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Article Open Access

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain

Corrigendum in: /10.3892/mmr.2022.12746
  • Authors:
    • Qingfu Deng
    • Li Luo
    • Zhen Quan
    • Nanjing Liu
    • Zhongbo Du
    • Wei Sun
    • Chunli Luo
    • Xiaohou Wu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, P.R. China, Key Laboratory of Diagnostics Medicine Designated by The Ministry of Education, Chongqing Medical University, Chongqing 400042, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2115-2124
    |
    Published online on: January 10, 2019
       https://doi.org/10.3892/mmr.2019.9841
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Abstract

Hepatocyte cell adhesion molecule (HepaCAM) is a tumour suppressor. However, the mechanism of HepaCAM function in prostate cancer (PCa) remains unknown. In the present study, HepaCAM, androgen receptor (AR) and Ran were analysed in 46 PCa tissue samples using immunohistochemistry. Subsequently, the influence of HepaCAM and its cytoplasmic domain on cell proliferation, migration, and invasion, and associated proteins was examined using MTT, wound healing, Transwell and western blotting assays, respectively. Furthermore, nuclear translocation of AR and Ran was analysed using immunofluorescence and Western blot assays. The results demonstrated that HepaCAM expression was reduced in PCa, and there was an association between downregulation of HepaCAM and changes in the distribution of AR and Ran. Furthermore, HepaCAM, specifically the cytoplasmic domain, was involved in cell proliferation, migration and invasion. Nuclear translocation of AR was dependent on HepaCAM and its cytoplasmic domain. Additionally, HepaCAM suppression of the nuclear translocation of AR occurred via Ran. The results suggest that HepaCAM and its cytoplasmic domain suppress the nuclear translocation of AR via Ran in PCa. The cytoplasmic domain of HepaCAM may serve as a novel target for therapy in PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Deng Q, Luo L, Quan Z, Liu N, Du Z, Sun W, Luo C and Wu X: HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746. Mol Med Rep 19: 2115-2124, 2019.
APA
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W. ... Wu, X. (2019). HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746. Molecular Medicine Reports, 19, 2115-2124. https://doi.org/10.3892/mmr.2019.9841
MLA
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W., Luo, C., Wu, X."HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746". Molecular Medicine Reports 19.3 (2019): 2115-2124.
Chicago
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W., Luo, C., Wu, X."HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746". Molecular Medicine Reports 19, no. 3 (2019): 2115-2124. https://doi.org/10.3892/mmr.2019.9841
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Q, Luo L, Quan Z, Liu N, Du Z, Sun W, Luo C and Wu X: HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746. Mol Med Rep 19: 2115-2124, 2019.
APA
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W. ... Wu, X. (2019). HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746. Molecular Medicine Reports, 19, 2115-2124. https://doi.org/10.3892/mmr.2019.9841
MLA
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W., Luo, C., Wu, X."HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746". Molecular Medicine Reports 19.3 (2019): 2115-2124.
Chicago
Deng, Q., Luo, L., Quan, Z., Liu, N., Du, Z., Sun, W., Luo, C., Wu, X."HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain Corrigendum in /10.3892/mmr.2022.12746". Molecular Medicine Reports 19, no. 3 (2019): 2115-2124. https://doi.org/10.3892/mmr.2019.9841
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