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Article

Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade

  • Authors:
    • Shyh‑Ren Chiang
    • Chun‑Shiang Lin
    • Hui‑Han Lin
    • Pei‑Chen Shieh
    • Shao‑Hsuan Kao
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chi Mei Medical Center, Tainan 710, Taiwan, R.O.C., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan, R.O.C., Surgical Department, Cardiovascular Division, China Medical University Hospital, Taichung 402, Taiwan, R.O.C.
  • Pages: 1972-1978
    |
    Published online on: January 2, 2019
       https://doi.org/10.3892/mmr.2019.9810
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Abstract

The principal subtype of lung cancer, non‑small cell lung cancer (NSCLC) is a life‑threatening malignancy that causes high mortality rates. Bergapten (5‑methoxypsoralen) has been identified to possess anticancer activity against a number of carcinomas. In the present study, the effects of bergapten on NSCLC cells were investigated. The cell viability was determined by MTT assay. Cell cycle distribution was analyzed using flow cytometry. Protein expression and kinase cascade were demonstrated using western blot analysis. The results demonstrated that treatment with bergapten (50 µM for 48 h) inhibited the viability of A549 and NCI‑H460 NSCLC cells to 79.1±2.8% and 74.5±3.1%, respectively, compared with the controls. It was identified that bergapten induced G1 phase accumulation in A549 and NCI‑H460 cells between ~58 and 75% (P<0.01). In addition, bergapten significantly increased the sub‑G1 phase ratio to ~9% (P<0.05) in the two cell types. Further investigation demonstrated that bergapten upregulated the expression of cellular tumor antigen p53 (p53) and its downstream proteins cyclin‑dependent kinase inhibitor 1 and cyclin‑dependent kinase inhibitor 1B, whereas, it downregulated the expression of cyclin D1 and CDK4. Overall, these results suggested that bergapten may inhibit cell viability and trigger G1 arrest and apoptosis in A549 and NCI‑H460 cells, which may be attributed to the activation of p53‑mediated cascades. Therefore, bergapten may be beneficial for NSCLC treatment.
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1 

Reck M, Heigener DF, Mok T, Soria JC and Rabe KF: Management of non-small-cell lung cancer: Recent developments. Lancet. 382:709–719. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Heger Z, Polanska H, Krizkova S, Balvan J, Raudenska M, Dostalova S, Moulick A, Masarik M and Adam V: Co-delivery of VP-16 and Bcl-2-targeted antisense on PEG-grafted oMWCNTs for synergistic in vitro anti-cancer effects in non-small and small cell lung cancer. Colloids Surf B Biointerfaces. 150:131–140. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Richardson JS, Sethi G, Lee GS and Malek SN: Chalepin: Isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells. BMC Complement Altern Med. 16:3892016. View Article : Google Scholar : PubMed/NCBI

4 

Tricker EM, Xu C, Uddin S, Capelletti M, Ercan D, Ogino A, Pratilas CA, Rosen N, Gray NS, Wong KK and Jänne PA: Combined EGFR/MEK inhibition prevents the emergence of resistance in EGFR-mutant lung cancer. Cancer Discov. 5:960–971. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Janne PA, Yang JC, Kim DW, Planchard D, Ohe Y, Ramalingam SS, Ahn MJ, Kim SW, Su WC, Horn L, et al: AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 372:1689–1699. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Travis WD: Pathology of lung cancer. Clin Chest Med. 32:669–692. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Panno ML, Giordano F, Rizza P, Pellegrino M, Zito D, Giordano C, Mauro L, Catalano S, Aquila S, Sisci D, et al: Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination. Breast Cancer Res Treat. 136:443–455. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Xia W, Gooden D, Liu L, Zhao S, Soderblom EJ, Toone EJ, Beyer WF Jr, Walder H and Spector NL: Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. PLoS One. 9:e889832014. View Article : Google Scholar : PubMed/NCBI

9 

De Amicis F, Aquila S, Morelli C, Guido C, Santoro M, Perrotta I, Mauro L, Giordano F, Nigro A, Andò S and Panno ML: Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells. Mol Cancer. 14:1302015. View Article : Google Scholar : PubMed/NCBI

10 

Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W and Knight RA: Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ. 12 Suppl 2:S1463–S1467. 2005. View Article : Google Scholar

11 

Indran IR, Tufo G, Pervaiz S and Brenner C: Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochim Biophys Acta 1807. 735–745. 2011.

12 

Li J and Yuan J: Caspases in apoptosis and beyond. Oncogene. 27:6194–6206. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Lin CH, Lin HH, Kuo CY and Kao SH: Aeroallergen Der p 2 promotes motility of human non-small cell lung cancer cells via toll-like receptor-mediated up-regulation of urokinase-type plasminogen activator and integrin/focal adhesion kinase signaling. Oncotarget. 8:11316–11328. 2017.PubMed/NCBI

14 

Hansen MB, Nielsen SE and Berg K: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods. 119:203–210. 1989. View Article : Google Scholar : PubMed/NCBI

15 

Wang WC, Tsai JJ, Kuo CY, Chen HM and Kao SH: Non-proteolytic house dust mite allergen, Der p 2, upregulated expression of tight junction molecule claudin-2 associated with Akt/GSK-3β/β-catenin signaling pathway. J Cell Biochem. 112:1544–1551. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lin CH, Hong YC and Kao SH: Aeroallergen Der p 2 induces apoptosis of bronchial epithelial BEAS-2B cells via activation of both intrinsic and extrinsic pathway. Cell Biosci. 5:712015. View Article : Google Scholar : PubMed/NCBI

17 

Liu JD, Wang YJ, Chen CH, Yu CF, Chen LC, Lin JK, Liang YC, Lin SY and Ho YS: Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells. Mol Carcinog. 37:39–50. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Keane TE, Petros JA, Velimirovich B, Yue KT and Graham SD Jr: Methoxypsoralen phototherapy of transitional cell carcinoma. Urology. 44:842–846. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Wu JZ, Situ ZQ, Wang W, Chen JY and Liu B: Antitumor activity of psoralen on mucoepidermoid carcinoma cell line MEC-1. Chin Med J (Engl). 105:913–917. 1992.PubMed/NCBI

20 

Lee YM, Wu TH, Chen SF and Chung JG: Effect of 5-methoxypsoralen (5-MOP) on cell apoptosis and cell cycle in human hepatocellular carcinoma cell line. Toxicol In Vitro. 17:279–287. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Sun SY, Yue P, Wu GS, El-Deiry WS, Shroot B, Hong WK and Lotan R: Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells. Cancer Res. 59:2829–2833. 1999.PubMed/NCBI

22 

Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science. 253:49–53. 1991. View Article : Google Scholar : PubMed/NCBI

23 

Tang D, Yue L, Yao R, Zhou L, Yang Y, Lu L and Gao W: P53 prevent tumor invasion and metastasis by down-regulating IDO in lung cancer. Oncotarget. 8:54548–54557. 2017.PubMed/NCBI

24 

Alaee M, Nool K and Pasdar M: Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β-catenin. Cancer Sci. 109:1876–1888. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Lu W, Cheng F, Yan W, Li X, Yao X, Song W, Liu M, Shen X, Jiang H, Chen J, et al: Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 36:4719–4731. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Janssen A and Medema RH: Mitosis as an anti-cancer target. Oncogene. 30:2799–2809. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Abukhdeir AM and Park BH: p21 and p27: Roles in carcinogenesis and drug resistance. Expert Rev Mol Med. 10:e192008. View Article : Google Scholar : PubMed/NCBI

28 

Valesky EM, Hrgovic I, Doll M, Wang XF, Pinter A, Kleemann J, Kaufmann R, Kippenberger S and Meissner M: Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest. Exp Dermatol. 25:200–205. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Z, Wang H, Li M, Agrawal S, Chen X and Zhang R: MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem. 279:16000–16006. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Hiyama H, Iavarone A, LaBaer J and Reeves SA: Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression. Oncogene. 14:2533–2542. 1997. View Article : Google Scholar : PubMed/NCBI

31 

LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A and Harlow E: New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847–862. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Lee HL, Lin CS, Kao SH and Chou MC: Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis. Anticancer Drugs. 28:1150–1156. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Chen SY, Lin CH, Lin JT, Cheng YF, Chen HM and Kao SH: Adenine causes cell cycle arrest and autophagy of chronic myelogenous leukemia K562 cells via AMP-activated protein kinase signaling. Oncol Lett. 14:5575–5580. 2017.PubMed/NCBI

34 

Huang WS, Kuo HY, Kuo HC, Hsieh MC, Huang CY, Lee KC, Lee KF, Shen CH, Tung SY and Teng CC: CIL-102-induced cell cycle arrest and apoptosis in colorectal cancer cells via upregulation of p21 and GADD45. PLoS One. 12:e01689892017. View Article : Google Scholar : PubMed/NCBI

35 

Evan GI, Brown L, Whyte M and Harrington E: Apoptosis and the cell cycle. Curr Opin Cell Biol. 7:825–834. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther. 1:639–649. 2002.PubMed/NCBI

37 

Kang KH, Kim WH and Choi KH: p21 promotes ceramide-induced apoptosis and antagonizes the antideath effect of Bcl-2 in human hepatocarcinoma cells. Exp Cell Res. 253:403–412. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Greco F and Vicent MJ: Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. Adv Drug Deliv Rev. 61:1203–1213. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Morth C and Valachis A: Single-agent versus combination chemotherapy as first-line treatment for patients with advanced non-small cell lung cancer and performance status 2: A literature-based meta-analysis of randomized studies. Lung Cancer. 84:209–214. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Masters GA, Temin S, Azzoli CG, Giaccone G, Baker S Jr, Brahmer JR, Ellis PM, Gajra A, Rackear N, Schiller JH, et al: Systemic therapy for stage IV non-small-cell lung cancer: American society of clinical oncology clinical practice guideline update. J Clin Oncol. 33:3488–3515. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chiang SR, Lin CS, Lin HH, Shieh PC and Kao SH: Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade. Mol Med Rep 19: 1972-1978, 2019.
APA
Chiang, S., Lin, C., Lin, H., Shieh, P., & Kao, S. (2019). Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade. Molecular Medicine Reports, 19, 1972-1978. https://doi.org/10.3892/mmr.2019.9810
MLA
Chiang, S., Lin, C., Lin, H., Shieh, P., Kao, S."Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade". Molecular Medicine Reports 19.3 (2019): 1972-1978.
Chicago
Chiang, S., Lin, C., Lin, H., Shieh, P., Kao, S."Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade". Molecular Medicine Reports 19, no. 3 (2019): 1972-1978. https://doi.org/10.3892/mmr.2019.9810
Copy and paste a formatted citation
x
Spandidos Publications style
Chiang SR, Lin CS, Lin HH, Shieh PC and Kao SH: Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade. Mol Med Rep 19: 1972-1978, 2019.
APA
Chiang, S., Lin, C., Lin, H., Shieh, P., & Kao, S. (2019). Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade. Molecular Medicine Reports, 19, 1972-1978. https://doi.org/10.3892/mmr.2019.9810
MLA
Chiang, S., Lin, C., Lin, H., Shieh, P., Kao, S."Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade". Molecular Medicine Reports 19.3 (2019): 1972-1978.
Chicago
Chiang, S., Lin, C., Lin, H., Shieh, P., Kao, S."Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade". Molecular Medicine Reports 19, no. 3 (2019): 1972-1978. https://doi.org/10.3892/mmr.2019.9810
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