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Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors

  • Authors:
    • Yuehua Shi
    • Jie Qian
    • Feng Zhang
    • Beibei Jia
    • Xiaoyan Liu
    • Yan Hu
    • Qinfen Zhang
    • Ye Yang
    • Dongdong Sun
    • Li Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Pediatrics, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Maternal and Child Health Care Center, Nanjing, Jiangsu 211100, P.R. China, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumors, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Pediatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 623-630
    |
    Published online on: December 6, 2019
       https://doi.org/10.3892/mmr.2019.10868
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Abstract

Placental structural abnormalities and dysfunction in those with gestational diabetes mellitus (GDM) can lead to increased placental permeability, which is in turn related to a poorer maternal and fetal prognosis. The present study sought to assess whether increased placental permeability in rats with GDM was accompanied by alterations in tight junction (TJ) factors and to evaluate the impact of low molecular weight heparin (LMWH) on these factors. The present study was conducted using pregnant female rats that were randomized into control, GDM and GDM + LMWH groups. Diabetes was induced via intraperitoneal administration of streptozotocin to rats in the GDM and GDM + LMWH groups, whereas rats in the GDM + LMWH group received daily subcutaneous LMWH starting on day 5 of pregnancy. On gestational day 16, all rats were sacrificed and Evans Blue (EB) assay was used to gauge vascular permeability based on EB dye leakage. Transmission electron microscopy was further used to assess TJ structures, and the TJ proteins zonular occludens‑1 (ZO‑1) and occludin (OCLN) were assessed using immunohistochemistry and western blotting. Blood samples were obtained from the abdominal aorta for ELISA measurements of advanced glycation end products (AGEs) concentrations, and placental receptor for AGEs (RAGE) and vascular endothelial growth factor (VEGF) expression was assessed using reverse transcription‑quantitative PCR. In addition, western blotting was used to measure placental NF‑κB. Compared with in the control group, EB leakage was markedly increased in GDM group rats; this was associated with reduced ZO‑1 and OCLN expression. Conversely, LMWH attenuated this increase in placental permeability in rats with GDM and also mediated a partial recovery of ZO‑1 and OCLN expression. Blood glucose and serum AGEs concentrations did not differ between the GDM and GDM + LMWH groups. Furthermore, LMWH treatment resulted in decreases in RAGE and VEGF mRNA expression levels, which were upregulated in the GDM group, whereas it had the opposite effect on the expression of NF‑κB. In conclusion, GDM was associated with increased placental permeability and this may be linked with changes in TJs. LMWH intervention mediated protection against this GDM‑associated shift in placental permeability via the RAGE/NF‑κB pathway.
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View References

1 

American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care. 37 (Suppl 1):S81–S90. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Jarmuzek P, Wielgos M and Bomba-Opon D: Placental pathologic changes in gestational diabetes mellitus. Neuro Endocrinol Lett. 36:101–105. 2015.PubMed/NCBI

3 

Aires MB and Dos Santos AC: Effects of maternal diabetes on trophoblast cells. World J Diabetes. 6:338–344. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sibley CP, Brownbill P, Glazier JD and Greenwood SL: Knowledge needed about the exchange physiology of the placenta. Placenta. 64 (Suppl 1):S9–S15. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Leach L, Lammiman MJ, Babawale MO, Hobson SA, Bromilou B, Lovat S and Simmonds MJ: Molecular organization of tight and adherens junctions in the human placental vascular tree. Placenta. 21:547–557. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Leach L, Taylor A and Sciota F: Vascular dysfunction in the diabetic placenta: Causes and consequences. J Anat. 215:69–76. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Sobrevia L, Salsoso R, Fuenzalida B, Barros E, Toledo L, Silva L, Pizarro C, Subiabre M, Villalobos R, Araos J, et al: Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus. Front Physiol. 7:1192016. View Article : Google Scholar : PubMed/NCBI

8 

Subiabre M, Silva L, Toledo F, Paublo M, López MA, Boric MP and Sobrevia L: Insulin therapy and its consequences for the mother, foetus, and newborn in gestational diabetes mellitus. Biochim Biophys Acta Mol Basis Dis. 1864:2949–2956. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Baumuller S, Lehnen H, Schmitz J, Fimmers R and Müller AM: The impact of insulin treatment on the expression of vascular endothelial cadherin and beta-catenin in human fetoplacental vessels. Pediatr Dev Pathol. 18:17–23. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Bartakova V, Kollarova R, Kuricova K, Sebekova K, Belobradkova J and Kankova K: Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 160:70–75. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Harsem NK, Braekke K, Torjussen T, Hanssen K and Staff AC: Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia. Hypertens Pregnancy. 27:374–386. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Guosheng L, Hongmei S, Chuan N, Haiying L, Xiaopeng Z and Xianqiong L: The relationship of serum AGE levels in diabetic mothers with adverse fetal outcome. J Perinatol. 29:483–488. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Stitt AW, Bhaduri T, McMullen CB, Gardiner TA and Archer DB: Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats. Mol Cell Biol Res Commun. 3:380–388. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Guo XH, Huang QB, Chen B, Wang SY, Li Q, Zhu YJ, Hou FF, Fu N, Brunk UT and Zhao M: Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells. APMIS. 114:874–883. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Xie J, Mendez JD, Méndez-Valenzuela V and Aguilar-Hernández MM: Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal. 25:2185–2197. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Boulanger E, Grossin N, Wautier MP, Taamma R and Wautier JL: Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation. Kidney Int. 71:126–133. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Rodger MA, Gris JC, de Vries JIP, Martinelli I, Rey É, Schleussne E, Middeldorp S, Kaaja R, Langlois NJ, Ramsay T, et al: Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: A meta-analysis of individual patient data from randomised controlled trials. Lancet. 388:2629–2641. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Wat JM, Hawrylyshyn K, Baczyk D, Greig IR and Kingdom JC: Effects of glycol-split low molecular weight heparin on placental, endothelial, and anti-inflammatory pathways relevant to preeclampsia. Biol Reprod. 99:1082–1090. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Gasowska K, Naumnik B, Klejna K and Myśliwiec M: The influence of unfractionated and low-molecular weight heparins on the properties of human umbilical vein endothelial cells (HUVEC). Folia Histochem Cytobiol. 47:17–23. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kevane B, Egan K, Allen S, Maguire P, Neary E, Lennon Á and Ní Áinle FN: Endothelial barrier protective properties of low molecular weight heparin: A novel potential tool in the prevention of cancer metastasis. Res Pract Thromb Haemost. 1:23–32. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Radu M and Chernoff J: An in vivo assay to test blood vessel permeability. J Vis Exp. 73:e500622013.

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Meng Q, Shao L, Luo X, Mu Y, Xu W, Gao C, Gao L, Liu J and Cui Y: Ultrastructure of placenta of gravidas with gestational diabetes mellitus. Obstet Gynecol Int. 2015:2831242015. View Article : Google Scholar : PubMed/NCBI

24 

Hayward CE, Jones RL and Sibley CP: Mechanisms of transfer across the human placenta. Placenta Intrauterine Environment. 12:121–133. 2008.

25 

Babawale MO, Lovat S, Mayhew TM, Lammiman MJ, James DK and Leach L: Effects of gestational diabetes on junctional adhesion molecules in human term placental vasculature. Diabetologia. 43:1185–1196. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Y, Zhao HJ, Xia XR, Diao FY, Ma X, Wang J, Gao L, Liu J, Gao C, Cui YG and Liu JY: Hypoxia-induced and HIF1 a-VEGF-mediated tight junction dysfunction in choriocarcinoma cells: Implications for preeclampsia. Clin Chim Acta. 489:203–211. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Li S and Yang H: Relationship between advanced glycation end products and gestational diabetes mellitus. J Matern Fetal Neonatal Med. 32:2783–2789. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Holman RR, Paul SK, Bethel MA, Matthews DR and Neil HA: 10-year follow-up of intensive glucose control in type 2 diabetes. New Engl J Med. 359:1577–1589. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Antonetti DA, Lieth E, Barber AJ and Gardner TW: Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol. 14:240–248. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Singh R, Barden A, Mori T and Beilin L: Advanced glycation end-products: A review. Diabetologia. 44:129–146. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Chilelli NC, Burlina S and Lapolla A: AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: A ‘glycoxidation-centric’ point of view. Nutr Metab Cardiovasc Dis. 23:913–919. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Svensjö E, Cyrino F, Michoud E, Ruggiero D, Bouskela E and Wiernsperger N: Vascular permeability increase as induced by histamine or bradykinin is enhanced by advanced glycation endproducts (AGEs). J Diabetes Complications. 13:187–190. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Wan W, Chen H and Li Y: The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease. Int J Neurosci. 124:75–81. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Schmidt AM, Yan SD, Yan SF and Stern DM: The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta. 1498:99–111. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Kisseleva T, Song L, Vorontchikhina M, Feirt N, Kitajewski J and Schindler C: NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer. J Clin Invest. 116:2955–2963. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Vandenbroucke E, Mehta D, Minshall R and Malik AB: Regulation of endothelial junctional permeability. Ann N Y Acad Sci. 1123:134–145. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Leach L, Gray C, Staton S, Babawale MO, Gruchy A, Foster C, Mayhew TM and James DK: Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by Type 1 diabetes: Associations with angiogenesis and perturbed barrier function. Diabetologia. 47:695–709. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Obert E, Strauss R, Brandon C, Grek C, Ghatnekar G, Gourdie R and Rohrer B: Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, aCT1, reduces VEGF-dependent RPE pathophysiology. J Mol Med (Berl). 95:535–552. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Krishnasamy S, Ravi V, Rajaraman B, Kumar Thulasingam S, Dhevasena CS, Pathak A, Swaminathan K, Sundaresan M, Ayyappa KA, Arunkumar G, et al: Role of VEGF165b/VEGFTOTAL ratio in gestational diabetes mellitus. Gynecol Endocrinol. 35:811–814. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL and Mihu CM: Vascular endothelial growth factor (VEGF)-key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 59:455–467. 2018.PubMed/NCBI

41 

Yan Y, Ji Y, Su N, Mei X, Wang Y, Du S, Zhu W, Zhang C, Lu Y and Xing XH: Non-anticoagulant effects of low molecular weight heparins in inflammatory disorders: A review. Carbohydr Polym. 160:71–81. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Abdel-Salam OM, Baiuomy AR, Ameen A and Hassan NS: A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat. Pharmacol Res. 51:59–67. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Nagy Z, Turcsik V and Blaskó G: The effect of LMWH (Nadroparin) on tumor progression. Pathol Oncol Res. 15:689–692. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Yalniz M, Demirel U, Orhan C, Bahcecioglu IH, Ozercan IH, Aygun C, Tuzcu M and Sahin K: Nadroparin sodium activates Nrf2/HO-1 pathway in acetic acid-induced colitis in rats. Inflammation. 35:1213–1221. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Delézay O, Hé Z, Sabido O, Hodin S, Bin V, Saleem MA, Mismetti P and Delavenne X: Effects of heparin and derivatives on podocytes: An in vitro functional and morphological evaluation. J Cell Physiol. Jan 26–2019.doi: 10.1002/jcp.28191 (Epub ahead of print). View Article : Google Scholar

46 

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA and Linder A: Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp. 4:332016. View Article : Google Scholar : PubMed/NCBI

47 

Takeuchi A, Yamamoto Y, Munesue S, Harashima A, Watanabe T, Yonekura H, Yamamoto H and Tsuchiya H: Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells. Cancer Sci. 104:740–749. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shi Y, Qian J, Zhang F, Jia B, Liu X, Hu Y, Zhang Q, Yang Y, Sun D, Jiang L, Jiang L, et al: Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors. Mol Med Rep 21: 623-630, 2020.
APA
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y. ... Jiang, L. (2020). Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors. Molecular Medicine Reports, 21, 623-630. https://doi.org/10.3892/mmr.2019.10868
MLA
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y., Zhang, Q., Yang, Y., Sun, D., Jiang, L."Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors". Molecular Medicine Reports 21.2 (2020): 623-630.
Chicago
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y., Zhang, Q., Yang, Y., Sun, D., Jiang, L."Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors". Molecular Medicine Reports 21, no. 2 (2020): 623-630. https://doi.org/10.3892/mmr.2019.10868
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Y, Qian J, Zhang F, Jia B, Liu X, Hu Y, Zhang Q, Yang Y, Sun D, Jiang L, Jiang L, et al: Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors. Mol Med Rep 21: 623-630, 2020.
APA
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y. ... Jiang, L. (2020). Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors. Molecular Medicine Reports, 21, 623-630. https://doi.org/10.3892/mmr.2019.10868
MLA
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y., Zhang, Q., Yang, Y., Sun, D., Jiang, L."Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors". Molecular Medicine Reports 21.2 (2020): 623-630.
Chicago
Shi, Y., Qian, J., Zhang, F., Jia, B., Liu, X., Hu, Y., Zhang, Q., Yang, Y., Sun, D., Jiang, L."Low molecular weight heparin (nadroparin) improves placental permeability in rats with gestational diabetes mellitus via reduction of tight junction factors". Molecular Medicine Reports 21, no. 2 (2020): 623-630. https://doi.org/10.3892/mmr.2019.10868
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