerve growth factor. Biol Pharm Bull. 34:1493–1498. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Kim HJ, Lee HJ, Jeong SJ, Lee HJ, Kim SH and Park EJ: Cortex mori radicis extract exerts antiasthmatic effects via enhancement of CD4(+)CD25(+)Foxp3(+) regulatory T cells and inhibition of Th2 cytokines in a mouse asthma model. J Ethnopharmacol. 138:40–46. 2011. View Article : Google Scholar : PubMed/NCBI

23 

You S and Kim GH: Protective effect of Mori Cortex radicis extract against high glucose-induced oxidative stress in PC12 cells. Biosci Biotechnol Biochem. 83:1893–1900. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Chen Z, Ye R, He Y, Li Y and Qiu X: Protective effect of jiaweibugan decoction against diabetic peripheral neuropathy. Neural Regen Res. 8:1113–1121. 2013.PubMed/NCBI

25 

Kim KJ, Namgung U and Cho CS: Protective effects of bogijetong decoction and its selected formula on neuropathic insults in streptozotocin-induced diabetic animals. Evid Based Complement Alternat Med. 2017:42963182017. View Article : Google Scholar : PubMed/NCBI

26 

Sarina, Yagi Y, Nakano O, Hashimoto T, Kimura K, Asakawa Y, Zhong M, Narimatsu S and Gohda E: Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways. Brain Res. 1490:61–71. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang D, Chan JD, Nogi T and Marchant JS: Opposing roles of voltage-gated Ca2+ channels in neuronal control of regenerative patterning. J Neurosci. 31:15983–15995. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Balasubramanyam M, Balaji RA, Subashini B and Mohan V: Evidence for mechanistic alterations of Ca2+ homeostasis in type 2 diabetes mellitus. Int J Exp Diabetes Res. 1:275–287. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Verkhratsky A and Fernyhough P: Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes. Cell Calcium. 44:112–122. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Cao XH, Byun HS, Chen SR and Pan HL: Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. J Neurochem. 119:594–603. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Chandramoorthy HC, Bin-Jaliah I, Karari H, Rajagopalan P, Ahmed Shariff ME, Al-Hakami A, Al-Humayad SM, Baptain FA, Ahmed HS, Yassin HZ and Haidara MA: MSCs ameliorates DPN induced cellular pathology via [Ca2+]i homeostasis and scavenging the pro-inflammatory cytokines. J Cell Physiol. 233:1330–1341. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Louhivuori LM: Calcium a key player in early neural development and migration: TRPCs and VGCCs. Argumentation. 1:201–207. 2015.

33 

Li M, Chen C, Zhou Z, Xu S and Yu Z: A TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells. Cell Calcium. 51:486–496. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kruglikov I, Gryshchenko O, Shutov L, Kostyuk E, Kostyuk P and Voitenko N: Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons. Pflugers Arch. 448:395–401. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P and Lieberman J: RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 9:347–351. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Vigont V, Kolobkova Y, Skopin A, Zimina O, Zenin V, Glushankova L and Kaznacheyeva E: Both Orai1 and TRPC1 are involved in excessive store-operated calcium entry in striatal neurons expressing mutant huntingtin Exon 1. Front Physiol. 6:3372015. View Article : Google Scholar : PubMed/NCBI

37 

Chen HC, Wang CH, Shih CP, Chueh SH, Liu SF, Chen HK and Lin YC: TRPC1 is required for survival and proliferation of cochlear spiral ganglion stem/progenitor cells. Int J Pediatr Otorhinolaryngol. 79:2290–2294. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL and Worley PF: Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. Neuron. 64:471–483. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Heo DK, Chung WY, Park HW, Yuan JP, Min GL and Kim JY: Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells. Cell Signal. 24:899–906. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Zhang D, Freedman BI, Flekac M, Santos E, Hicks PJ, Bowden DW, Efendic S, Brismar K and Gu HF: Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. Am J Nephrol. 29:244–251. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich JN, Singh BB and Claycombe-Larson KJ: The TRPC1 Ca2+-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes. J Biol Chem. 292:20799–20807. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Yu JS and Cui W: Proliferation, survival and metabolism: The role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development. 17:3050–3060. 2016. View Article : Google Scholar

43 

Li R, Li Y, Wu Y, Zhao Y, Chen H, Yuan Y, Xu K, Zhang H, Lu Y, Wang J, et al: Heparin-poloxamer thermosensitive hydrogel loaded with bFGF and NGF enhances peripheral nerve regeneration in diabetic rats. Biomaterials. 168:24–37. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Chen L, Gong HY and Xu L: PVT1 protects diabetic peripheral neuropathy via PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 22:6905–6911. 2018.PubMed/NCBI

45 

Zhang YP, Liu SY, Sun QY, Ren J, Liu HX and Li H: Proanthocyanidin B2 attenuates high-glucose-induced neurotoxicity of dorsal root ganglion neurons through the PI3K/Akt signaling pathway. Neural Regen Res. 13:1628–1636. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu M, Yi T, Xiong Y, Wang Q and Yin N: Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008. Mol Med Rep 21: 320-328, 2020.
APA
Lu, M., Yi, T., Xiong, Y., Wang, Q., & Yin, N. (2020). Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008. Molecular Medicine Reports, 21, 320-328. https://doi.org/10.3892/mmr.2019.10839
MLA
Lu, M., Yi, T., Xiong, Y., Wang, Q., Yin, N."Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008". Molecular Medicine Reports 21.1 (2020): 320-328.
Chicago
Lu, M., Yi, T., Xiong, Y., Wang, Q., Yin, N."Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008". Molecular Medicine Reports 21, no. 1 (2020): 320-328. https://doi.org/10.3892/mmr.2019.10839
Copy and paste a formatted citation
x
Spandidos Publications style
Lu M, Yi T, Xiong Y, Wang Q and Yin N: Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008. Mol Med Rep 21: 320-328, 2020.
APA
Lu, M., Yi, T., Xiong, Y., Wang, Q., & Yin, N. (2020). Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008. Molecular Medicine Reports, 21, 320-328. https://doi.org/10.3892/mmr.2019.10839
MLA
Lu, M., Yi, T., Xiong, Y., Wang, Q., Yin, N."Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008". Molecular Medicine Reports 21.1 (2020): 320-328.
Chicago
Lu, M., Yi, T., Xiong, Y., Wang, Q., Yin, N."Cortex Mori Radicis extract promotes neurite outgrowth in diabetic rats by activating PI3K/AKT signaling and inhibiting Ca2+ influx associated with the upregulation of transient receptor potential canonical channel 1 Corrigendum in /10.3892/mmr.2020.11008". Molecular Medicine Reports 21, no. 1 (2020): 320-328. https://doi.org/10.3892/mmr.2019.10839
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