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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-2020 Volume 21 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory effect of chemerin and therapeutic efficacy of chemerin‑9 in pancreatogenic diabetes mellitus

Jianfeng Tu, Yue Yang, Jingzhu Zhang, Guotao Lu, Lu Ke, Zhihui Tong, Maimaitijiang Kasimu, Dejun Hu, Qiuran Xu, Weiqin Li
Pages: 981-988
Published online on: 08 January 2020

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Article Open Access

Low‑intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS‑miR‑21‑PTEN axis

Chunhua Xia, Huabei Zeng, Yanfen Zheng
Pages: 989-998
Published online on: 13 January 2020

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Article Open Access

Construction of a prognosis‑associated long noncoding RNA‑mRNA network for multiple myeloma based on microarray and bioinformatics analysis

Fang‑Xiao Zhu, Xiao‑Tao Wang, Zhi‑Zhong Ye, Zhao‑Ping Gan, Yong‑Rong Lai
Pages: 999-1010
Published online on: 13 January 2020

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Article Open Access

miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling

Jing Xi, Qiang‑Qiang Li, Bing‑Qiang Li, Ning Li
Pages: 1011-1020
Published online on: 09 January 2020

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Article Open Access

General mechanism of JQ1 in inhibiting various types of cancer

Guojuan Jiang, Wanglong Deng, Yang Liu, Chengde Wang
Pages: 1021-1034
Published online on: 10 January 2020

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Article Open Access

Isoferulic acid inhibits human leukemia cell growth through induction of G2/M‑phase arrest and inhibition of Akt/mTOR signaling

Zhiguo Long, Guangjia Feng, Na Zhao, Lei Wu, Hongbo Zhu
Pages: 1035-1042
Published online on: 09 January 2020

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Article Open Access

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection

Xin Yang, Han‑Mei Wei, Guo‑Yan Hu, Jun Zhao, Li‑Na Long, Chang‑Jian Li, Zi‑Jun Zhao, He‑Kun Zeng, Hong Nie
Pages: 1043-1050
Published online on: 09 January 2020

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Article Open Access

Overexpression of long noncoding RNA CUDR promotes hepatic differentiation of human umbilical cord mesenchymal stem cells

Yabin Yu, Meng Li, Yan Song, Jianbo Xu, Fuzhen Qi
Pages: 1051-1058
Published online on: 19 December 2019

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Article Open Access

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yin Yao
Pages: 1059-1070
Published online on: 13 January 2020

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Article Open Access

Study of minimally invasive radiofrequency ablation of the ciliary body for the treatment of glaucoma in rabbits

Baoke Hou, Fengxiang Wang, Zi Ye, Xin Jin, Yu Fu, Zhaohui Li
Pages: 1071-1076
Published online on: 31 December 2019

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Article Open Access

Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway

Miao Zhang, Zhiqiang Wang, Baojie Li, Fengyi Sun, Anzhong Chen, Mingzhi Gong
Pages: 1077-1088
Published online on: 14 January 2020

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Article Open Access

Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration

Yan Zhu, Zhiquan Qiu, Yiliang Zhang, Bin Li, Xiaoqing Jiang
Pages: 1089-1096
Published online on: 27 December 2019

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Article Open Access

The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway

Tu Wang, Xiaoxu Sun, Haipeng Cui, Kai Liu, Juan Zhao
Pages: 1097-1106
Published online on: 13 January 2020

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Article Open Access

Phellinus gilvus‑derived protocatechualdehyde induces G0/G1 phase arrest and apoptosis in murine B16‑F10 cells

Shi Zhong, Qinshen Jin, Taihen Yu, Jianxun Zhu, Yougui Li
Pages: 1107-1114
Published online on: 19 December 2019

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Article Open Access

Auxiliary genetic analysis in a Chinese adolescent NPH family by single nucleotide polymorphism screening

Chunrong Tang, Daoyuan Zhou, Rongshao Tan, Xiaoshi Zhong, Xiao Xiao, Danping Qin, Yun Liu, Jianguang Hu, Yan Liu
Pages: 1115-1124
Published online on: 08 January 2020

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Article Open Access

miR‑21 promotes osteoclastogenesis through activation of PI3K/Akt signaling by targeting Pten in RAW264.7 cells

Shengli Wang, Zhigang Liu, Jingchun Wang, Xinying Ji, Zhenqiang Yao, Xinchun Wang
Pages: 1125-1132
Published online on: 13 January 2020

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Article Open Access

Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice

Yu Xie, Fei Ding, Wenjuan Di, Yifan Lv, Fan Xia, Yunlu Sheng, Jing Yu, Guoxian Ding
Pages: 1133-1144
Published online on: 13 January 2020

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Article Open Access

miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

Yan‑Yan Bai, Jun‑Zhi Niu
Pages: 1145-1153
Published online on: 23 December 2019

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Article Open Access

Silencing of RIPK4 inhibits epithelial‑mesenchymal transition by inactivating the Wnt/β‑catenin signaling pathway in osteosarcoma Corrigendum in /10.3892/mmr.2022.12585

Zhigang Yi, Yanchuan Pu, Ruoyan Gou, Yonggang Chen, Xiaojun Ren, Wenzhong Liu, Ping Dong
Pages: 1154-1162
Published online on: 14 January 2020

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Article Open Access

Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus

Mingwei He, Jinlei Pang, Haiyan Sun, Guanrong Zheng, Yan Lin, Weipeng Ge
Pages: 1163-1171
Published online on: 09 January 2020

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Article Open Access

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Qing Zhu, Nianping Zhang, Nan Hu, Rongrong Jiang, Huicong Lu, Aiguo Xuan, Dahong Long, Yan Chen
Pages: 1172-1180
Published online on: 08 January 2020

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Article Open Access

Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response

Akihito Tanaka, Shuji Kanmura, Yuko Morinaga, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Masahiko Takeshita, Shiro Takeda, Akio Ido
Pages: 1181-1191
Published online on: 09 January 2020

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Article Open Access

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension in rats

Yonghui Wu, Changhong Cai, Lebing Yang, Yijia Xiang, Huan Zhao, Chunlai Zeng
Pages: 1192-1200
Published online on: 03 January 2020

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Article Open Access

SRY‑related HMG box‑2 role in anaplastic thyroid cancer aggressiveness is related to the fibronectin 1 and PI3K/AKT pathway

Peng Wang, Jinbiao Shang, Jianqiang Zhao, Kejing Wang, Liang Guo, Jialei Gu, Wendong Wang
Pages: 1201-1207
Published online on: 02 January 2020

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Article Open Access

ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells

Wei Lu, Yu‑Yan Ma, Qian‑Qian Shao, Jie Liang, Tong‑Tong Qi, Yi Huang, Qing‑Jie Wang
Pages: 1208-1216
Published online on: 20 December 2019

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Article Open Access

Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA‑432 sponge

Ping Huang, Bingli Qi, Hairong Yao, Liang Zhang, Yanying Li, Qian Li
Pages: 1217-1223
Published online on: 03 January 2020

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Article Open Access

FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial‑mesenchymal transition through β‑catenin activation

Ting Liu, Jing‑Zhuo Huang, Ze‑Yuan Lei, Rong‑Shuai Yan, Dong‑Li Fan
Pages: 1224-1232
Published online on: 03 January 2020

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Article Open Access

Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion

Yaping Chen, Wenyu Bian, Bo Xu
Pages: 1233-1241
Published online on: 14 January 2020

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Article Open Access

Quantitative analysis of protein crotonylation identifies its association with immunoglobulin A nephropathy

Hua Lin, Donge Tang, Yong Xu, Ruohan Zhang, Minglin Ou, Fengping Zheng, Jiejing Chen, Yue Zhang, Guimian Zou, Wen Xue, Yaoshuang Zou, Weier Dai, Weiguo Sui, Yong Dai
Pages: 1242-1250
Published online on: 13 January 2020

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Article Open Access

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

Jun Ding, Daming Qin, Yong Zhang, Qinghe Li, Yi Li, Jinmao Li
Pages: 1251-1257
Published online on: 03 January 2020

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Article Open Access

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

Yosuke Nakazawa, Miki Aoki, Sho Ishiwa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Megumi Funakoshi‑Tago, Hiroomi Tamura
Pages: 1258-1266
Published online on: 14 January 2020

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Article Open Access

Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells

Daofu Shen, Yu Wang, Hongmei Niu, Chunying Liu
Pages: 1267-1275
Published online on: 03 January 2020

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Article Open Access

Aflatoxin influences achalasia symptomatology

Shengli Lin, Pingting Gao, Quanlin Li, Yiqun Zhang, Jianwei Hu, Mingyan Cai, Wenzheng Qin, Lili Ma, Zhong Ren, Zhen Zhang, Xianli Cai, Liqing Yao, Weifeng Chen, Pinghong Zhou
Pages: 1276-1284
Published online on: 08 January 2020

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Article Open Access

Methylation‑driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma

Qingqing Zhu, Jia Wang, Qiujing Zhang, Fuxia Wang, Lihua Fang, Bao Song, Chao Xie, Jie Liu
Pages: 1285-1295
Published online on: 13 January 2020

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Article

Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis

Yajun Chen, Fanghua Qiu, Lichan Huang, Weiping Liu, Liqin Li, Canhua Ji, Xianqi Zeng, Lingli Qiao, Mengqin Liu, Xiaoqian Gong
Pages: 1296-1303
Published online on: 18 December 2019

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Article

lncRNA HAND2‑AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion

Lijing Jiang, Yunfen He, Guofeng Shen, Jindi Ni, Zhuye Xia, Hongjie Liu, Yunshan Cao, Xiang Li
Pages: 1304-1309
Published online on: 10 January 2020

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Article

Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis

Qinghui Ji, Xiaofeng Qiao, Yongxiang Liu, Dawei Wang, Jinglong Yan
Pages: 1310-1319
Published online on: 20 December 2019

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Article

Effects of antibodies against human parvovirus B19 on angiogenic signaling

Chia‑Cheng Su, Tsai‑Ching Hsu, Chao‑Hsiang Hsiao, Chun‑Ching Chiu, Bor‑Show Tzang
Pages: 1320-1327
Published online on: 09 January 2020

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Article

Protocatechuic acid attenuates β‑secretase activity and okadaic acid‑induced autophagy via the Akt/GSK‑3β/MEF2D pathway in PC12 cells

Liping Huang, Xiaoqin Zhong, Shaochen Qin, Minzhen Deng
Pages: 1328-1335
Published online on: 30 December 2019

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Article

KLF15 is a protective regulatory factor of heart failure induced by pressure overload

Shu‑Fan Zou, Yang Yu, Yan Peng, Ying‑Bin Xiao, Zhao Jian, Yun‑Han Jiang, Sai Chen, Fu‑Qin Tang, Lin Chen
Pages: 1336-1345
Published online on: 08 January 2020

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Article

7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts

Yu‑Kyoung Park, Anil Kumar Yadav, Amir Roshanzadeh, Young‑Wook Ryoo, Bae‑Hwan Kim, Ji Yun Cha, Yeon Kyung Son, Na Young Lee, Byeong‑Churl Jang
Pages: 1346-1355
Published online on: 20 December 2019

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Article

Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line

Yongjun Chen, Tao Zhang, Xiongwei Liu, Zengyan Li, Dongming Zhou, Wensheng Xu
Pages: 1356-1364
Published online on: 23 December 2019

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Article

Long non‑coding RNA MALAT1 serves as an independent predictive biomarker for the diagnosis, severity and prognosis of patients with sepsis

Jianjun Chen, Yingfeng He, Liangliang Zhou, Yijun Deng, Linjie Si
Pages: 1365-1373
Published online on: 09 January 2020

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Article

Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells

Min‑Gu Lee, Kyu‑Shik Lee , Kyung‑Soo Nam
Pages: 1374-1382
Published online on: 13 January 2020

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Article

Iron deficiency attenuates catecholamine‑stimulated lipolysis via downregulation of lipolysis‑related proteins and glucose utilization in 3T3‑L1 adipocytes

Kazuhiko Higashida, Nodoka Takeuchi, Sachika Inoue, Takeshi Hashimoto, Naoya Nakai
Pages: 1383-1389
Published online on: 13 January 2020

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Article

Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation

Wenhsu Chen, Yingxiao Li, Chao‑Tien Hsu, Chiang‑Shan Niu, Wen‑Huang Pen, Kai‑Chun Cheng, Ho‑Shan Niu
Pages: 1390-1398
Published online on: 08 January 2020

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Article

Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells

Peiguang Niu, Jinsui Li, Huajiao Chen, Yanting Zhu, Jintuo Zhou, Daohua Shi
Pages: 1399-1407
Published online on: 20 December 2019

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Correction Open Access

[Corrigendum] Angiopoietin‑like protein 2 expression is suppressed by angiotensin II via the angiotensin II type 1 receptor in rat cardiomyocytes

Shuya Wang, Ying Li, Wei Miao, Hong Zhao, Feng Zhang, Nan Liu, Guohai Su, Xiaojun Cai
Pages: 1408-1408
Published online on: 09 January 2020

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Review Open Access

Roles of inflammation factors in melanogenesis (Review)

Chuhan Fu, Jing Chen, Jianyun Lu, Lu Yi, Xiaoliang Tong, Liyang Kang, Shiyao Pei, Yujie Ouyang, Ling Jiang, Yufang Ding, Xiaojiao Zhao, Si Li, Yan Yang, Jinhua Huang, Qinghai Zeng
Pages: 1421-1430
Published online on: 17 January 2020

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Article Open Access

Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model

Mario S. Oliveira, Leonardo Y. Tanaka, Ednei L. Antonio, Laura I. Brandizzi, Andrey J. Serra, Leonardo Dos Santos, José E. Krieger, Francisco R.M. Laurindo, Paulo J.F. Tucci
Pages: 1431-1438
Published online on: 29 January 2020

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Article Open Access

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4 Retraction in /10.3892/mmr.2024.13284

Yimin Li, Jin Huang, Hong Yan, Xiangyu Li, Chang Ding, Qian Wang, Zhiping Lu
Pages: 1439-1448
Published online on: 22 January 2020

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Article Open Access

Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance

Lingling Ou, Xiuzhen He, Naihua Liu, Yuwei Song, Jinyuan Li, Lvfen Gao, Xinke Huang, Zhendong Deng, Xiaoyu Wang, Shaoqiang Lin
Pages: 1449-1460
Published online on: 20 January 2020

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Article Open Access

Use of Bao Gui capsule in treatment of a polycystic ovary syndrome rat model

Yuling Lian, Fangui Zhao, Wenjun Wang
Pages: 1461-1470
Published online on: 20 January 2020

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Article Open Access

Propofol inhibits proliferation and cisplatin resistance in ovarian cancer cells through regulating the microRNA‑374a/forkhead box O1 signaling axis

Yang Sun, Yong‑Bao Peng, Ling‑Ling Ye, Long‑Xian Ma, Mei‑Yan Zou, Zhong‑Gui Cheng
Pages: 1471-1480
Published online on: 16 January 2020

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Article Open Access

MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels Retraction in /10.3892/mmr.2023.13045

Fei Guo, Jun Xue
Pages: 1481-1490
Published online on: 16 January 2020

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Article Open Access

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway

Pengran Liu, Hui Chen, Lianqi Yan, Yu Sun
Pages: 1491-1500
Published online on: 28 January 2020

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Article Open Access

Lithium chloride increases sensitivity to photon irradiation treatment in primary mesenchymal colon cancer cells

Francesca Cammarota, Andrea Conte, Antonietta Aversano, Paolo Muto, Gianluca Ametrano, Patrizia Riccio, Mimmo Turano, Valeria Valente, Paolo Delrio, Paola Izzo, Giovanna Maria Pierantoni, Marina De Rosa
Pages: 1501-1508
Published online on: 21 January 2020

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Article Open Access

Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer Retraction in /10.3892/mmr.2024.13380

Ning Lang, Chunyang Wang, Jiangyang Zhao, Feng Shi, Tong Wu, Hongyan Cao
Pages: 1509-1516
Published online on: 16 January 2020

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Article Open Access

Role of downregulated ADARB1 in lung squamous cell carcinoma

Xiang Wang, Xinxin Ren, Wanli Liu, Xi Chen, Jie Wei, Zhicheng Gong, Yuanliang Yan, Zhijie Xu
Pages: 1517-1526
Published online on: 23 January 2020

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Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning

Jin Li, Wenjing Zhou, Wei Chen, Haiying Wang, Yu Zhang, Tian Yu
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Published online on: 28 January 2020

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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation

Maciej Brązert, Wiesława Kranc, Mariusz J. Nawrocki, Patrycja Sujka‑Kordowska, Aneta Konwerska, Maurycy Jankowski, Ievgeniia Kocherova, Piotr Celichowski, Michal Jeseta, Katarzyna Ożegowska, Paweł Antosik, Dorota Bukowska, Mariusz T. Skowroński, Małgorzata Bruska, Leszek Pawelczyk, Maciej Zabel, Hanna Piotrowska‑Kempisty, Michał Nowicki, Bartosz Kempisty
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Indirubin promotes adipocyte differentiation and reduces lipid accumulation in 3T3‑L1 cells via peroxisome proliferator‑activated receptor γ activation

Taisuke Konno, Kenroh Sasaki, Kyoko Kobayashi, Toshihiro Murata
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A six‑gene support vector machine classifier contributes to the diagnosis of pediatric septic shock

Guoli Long, Chen Yang
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Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two‑hybrid assays

Zhenjie Sun, Yuhui Sun, Yumeng Li, Xiuli Luan, Hui Chen, Haiying Wu, Bo Peng, Chunxue Lu
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SP1/TGF‑β1/SMAD2 pathway is involved in angiogenesis during osteogenesis

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Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

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Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway

Yejing Chai, Kangsheng Zhu, Chao Li, Xiaofan Wang, Junmei Shen, Fangfang Yong, Huiqun Jia
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Integrative analysis of an lncRNA‑associated competing endogenous RNA network in human trabecular meshwork cells under oxidative stress

Ke Yao, Yixian Yu, Fei Li, Peiming Jin, Chaohua Deng, Hong Zhang
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MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer

Kai Li, Xiangrong Zhu, Xihua Chen, Xiongtie Wang
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Monocyte chemoattractant protein‑1 promotes the proliferation, migration and differentiation potential of fibroblast‑like synoviocytes via the PI3K/P38 cellular signaling pathway

Xiang Tong, Huangjian Zeng, Pengchen Gu, Kai Wang, Han Zhang, Xiangjin Lin
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Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion

Ning Cui, Hesheng Luo, Yu Zhao
Pages: 1633-1639
Published online on: 24 January 2020

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Schwann cell‑derived exosomes induce bone marrow‑derived mesenchymal stem cells to express Schwann cell markers in vitro

Hui Wang, Yanjun Jia, Jiamou Li, Qingsong Liu
Pages: 1640-1646
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Identifying potential prognostic biomarkers in head and neck cancer based on the analysis of microRNA expression profiles in TCGA database

Xiaobin Wang, Zeli Yin, Yanyun Zhao, Miao He, Chengyong Dong, Ming Zhong
Pages: 1647-1657
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Resveratrol attenuates IL‑33‑induced mast cell inflammation associated with inhibition of NF‑κB activation and the P38 signaling pathway

Yundan Xu, Qiang Liu, Xiaohong Guo, Lei Xiang, Gang Zhao
Pages: 1658-1666
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Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279

Erin Conn, Sarah Hour, David Allegakoen, Garrett Graham, Jeff Petro, Marilyn Kouassi‑Brou, Sung Hyeok Hong, Saravana Selvanathan, Haydar Çelik, Jeffrey Toretsky, Aykut Üren
Pages: 1667-1675
Published online on: 16 January 2020

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

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Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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