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Review

Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)

  • Authors:
    • Emmanuele Venanzi Rullo
    • Manuela Ceccarelli
    • Fabrizio Condorelli
    • Alessio Facciolà
    • Giuseppa Visalli
    • Francesco D'Aleo
    • Ivana Paolucci
    • Bruno Cacopardo
    • Marilia Rita Pinzone
    • Michele Di Rosa
    • Giuseppe Nunnari
    • Giovanni F. Pellicanò
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I-90124 Messina, Italy, Department of Pharmacological Sciences, University of Eastern Piedmont ‘A. Avogadro’, I-13100 Novara, Italy, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, I-90124 Messina, Italy, Department of Clinical and Experimental Medicine, University of Catania, I-95123 Catania, Italy, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA, Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, University of Catania, I-95123 Catania, Italy, Department of Human Pathology of the Adult and the Developmental Age ‘G. Barresi’, Unit of Infectious Diseases, University of Messina, I-98122 Messina, Italy
  • Pages: 1987-1995
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    Published online on: January 10, 2019
       https://doi.org/10.3892/mmr.2019.9840
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Abstract

Despite the profound changes and improvements reached in the field of HIV treatment, tolerability and adherence to highly active antiretroviral therapy remains a challenge. Furthermore, multi-experienced patients could take advantage of drugs with different mechanisms of action to combat the spread of resistance to actual therapy. For these reasons identification of new HIV drugs is crucial. Among all the molecules that at present are under investigation, entry and fusion inhibitors pose an interesting class owing to their peculiar characteristics, including prevention of entry of the virus into the human cells. In this study, we reviewed articles, clinical trials, and conference communications about all the drugs under investigation belonging to the class of entry and fusion inhibitors that are at least in phase I clinical trials.
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Copy and paste a formatted citation
Spandidos Publications style
Venanzi Rullo E, Ceccarelli M, Condorelli F, Facciolà A, Visalli G, D'Aleo F, Paolucci I, Cacopardo B, Pinzone MR, Di Rosa M, Di Rosa M, et al: Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Mol Med Rep 19: 1987-1995, 2019.
APA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F. ... Pellicanò, G.F. (2019). Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Molecular Medicine Reports, 19, 1987-1995. https://doi.org/10.3892/mmr.2019.9840
MLA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19.3 (2019): 1987-1995.
Chicago
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19, no. 3 (2019): 1987-1995. https://doi.org/10.3892/mmr.2019.9840
Copy and paste a formatted citation
x
Spandidos Publications style
Venanzi Rullo E, Ceccarelli M, Condorelli F, Facciolà A, Visalli G, D'Aleo F, Paolucci I, Cacopardo B, Pinzone MR, Di Rosa M, Di Rosa M, et al: Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Mol Med Rep 19: 1987-1995, 2019.
APA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F. ... Pellicanò, G.F. (2019). Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Molecular Medicine Reports, 19, 1987-1995. https://doi.org/10.3892/mmr.2019.9840
MLA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19.3 (2019): 1987-1995.
Chicago
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19, no. 3 (2019): 1987-1995. https://doi.org/10.3892/mmr.2019.9840
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