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Article

Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism

  • Authors:
    • Liping Huang
    • Mingqin Lin
    • Xiaoqin Zhong
    • Hongyan Yang
    • Minzhen Deng
  • View Affiliations / Copyright

    Affiliations: School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang, Guangdong 524048, P.R. China, College of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, P.R. China, Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 1767-1774
    |
    Published online on: January 4, 2019
       https://doi.org/10.3892/mmr.2019.9824
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Abstract

Okadaic acid (OA)‑induced neurotoxicity may be considered a novel tool used to study Alzheimer's disease (AD) pathology, and may be helpful in the development of a novel therapeutic approach. It has been reported that galangin inhibits β‑site amyloid precursor protein‑cleaving enzyme 1 expression, which is a key enzyme for amyloid β (Aβ) generation and is a potential drug candidate for AD therapy. However, further studies are required to confirm its neuroprotective effects in other AD models. The present study aimed to explore the neuroprotective effects of galangin on OA‑induced neurotoxicity in PC12 cells. The cells were divided into the following groups: Control group, model group (175 nM OA for 48 h) and galangin groups (0.25, 0.5 and 1 µg/ml). Beclin‑1, phosphorylated (p)‑protein kinase B (Akt), p‑glycogen synthase kinase (GSK)3β and p‑mechanistic target of rapamycin (mTOR) expression was also measured in the following PC12 cell groups: Control group, model group, 3‑methyladenine group (5 nM), rapamycin group (100 nM) and galangin group (1 µg/ml). The levels of β‑secretase, Aβ42 and p‑tau were detected by ELISA, Beclin‑1 expression was examined by immunohistochemistry and the protein expression levels of p‑Akt, p‑mTOR p‑GSK3β, and Beclin‑1 were detected by western blotting. Galangin treatment enhanced cell viability in cells treated with OA, and decreased β‑secretase, Aβ42 and p‑tau levels. In addition, it suppressed Beclin‑1 and p‑GSK3β expression, but promoted p‑Akt and p‑mTOR expression by regulating the Akt/GSK3β/mTOR pathway. These results indicated that galangin protected PC12 cells from OA‑induced cytotoxicity and inhibited autophagy via the Akt/GSK3β/mTOR pathway, thus suggesting that it may be considered a potential therapeutic agent for AD.
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1 

Swomley AM, Förster S, Keeney JT, Triplett J, Zhang Z, Sultana R and Butterfield DA: Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies. Biochim Biophys Acta 1842. 1248–1257. 2014.

2 

Guerreiro RJ, Gustafson DR and Hardy J: The genetic architecture of Alzheimer's disease: Beyond APP, PSENs and APOE. Neurobiol Aging. 33:437–456. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Yen CH, Wang CH, Wu WT and Chen HL: Fructo-oligosaccharide improved brain β-amyloid, β-secretase, cognitive function, and plasma antioxidant levels in D-galactose-treated Balb/cJ mice. Nutr Neurosci. 20:228–237. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Wolfe MS: Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease. Biol Chem. 393:899–905. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Imbimbo BP and Giardina GA: γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: Disappointments and hopes. Curr Top Med Chem. 11:1555–1570. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wang X, Gong G, Yang W, Li Y, Jiang M and Li L: Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. Environ Toxicol Pharmacol. 36:288–295. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Huh JE, Jung IT, Choi J, Baek YH, Lee JD, Park DS and Choi DY: The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. Eur J Pharmacol. 698:57–66. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zeng H, Huang P, Wang X, Wu J, Wu M and Huang J: Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. Neuroscience. 294:172–181. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Penke B, Bogár F and Fülöp L: Protein folding and misfolding, endoplasmic reticulum stress in neurodegenerative diseases: In trace of novel drug targets. Curr Protein Pept Sci. 17:169–182. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Viola KL and Klein WL: Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol. 129:183–206. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Guo JL and Lee VM: Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem. 286:15317–15331. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B and Wyss-Coray T: The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest. 118:2190–2199. 2008.PubMed/NCBI

13 

Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR and Yuan J: Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci USA. 107:14164–14169. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Kamat PK and Nath C: Okadaic acid: A tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer's disease. Neural Regen Res. 10:365–367. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Li Q, Liu Y and Sun M: Autophagy and Alzheimer's disease. Cell Mol Neurobiol. 37:377–388. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H and Hiltunen M: Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol. 106-107:33–54. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Li RC, Pouranfar F, Lee SK, Morris MW, Wang Y and Gozal D: Neuroglobin protects PC12 cells against beta-amyloid-induced cell injury. Neurobiol Aging. 29:1815–1822. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, McMillan-Ward E, Kong J, Israels SJ and Gibson SB: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 15:171–182. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Wang H, Ma J, Tan Y, Wang Z, Sheng C, Chen S and Ding J: Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells. J Alzheimers Dis. 21:597–610. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V and Nixon RA: Abeta localization in abnormal endosomes: Association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging. 25:1263–1272. 2004. View Article : Google Scholar : PubMed/NCBI

21 

LaFerla FM, Green KN and Oddo S: Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci. 8:499–509. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Choy RW, Cheng Z and Schekman R: Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network. Proc Natl Acad Sci USA. 109:E2077–E2082. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Omata Y, Lim YM, Akao Y and Tsuda L: Age-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer's disease. Am J Neurodegener Dis. 3:134–142. 2014.PubMed/NCBI

24 

Kim YD, Jeong EI, Nah J, Yoo SM, Lee WJ, Kim Y, Moon S, Hong SH and Jung YK: Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate-activated protein kinase-mediated autophagy. J Neurochem. 142:734–746. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Cakir M, Duzova H, Tekin S, Taslıdere E, Kaya GB, Cigremis Y, Ozgocer T and Yologlu S: ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats. Life Sci. 176:10–20. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Wu X, Kosaraju J and Tam KY: SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells. Eur J Pharm Sci. 110:101–108. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Zhang J, Cheng Y and Zhang JT: Protective effect of (−) clausenamide against neurotoxicity induced by okadaic acid and beta-amyloid peptide25-3. Yao Xue Xue Bao. 42:935–942. 2007.(In Chinese). PubMed/NCBI

28 

Kamat PK, Rai S and Nath C: Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology. Neurotoxicology. 37:163–172. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhao XJ, Gong DM, Jiang YR, Guo D, Zhu Y and Deng YC: Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates. Eur J Med Chem. 138:738–747. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Yang CC, Kuai XX, Gao WB, Yu JC, Wang Q, Li L and Zhang L: Morroniside-induced PP2A activation antagonizes Tau hyperphosphorylation in a cellular model of neurodegeneration. J Alzheimers Dis. 51:33–44. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Aminyavari S, Zahmatkesh M, Farahmandfar M, Khodagholi F, Dargahi L and Zarrindast MR: Protective role of Apelin-13 on amyloid β25-35-induced memory deficit; Involvement of autophagy and apoptosis process. Prog Neuropsychopharmacol Biol Psychiatry. 89:322–334. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Yu J, Lan L, Lewin SJ, Rogers SA, Roy A, Wu X, Gao P, Karanicolas J, Aubé J, Sun B and Xu L: Identification of novel small molecule Beclin 1 mimetics activating autophagy. Oncotarget. 8:51355–51369. 2017.PubMed/NCBI

33 

Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E and Wyss-Coray T: Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One. 5:e111022010. View Article : Google Scholar : PubMed/NCBI

34 

Hotfilder M, Sondermann P, Senss A, van Valen F, Jürgens H and Vormoor J: PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death. Br J Cancer. 92:705–710. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Du C, Zhang T, Xiao X, Shi Y, Duan H and Ren Y: Protease-Activated Receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway. Biochem J. 474:2733–2747. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Ma T, Tzavaras N, Tsokas P, Landau EM and Blitzer RD: Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci. 31:17537–17546. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Yang S, Chen Z, Cao M, Li R, Wang Z and Zhang M: Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation. Mol Med Rep. 15:2588–2594. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang L, Lin M, Zhong X, Yang H and Deng M: Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism. Mol Med Rep 19: 1767-1774, 2019.
APA
Huang, L., Lin, M., Zhong, X., Yang, H., & Deng, M. (2019). Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism. Molecular Medicine Reports, 19, 1767-1774. https://doi.org/10.3892/mmr.2019.9824
MLA
Huang, L., Lin, M., Zhong, X., Yang, H., Deng, M."Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism". Molecular Medicine Reports 19.3 (2019): 1767-1774.
Chicago
Huang, L., Lin, M., Zhong, X., Yang, H., Deng, M."Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism". Molecular Medicine Reports 19, no. 3 (2019): 1767-1774. https://doi.org/10.3892/mmr.2019.9824
Copy and paste a formatted citation
x
Spandidos Publications style
Huang L, Lin M, Zhong X, Yang H and Deng M: Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism. Mol Med Rep 19: 1767-1774, 2019.
APA
Huang, L., Lin, M., Zhong, X., Yang, H., & Deng, M. (2019). Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism. Molecular Medicine Reports, 19, 1767-1774. https://doi.org/10.3892/mmr.2019.9824
MLA
Huang, L., Lin, M., Zhong, X., Yang, H., Deng, M."Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism". Molecular Medicine Reports 19.3 (2019): 1767-1774.
Chicago
Huang, L., Lin, M., Zhong, X., Yang, H., Deng, M."Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism". Molecular Medicine Reports 19, no. 3 (2019): 1767-1774. https://doi.org/10.3892/mmr.2019.9824
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