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The potential roles of circular RNAs in osteonecrosis of the femoral head (Review)

  • Authors:
    • Jun Zhao
    • Long Mu
    • Zhengchun Wang
    • Xiangchun Fang
    • Xuefeng He
    • Xiaofeng Zhang
    • Xilin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Orthopaedics, Harbin Fifth Hospital, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 533-539
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    Published online on: December 6, 2019
       https://doi.org/10.3892/mmr.2019.10866
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Abstract

Circular RNAs (circRNAs) are categorized as non‑coding RNAs that, unlike widely known canonical linear RNAs, form a covalently closed continuous loop without 5' or 3' polarities, which enables them to resist digestion by RNA exonucleases. Although the functions of circRNAs remain largely unknown, accumulated evidence has demonstrated that circRNAs can act as microRNA sponges, which allows them to regulate numerous biological processes and disease mechanisms, including apoptosis, angiogenesis, invasion, metastasis and stem cell differentiation. Although research into circRNAs is in its infancy, studies have identified critical roles for circRNAs in the initiation and progression of disease. The present study delineated the characteristics and functions of circRNAs, and focused on the potential relationship between circRNAs and osteonecrosis of the femoral head (ONFH). CircRNAs represent a novel avenue for studying the mechanisms underlying ONFH as well as possible treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Mu L, Wang Z, Fang X, He X, Zhang X and Xu X: The potential roles of circular RNAs in osteonecrosis of the femoral head (Review). Mol Med Rep 21: 533-539, 2020.
APA
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., & Xu, X. (2020). The potential roles of circular RNAs in osteonecrosis of the femoral head (Review). Molecular Medicine Reports, 21, 533-539. https://doi.org/10.3892/mmr.2019.10866
MLA
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., Xu, X."The potential roles of circular RNAs in osteonecrosis of the femoral head (Review)". Molecular Medicine Reports 21.2 (2020): 533-539.
Chicago
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., Xu, X."The potential roles of circular RNAs in osteonecrosis of the femoral head (Review)". Molecular Medicine Reports 21, no. 2 (2020): 533-539. https://doi.org/10.3892/mmr.2019.10866
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Mu L, Wang Z, Fang X, He X, Zhang X and Xu X: The potential roles of circular RNAs in osteonecrosis of the femoral head (Review). Mol Med Rep 21: 533-539, 2020.
APA
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., & Xu, X. (2020). The potential roles of circular RNAs in osteonecrosis of the femoral head (Review). Molecular Medicine Reports, 21, 533-539. https://doi.org/10.3892/mmr.2019.10866
MLA
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., Xu, X."The potential roles of circular RNAs in osteonecrosis of the femoral head (Review)". Molecular Medicine Reports 21.2 (2020): 533-539.
Chicago
Zhao, J., Mu, L., Wang, Z., Fang, X., He, X., Zhang, X., Xu, X."The potential roles of circular RNAs in osteonecrosis of the femoral head (Review)". Molecular Medicine Reports 21, no. 2 (2020): 533-539. https://doi.org/10.3892/mmr.2019.10866
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