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Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet

  • Authors:
    • Bing Chen
    • Yaluan Ma
    • Xin Xue
    • Jie Wei
    • Gang Hu
    • Yajun Lin
  • View Affiliations / Copyright

    Affiliations: Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China, Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2561-2568
    |
    Published online on: February 1, 2019
       https://doi.org/10.3892/mmr.2019.9928
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Abstract

The present study aimed to assess the protective effects of tetramethylpyrazine (TMP) on the livers of mice fed a high fat diet. The mice were divided into five groups: Regular diet; high fat diet; simvastatin‑treated; and low and high dose TMP‑treated groups. The results demonstrated that, compared with the control group, serum glucose, total cholesterol (TC) and low‑density lipoprotein cholesterol levels were increased in the model group. Additionally, compared with the model group, simvastatin lowered the TC level, whereas TMP did not. Compared with the control group, the level of malondialdehyde (MDA) in the liver tissue was increased and the level of glutathione peroxidase (GSH‑pX) in the liver tissue was decreased in the model group. Furthermore, compared with the model group, TMP decreased the level of MDA and increased the level of GSH‑Px; however, simvastatin did not have these effects. Immunohistochemistry and western blotting were performed; the results showed that, compared with the control group, the levels of inflammatory factors (tumor necrosis factor‑α and interleukin‑6) in the liver tissue were increased, and the ratio of phosphorylated (p)‑nuclear factor κB (NF‑κB)/NF‑κB was also increased in the model group. The addition of TMP and simvastatin demonstrated that, compared with the model group, the inflammatory factor levels and the ratio of p‑NF‑κB/NF‑κB were decreased. In addition, liver lipid deposition was examined in the model group using hematoxylin and eosin staining and Oil Red O staining, and the results showed that TMP and simvastatin reduced liver lipid deposition. Furthermore, compared with the control group, the reactive oxygen species (ROS) level in the liver tissue was increased. Compared with that in the model group, TMP and simvastatin decreased the ROS level. In conclusion, TMP, similar to simvastatin, exerted a notable hepatoprotective effect on mice fed a high fat diet with non‑alcoholic fatty liver disease, by inhibiting inflammatory factors and the p‑NF‑κB/ROS signaling pathway.
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View References

1 

Ghaemi A, Hosseini N, Osati S, Naghizadeh MM, Dehghan A, Ehrampoush E, Honarvar B and Homayounfar R: Waist circumference is a mediator of dietary pattern in non-alcoholic fatty liver disease. Sci Rep. 8:47882018. View Article : Google Scholar : PubMed/NCBI

2 

Komazaki R, Katagiri S, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, et al: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism. Sci Rep. 7:139502017. View Article : Google Scholar : PubMed/NCBI

3 

Torres DM, Williams CD and Harrison SA: Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 10:837–858. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Schröder T, Kucharczyk D, Bär F, Pagel R, Derer S, Jendrek ST, Sünderhauf A, Brethack AK, Hirose M, Möller S, et al: Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis. Mol Metab. 5:283–295. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Schuppan D and Schattenberg JM: Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol. 28 (Suppl 1):S68–S76. 2013. View Article : Google Scholar

6 

Ekstedt M, Franzén LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G and Kechagias S: Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 44:865–873. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Schattenberg JM and Schuppan D: Nonalcoholic steatohepatitis: The therapeutic challenge of a global epidemic. Curr Opin Lipidol. 22:479–488. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Yeom GG, Min S and Kim SY: 2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system. Int Immunopharmacol. 18:262–269. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Ran X, Ma L, Peng C, Zhang H and Qin LP: Ligusticum chuanxiong Hort: A review of chemistry and pharmacology. Pharm Biol. 49:1180–1189. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Shao Z, Wang L, Liu S and Wang X: Tetramethylpyrazine protects neurons from oxygen-glucose deprivation-induced death. Med Sci Monit. 23:5277–5282. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Gong X, Ivanov VN, Davidson MM and Hei TK: Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death. Arch Toxico. 89:1057–1070. 2015. View Article : Google Scholar

12 

Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, et al: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–1321. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Staroń R, Van Swelm RP, Lipiński P, Gajowiak A, Lenartowicz M, Bednarz A, Gajewska M, Pieszka M, Laarakkers CM, Swinkels DW and Starzyński RR: Urinary hepcidin levels in iron-deficient and iron-supplemented piglets correlate with hepcidin hepatic mRNA and serum levels and with body iron status. PLoS One. 10:e1366952015. View Article : Google Scholar

14 

Wei J, Zhen YZ, Cui J, He FL, Shen T, Hu G, Ren XH and Lin YJ: Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease. Arch Pharm Res. 39. 960–969. 2016.

15 

Rinella ME: Nonalcoholic fatty liver disease: A systematic review. JAMA. 313:2263–2273. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Fujii H and Kawada N: Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol. 47:215–225. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Morrison MC, Kleemann R, van Koppen A, Hanemaaijer R and Verschuren L: Key inflammatory processes in human NASH are reflected in Ldlr−/−. Leiden mice: A translational gene profiling study. Front Physiol. 9:1322018. View Article : Google Scholar : PubMed/NCBI

18 

Henkel J, Alfine E, Saín J, Jöhrens K, Weber D, Castro JP, König J, Stuhlmann C, Vahrenbrink M, Jonas W, et al: Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol. Nutrients. 10(pii): E13262018. View Article : Google Scholar : PubMed/NCBI

19 

Hebbard L and George J: Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 8:35–44. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Hayden MS and Ghosh S: Regulation of NF-κB by TNF family cytokines. Semin Immunol. 26:253–266. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Abd El-Kader SM, Al-Shreef FM and Al-Jiffri OH: Biochemical parameters response to weight loss in patients with non-alcoholic steatohepatitis. Afr Health Sci. 16:242–249. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Kastl L, Sauer SW, Ruppert T, Beissbarth T, Becker MS, Süss D, Krammer PH and Gülow K: TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells. FEBS Lett. 588:175–183. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Blaser H, Dostert C, Mak TW and Brenner D: TNF and ROS crosstalk in inflammation. Trends Cell Biol. 26:249–261. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Montezano AC and Touyz RM: Reactive oxygen species and endothelial function-role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Basic Clin Pharmacol Toxicol. 110:87–94. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Togo M, Konari N, Tsukamoto M, Kimoto R, Yamaguchi T, Takeda H and Kambayashi I: Effects of a high-fat diet on superoxide anion generation and membrane fluidity in liver mitochondria in rats. J Int Soc Sports Nutr. 15:132018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Ma Y, Xue X, Wei J, Hu G and Lin Y: Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. Mol Med Rep 19: 2561-2568, 2019.
APA
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., & Lin, Y. (2019). Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. Molecular Medicine Reports, 19, 2561-2568. https://doi.org/10.3892/mmr.2019.9928
MLA
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., Lin, Y."Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet". Molecular Medicine Reports 19.4 (2019): 2561-2568.
Chicago
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., Lin, Y."Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet". Molecular Medicine Reports 19, no. 4 (2019): 2561-2568. https://doi.org/10.3892/mmr.2019.9928
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Ma Y, Xue X, Wei J, Hu G and Lin Y: Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. Mol Med Rep 19: 2561-2568, 2019.
APA
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., & Lin, Y. (2019). Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. Molecular Medicine Reports, 19, 2561-2568. https://doi.org/10.3892/mmr.2019.9928
MLA
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., Lin, Y."Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet". Molecular Medicine Reports 19.4 (2019): 2561-2568.
Chicago
Chen, B., Ma, Y., Xue, X., Wei, J., Hu, G., Lin, Y."Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet". Molecular Medicine Reports 19, no. 4 (2019): 2561-2568. https://doi.org/10.3892/mmr.2019.9928
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