Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

  • Authors:
    • Yan‑Yan Bai
    • Jun‑Zhi Niu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Hospital of Yulin, Yulin, Shaanxi 719000, P.R. China, Department of Information, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1145-1153
    |
    Published online on: December 23, 2019
       https://doi.org/10.3892/mmr.2019.10903
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological processes in cardiovascular diseases. However, its role in ICH remains largely unknown. The aim of the present study was to evaluate the potential effect of miR‑222 on brain injury in ICH. The results revealed that the expression of miR‑222 was significantly increased in ICH, and downregulation of miR‑222 significantly reduced erythrocyte lysate‑induced cell apoptosis by decreasing the levels of cleaved caspase‑3, cleaved caspase‑9 and Bax and increasing the level of Bcl‑2. In addition, downregulation of miR‑222 suppressed the inflammatory responses in erythrocyte lysate‑induced microglia, and inhibited inflammation, brain water content and improved neurological functions in ICH mice. Mechanistically, integrin subunit β8 (ITGB8) was identified as a direct target of negative regulation by miR‑222 in microglia cells, and up‑regulation of ITGB8 led to the attenuation of inflammation and apoptosis. Collectively, the present findings indicated that miR‑222 was a crucial regulator of inflammation via targeting of ITGB8, and represented a promising therapeutic strategy for ICH.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Wang MD, Wang Y, Xia YP, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, et al: High serum MiR-130a levels are associated with severe perihematomal edema and predict adverse outcome in acute ICH. Mol Neurobiol. 53:1310–1321. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Min H, Jang YH, Cho IH, Yu SW and Lee SJ: Alternatively activated braininfiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage. Mol Brain. 9:422016. View Article : Google Scholar : PubMed/NCBI

3 

Rodríguez JA, Sobrino T, López-Arias E, Ugarte A, Sánchez-Arias JA, Vieites-Prado A, de Miguel I, Oyarzabal J, Páramo JA, Campos F, et al: CM352 reduces brain damage and improves functional recovery in a rat model of intracerebral hemorrhage. J Am Heart Assoc. 6(pii): e0060422017.PubMed/NCBI

4 

Keep RF, Hua Y and Xi G: Intracerebral haemorrhage: Mechanisms of injury and therapeutic targets. Lancet Neurol. 11:720–731. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Sheth KN and Rosand J: Targeting the immune system in intracerebral hemorrhage. JAMA Neurol. 71:1083–1084. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wu H, Zhang Z, Li Y, Zhao R, Li H, Song Y, Qi J and Wang J: Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: Correlation with brain edema. Neurochem Int. 57:248–253. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Z, Zhang Z, Lu H, Yang Q, Wu H and Wang J: Microglial polarization and inflammatory mediators after intracerebral hemorrhage. Mol Neurobiol. 54:1874–1886. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhao X, Wu T, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J and Wang J: Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun. 46:293–310. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L, Han S, Yuan Q and Yang M: fMiRNA-192 and miRNA-204 directly suppress lncRNA HOTTIP and interrupt GLS1-Mediated glutaminolysis in hepatocellular carcinoma. PLoS Genet. 11:e10057262015. View Article : Google Scholar : PubMed/NCBI

10 

Martignani E, Miretti S, Accornero P and Baratta M: miRNAs highlights in stemand cancer cells. Mini Rev Med Chem. 11:1165–1182. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Veremeyko T, Siddiqui S, Sotnikov I, Yung A and Ponomarev ED: IL-4/IL-13-dependent and independent expression of miR-124 and itscontribution to M2 phenotype of monocytic cells in normal conditions andduring allergic inflammation. PLoS One. 8:e817742013. View Article : Google Scholar : PubMed/NCBI

12 

Moore CS, Rao VT, Durafourt BA, Bedell BJ, Ludwin SK, Bar-Or A and Antel JP: miR-155 as a multiple sclerosis-relevant regulator of myeloid cellpolarization. Ann Neurol. 74:709–720. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Xi T, Jin F, Zhu Y, Wang J, Tang L, Wang Y, Liebeskind DS and He Z: MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt. Biochem Biophys Res Commun. 494:144–151. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Yu A, Zhang T, Duan H, Pan Y, Zhang X, Yang G, Wang J, Deng Y and Yang Z: MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage. Immunol Lett. 182:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafre SA and Farace MG: miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem. 282:23716–23724. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Sun T, Wang X, He HH, Sweeney CJ, Liu SX, Brown M, Balk S, Lee GS and Kantoff PW: miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. Oncogene. 33:2790–2800. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Zhou Z, Zhou L, Jiang F, Zeng B, Wei C, Zhao W and Yu D: Downregulation of miR-222 induces apoptosis and cellular migration in adenoid cystic carcinoma cells. Oncol Res. 25:207–214. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Kinoshita K, Matsumoto K, Kurauchi Y, Hisatsune A, Seki T and Katsuki H: A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 330:48–54. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Chen D, Wu X, Zhao J and Zhao X: MicroRNA-634 functions as a tumor suppressor in pancreatic cancer via directly targeting heat shock-related 70-kDa protein 2. Exp Ther Med. 17:3949–3956. 2019.PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yu A, Duan H, Zhang T, Pan Y, Kou Z, Zhang X, Lu Y, Wang S and Yang Z: IL-17A promotes microglial activation and neuroinflammation in mousemodels of intracerebral haemorrhage. Mol Immunol. 73:151–157. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wasserman JK, Zhu X and Schlichter LC: Evolution of the inflammatoryresponse in the brain following intracerebral hemorrhage and effects of delayedminocycline treatment. Brain Res. 1180:140–154. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Xie WJ, Yu HQ, Zhang Y, Liu Q and Meng HM: CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage. Neural Regen Res. 11:1122–1127. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Corsten MF, Heggermont W, Papageorgiou AP, Deckx S, Tijsma A, Verhesen W, van Leeuwen R, Carai P, Thibaut HJ, Custers K, et al: The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis. Eur Heart J. 36:2909–2919. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ribeiro-Rodrigues TM, Laundos TL, Pereira-Carvalho R, Batista-Almeida D, Pereira R, Coelho-Santos V, Silva AP, Fernandes R, Zuzarte M, Enguita FJ, et al: Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovasc Res. 1113:1338–1350. 2017. View Article : Google Scholar

26 

Zhao X, Sun G, Ting SM, Song S, Zhang J, Edwards NJ and Aronowski J: Cleaning up after ICH: The role of Nrf2 in modulating microglia function and hematoma clearance. J Neurochem. 133:144–152. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Yang Z, Zhao T, Zou Y, Zhang JH and Feng H: Curcumin inhibits microglia inflammation and confers neuroprotection in intracerebral hemorrhage. Immunol Lett. 160:89–95. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Qureshi AI, Suri MF, Ostrow PT, Kim SH, Ali Z, Shatla AA, Guterman LR and Hopkins LN: Apoptosis as a form of cell death in intracerebral hemorrhage. Neurosurgery. 52:1041–1047. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Beufler B: Innate immunity: An overview. Mol Immunol. 40:845–859. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Gebel JM, Brott TG, Sila CA, Tomsick TA, Jauch E, Salisbury S, Khoury J, Miller R, Pancioli A, Duldner JE, et al: Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intrscerebral hemorrhage. Stroke. 31:596–600. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Xi G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM, Broderick JP, Brott TG and Hoff JT: Role of blood clot formation on early edema development after experimental intracerbral hemorrhage. Stroke. 29:2580–2586. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Wei P, You C, Jin H, Chen H and Lin B: Correlation between serum IL-1beta levels and cerebral edema extent in a hypertensive intracerebral hemorrhage rat model. Neurol Res. 36:170–175. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Hu YL, Wang H, Huang Q, Wang G and Zhang HB: MicroRNA-23a-3p promotes the perihematomal edema formation after intracerebral hemorrhagevia ZO-1. Eur Rev Med Pharmacol Sci. 22:2809–2816. 2018.PubMed/NCBI

34 

Kumar V, Soni UK, Maurya VK, Singh K and Jha RK: Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation. Sci Rep. 7:18852017. View Article : Google Scholar : PubMed/NCBI

35 

Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N and Nishimura SL: Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: An angiogenic control switch. Am J Pathol. 166:1883–1894. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL and Su H: Integrin β8 deletion enhances vascular dysplasia and hemorrhage in thebrain of adult alk1 heterozygous mice. Transl Stroke Res. 7:488–496. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bai YY and Niu JZ: miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. Mol Med Rep 21: 1145-1153, 2020.
APA
Bai, Y., & Niu, J. (2020). miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. Molecular Medicine Reports, 21, 1145-1153. https://doi.org/10.3892/mmr.2019.10903
MLA
Bai, Y., Niu, J."miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8". Molecular Medicine Reports 21.3 (2020): 1145-1153.
Chicago
Bai, Y., Niu, J."miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8". Molecular Medicine Reports 21, no. 3 (2020): 1145-1153. https://doi.org/10.3892/mmr.2019.10903
Copy and paste a formatted citation
x
Spandidos Publications style
Bai YY and Niu JZ: miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. Mol Med Rep 21: 1145-1153, 2020.
APA
Bai, Y., & Niu, J. (2020). miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. Molecular Medicine Reports, 21, 1145-1153. https://doi.org/10.3892/mmr.2019.10903
MLA
Bai, Y., Niu, J."miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8". Molecular Medicine Reports 21.3 (2020): 1145-1153.
Chicago
Bai, Y., Niu, J."miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8". Molecular Medicine Reports 21, no. 3 (2020): 1145-1153. https://doi.org/10.3892/mmr.2019.10903
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team