Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2019 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2019 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma

  • Authors:
    • Hui Gong
    • Xiaomin Sheng
    • Jianhua Xue
    • Dongbo Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 2906-2912
    |
    Published online on: January 24, 2019
       https://doi.org/10.3892/mmr.2019.9893
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe trauma can result in secondary multiple organ dysfunction syndrome (MODS) and death. Inflammation response and oxidative stress promote the occurrence and development of MODS. TNFAIP3‑interacting protein 2 (TNIP2), which can repress the activation of nuclear factor‑κB (NF‑κB) and may be involved in MODS progression, has not been studied in regards to MODS. The present study aimed to investigate the expression, role and mechanism of TNIP2 in MODS following severe trauma. The expression level of TNIP2 was initially detected in the blood of patients with MODS using reverse transcription‑quantitative polymerase chain reaction and western blot assay. Then, to investigate the role of TNIP2 in MODS, a MODS rat model was conducted by trauma and the model rats were treated with TNIP2‑plasmid (intraperitoneal injection). Blood levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatine (Cr) and creatine kinase (CK); and tumor necrosis factor α (TNF‑α), high‑mobility group box 1 (HMGB‑1), malondialdehyde (MDA) and total antioxidant capacity (TAC) in the different groups were assessed. In addition, activation of NF‑κB was assessed by detecting the level of phospho‑p65. The results showed that TNIP2 was significantly decreased in the blood of patients with MODS. TNIP2 was also significantly downregulated in the blood and the pulmonary, renal and hepatic tissues of MODS rats. The levels of ALT, AST, LDH, BUN, Cr and CK were markedly increased in the blood of MODS rats, and these increases were inhibited by TNIP2‑plasmid administration. Moreover, blood levels of TNF‑α, HMGB‑1 and MDA were significantly increased in MODS rats, while TAC was notably decreased, and these changes were prevented by TNIP2‑plasmid administration. Furthermore, it was found that activation of NF‑κB induced by MODS was eliminated by TNIP2‑plasmid. In conclusion, the data indicated that TNIP2 is significantly decreased in MODS following severe trauma, and it plays a protective role in MODS development by inhibiting the inflammation response and oxidative stress by preventing NF‑κB activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Uzzan B, Cohen R, Nicolas P, Cucherat M and Perret GY: Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis. Crit Care Med. 34:1996–2003. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Fabiano G, Pezzolla A, Filograna MA and Ferrarese F: Traumatic shock-physiopathologic aspects. G Chir. 29:51–57. 2008.PubMed/NCBI

3 

Hanisch E, Brause R, Paetz J and Arlt B: Review of a large clinical series: Predicting death for patients with abdominal septic shock. J Intensive Care Med. 26:27–33. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Mera S, Tatulescu D, Cismaru C, Bondor C, Slavcovici A, Zanc V, Carstina D and Oltean M: Multiplex cytokine profiling in patients with sepsis. APMIS. 119:155–163. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Nguyen LN and Nguyen TG: Characteristics and outcomes of multiple organ dysfunction syndrome among severe-burn patients. Burns. 35:937–941. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Walsh CR: Multiple organ dysfunction syndrome after multiple trauma. Orthop Nurs. 24:324–333. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Bhatia M: Inflammatory response on the pancreatic acinar cell injury. Scand J Surg. 94:97–102. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Liu F, Yang S, Liu W, Tang B, Zhang W, Zhang C, Liao W and Hu A: Early thrombolytic failure in a patient with massive pulmonary embolism combined with multiple organ dysfunction syndrome: What next? J Int Med Res. 46:3440–3445. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Huster D, Härtel F, Nuding S, Schroeder J, Zhang Y, Werdan K and Ebelt H: Prognostic relevance of tissue oxygen saturation in patients in the early stage of multiple organ dysfunction syndrome. Med Klin Intensivmed Notfmed. 2018.PubMed/NCBI

10 

Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Brasier AR: The NF-kappaB regulatory network. Cardiovas Toxicol. 6:111–130. 2006. View Article : Google Scholar

12 

Perkins ND: Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 8:49–62. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Pasparakis M: Regulation of tissue homeostasis by NF-κB signalling: Implications for inflammatory diseases. Nat Rev Immunol. 9:778–788. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Baker RG, Hayden MS and Ghosh S: NF-κB, inflammation, and metabolic disease. Cell metabolism. 13:11–22. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wang YT, Fu JJ, Li XL, Li YR, Li CF and Zhou CY: Effects of hemodialysis and hemoperfusion on inflammatory factors and nuclear transcriptionfactors in peripheral blood cell of multiple organ dysfunction syndrome. Eur Rev Med Pharmacol Sci. 20:745–750. 2016.PubMed/NCBI

16 

Wang YL, Shen HH, Cheng PY, Chu YJ, Hwang HR, Lam KK and Lee YM: 17-DMAG, an HSP90 inhibitor, ameliorates multiple organ dysfunction syndrome via induction of HSP70 in endotoxemic rats. PLoS One. 11:e01555832016. View Article : Google Scholar : PubMed/NCBI

17 

Banks CAS, Boanca G, Lee ZT, Eubanks CG, Hattem GL, Peak A, Weems LE, Conkright JJ, Florens L and Washburn MP: TNIP2 is a hub protein in the NF-κB network with both protein and RNA mediated interactions. Mol Cell Proteomics. 15:3435–3449. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Verstrepen L, Carpentier I, Verhelst K and Beyaert R: ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. Biochem Pharmacol. 78:105–114. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Xie H, Yang M, Zhang B, Liu M and Han S: Protective role of TNIP2 in myocardial injury induced by acute pancreatitis and its mechanism. Med Sci Monit. 23:5650–5656. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Wang W, Gao J and Wang F: MiR-663a/MiR-423-5p are involved in the pathogenesis of lupus nephritis via modulating the activation of NF-κB by targeting TNIP2. Am J Transl Res. 9:3796–3803. 2017.PubMed/NCBI

21 

Bayne K: Revised Guide for the Care and Use of Laboratory Animals available. American Physiological Society. Physiologist. 39:208, 199–211. 1996.

22 

Teng L, Yu M, Li JM, Tang H, Yu J, Mo LH, Jin J and Liu XZ: Matrix metalloproteinase-9 as new biomarkers of severity in multiple organ dysfunction syndrome caused by trauma and infection. Mol Cell Biochem. 360:271–277. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Cuzzocrea S, Mazzon E, Di Paola R, Genovese T, Serraino I, Dugo L, Cuzzocrea E, Fulia F, Caputi AP and Salvemini D: Protective effect of M40401, selective superoxide dismutase mimetic, on zymosan-induced nonseptic shock. Crit Care Med. 32:157–167. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Liu C, Wang L, Chen W, Zhao S, Yin C, Lin Y, Jiang A and Zhang P: USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2. Oncotarget. 6:27891–27906. 2015.PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Brongel L: Guidelines for severe multiple and multiorgan traumatic injuries. Przegl Lek. 60:56–62. 2003.PubMed/NCBI

27 

Frohlich M, Lefering R, Probst C, Paffrath T, Schneider MM, Maegele M, Sakka SG, Bouillon B and Wafaisade A; Committee on Emergency Medicine, Intensive Care, Trauma Management of the German Trauma Society Sektion NIS, : Epidemiology and risk factors of multiple-organ failure after multiple trauma: An analysis of 31,154 patients from the TraumaRegister DGU. J Trauma Acute Care Surg. 76:921–927. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Vogel JA, Liao MM, Hopkins E, Seleno N, Byyny RL, Moore EE, Gravitz C and Haukoos JS: Prediction of postinjury multiple-organ failure in the emergency department: Development of the denver emergency department trauma organ failure score. J Trauma Acute Care Surg. 76:140–145. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Liu MH, Tian J, Su YP, Wang T, Xiang Q and Wen L: Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients. Med Sci Monit. 19:194–201. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Pierce A and Pittet JF: Inflammatory response to trauma: Implications for coagulation and resuscitation. Curr Opin Anaesthesiol. 27:246–252. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Wang Z, Chen R, Zhu Z, Zhang X and Wang S: Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. Am J Emerg Med. 34:2154–2158. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Osterbur K, Mann FA, Kuroki K and DeClue A: Multiple organ dysfunction syndrome in humans and animals. J Vet Intern Med. 28:1141–1151. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J and Baud V: A20-binding inhibitor of nuclear factor-κB (NF-κB)-2 (ABIN-2) is an activator of inhibitor of NF-κB (IκB) kinase α (IKKα)-mediated NF-κB transcriptional activity. J Biol Chem. 286:32277–32288. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Liang Y, Zhou Y and Shen P: NF-kappaB and its regulation on the immune system. Cell Mol Immunol. 1:343–350. 2004.PubMed/NCBI

35 

Vallabhapurapu S and Karin M: Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol. 27:693–733. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O and Francis J: NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res. 85:473–483. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Liu S, Zhang J, Pang Q, Song S, Miao R, Chen W, Zhou Y and Liu C: The protective role of curcumin in zymosan-induced multiple organ dysfunction syndrome in mice. Shock. 45:209–219. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gong H, Sheng X, Xue J and Zhu D: Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma. Mol Med Rep 19: 2906-2912, 2019.
APA
Gong, H., Sheng, X., Xue, J., & Zhu, D. (2019). Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma. Molecular Medicine Reports, 19, 2906-2912. https://doi.org/10.3892/mmr.2019.9893
MLA
Gong, H., Sheng, X., Xue, J., Zhu, D."Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma". Molecular Medicine Reports 19.4 (2019): 2906-2912.
Chicago
Gong, H., Sheng, X., Xue, J., Zhu, D."Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma". Molecular Medicine Reports 19, no. 4 (2019): 2906-2912. https://doi.org/10.3892/mmr.2019.9893
Copy and paste a formatted citation
x
Spandidos Publications style
Gong H, Sheng X, Xue J and Zhu D: Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma. Mol Med Rep 19: 2906-2912, 2019.
APA
Gong, H., Sheng, X., Xue, J., & Zhu, D. (2019). Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma. Molecular Medicine Reports, 19, 2906-2912. https://doi.org/10.3892/mmr.2019.9893
MLA
Gong, H., Sheng, X., Xue, J., Zhu, D."Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma". Molecular Medicine Reports 19.4 (2019): 2906-2912.
Chicago
Gong, H., Sheng, X., Xue, J., Zhu, D."Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma". Molecular Medicine Reports 19, no. 4 (2019): 2906-2912. https://doi.org/10.3892/mmr.2019.9893
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team