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Aflatoxin influences achalasia symptomatology

  • Authors:
    • Shengli Lin
    • Pingting Gao
    • Quanlin Li
    • Yiqun Zhang
    • Jianwei Hu
    • Mingyan Cai
    • Wenzheng Qin
    • Lili Ma
    • Zhong Ren
    • Zhen Zhang
    • Xianli Cai
    • Liqing Yao
    • Weifeng Chen
    • Pinghong Zhou
  • View Affiliations / Copyright

    Affiliations: Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1276-1284
    |
    Published online on: January 8, 2020
       https://doi.org/10.3892/mmr.2020.10914
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Abstract

Achalasia is characterized by impaired swallowing due to lower esophageal sphincter (LES) dysfunction and an increased risk of esophageal carcinoma. Aflatoxin is a known carcinogen. Esophageal retention is relieved by per oral endoscopic myotomy (POEM), which lowers the esophageal cancer risk. The present study determined whether aflatoxin is involved in the pathogenesis of achalasia or esophageal cancer. A total of 75 patients with achalasia were prospectively enrolled from a tertiary center. Aflatoxin levels in their esophageal contents were measured using ELISA, and esophageal mucosal specimens were immunohistochemically evaluated for Ki67 and p53 expression prior to and 3 months after POEM. The effect of aflatoxin on esophageal contractility was assessed using murine specimens. Aflatoxin was detected in 67 patients before POEM and only 2 patients after POEM. The number of Ki67‑ and p53‑immunopositive cells in the esophageal mucosa significantly decreased after POEM: [Ki67: 27.8% (95% confidence interval (CI), 25.98‑29.70) vs. 20.7% (95% CI, 19.78‑24.03), P=0.04 and p53: 2.14% (95% CI, 1.85‑2.41) vs. 1.45% (95% CI, 1.22‑1.68), P=0.03]. In vitro experiments revealed that 500 ng/ml aflatoxin significantly increased the amplitude (P<0.05) and frequency (P<0.05) of spontaneous LES contractions compared with the control group. These increases were blocked by co‑treatment with atropine sulfate (P<0.05), but not with a nitric oxide synthase inhibitor (P>0.05). Aflatoxin was found in most patients with achalasia and was eliminated following POEM. Reduced Ki67 and p53 expression after POEM indicated a decreased risk of carcinogenesis. Aflatoxin accumulation increased LES contractility via cholinergic signaling. Therefore, aflatoxin may maintain achalasia symptoms and increase esophageal cancer risk.
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1 

Sadowski DC, Ackah F, Jiang B and Svenson LW: Achalasia: Incidence, prevalence and survival. A population-based study. Neurogastroenterol Motil. 22:e256–e261. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Birgisson S and Richter JE: Achalasia in Iceland, 1952–2002: An epidemiologic study. Dig Dis Sci. 52:1855–1860. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gennaro N, Portale G, Gallo C, Rocchietto S, Caruso V, Costantini M, Salvador R, Ruol A and Zaninotto G: Esophageal achalasia in the veneto region: Epidemiology and treatment. Epidemiology and treatment of achalasia. J Gastrointest Surg. 15:423–428. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Marlais M, Fishman JR, Fell JM, Haddad MJ and Rawat DJ: UK incidence of achalasia: An 11 year national epidemiological study. Arch Dis Child. 96:192–194. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Clark SB, Rice TW, Tubbs RR, Richter JE and Goldblum JR: The nature of the myenteric infiltrate in achalasia: An immunohistochemical analysis. Am J Surg Pathol. 24:1153–1158. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Villanacci V, Annese V, Cuttitta A, Fisogni S, Scaramuzzi G, De Santo E, Corazzi N and Bassotti G: An immunohistochemical study of the myenteric plexus in idiopathic achalasia. J Clin Gastroenterol. 44:407–410. 2010.PubMed/NCBI

7 

Park W and Vaezi MF: Etiology and pathogenesis of achalasia: The current understanding. Am J Gastroenterol. 100:1404–1414. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Mohamed AA, Lu XL and Mounmin FA: Diagnosis and treatment of esophageal candidiasis: Current updates. Can J Gastroenterol Hepatol. 20:35851362019.

9 

Meijssen MA, Tilanus HW, van Blankenstein M, Hop WC and Ong GL: Achalasia complicated by oesophageal squamous cell carcinoma: A prospective study in 195 patients. Gut. 33:155–158. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Streitz JM, Ellis FH, Gibb SP and Heatley GM: Achalasia and squamous cell carcinoma of the esophagus: Analysis of 241 patients. Ann Thorac Surg. 59:1604–1609. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Tustumi F, Bernardo WM, da Rocha JRM, Szachnowicz S, Seguro FC, Bianchi ET, Sallum RAA and Cecconello I: Esophageal achalasia: A risk factor for carcinoma. A systematic review and meta-analysis. Dis Esophagus. 30:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ghasemi-Kebria F, Joshaghani H, Taheri NS, Semnani S, Aarabi M, Salamat F and Roshandel G: Aflatoxin contamination of wheat flour and the risk of esophageal cancer in a high risk area in Iran. Cancer Epidemiol. 37:290–293. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Marchese S, Polo A, Ariano A, Velotto S, Costantini S and Severino L: Aflatoxin B1 and M1: Biological properties and their involvement in cancer development. Toxins (Basel). 24:E2142018. View Article : Google Scholar

14 

Rawal S, Kim JE and Coulombe R Jr: Aflatoxin B1 in poultry: Toxicology, metabolism and prevention. Res Vet Sci. 89:325–331. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Raisuddin S, Singh K, Zaidi S, Paul BN and Ray PK: Immunosuppressive effects of aflatoxin in growing rats. Mycopathologia. 124:189–194. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Marin D, Taranu I, Bunaciu RP, Pascale F, Tudor DS, Avram N, Sarca M, Cureu I, Criste RD, Suta V and Oswald IP: Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin. J Anim Sci. 80:1250–1257. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Park JW, Kim EK, Shon DH and Kim YB: Natural co-occurrence of aflatoxin B1, fumonsin B1, and ochratoxin A in barley and maize foods from Korea. Food Addit Contam. 19:1073–1080. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Inoue H, Minami H, Kobayashi Y, Sato Y, Kaga M, Suzuki M, Satodate H, Odaka N, Itoh H and Kudo S: Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 42:265–271. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Zhou PH, Li QL, Yao LQ, Xu MD, Chen WF, Cai MY, Hu JW, Li L, Zhang YQ, Zhong YS, et al: Peroral endoscopic remyotomy for failed heller myotomy: A prospective single-center study. Endoscopy. 45:161–166. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Khashab MA, Messallam AA, Onimaru M, Teitelbaum EN, Ujiki MB, Gitelis ME, Modayil RJ, Hungness ES, Stavropoulos SN, El Zein MH, et al: International multi-center experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Gastrointest Endosc. 81:1170–1177. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Jones EL, Meara MP, Pittman MR, Hazey JW and Perry KA: Prior treatment does not influence the performance or early outcome of per-oral endoscopic myotomy for achalasia. Surg Endosc. 30:1282–1286. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Inoue H, Sato H, Ikeda H, Onimaru M, Sato C, Minami H, Yokomichi H, Kobayashi Y, Grimes KL and Kudo SE: Per-Oral endoscopic myotomy: A series of 500 patients. J Am Coll Surg. 221:256–264. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Minami H, Yamaguchi N, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, Nakayama T, Hayashi T, Inoue H, Nakao K and Isomoto H: Improvement of endocytoscopic findings after per oral endoscopic myotomy (POEM) in esophageal achalasia; does POEM reduce the risk of developing esophageal carcinoma? Per oral endoscopic myotomy, endocytoscopy and carcinogenesis. BMC Gastroenterol. 30:222013. View Article : Google Scholar

24 

Wang J and Liu XM: Assessment of dietary aflatoxin exposure in Chinese residents. Chin J Food Hyg. 19:238–240. 2007.(In Chinese).

25 

Eckardt V: Clinical presentations and complications of achalasia. Gastrointest Endosc Clin N Am. 11281–292. (vi)2001. View Article : Google Scholar : PubMed/NCBI

26 

Pandolfino JE, Kwiatek MA, Nealis T, Bulsiewicz W, Post J and Kahrilas PJ: Achalasia: A new clinically relevant classification by high-resolution manometry. Gastroenterology. 135:1526–1533. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Eckardt AJ and Eckardt VF: Treatment and surveillance strategies in achalasia: An update. Nat Rev Gastroenterol Hepatol. 8:311–319. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Ferri F, Brera C, De Santis B, Fedrizzi G, Bacci T, Bedogni L, Capanni S, Collini G, Crespi E, Debegnach F, et al: Survey on urinary levels of aflatoxins in professionally exposed workers. Toxins (Basel). 9:E1172017. View Article : Google Scholar : PubMed/NCBI

29 

Yard EE, Daniel JH, Lewis LS, Rybak ME, Paliakov EM, Kim AA, Montgomery JM, Bunnell R, Abudo MU, Akhwale W, et al: Human aflatoxin exposure in Kenya, 2007: A cross-sectional study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30:1322–1331. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Fujii T, Yamana H, Sueyoshi S, Fujita H, Tanaka Y, Kubota M, Toh U, Mine T, Sasahara H, Shirouzu K, et al: Histopathological analysis of non-malignant and malignant epithelium in achalasia of the esophagus. Dis Esophagus. 13:110–116. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Leeuwenburgh I, Gerrits MM, Capello A, van den Bogert B, van Dekken H, Steyerberg EW, Siersema PD and Kuipers EJ: Expression of p53 as predictor for the development of esophageal cancer in achalasia patients. Dis Esophagus. 23:506–511. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Peraica M, Radic B, Lucic A and Pavlović M: Toxic effects of mycotoxins in humans. Bull World Health Organ. 77:754–766. 1999.PubMed/NCBI

33 

Luzi A, Cometa MF and Palmery M: Acute effects of aflatoxins on guinea pig isolated ileum. Toxicol In Vitro. 6:525–529. 2002. View Article : Google Scholar

34 

Gursoy N, Durmus N, Bagcivan I, Sarac B, Parlak A, Yildirim S and Kaya T: Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions. Food Chem Toxicol. 46:2876–2880. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Gockel HR, Schumacher J, Gockel I, Lang H, Haaf T and Nöthen MM: Achalasia: Will genetic studies provide insights? Hum Genet. 128:353–364. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Boeckxstaens GE: Achalasia: Virus-induced euthanasia of neurons? Am J Gastroenterol. 103:1610–1612. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Rohof WO, Salvador R, Annese V, Bruley des Varannes S, Chaussade S, Costantini M, Elizalde JI, Gaudric M, Smout AJ, Tack J, et al: Outcomes of treatment for achalasia depend on manometric subtype. Gastroenterology. 144:718–725. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Eckardt VF, Kohne U, Junginger T and Westermeier T: Risk factors for diagnostic delay in achalasia. Dig Dis Sci. 42:580–585. 1997. View Article : Google Scholar : PubMed/NCBI

39 

El-Takli I, O'Brien P and Paterson WG: Clinical diagnosis of achalasia: How reliable is the barium x-ray? Can J Gastroenterol. 20:335–337. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Ghoshal UC, Daschakraborty SB and Singh R: Pathogenesis of achalasia cardia. World J Gastroenterol. 28:3050–3057. 2012. View Article : Google Scholar

41 

Moon EY and Pyo S: Aflatoxin B(1) inhibits CD14-mediated nitric oxide production in murine peritoneal macrophages. Int J Immunopharmacol. 22:237–246. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Moon EY, Rhee DK and Pyo S: Inhibition of various functions in murine peritoneal macrophages by aflatoxin B1 exposure in vivo. Int J Immunopharmacol. 21:47–58. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Moon EY, Han JJ, Rhee DK and Pyo S: Aflatoxin B1-induced suppression of nitric oxide production in murine peritoneal macrophages. J Toxicol Environ Health A. 55:517–530. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Khajanchee YS, VanAndel R, Jobe BA, Barra MJ, Hansen PD and Swanstrom LL: Electrical stimulation of the vagus nerve restores motility in an animal model of achalasia. J Gastrointest Surg. 7:843–849. 2003. View Article : Google Scholar : PubMed/NCBI

45 

de Souza EM, Rivera MT, Araujo-Jorge TC and de Castro SL: Modulation induced by estradiol in the acute phase of Trypanosoma cruzi infection in mice. Parasitol Res. 87:513–520. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Ming Z and Davis CD: CD8+ T lymphocytes required for enhanced survival of Trypanosoma cruzi-infected mice at elevated environmental temperature. J Parasitol. 89:630–632. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin S, Gao P, Li Q, Zhang Y, Hu J, Cai M, Qin W, Ma L, Ren Z, Zhang Z, Zhang Z, et al: Aflatoxin influences achalasia symptomatology. Mol Med Rep 21: 1276-1284, 2020.
APA
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M. ... Zhou, P. (2020). Aflatoxin influences achalasia symptomatology. Molecular Medicine Reports, 21, 1276-1284. https://doi.org/10.3892/mmr.2020.10914
MLA
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M., Qin, W., Ma, L., Ren, Z., Zhang, Z., Cai, X., Yao, L., Chen, W., Zhou, P."Aflatoxin influences achalasia symptomatology". Molecular Medicine Reports 21.3 (2020): 1276-1284.
Chicago
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M., Qin, W., Ma, L., Ren, Z., Zhang, Z., Cai, X., Yao, L., Chen, W., Zhou, P."Aflatoxin influences achalasia symptomatology". Molecular Medicine Reports 21, no. 3 (2020): 1276-1284. https://doi.org/10.3892/mmr.2020.10914
Copy and paste a formatted citation
x
Spandidos Publications style
Lin S, Gao P, Li Q, Zhang Y, Hu J, Cai M, Qin W, Ma L, Ren Z, Zhang Z, Zhang Z, et al: Aflatoxin influences achalasia symptomatology. Mol Med Rep 21: 1276-1284, 2020.
APA
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M. ... Zhou, P. (2020). Aflatoxin influences achalasia symptomatology. Molecular Medicine Reports, 21, 1276-1284. https://doi.org/10.3892/mmr.2020.10914
MLA
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M., Qin, W., Ma, L., Ren, Z., Zhang, Z., Cai, X., Yao, L., Chen, W., Zhou, P."Aflatoxin influences achalasia symptomatology". Molecular Medicine Reports 21.3 (2020): 1276-1284.
Chicago
Lin, S., Gao, P., Li, Q., Zhang, Y., Hu, J., Cai, M., Qin, W., Ma, L., Ren, Z., Zhang, Z., Cai, X., Yao, L., Chen, W., Zhou, P."Aflatoxin influences achalasia symptomatology". Molecular Medicine Reports 21, no. 3 (2020): 1276-1284. https://doi.org/10.3892/mmr.2020.10914
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