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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-2020 Volume 21 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory effect of chemerin and therapeutic efficacy of chemerin‑9 in pancreatogenic diabetes mellitus

Jianfeng Tu, Yue Yang, Jingzhu Zhang, Guotao Lu, Lu Ke, Zhihui Tong, Maimaitijiang Kasimu, Dejun Hu, Qiuran Xu, Weiqin Li
Pages: 981-988
Published online on: 08 January 2020

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Article Open Access

Low‑intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS‑miR‑21‑PTEN axis

Chunhua Xia, Huabei Zeng, Yanfen Zheng
Pages: 989-998
Published online on: 13 January 2020

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Article Open Access

Construction of a prognosis‑associated long noncoding RNA‑mRNA network for multiple myeloma based on microarray and bioinformatics analysis

Fang‑Xiao Zhu, Xiao‑Tao Wang, Zhi‑Zhong Ye, Zhao‑Ping Gan, Yong‑Rong Lai
Pages: 999-1010
Published online on: 13 January 2020

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Article Open Access

miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling

Jing Xi, Qiang‑Qiang Li, Bing‑Qiang Li, Ning Li
Pages: 1011-1020
Published online on: 09 January 2020

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Article Open Access

General mechanism of JQ1 in inhibiting various types of cancer

Guojuan Jiang, Wanglong Deng, Yang Liu, Chengde Wang
Pages: 1021-1034
Published online on: 10 January 2020

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Article Open Access

Isoferulic acid inhibits human leukemia cell growth through induction of G2/M‑phase arrest and inhibition of Akt/mTOR signaling

Zhiguo Long, Guangjia Feng, Na Zhao, Lei Wu, Hongbo Zhu
Pages: 1035-1042
Published online on: 09 January 2020

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Article Open Access

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection

Xin Yang, Han‑Mei Wei, Guo‑Yan Hu, Jun Zhao, Li‑Na Long, Chang‑Jian Li, Zi‑Jun Zhao, He‑Kun Zeng, Hong Nie
Pages: 1043-1050
Published online on: 09 January 2020

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Article Open Access

Overexpression of long noncoding RNA CUDR promotes hepatic differentiation of human umbilical cord mesenchymal stem cells

Yabin Yu, Meng Li, Yan Song, Jianbo Xu, Fuzhen Qi
Pages: 1051-1058
Published online on: 19 December 2019

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Article Open Access

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yin Yao
Pages: 1059-1070
Published online on: 13 January 2020

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Article Open Access

Study of minimally invasive radiofrequency ablation of the ciliary body for the treatment of glaucoma in rabbits

Baoke Hou, Fengxiang Wang, Zi Ye, Xin Jin, Yu Fu, Zhaohui Li
Pages: 1071-1076
Published online on: 31 December 2019

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Article Open Access

Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway

Miao Zhang, Zhiqiang Wang, Baojie Li, Fengyi Sun, Anzhong Chen, Mingzhi Gong
Pages: 1077-1088
Published online on: 14 January 2020

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Article Open Access

Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration

Yan Zhu, Zhiquan Qiu, Yiliang Zhang, Bin Li, Xiaoqing Jiang
Pages: 1089-1096
Published online on: 27 December 2019

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Article Open Access

The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway

Tu Wang, Xiaoxu Sun, Haipeng Cui, Kai Liu, Juan Zhao
Pages: 1097-1106
Published online on: 13 January 2020

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Article Open Access

Phellinus gilvus‑derived protocatechualdehyde induces G0/G1 phase arrest and apoptosis in murine B16‑F10 cells

Shi Zhong, Qinshen Jin, Taihen Yu, Jianxun Zhu, Yougui Li
Pages: 1107-1114
Published online on: 19 December 2019

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Article Open Access

Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening

Chunrong Tang, Daoyuan Zhou, Rongshao Tan, Xiaoshi Zhong, Xiao Xiao, Danping Qin, Yun Liu, Jianguang Hu, Yan Liu
Pages: 1115-1124
Published online on: 08 January 2020

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Article Open Access

miR‑21 promotes osteoclastogenesis through activation of PI3K/Akt signaling by targeting Pten in RAW264.7 cells

Shengli Wang, Zhigang Liu, Jingchun Wang, Xinying Ji, Zhenqiang Yao, Xinchun Wang
Pages: 1125-1132
Published online on: 13 January 2020

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Article Open Access

Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice

Yu Xie, Fei Ding, Wenjuan Di, Yifan Lv, Fan Xia, Yunlu Sheng, Jing Yu, Guoxian Ding
Pages: 1133-1144
Published online on: 13 January 2020

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Article Open Access

miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

Yan‑Yan Bai, Jun‑Zhi Niu
Pages: 1145-1153
Published online on: 23 December 2019

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Article Open Access

Silencing of RIPK4 inhibits epithelial‑mesenchymal transition by inactivating the Wnt/β‑catenin signaling pathway in osteosarcoma Corrigendum in /10.3892/mmr.2022.12585

Zhigang Yi, Yanchuan Pu, Ruoyan Gou, Yonggang Chen, Xiaojun Ren, Wenzhong Liu, Ping Dong
Pages: 1154-1162
Published online on: 14 January 2020

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Article Open Access

Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus

Mingwei He, Jinlei Pang, Haiyan Sun, Guanrong Zheng, Yan Lin, Weipeng Ge
Pages: 1163-1171
Published online on: 09 January 2020

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Article Open Access

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Qing Zhu, Nianping Zhang, Nan Hu, Rongrong Jiang, Huicong Lu, Aiguo Xuan, Dahong Long, Yan Chen
Pages: 1172-1180
Published online on: 08 January 2020

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Article Open Access

Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response

Akihito Tanaka, Shuji Kanmura, Yuko Morinaga, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Masahiko Takeshita, Shiro Takeda, Akio Ido
Pages: 1181-1191
Published online on: 09 January 2020

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Article Open Access

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension in rats

Yonghui Wu, Changhong Cai, Lebing Yang, Yijia Xiang, Huan Zhao, Chunlai Zeng
Pages: 1192-1200
Published online on: 03 January 2020

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Article Open Access

SRY‑related HMG box‑2 role in anaplastic thyroid cancer aggressiveness is related to the fibronectin 1 and PI3K/AKT pathway

Peng Wang, Jinbiao Shang, Jianqiang Zhao, Kejing Wang, Liang Guo, Jialei Gu, Wendong Wang
Pages: 1201-1207
Published online on: 02 January 2020

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Article Open Access

ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells

Wei Lu, Yu‑Yan Ma, Qian‑Qian Shao, Jie Liang, Tong‑Tong Qi, Yi Huang, Qing‑Jie Wang
Pages: 1208-1216
Published online on: 20 December 2019

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Article Open Access

Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA‑432 sponge

Ping Huang, Bingli Qi, Hairong Yao, Liang Zhang, Yanying Li, Qian Li
Pages: 1217-1223
Published online on: 03 January 2020

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Article Open Access

FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial‑mesenchymal transition through β‑catenin activation

Ting Liu, Jing‑Zhuo Huang, Ze‑Yuan Lei, Rong‑Shuai Yan, Dong‑Li Fan
Pages: 1224-1232
Published online on: 03 January 2020

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Article Open Access

Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion

Yaping Chen, Wenyu Bian, Bo Xu
Pages: 1233-1241
Published online on: 14 January 2020

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Article Open Access

Quantitative analysis of protein crotonylation identifies its association with immunoglobulin A nephropathy

Hua Lin, Donge Tang, Yong Xu, Ruohan Zhang, Minglin Ou, Fengping Zheng, Jiejing Chen, Yue Zhang, Guimian Zou, Wen Xue, Yaoshuang Zou, Weier Dai, Weiguo Sui, Yong Dai
Pages: 1242-1250
Published online on: 13 January 2020

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Article Open Access

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

Jun Ding, Daming Qin, Yong Zhang, Qinghe Li, Yi Li, Jinmao Li
Pages: 1251-1257
Published online on: 03 January 2020

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Article Open Access

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

Yosuke Nakazawa, Miki Aoki, Sho Ishiwa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Megumi Funakoshi‑Tago, Hiroomi Tamura
Pages: 1258-1266
Published online on: 14 January 2020

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Article Open Access

Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells

Daofu Shen, Yu Wang, Hongmei Niu, Chunying Liu
Pages: 1267-1275
Published online on: 03 January 2020

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Article Open Access

Aflatoxin influences achalasia symptomatology

Shengli Lin, Pingting Gao, Quanlin Li, Yiqun Zhang, Jianwei Hu, Mingyan Cai, Wenzheng Qin, Lili Ma, Zhong Ren, Zhen Zhang, Xianli Cai, Liqing Yao, Weifeng Chen, Pinghong Zhou
Pages: 1276-1284
Published online on: 08 January 2020

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Article Open Access

Methylation‑driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma

Qingqing Zhu, Jia Wang, Qiujing Zhang, Fuxia Wang, Lihua Fang, Bao Song, Chao Xie, Jie Liu
Pages: 1285-1295
Published online on: 13 January 2020

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Article

Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis

Yajun Chen, Fanghua Qiu, Lichan Huang, Weiping Liu, Liqin Li, Canhua Ji, Xianqi Zeng, Lingli Qiao, Mengqin Liu, Xiaoqian Gong
Pages: 1296-1303
Published online on: 18 December 2019

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Article

lncRNA HAND2‑AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion

Lijing Jiang, Yunfen He, Guofeng Shen, Jindi Ni, Zhuye Xia, Hongjie Liu, Yunshan Cao, Xiang Li
Pages: 1304-1309
Published online on: 10 January 2020

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Article

Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis

Qinghui Ji, Xiaofeng Qiao, Yongxiang Liu, Dawei Wang, Jinglong Yan
Pages: 1310-1319
Published online on: 20 December 2019

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Article

Effects of antibodies against human parvovirus B19 on angiogenic signaling

Chia‑Cheng Su, Tsai‑Ching Hsu, Chao‑Hsiang Hsiao, Chun‑Ching Chiu, Bor‑Show Tzang
Pages: 1320-1327
Published online on: 09 January 2020

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Article

Protocatechuic acid attenuates β‑secretase activity and okadaic acid‑induced autophagy via the Akt/GSK‑3β/MEF2D pathway in PC12 cells

Liping Huang, Xiaoqin Zhong, Shaochen Qin, Minzhen Deng
Pages: 1328-1335
Published online on: 30 December 2019

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Article

KLF15 is a protective regulatory factor of heart failure induced by pressure overload

Shu‑Fan Zou, Yang Yu, Yan Peng, Ying‑Bin Xiao, Zhao Jian, Yun‑Han Jiang, Sai Chen, Fu‑Qin Tang, Lin Chen
Pages: 1336-1345
Published online on: 08 January 2020

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Article

7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts

Yu‑Kyoung Park, Anil Kumar Yadav, Amir Roshanzadeh, Young‑Wook Ryoo, Bae‑Hwan Kim, Ji Yun Cha, Yeon Kyung Son, Na Young Lee, Byeong‑Churl Jang
Pages: 1346-1355
Published online on: 20 December 2019

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Article

Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line

Yongjun Chen, Tao Zhang, Xiongwei Liu, Zengyan Li, Dongming Zhou, Wensheng Xu
Pages: 1356-1364
Published online on: 23 December 2019

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Article

Long non‑coding RNA MALAT1 serves as an independent predictive biomarker for the diagnosis, severity and prognosis of patients with sepsis

Jianjun Chen, Yingfeng He, Liangliang Zhou, Yijun Deng, Linjie Si
Pages: 1365-1373
Published online on: 09 January 2020

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Article

Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells

Min‑Gu Lee, Kyu‑Shik Lee , Kyung‑Soo Nam
Pages: 1374-1382
Published online on: 13 January 2020

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Article

Iron deficiency attenuates catecholamine‑stimulated lipolysis via downregulation of lipolysis‑related proteins and glucose utilization in 3T3‑L1 adipocytes

Kazuhiko Higashida, Nodoka Takeuchi, Sachika Inoue, Takeshi Hashimoto, Naoya Nakai
Pages: 1383-1389
Published online on: 13 January 2020

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Article

Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation

Wenhsu Chen, Yingxiao Li, Chao‑Tien Hsu, Chiang‑Shan Niu, Wen‑Huang Pen, Kai‑Chun Cheng, Ho‑Shan Niu
Pages: 1390-1398
Published online on: 08 January 2020

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Article

Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells

Peiguang Niu, Jinsui Li, Huajiao Chen, Yanting Zhu, Jintuo Zhou, Daohua Shi
Pages: 1399-1407
Published online on: 20 December 2019

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Correction Open Access

[Corrigendum] Angiopoietin‑like protein 2 expression is suppressed by angiotensin II via the angiotensin II type 1 receptor in rat cardiomyocytes

Shuya Wang, Ying Li, Wei Miao, Hong Zhao, Feng Zhang, Nan Liu, Guohai Su, Xiaojun Cai
Pages: 1408-1408
Published online on: 09 January 2020

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Review Open Access

Roles of inflammation factors in melanogenesis (Review)

Chuhan Fu, Jing Chen, Jianyun Lu, Lu Yi, Xiaoliang Tong, Liyang Kang, Shiyao Pei, Yujie Ouyang, Ling Jiang, Yufang Ding, Xiaojiao Zhao, Si Li, Yan Yang, Jinhua Huang, Qinghai Zeng
Pages: 1421-1430
Published online on: 17 January 2020

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Article Open Access

Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model

Mario S. Oliveira, Leonardo Y. Tanaka, Ednei L. Antonio, Laura I. Brandizzi, Andrey J. Serra, Leonardo Dos Santos, José E. Krieger, Francisco R.M. Laurindo, Paulo J.F. Tucci
Pages: 1431-1438
Published online on: 29 January 2020

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Article Open Access

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4 Retraction in /10.3892/mmr.2024.13284

Yimin Li, Jin Huang, Hong Yan, Xiangyu Li, Chang Ding, Qian Wang, Zhiping Lu
Pages: 1439-1448
Published online on: 22 January 2020

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Article Open Access

Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance

Lingling Ou, Xiuzhen He, Naihua Liu, Yuwei Song, Jinyuan Li, Lvfen Gao, Xinke Huang, Zhendong Deng, Xiaoyu Wang, Shaoqiang Lin
Pages: 1449-1460
Published online on: 20 January 2020

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Article Open Access

Use of Bao Gui capsule in treatment of a polycystic ovary syndrome rat model

Yuling Lian, Fangui Zhao, Wenjun Wang
Pages: 1461-1470
Published online on: 20 January 2020

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Article Open Access

Propofol inhibits proliferation and cisplatin resistance in ovarian cancer cells through regulating the microRNA‑374a/forkhead box O1 signaling axis

Yang Sun, Yong‑Bao Peng, Ling‑Ling Ye, Long‑Xian Ma, Mei‑Yan Zou, Zhong‑Gui Cheng
Pages: 1471-1480
Published online on: 16 January 2020

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Article Open Access

MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels Retraction in /10.3892/mmr.2023.13045

Fei Guo, Jun Xue
Pages: 1481-1490
Published online on: 16 January 2020

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Article Open Access

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway

Pengran Liu, Hui Chen, Lianqi Yan, Yu Sun
Pages: 1491-1500
Published online on: 28 January 2020

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Article Open Access

Lithium chloride increases sensitivity to photon irradiation treatment in primary mesenchymal colon cancer cells

Francesca Cammarota, Andrea Conte, Antonietta Aversano, Paolo Muto, Gianluca Ametrano, Patrizia Riccio, Mimmo Turano, Valeria Valente, Paolo Delrio, Paola Izzo, Giovanna Maria Pierantoni, Marina De Rosa
Pages: 1501-1508
Published online on: 21 January 2020

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Article Open Access

Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer Retraction in /10.3892/mmr.2024.13380

Ning Lang, Chunyang Wang, Jiangyang Zhao, Feng Shi, Tong Wu, Hongyan Cao
Pages: 1509-1516
Published online on: 16 January 2020

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Article Open Access

Role of downregulated ADARB1 in lung squamous cell carcinoma

Xiang Wang, Xinxin Ren, Wanli Liu, Xi Chen, Jie Wei, Zhicheng Gong, Yuanliang Yan, Zhijie Xu
Pages: 1517-1526
Published online on: 23 January 2020

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Article Open Access

Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning

Jin Li, Wenjing Zhou, Wei Chen, Haiying Wang, Yu Zhang, Tian Yu
Pages: 1527-1536
Published online on: 28 January 2020

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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation

Maciej Brązert, Wiesława Kranc, Mariusz J. Nawrocki, Patrycja Sujka‑Kordowska, Aneta Konwerska, Maurycy Jankowski, Ievgeniia Kocherova, Piotr Celichowski, Michal Jeseta, Katarzyna Ożegowska, Paweł Antosik, Dorota Bukowska, Mariusz T. Skowroński, Małgorzata Bruska, Leszek Pawelczyk, Maciej Zabel, Hanna Piotrowska‑Kempisty, Michał Nowicki, Bartosz Kempisty
Pages: 1537-1551
Published online on: 27 January 2020

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Indirubin promotes adipocyte differentiation and reduces lipid accumulation in 3T3‑L1 cells via peroxisome proliferator‑activated receptor γ activation

Taisuke Konno, Kenroh Sasaki, Kyoko Kobayashi, Toshihiro Murata
Pages: 1552-1560
Published online on: 16 January 2020

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A six‑gene support vector machine classifier contributes to the diagnosis of pediatric septic shock

Guoli Long, Chen Yang
Pages: 1561-1571
Published online on: 23 January 2020

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Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two‑hybrid assays

Zhenjie Sun, Yuhui Sun, Yumeng Li, Xiuli Luan, Hui Chen, Haiying Wu, Bo Peng, Chunxue Lu
Pages: 1572-1580
Published online on: 16 January 2020

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SP1/TGF‑β1/SMAD2 pathway is involved in angiogenesis during osteogenesis

Ao Ding, Ying‑Ying Bian, Zhi‑Hong Zhang
Pages: 1581-1589
Published online on: 27 January 2020

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Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

Zengfa Huang, Hui Wei, Xiang Wang, Jianwei Xiao, Zuoqin Li, Yuanliang Xie, Yun Hu, Xiang Li, Zheng Wang, Shutong Zhang
Pages: 1590-1596
Published online on: 20 January 2020

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Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway

Yejing Chai, Kangsheng Zhu, Chao Li, Xiaofan Wang, Junmei Shen, Fangfang Yong, Huiqun Jia
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Published online on: 24 January 2020

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Integrative analysis of an lncRNA‑associated competing endogenous RNA network in human trabecular meshwork cells under oxidative stress

Ke Yao, Yixian Yu, Fei Li, Peiming Jin, Chaohua Deng, Hong Zhang
Pages: 1606-1614
Published online on: 21 January 2020

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MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer

Kai Li, Xiangrong Zhu, Xihua Chen, Xiongtie Wang
Pages: 1615-1622
Published online on: 17 January 2020

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Monocyte chemoattractant protein‑1 promotes the proliferation, migration and differentiation potential of fibroblast‑like synoviocytes via the PI3K/P38 cellular signaling pathway

Xiang Tong, Huangjian Zeng, Pengchen Gu, Kai Wang, Han Zhang, Xiangjin Lin
Pages: 1623-1632
Published online on: 29 January 2020

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Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion

Ning Cui, Hesheng Luo, Yu Zhao
Pages: 1633-1639
Published online on: 24 January 2020

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Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro

Hui Wang, Yanjun Jia, Jiamou Li, Qingsong Liu
Pages: 1640-1646
Published online on: 24 January 2020

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Identifying potential prognostic biomarkers in head and neck cancer based on the analysis of microRNA expression profiles in TCGA database

Xiaobin Wang, Zeli Yin, Yanyun Zhao, Miao He, Chengyong Dong, Ming Zhong
Pages: 1647-1657
Published online on: 27 January 2020

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Resveratrol attenuates IL‑33‑induced mast cell inflammation associated with inhibition of NF‑κB activation and the P38 signaling pathway

Yundan Xu, Qiang Liu, Xiaohong Guo, Lei Xiang, Gang Zhao
Pages: 1658-1666
Published online on: 20 January 2020

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Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279

Erin Conn, Sarah Hour, David Allegakoen, Garrett Graham, Jeff Petro, Marilyn Kouassi‑Brou, Sung Hyeok Hong, Saravana Selvanathan, Haydar Çelik, Jeffrey Toretsky, Aykut Üren
Pages: 1667-1675
Published online on: 16 January 2020

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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Expression of Concern Open Access

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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Expression of Concern Open Access

[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 33 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Retraction Open Access

[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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