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Article

Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine

  • Authors:
    • Zhicao Zhang
    • Aimin Pu
    • Min Yu
    • Weidong Xiao
    • Lihua Sun
    • Yujiao Cai
    • Hua Yang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China
  • Pages: 1840-1848
    |
    Published online on: January 4, 2019
       https://doi.org/10.3892/mmr.2019.9823
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Abstract

The pathogenesis of intestinal ischemia/reperfusion (I/R) is associated with dysregulation of the intestinal immune system. The aryl hydrocarbon receptor (AhR), a receptor expressed in gamma‑delta (γδ) intraepithelial lymphocytes (IELs), is thought to regulate inflammation in the bowel. γδIELs are a key immunologic compartment with a capacity to modulate immune responses. In the present study, the function of the AhR in γδIELs in a mouse model of intestinal I/R injury was investigated to determine whether the AhR attenuates intestinal injury induced by intestinal I/R. Mice were assigned to three groups: sham, I/R and I/R+6‑formylindolo(3,2‑b)carbazole (FICZ). The sham group received no ischemia treatment, whereas the I/R and I/R+FICZ groups underwent upper mesenteric vessel ischemia for 30 min. The I/R group was injected intraperitoneally with 0.3 ml saline and the I/R+FICZ group was administered 1 µg of FICZ before a subsequent 6 h reperfusion. Then, the mice were sacrificed and the entire small intestinal tissues were collected for histologic examination. The phenotype and apoptosis of γδIELs and activation of CD4+ and CD8+ IELs were examined using flow cytometry. The cytokine mRNA and anti‑apoptosis gene expression in IELs were measured by qPCR. FICZ increased the γδIEL population and anti‑apoptosis genes in the γδIELs. FICZ reduced the percentage of activated CD4+ and CD8+ subpopulations and the expression of pro‑inflammatory mediator genes in IELs. FICZ inhibited inflammation in the gastrointestinal tract of mice with I/R injury. These results suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.
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1 

Gennaro M, Ascer E, Matano R, Jacobowitz IJ, Cunningham JN Jr and Uceda P: Acute mesenteric ischemia after cardiopulmonary bypass. Am J Surg. 166:231–236. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Guan YF, Pritts TA and Montrose MH: Ischemic post-conditioning to counteract intestinal ischemia/reperfusion injury. World J Gastrointest Pathophysiol. 1:137–143. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Nguyen LP and Bradfield CA: The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol. 21:102–116. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Kewley RJ, Whitelaw ML and Chapman-Smith A: The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Boil. 36:189–204. 2004. View Article : Google Scholar

5 

Schrenk D: Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics. Biochem Pharmacol. 55:1155–1162. 1998.PubMed/NCBI

6 

Esser C: Biology and function of the aryl hydrocarbon receptor: Report of an international and interdisciplinary conference. Arch Toxicol. 86:1323–1329. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Lahoti TS, Boyer JA, Kusnadi A, Muku GE, Murray IA and Perdew GH: Aryl hydrocarbon receptor activation synergistically induces lipopolysaccharide-mediated expression of proinflammatory chemokine (c-c motif) ligand 20. Toxicol Sci. 148:229–240. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Gras D, Chanez P, Vachier I, Petit A and Bourdin A: Bronchial epithelium as a target for innovative treatments in asthma. Pharmacol Ther. 140:290–305. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Zimmerman BJ and Granger DN: Mechanisms of reperfusion injury. Am J Med Sci. 307:284–292. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Mallick IH, Yang W, Winslet MC and Seifalian AM: Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci. 49:1359–1377. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Ye Y, Yue M, Jin X, Chen S and Li Y: Isolation of murine small intestinal intraepithelial gammadeltat cells. Immunol Invest. 39:661–673. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kuhl AA, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M and Hoffmann JC: Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Boil. 81:168–175. 2007. View Article : Google Scholar

13 

Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y and Yoshimura A: Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol. 173:1390–1398. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Yang H, Antony PA, Wildhaber BE and Teitelbaum DH: Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol. 172:4151–4158. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Ismail AS, Behrendt CL and Hooper LV: Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury. J Immunol. 182:3047–3054. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Qiu Y, Yu M, Yang Y, Sheng H, Wang W, Sun L, Chen G, Liu Y, Xiao W and Yang H: Disturbance of intraepithelial lymphocytes in a murine model of acute intestinal ischemia/reperfusion. J Mol Histol. 45:217–227. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ji T, Xu C, Sun L, Yu M, Peng K, Qiu Y, Xiao W and Yang H: Aryl hydrocarbon receptor activation down-regulates IL-7 and reduces inflammation in a mouse model of DSS-induced colitis. Dig Dis Sci. 60:1958–1966. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, Grigorieva EF, Wilhelm C and Veldhoen M: Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell. 147:629–640. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–8. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Vajdovich P: Free radicals and antioxidants in inflammatory processes and ischemia-reperfusion injury. Vet Clin North Am Small Anim Pract. 38:31–123. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Edrees WK, Lau LL, Young IS, Smye MG, Gardiner KR, Lee B, Hannon RJ and Soong CV: The effect of lower limb ischaemia-reperfusion on intestinal permeability and the systemic inflammatory response. Eur J Vasc Endovasc Surg. 25:330–335. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, et al: Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 300:G853–G861. 2001. View Article : Google Scholar

23 

Vidali F, Di Sabatino A, Broglia F, Cazzola P, Biancheri P, Viera FT, Vanoli A, Alvisi C, Perego M and Corazza GR: Increased CD8+ intraepithelial lymphocyte infiltration and reduced surface area to volume ratio in the duodenum of patients with ulcerative colitis. Scand J Gastroenterol. 45:684–689. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Lindsey WB, Lowdell MW, Marti GE, Abbasi F, Zenger V, King KM and Lamb LS Jr: CD69 expression as an index of T-cell function: Assay standardization, validation and use in monitoring immune recovery. Cytotherapy. 9:123–132. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Montufar-Solis D, Garza T and Klein JR: T-cell activation in the intestinal mucosa. Immunol Rev. 215:189–201. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Ekong UD, Luo X, Yu M, Wang D, Miller SD and O'Gorman MR: Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. Hum Immunol. 72:392–397. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Boismenu R and Havran WL: Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science. 266:1253–1255. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Schluns KS and Lefrancois L: Cytokine control of memory T-cell development and survival. Nat Rev Immunol. 3:269–279. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki JI and Ikuta K: Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci USA. 93:7172–7177. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Cai YJ, Wang WS, Liang HY, Sun LH, Teitelbaum DH and Yang H: Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. Int J Clin Exp Pathol. 5:569–580. 2012.PubMed/NCBI

31 

Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P and Denning PW: Small intestinal intraepithelial TCRgammadelta+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis. PloS One. 9:e990422014. View Article : Google Scholar : PubMed/NCBI

32 

Haas E, Rutgen BC, Gerner W, Richter B, Tichy A, Galler A, Bilek A, Thalhammer JG, Saalmüller A and Luckschander-Zeller N: Phenotypic characterization of canine intestinal intraepithelial lymphocytes in dogs with inflammatory bowel disease. J Vet Intern Med. 28:1708–1715. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Lee WY, Hu YM, Ko TL, Yeh SL and Yeh CL: Glutamine modulates sepsis-induced changes to intestinal intraepithelial gammadeltaT lymphocyte expression in mice. Shock. 38:288–293. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Khoshnan A, Tindell C, Laux I, Bae D, Bennett B and Nel AE: The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes. J Immunol. 165:1743–1754. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Cai Y, Wang W, Liang H, Sun L, Teitelbaum DH and Yang H: Keratinocyte growth factor improves epithelial structure and function in a mouse model of intestinal ischemia/reperfusion. PloS One. 7:e447722012. View Article : Google Scholar : PubMed/NCBI

36 

Maretta M, Toth S, Bujdos M, Toth S Jr, Jonecova Z and Vesela J: Alterations of epithelial layer after ischemic preconditioning of small intestine in rats. J Mol Histol. 43:171–178. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Cerqueira NF, Hussni CA and Yoshida WB: Pathophysiology of mesenteric ischemia/reperfusion: A review. Acta Cir Bras. 20:336–343. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Pu A, Yu M, Xiao W, Sun L, Cai Y and Yang H: Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine. Mol Med Rep 19: 1840-1848, 2019.
APA
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., & Yang, H. (2019). Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine. Molecular Medicine Reports, 19, 1840-1848. https://doi.org/10.3892/mmr.2019.9823
MLA
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., Yang, H."Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine". Molecular Medicine Reports 19.3 (2019): 1840-1848.
Chicago
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., Yang, H."Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine". Molecular Medicine Reports 19, no. 3 (2019): 1840-1848. https://doi.org/10.3892/mmr.2019.9823
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Pu A, Yu M, Xiao W, Sun L, Cai Y and Yang H: Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine. Mol Med Rep 19: 1840-1848, 2019.
APA
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., & Yang, H. (2019). Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine. Molecular Medicine Reports, 19, 1840-1848. https://doi.org/10.3892/mmr.2019.9823
MLA
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., Yang, H."Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine". Molecular Medicine Reports 19.3 (2019): 1840-1848.
Chicago
Zhang, Z., Pu, A., Yu, M., Xiao, W., Sun, L., Cai, Y., Yang, H."Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine". Molecular Medicine Reports 19, no. 3 (2019): 1840-1848. https://doi.org/10.3892/mmr.2019.9823
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