Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2019 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 19 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

  • Authors:
    • Xiu‑Hua Xu
    • Lian‑Cui Kou
    • Hai‑Mei Wang
    • Chun‑Mei Bo
    • Xiao‑Cui Song
  • View Affiliations / Copyright

    Affiliations: Obstetrics and Gynecology Clinic, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Blood Rheumatism, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Marketing and Customer Service, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Reproductive Medicine, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2220-2230
    |
    Published online on: January 17, 2019
       https://doi.org/10.3892/mmr.2019.9872
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Polycystic ovary syndrome (PCOS) is a condition in which a woman's levels of the sex hormones (estrogen and progesterone) are out of balance, leading to the growth of ovarian cysts. PCOS can affect the menstrual cycle, fertility, cardiac function and even appearance of women. Therefore, we aimed to explore the genetic polymorphism of the melatonin receptors 1A and 1B in obese patients with PCOS to identify a new theoretical basis for its treatment. Patients presenting with PCOS (n=359) were enrolled and classified into an obese OB‑PCOS group [body mass index (BMI) of PCOS patients ≥25 kg/m2] or a nonobese NOB‑PCOS group, and 215 oviduct infertile patients who experienced normal ovulation were used as the control group. All baseline characteristics, endocrine hormone levels, lipid and glucose metabolism, and insulin indices were measured. The genotypes of rs2119882 within the MTNR1A gene and of rs10830963 within the MTNR1B gene were determined by PCR‑RFLP; the genotype frequency and the difference in the distribution of allele frequency were compared. For rs2119882, C allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS, and C allele carriers with PCOS had an increased risk of developing OB‑PCOS. For rs10830963, G allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS. The TT genotype in rs2119882 and the CC genotype in rs10830963 were protective factors for OB‑PCOS, and increased levels of LH, testosterone, and estradiol and abnormal menstruation were key risk factors for PCOS. Furthermore, the TT genotype at the rs2119882 site was the key protective factor for OB‑PCOS patients. Our study found that MTNR1A rs2119882 and MTNR1B rs10830963 could increase the risk for PCOS and cause glycolipid metabolism disorder in PCOS patients.
View Figures

Figure 1

Figure 2

View References

1 

Swaroop A, Jaipuriar AS, Gupta SK, Bagchi M, Kumar P, Preuss HG and Bagchi D: Efficacy of a novel fenugreek seed extract (Trigonella foenum-graecum, Furocyst) in polycystic ovary syndrome (PCOS). Int J Med Sci. 12:825–831. 2015. View Article : Google Scholar : PubMed/NCBI

2 

March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ and Davies MJ: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 25:544–551. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Goodarzi MO, Dumesic DA, Chazenbalk G and Azziz R: Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 7:219–231. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Stener-Victorin E, Holm G, Janson PO, Gustafson D and Waern M: Acupuncture and physical exercise for affective symptoms and health-related quality of life in polycystic ovary syndrome: Secondary analysis from a randomized controlled trial. BMC Complement Altern Med. 13:1312013. View Article : Google Scholar : PubMed/NCBI

5 

Costello MF, Misso ML, Wong J, Hart R, Rombauts L, Melder A, Norman RJ and Teede HJ: The treatment of infertility in polycystic ovary syndrome: A brief update. Aust N Z J Obstet Gynaecol. 52:400–403. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wehr E, Pieber TR and Obermayer-Pietsch B: Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: A pilot study. J Endocrinol Invest. 34:757–763. 2011.PubMed/NCBI

7 

Gourgari E, Spanakis E and Dobs AS: Pathophysiology, risk factors, and screening methods for prediabetes in women with polycystic ovary syndrome. Int J Womens Health. 8:381–387. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Li C, Shi Y, You L, Wang L and Chen ZJ: Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome. Gynecol Obstet Invest. 72:130–134. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM and Pandi-Perumal SR: Melatonin-a pleiotropic, orchestrating regulator molecule. Prog Neurobiol. 93:350–384. 2011. View Article : Google Scholar : PubMed/NCBI

10 

McClay DR: Evolutionary crossroads in developmental biology: Sea urchins. Development. 138:2639–2648. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Carcangiu V, Luridiana S, Vacca GM, Daga C and Mura MC: A polymorphism at the melatonin receptor 1A (MTNR1A) gene in Sarda ewes affects fertility after AI in the spring. Reprod Fertil Dev. 23:376–380. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Tobias DK, Gaskins AJ, Missmer SA, Hu FB, Manson JE, Buck Louis GM, Zhang C and Chavarro JE: History of infertility and risk of type 2 diabetes mellitus: A prospective cohort study. Diabetologia. 58:707–715. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Ren T, Zhu Y and Kan J: Zanthoxylum alkylamides activate phosphorylated AMPK and ameliorate glycolipid metabolism in the streptozotocin-induced diabetic rats. Clin Exp Hypertens. 39:330–338. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, et al: Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 41:82–88. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS and Slominski AT: Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol. 351:152–166. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Slominski AT, Zmijewski MA, Semak I, Kim TK, Janjetovic Z, Slominski RM and Zmijewski JW: Melatonin, mitochondria, and the skin. Cell Mol Life Sci. 74:3913–3925. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Ying X, Qian Y, Jiang Y, Jiang Z, Song Z and Zhao C: Association of the apolipoprotein B/apolipoprotein A-I ratio and low-density lipoprotein cholesterol with insulin resistance in a Chinese population with abdominal obesity. Acta Diabetol. 49:465–472. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Chin R and Miyazaki S: Criteria of obesity and obesity disease in Japan. Nihon Rinsho. 67:297–300. 2009.(In Japanese). PubMed/NCBI

19 

Ferriman D and Gallwey JD: Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 21:1440–1447. 1961. View Article : Google Scholar : PubMed/NCBI

20 

Lucky AW, McGuire J, Rosenfield RL, Lucky PA and Rich BH: Plasma androgens in women with acne vulgaris. J Invest Dermatol. 81:70–74. 1983. View Article : Google Scholar : PubMed/NCBI

21 

Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, Renn W and Gerich J: Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 23:295–301. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Abbasi F, Blasey C, Feldman D, Caulfield MP, Hantash FM and Reaven GM: Low circulating 25-hydroxyvitamin D concentrations are associated with defects in insulin action and insulin secretion in persons with prediabetes. J Nutr. 145:714–719. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Macut D, Bjekić-Macut J, Rahelić D and Doknić M: Insulin and the polycystic ovary syndrome. Diabetes Res Clin Pract. 130:163–170. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Genazzani AR and Genazzani AD: Polycystic ovary syndrome: From contraception to hormone replacement therapy. Front Gynecol Endocrinol. Springer International Publishing. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Wu D, Kimura F, Takashima A, Shimizu Y, Takebayashi A, Kita N, Zhang G and Murakami T: Intake of vinegar beverage is associated with restoration of ovulatory function in women with polycystic ovary syndrome. Tohoku J Exp Med. 230:17–23. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Costello M, Shrestha B, Eden J, Sjoblom P and Johnson N: Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev. CD0055522007.PubMed/NCBI

27 

Esmaeilzadeh S, Andarieh MG, Ghadimi R and Delavar MA: Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome. Glob J Health Sci. 7:101–106. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ramezanali F, Khalili G, Arabipoor A, Bagheri Lankarani N and Moini A: Relationships between serum luteinizing hormone level, endometrial thickness and body mass index in polycystic ovary syndrome patients with and without endometrial hyperplasia. Int J Fertil Steril. 10:36–41. 2016.PubMed/NCBI

29 

Kawwass JF, Sanders KM, Loucks TL, Rohan LC and Berga SL: Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome. Hum Reprod. 32:1450–1456. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Njelekela MA, Negishi H, Nara Y, Sato T, Tomohiro M, Kuga S, Noguchi T, Kanda T, Yamori M, Mashalla Y, et al: Obesity and lipid profiles in middle aged men and women in Tanzania. East Afr Med J. 79:58–64. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Kalani Z, Salimi T and Rafiei M: Comparison of obesity indexes BMI WHR and WC in association with Hypertension: Results from a blood pressure status survey in Iran. J Cardiovasc Dis Res. 6:72–77. 2015. View Article : Google Scholar

32 

Zaki M, Kholoussi S, Ismail S, Raouf HA, Helwa I, Hassan N, Youness E, Mohamed NA, Kamal S, Yousef W, et al: Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ, gene variants and body fat phenotype. Egypt J Med Hum Genet. 16:367–374. 2015. View Article : Google Scholar

33 

Jaworek J, Nawrot-Porabka K, Leja-Szpak A, Bonior J, Szklarczyk J, Kot M, Konturek SJ and Pawlik WW: Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 58 Suppl 6:S65–S80. 2007.

34 

Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ and Paus R: Melatonin: A cutaneous perspective on its production, metabolism, and functions. J Invest Dermatol. 138:490–499. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczynski K, Hardeland R and Reiter RJ: Metabolism of melatonin in the skin: Why is it important? Exp Dermatol. 26:563–568. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Lin FY, Lin CW, Yang SF, Lee WJ, Lin YW, Lee LM, Chang JL, Weng WC, Lin CH and Chien MH: Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. PLoS One. 10:e01216772015. View Article : Google Scholar : PubMed/NCBI

37 

Song X, Sun X, Ma G, Sun Y, Shi Y, Du Y and Chen ZJ: Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese. Eur J Obstet Gynecol Reprod Biol. 195:108–112. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Park HJ, Park JK, Kim SK, Cho AR, Kim JW, Yim SV and Chung JH: Association of polymorphism in the promoter of the melatonin receptor 1A gene with schizophrenia and with insomnia symptoms in schizophrenia patients. J Mol Neurosci. 45:304–308. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Del Campo JA, Ampuero J, Rojas L, Conde M, Rojas A, Maraver M, Millán R, García-Valdecasas M, García-Lozano JR, González-Escribano MF and Romero-Gómez M: Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism. Aliment Pharmacol Ther. 37:74–80. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Chen Z, Liu W, Sun X and Zhu L: Clinical study on the association between pregnancy-induced hypertension and insulin resistance. Exp Ther Med. 13:2065–2070. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Diamanti-Kandarakis E: Insulin resistance in PCOS. Endocrine. 30:13–17. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Li Q, Yin RX, Yan TT, Miao L, Cao XL, Hu XJ, Aung LH, Wu DF, Wu JZ and Lin WX: Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations. Lipids Health Dis. 10:1602011. View Article : Google Scholar : PubMed/NCBI

43 

Li C, Shi Y, You L, Wang L and Chen ZJ: Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod. 17:193–198. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu XH, Kou LC, Wang HM, Bo CM and Song XC: Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome. Mol Med Rep 19: 2220-2230, 2019.
APA
Xu, X., Kou, L., Wang, H., Bo, C., & Song, X. (2019). Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome. Molecular Medicine Reports, 19, 2220-2230. https://doi.org/10.3892/mmr.2019.9872
MLA
Xu, X., Kou, L., Wang, H., Bo, C., Song, X."Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome". Molecular Medicine Reports 19.3 (2019): 2220-2230.
Chicago
Xu, X., Kou, L., Wang, H., Bo, C., Song, X."Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome". Molecular Medicine Reports 19, no. 3 (2019): 2220-2230. https://doi.org/10.3892/mmr.2019.9872
Copy and paste a formatted citation
x
Spandidos Publications style
Xu XH, Kou LC, Wang HM, Bo CM and Song XC: Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome. Mol Med Rep 19: 2220-2230, 2019.
APA
Xu, X., Kou, L., Wang, H., Bo, C., & Song, X. (2019). Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome. Molecular Medicine Reports, 19, 2220-2230. https://doi.org/10.3892/mmr.2019.9872
MLA
Xu, X., Kou, L., Wang, H., Bo, C., Song, X."Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome". Molecular Medicine Reports 19.3 (2019): 2220-2230.
Chicago
Xu, X., Kou, L., Wang, H., Bo, C., Song, X."Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome". Molecular Medicine Reports 19, no. 3 (2019): 2220-2230. https://doi.org/10.3892/mmr.2019.9872
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team