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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-2020 Volume 21 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory effect of chemerin and therapeutic efficacy of chemerin‑9 in pancreatogenic diabetes mellitus

Jianfeng Tu, Yue Yang, Jingzhu Zhang, Guotao Lu, Lu Ke, Zhihui Tong, Maimaitijiang Kasimu, Dejun Hu, Qiuran Xu, Weiqin Li
Pages: 981-988
Published online on: 08 January 2020

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Article Open Access

Low‑intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS‑miR‑21‑PTEN axis

Chunhua Xia, Huabei Zeng, Yanfen Zheng
Pages: 989-998
Published online on: 13 January 2020

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Article Open Access

Construction of a prognosis‑associated long noncoding RNA‑mRNA network for multiple myeloma based on microarray and bioinformatics analysis

Fang‑Xiao Zhu, Xiao‑Tao Wang, Zhi‑Zhong Ye, Zhao‑Ping Gan, Yong‑Rong Lai
Pages: 999-1010
Published online on: 13 January 2020

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Article Open Access

miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling

Jing Xi, Qiang‑Qiang Li, Bing‑Qiang Li, Ning Li
Pages: 1011-1020
Published online on: 09 January 2020

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Article Open Access

General mechanism of JQ1 in inhibiting various types of cancer

Guojuan Jiang, Wanglong Deng, Yang Liu, Chengde Wang
Pages: 1021-1034
Published online on: 10 January 2020

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Article Open Access

Isoferulic acid inhibits human leukemia cell growth through induction of G2/M‑phase arrest and inhibition of Akt/mTOR signaling

Zhiguo Long, Guangjia Feng, Na Zhao, Lei Wu, Hongbo Zhu
Pages: 1035-1042
Published online on: 09 January 2020

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Article Open Access

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection

Xin Yang, Han‑Mei Wei, Guo‑Yan Hu, Jun Zhao, Li‑Na Long, Chang‑Jian Li, Zi‑Jun Zhao, He‑Kun Zeng, Hong Nie
Pages: 1043-1050
Published online on: 09 January 2020

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Article Open Access

Overexpression of long noncoding RNA CUDR promotes hepatic differentiation of human umbilical cord mesenchymal stem cells

Yabin Yu, Meng Li, Yan Song, Jianbo Xu, Fuzhen Qi
Pages: 1051-1058
Published online on: 19 December 2019

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Article Open Access

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yin Yao
Pages: 1059-1070
Published online on: 13 January 2020

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Article Open Access

Study of minimally invasive radiofrequency ablation of the ciliary body for the treatment of glaucoma in rabbits

Baoke Hou, Fengxiang Wang, Zi Ye, Xin Jin, Yu Fu, Zhaohui Li
Pages: 1071-1076
Published online on: 31 December 2019

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Article Open Access

Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway

Miao Zhang, Zhiqiang Wang, Baojie Li, Fengyi Sun, Anzhong Chen, Mingzhi Gong
Pages: 1077-1088
Published online on: 14 January 2020

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Article Open Access

Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration

Yan Zhu, Zhiquan Qiu, Yiliang Zhang, Bin Li, Xiaoqing Jiang
Pages: 1089-1096
Published online on: 27 December 2019

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Article Open Access

The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway

Tu Wang, Xiaoxu Sun, Haipeng Cui, Kai Liu, Juan Zhao
Pages: 1097-1106
Published online on: 13 January 2020

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Article Open Access

Phellinus gilvus‑derived protocatechualdehyde induces G0/G1 phase arrest and apoptosis in murine B16‑F10 cells

Shi Zhong, Qinshen Jin, Taihen Yu, Jianxun Zhu, Yougui Li
Pages: 1107-1114
Published online on: 19 December 2019

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Article Open Access

Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening

Chunrong Tang, Daoyuan Zhou, Rongshao Tan, Xiaoshi Zhong, Xiao Xiao, Danping Qin, Yun Liu, Jianguang Hu, Yan Liu
Pages: 1115-1124
Published online on: 08 January 2020

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Article Open Access

miR‑21 promotes osteoclastogenesis through activation of PI3K/Akt signaling by targeting Pten in RAW264.7 cells

Shengli Wang, Zhigang Liu, Jingchun Wang, Xinying Ji, Zhenqiang Yao, Xinchun Wang
Pages: 1125-1132
Published online on: 13 January 2020

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Article Open Access

Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice

Yu Xie, Fei Ding, Wenjuan Di, Yifan Lv, Fan Xia, Yunlu Sheng, Jing Yu, Guoxian Ding
Pages: 1133-1144
Published online on: 13 January 2020

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Article Open Access

miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8 Retraction in /10.3892/mmr.2026.13841

Yan‑Yan Bai, Jun‑Zhi Niu
Pages: 1145-1153
Published online on: 23 December 2019

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Article Open Access

Silencing of RIPK4 inhibits epithelial‑mesenchymal transition by inactivating the Wnt/β‑catenin signaling pathway in osteosarcoma Corrigendum in /10.3892/mmr.2022.12585

Zhigang Yi, Yanchuan Pu, Ruoyan Gou, Yonggang Chen, Xiaojun Ren, Wenzhong Liu, Ping Dong
Pages: 1154-1162
Published online on: 14 January 2020

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Article Open Access

Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus

Mingwei He, Jinlei Pang, Haiyan Sun, Guanrong Zheng, Yan Lin, Weipeng Ge
Pages: 1163-1171
Published online on: 09 January 2020

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Article Open Access

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Qing Zhu, Nianping Zhang, Nan Hu, Rongrong Jiang, Huicong Lu, Aiguo Xuan, Dahong Long, Yan Chen
Pages: 1172-1180
Published online on: 08 January 2020

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Article Open Access

Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response

Akihito Tanaka, Shuji Kanmura, Yuko Morinaga, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Masahiko Takeshita, Shiro Takeda, Akio Ido
Pages: 1181-1191
Published online on: 09 January 2020

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Article Open Access

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension in rats

Yonghui Wu, Changhong Cai, Lebing Yang, Yijia Xiang, Huan Zhao, Chunlai Zeng
Pages: 1192-1200
Published online on: 03 January 2020

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Article Open Access

SRY‑related HMG box‑2 role in anaplastic thyroid cancer aggressiveness is related to the fibronectin 1 and PI3K/AKT pathway

Peng Wang, Jinbiao Shang, Jianqiang Zhao, Kejing Wang, Liang Guo, Jialei Gu, Wendong Wang
Pages: 1201-1207
Published online on: 02 January 2020

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Article Open Access

ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells

Wei Lu, Yu‑Yan Ma, Qian‑Qian Shao, Jie Liang, Tong‑Tong Qi, Yi Huang, Qing‑Jie Wang
Pages: 1208-1216
Published online on: 20 December 2019

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Article Open Access

Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA‑432 sponge

Ping Huang, Bingli Qi, Hairong Yao, Liang Zhang, Yanying Li, Qian Li
Pages: 1217-1223
Published online on: 03 January 2020

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Article Open Access

FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial‑mesenchymal transition through β‑catenin activation

Ting Liu, Jing‑Zhuo Huang, Ze‑Yuan Lei, Rong‑Shuai Yan, Dong‑Li Fan
Pages: 1224-1232
Published online on: 03 January 2020

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Article Open Access

Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion

Yaping Chen, Wenyu Bian, Bo Xu
Pages: 1233-1241
Published online on: 14 January 2020

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Article Open Access

Quantitative analysis of protein crotonylation identifies its association with immunoglobulin A nephropathy

Hua Lin, Donge Tang, Yong Xu, Ruohan Zhang, Minglin Ou, Fengping Zheng, Jiejing Chen, Yue Zhang, Guimian Zou, Wen Xue, Yaoshuang Zou, Weier Dai, Weiguo Sui, Yong Dai
Pages: 1242-1250
Published online on: 13 January 2020

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Article Open Access

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

Jun Ding, Daming Qin, Yong Zhang, Qinghe Li, Yi Li, Jinmao Li
Pages: 1251-1257
Published online on: 03 January 2020

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Article Open Access

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

Yosuke Nakazawa, Miki Aoki, Sho Ishiwa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Megumi Funakoshi‑Tago, Hiroomi Tamura
Pages: 1258-1266
Published online on: 14 January 2020

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Article Open Access

Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells

Daofu Shen, Yu Wang, Hongmei Niu, Chunying Liu
Pages: 1267-1275
Published online on: 03 January 2020

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Article Open Access

Aflatoxin influences achalasia symptomatology

Shengli Lin, Pingting Gao, Quanlin Li, Yiqun Zhang, Jianwei Hu, Mingyan Cai, Wenzheng Qin, Lili Ma, Zhong Ren, Zhen Zhang, Xianli Cai, Liqing Yao, Weifeng Chen, Pinghong Zhou
Pages: 1276-1284
Published online on: 08 January 2020

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Article Open Access

Methylation‑driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma

Qingqing Zhu, Jia Wang, Qiujing Zhang, Fuxia Wang, Lihua Fang, Bao Song, Chao Xie, Jie Liu
Pages: 1285-1295
Published online on: 13 January 2020

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Article

Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis

Yajun Chen, Fanghua Qiu, Lichan Huang, Weiping Liu, Liqin Li, Canhua Ji, Xianqi Zeng, Lingli Qiao, Mengqin Liu, Xiaoqian Gong
Pages: 1296-1303
Published online on: 18 December 2019

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Article

lncRNA HAND2‑AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion

Lijing Jiang, Yunfen He, Guofeng Shen, Jindi Ni, Zhuye Xia, Hongjie Liu, Yunshan Cao, Xiang Li
Pages: 1304-1309
Published online on: 10 January 2020

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Article

Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis

Qinghui Ji, Xiaofeng Qiao, Yongxiang Liu, Dawei Wang, Jinglong Yan
Pages: 1310-1319
Published online on: 20 December 2019

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Article

Effects of antibodies against human parvovirus B19 on angiogenic signaling

Chia‑Cheng Su, Tsai‑Ching Hsu, Chao‑Hsiang Hsiao, Chun‑Ching Chiu, Bor‑Show Tzang
Pages: 1320-1327
Published online on: 09 January 2020

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Article

Protocatechuic acid attenuates β‑secretase activity and okadaic acid‑induced autophagy via the Akt/GSK‑3β/MEF2D pathway in PC12 cells

Liping Huang, Xiaoqin Zhong, Shaochen Qin, Minzhen Deng
Pages: 1328-1335
Published online on: 30 December 2019

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Article

KLF15 is a protective regulatory factor of heart failure induced by pressure overload

Shu‑Fan Zou, Yang Yu, Yan Peng, Ying‑Bin Xiao, Zhao Jian, Yun‑Han Jiang, Sai Chen, Fu‑Qin Tang, Lin Chen
Pages: 1336-1345
Published online on: 08 January 2020

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Article

7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts

Yu‑Kyoung Park, Anil Kumar Yadav, Amir Roshanzadeh, Young‑Wook Ryoo, Bae‑Hwan Kim, Ji Yun Cha, Yeon Kyung Son, Na Young Lee, Byeong‑Churl Jang
Pages: 1346-1355
Published online on: 20 December 2019

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Article

Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line

Yongjun Chen, Tao Zhang, Xiongwei Liu, Zengyan Li, Dongming Zhou, Wensheng Xu
Pages: 1356-1364
Published online on: 23 December 2019

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Article

Long non‑coding RNA MALAT1 serves as an independent predictive biomarker for the diagnosis, severity and prognosis of patients with sepsis

Jianjun Chen, Yingfeng He, Liangliang Zhou, Yijun Deng, Linjie Si
Pages: 1365-1373
Published online on: 09 January 2020

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Article

Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells

Min‑Gu Lee, Kyu‑Shik Lee , Kyung‑Soo Nam
Pages: 1374-1382
Published online on: 13 January 2020

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Article

Iron deficiency attenuates catecholamine‑stimulated lipolysis via downregulation of lipolysis‑related proteins and glucose utilization in 3T3‑L1 adipocytes

Kazuhiko Higashida, Nodoka Takeuchi, Sachika Inoue, Takeshi Hashimoto, Naoya Nakai
Pages: 1383-1389
Published online on: 13 January 2020

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Article

Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation

Wenhsu Chen, Yingxiao Li, Chao‑Tien Hsu, Chiang‑Shan Niu, Wen‑Huang Pen, Kai‑Chun Cheng, Ho‑Shan Niu
Pages: 1390-1398
Published online on: 08 January 2020

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Article

Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells

Peiguang Niu, Jinsui Li, Huajiao Chen, Yanting Zhu, Jintuo Zhou, Daohua Shi
Pages: 1399-1407
Published online on: 20 December 2019

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Correction Open Access

[Corrigendum] Angiopoietin‑like protein 2 expression is suppressed by angiotensin II via the angiotensin II type 1 receptor in rat cardiomyocytes

Shuya Wang, Ying Li, Wei Miao, Hong Zhao, Feng Zhang, Nan Liu, Guohai Su, Xiaojun Cai
Pages: 1408-1408
Published online on: 09 January 2020

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Review Open Access

Roles of inflammation factors in melanogenesis (Review)

Chuhan Fu, Jing Chen, Jianyun Lu, Lu Yi, Xiaoliang Tong, Liyang Kang, Shiyao Pei, Yujie Ouyang, Ling Jiang, Yufang Ding, Xiaojiao Zhao, Si Li, Yan Yang, Jinhua Huang, Qinghai Zeng
Pages: 1421-1430
Published online on: 17 January 2020

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Article Open Access

Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model

Mario S. Oliveira, Leonardo Y. Tanaka, Ednei L. Antonio, Laura I. Brandizzi, Andrey J. Serra, Leonardo Dos Santos, José E. Krieger, Francisco R.M. Laurindo, Paulo J.F. Tucci
Pages: 1431-1438
Published online on: 29 January 2020

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Article Open Access

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4 Retraction in /10.3892/mmr.2024.13284

Yimin Li, Jin Huang, Hong Yan, Xiangyu Li, Chang Ding, Qian Wang, Zhiping Lu
Pages: 1439-1448
Published online on: 22 January 2020

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Article Open Access

Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance

Lingling Ou, Xiuzhen He, Naihua Liu, Yuwei Song, Jinyuan Li, Lvfen Gao, Xinke Huang, Zhendong Deng, Xiaoyu Wang, Shaoqiang Lin
Pages: 1449-1460
Published online on: 20 January 2020

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Article Open Access

Use of Bao Gui capsule in treatment of a polycystic ovary syndrome rat model

Yuling Lian, Fangui Zhao, Wenjun Wang
Pages: 1461-1470
Published online on: 20 January 2020

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Article Open Access

Propofol inhibits proliferation and cisplatin resistance in ovarian cancer cells through regulating the microRNA‑374a/forkhead box O1 signaling axis

Yang Sun, Yong‑Bao Peng, Ling‑Ling Ye, Long‑Xian Ma, Mei‑Yan Zou, Zhong‑Gui Cheng
Pages: 1471-1480
Published online on: 16 January 2020

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Article Open Access

MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels Retraction in /10.3892/mmr.2023.13045

Fei Guo, Jun Xue
Pages: 1481-1490
Published online on: 16 January 2020

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Article Open Access

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway

Pengran Liu, Hui Chen, Lianqi Yan, Yu Sun
Pages: 1491-1500
Published online on: 28 January 2020

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Article Open Access

Lithium chloride increases sensitivity to photon irradiation treatment in primary mesenchymal colon cancer cells

Francesca Cammarota, Andrea Conte, Antonietta Aversano, Paolo Muto, Gianluca Ametrano, Patrizia Riccio, Mimmo Turano, Valeria Valente, Paolo Delrio, Paola Izzo, Giovanna Maria Pierantoni, Marina De Rosa
Pages: 1501-1508
Published online on: 21 January 2020

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Article Open Access

Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer Retraction in /10.3892/mmr.2024.13380

Ning Lang, Chunyang Wang, Jiangyang Zhao, Feng Shi, Tong Wu, Hongyan Cao
Pages: 1509-1516
Published online on: 16 January 2020

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Article Open Access

Role of downregulated ADARB1 in lung squamous cell carcinoma

Xiang Wang, Xinxin Ren, Wanli Liu, Xi Chen, Jie Wei, Zhicheng Gong, Yuanliang Yan, Zhijie Xu
Pages: 1517-1526
Published online on: 23 January 2020

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Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning

Jin Li, Wenjing Zhou, Wei Chen, Haiying Wang, Yu Zhang, Tian Yu
Pages: 1527-1536
Published online on: 28 January 2020

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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation

Maciej Brązert, Wiesława Kranc, Mariusz J. Nawrocki, Patrycja Sujka‑Kordowska, Aneta Konwerska, Maurycy Jankowski, Ievgeniia Kocherova, Piotr Celichowski, Michal Jeseta, Katarzyna Ożegowska, Paweł Antosik, Dorota Bukowska, Mariusz T. Skowroński, Małgorzata Bruska, Leszek Pawelczyk, Maciej Zabel, Hanna Piotrowska‑Kempisty, Michał Nowicki, Bartosz Kempisty
Pages: 1537-1551
Published online on: 27 January 2020

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Indirubin promotes adipocyte differentiation and reduces lipid accumulation in 3T3‑L1 cells via peroxisome proliferator‑activated receptor γ activation

Taisuke Konno, Kenroh Sasaki, Kyoko Kobayashi, Toshihiro Murata
Pages: 1552-1560
Published online on: 16 January 2020

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A six‑gene support vector machine classifier contributes to the diagnosis of pediatric septic shock

Guoli Long, Chen Yang
Pages: 1561-1571
Published online on: 23 January 2020

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Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two‑hybrid assays

Zhenjie Sun, Yuhui Sun, Yumeng Li, Xiuli Luan, Hui Chen, Haiying Wu, Bo Peng, Chunxue Lu
Pages: 1572-1580
Published online on: 16 January 2020

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SP1/TGF‑β1/SMAD2 pathway is involved in angiogenesis during osteogenesis

Ao Ding, Ying‑Ying Bian, Zhi‑Hong Zhang
Pages: 1581-1589
Published online on: 27 January 2020

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Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

Zengfa Huang, Hui Wei, Xiang Wang, Jianwei Xiao, Zuoqin Li, Yuanliang Xie, Yun Hu, Xiang Li, Zheng Wang, Shutong Zhang
Pages: 1590-1596
Published online on: 20 January 2020

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Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway

Yejing Chai, Kangsheng Zhu, Chao Li, Xiaofan Wang, Junmei Shen, Fangfang Yong, Huiqun Jia
Pages: 1597-1605
Published online on: 24 January 2020

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Integrative analysis of an lncRNA‑associated competing endogenous RNA network in human trabecular meshwork cells under oxidative stress

Ke Yao, Yixian Yu, Fei Li, Peiming Jin, Chaohua Deng, Hong Zhang
Pages: 1606-1614
Published online on: 21 January 2020

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MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer

Kai Li, Xiangrong Zhu, Xihua Chen, Xiongtie Wang
Pages: 1615-1622
Published online on: 17 January 2020

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Monocyte chemoattractant protein‑1 promotes the proliferation, migration and differentiation potential of fibroblast‑like synoviocytes via the PI3K/P38 cellular signaling pathway

Xiang Tong, Huangjian Zeng, Pengchen Gu, Kai Wang, Han Zhang, Xiangjin Lin
Pages: 1623-1632
Published online on: 29 January 2020

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Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion

Ning Cui, Hesheng Luo, Yu Zhao
Pages: 1633-1639
Published online on: 24 January 2020

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Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro

Hui Wang, Yanjun Jia, Jiamou Li, Qingsong Liu
Pages: 1640-1646
Published online on: 24 January 2020

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Identifying potential prognostic biomarkers in head and neck cancer based on the analysis of microRNA expression profiles in TCGA database

Xiaobin Wang, Zeli Yin, Yanyun Zhao, Miao He, Chengyong Dong, Ming Zhong
Pages: 1647-1657
Published online on: 27 January 2020

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Resveratrol attenuates IL‑33‑induced mast cell inflammation associated with inhibition of NF‑κB activation and the P38 signaling pathway

Yundan Xu, Qiang Liu, Xiaohong Guo, Lei Xiang, Gang Zhao
Pages: 1658-1666
Published online on: 20 January 2020

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Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279

Erin Conn, Sarah Hour, David Allegakoen, Garrett Graham, Jeff Petro, Marilyn Kouassi‑Brou, Sung Hyeok Hong, Saravana Selvanathan, Haydar Çelik, Jeffrey Toretsky, Aykut Üren
Pages: 1667-1675
Published online on: 16 January 2020

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Journal Cover
August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Retraction Open Access

[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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