Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation

  • Authors:
    • Yosuke Nakazawa
    • Miki Aoki
    • Sho Ishiwa
    • Naoki Morishita
    • Shin Endo
    • Noriaki Nagai
    • Naoki Yamamoto
    • Megumi Funakoshi‑Tago
    • Hiroomi Tamura
  • View Affiliations / Copyright

    Affiliations: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Tokyo 105‑8512, Japan, R&D Division, Hayashibara Co., Ltd, Okayama 702‑8006, Japan, Department of Advanced Design for Pharmaceuticals, Faculty of Pharmacy, Kindai University, Osaka 577‑8502, Japan, Regenerative Medicine Support Promotion Facility, Center for Research Promotion and Support, Fujita Health University, Toyoake, Aichi 470‑1192, Japan
    Copyright: © Nakazawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1258-1266
    |
    Published online on: January 14, 2020
       https://doi.org/10.3892/mmr.2020.10941
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hesperetin is a natural flavonoid with robust antioxidant properties. Our previous study reported that hesperetin can prevent cataract formation. However, an important consideration regarding hesperetin consumption is the limited bioavailability due to its poor solubility. The present study investigated the anti‑cataract effects of α‑glucosyl hesperidin in vivo and in vitro using a selenite‑induced cataract model. SD rats (age, 13 days) were orally administered PBS (0.2 ml) or α‑glucosyl hesperidin (200 mg/kg) on days 0, 1 and 2. Sodium selenite was subcutaneously administered to the rats 4 h after the first oral administration on day 0. Antioxidant levels in the lens and blood were measured on day 6. In vitro, human lens epithelial cells were treated with sodium selenite (10 µM) and/or hesperetin (50 or 100 mM) for 24 h and analyzed for apoptosis markers using sub‑G1 population and Annexin V‑FITC/propidium iodide staining and DNA ladder formation. α‑glucosyl hesperidin treatment significantly reduced the severity of selenite‑induced cataract. The level of antioxidants was significantly reduced in the selenite‑treated rats compared with in the controls; however, they were normalized with α‑glucosyl hesperidin treatment. In vitro, hesperetin could significantly reduce the number of cells undergoing apoptosis induced by sodium selenite in human lens epithelial cell lines. Overall, oral consumption of α‑glucosyl hesperidin could delay the onset of selenite‑induced cataract, at least in part by modulating the selenite‑induced cell death in lens epithelial cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Hegde KR and Varma SD: Protective effect of ascorbate against oxidative stress in the mouse lens. Biochim Biophys Acta. 1670:12–18. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Zigman S, Reddan J, Schultz JB and McDaniel T: Structural and functional changes in catalase induced by near-UV radiation. Photochem Photobiol. 63:818–824. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Fan X, Liu X, Hao S, Wang B, Robinson ML and Monnier VM: The LEGSKO mouse: A mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One. 7:e508322012. View Article : Google Scholar : PubMed/NCBI

4 

Grey AC, Demarais NJ, West BJ and Donaldson PJ: A quantitative map of glutathione in the aging human lens. Int J Mass Spectrom. 437:58–68. 2019. View Article : Google Scholar

5 

Katta AV, Katkam RV and Geetha H: Lipid peroxidation and the total antioxidant status in the pathogenesis of age related and diabetic cataracts: A study on the lens and blood. J Clin Diagn Res. 7:978–981. 2013.PubMed/NCBI

6 

Kim JH, Baik HW, Yoon YS, Joung HJ, Park JS, Park SJ, Jang EJ, Park SW, Kim SJ, Kim MJ, et al: Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome. Korean J Intern Med. 29:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Fridovich I: Superoxide radical and superoxide dismutases. Annu Rev Biochem. 64:97–112. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Nakazawa Y, Oka M, Bando M and Takehana M: Hesperetin prevents selenite-induced cataract in rats. Mol Vis. 21:804–810. 2015.PubMed/NCBI

9 

Nakazawa Y, Oka M, Tamura H and Takehana M: Effect of hesperetin on chaperone activity in selenite-induced cataract. Open Med (Wars). 11:183–189. 2016.PubMed/NCBI

10 

Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y and Kibata M: Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality. J Nutr Sci Vitaminol (Tokyo). 51:460–470. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Akiyama S, Katsumata S, Suzuki K, Nakaya Y, Ishimi Y and Uehara M: Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. Biosci Biotechnol Biochem. 73:2779–2782. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Alu'datt MH, Rababah T, Alhamad MN, Al-Mahasneh MA, Ereifej K, Al-Karaki G, Al-Duais M, Andrade JE, Tranchant CC, Kubow S and Ghozlan KA: Profiles of free and bound phenolics extracted from Citrus fruits and their roles in biological systems: Content, and antioxidant, anti-diabetic and anti-hypertensive properties. Food Funct. 8:3187–3197. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Hijiya H and Miyake T: α-glycosyl hesperidin, and its preparation and uses. Eur Patent no. EP0402049A2. Filed June 31, 1990; issued July 12, 1995.

14 

Cvekl A and Ashery-Padan R: The cellular and molecular mechanisms of vertebrate lens development. Development. 141:4432–4447. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ishimori N, Oguchi J, Nakazawa Y, Kobata K, Funakoshi-Tago M and Tamura H: Roasting enhances the anti-cataract effect of coffee beans: Ameliorating selenite-induced cataracts in rats. Curr Eye Res. 42:864–870. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Nakazawa Y, Pauze M, Fukuyama K, Nagai N, Funakoshi-Tago M, Sugai T and Tamura H: Effect of hesperetin derivatives on the development of selenite-induced cataracts in rats. Mol Med Rep. 18:1043–1050. 2018.PubMed/NCBI

17 

Nakazawa Y, Ishimori N, Oguchi J, Nagai N, Kimura M, Funakoshi-Tago M and Tamura H: Coffee brew intake can prevent the reduction of lens glutathione and ascorbic acid levels in HFD-fed animals. Exp Ther Med. 17:1420–1425. 2019.PubMed/NCBI

18 

Yamamoto N, Kato Y, Sato A, Hiramatsu N, Yamashita H, Ohkuma M, Miyachi E, Horiguchi M, Hirano K and Kojima H: Establishment of a new immortalized human corneal epithelial cell line (iHCE-NY1) for use in evaluating eye irritancy by in vitro test methods. In Vitro Cell Dev Biol Anim. 52:742–748. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Samie A, Sedaghat R, Baluchnejadmojarad T and Roghani M: Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis. Life Sci. 210:132–139. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Hanchang W, Khamchan A, Wongmanee N and Seedadee C: Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model. Life Sci. 235:1168582019. View Article : Google Scholar : PubMed/NCBI

21 

Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ and Rice-Evans C: Interaction between flavonoids and the blood-brain barrier: In vitro studies. J Neurochem. 85:180–192. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Takumi H, Mukai R, Ishiduka S, Kometani T and Terao J: Tissue distribution of hesperetin in rats after a dietary intake. Biosci Biotechnol Biochem. 75:1608–1610. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Javadzadeh A, Ghorbanihaghjo A, Arami S, Rashtchizadeh N, Mesgari M, Rafeey M and Omidi Y: Prevention of selenite-induced cataractogenesis in Wistar albino rats by aqueous extract of garlic. J Ocul Pharmacol Ther. 25:395–400. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Cao J, Wang T and Wang M: Investigation of the anti-cataractogenic mechanisms of curcumin through in vivo and in vitro studies. BMC Ophthalmol. 18:482018. View Article : Google Scholar : PubMed/NCBI

25 

Schrauzer GN: Selenium and selenium-antagonistic elements in nutritional cancer prevention. Crit Rev Biotechnol. 29:10–17. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Terry PD, Qin B, Camacho F, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Guertin KA, et al: Supplemental selenium may decrease ovarian cancer risk in African-American Women. J Nutr. 147:621–627. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Woth G, Nagy B, Mérei Á, Ernyey B, Vincze R, Kaurics Z, Lantos J, Bogár L and Mühl D: The effect of Na-selenite treatment on the oxidative stress-antioxidants balance of multiple organ failure. J Crit Care. 29:e7–e11. 2014. View Article : Google Scholar

28 

lçe F, Gök G and Pandir D: Acute effects of lipopolysaccharide (LPS) in kidney of rats and preventive role of vitamin E and sodium selenite. Hum Exp Toxicol. 38:547–560. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Tamada Y, Fukiage C, Nakamura Y, Azuma M, Kim YH and Shearer TR: Evidence for apoptosis in the selenite rat model of cataract. Biochem Biophys Res Commun. 275:300–306. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nakazawa Y, Aoki M, Ishiwa S, Morishita N, Endo S, Nagai N, Yamamoto N, Funakoshi‑Tago M and Tamura H: Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation. Mol Med Rep 21: 1258-1266, 2020.
APA
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N. ... Tamura, H. (2020). Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation. Molecular Medicine Reports, 21, 1258-1266. https://doi.org/10.3892/mmr.2020.10941
MLA
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Funakoshi‑Tago, M., Tamura, H."Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation". Molecular Medicine Reports 21.3 (2020): 1258-1266.
Chicago
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Funakoshi‑Tago, M., Tamura, H."Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation". Molecular Medicine Reports 21, no. 3 (2020): 1258-1266. https://doi.org/10.3892/mmr.2020.10941
Copy and paste a formatted citation
x
Spandidos Publications style
Nakazawa Y, Aoki M, Ishiwa S, Morishita N, Endo S, Nagai N, Yamamoto N, Funakoshi‑Tago M and Tamura H: Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation. Mol Med Rep 21: 1258-1266, 2020.
APA
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N. ... Tamura, H. (2020). Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation. Molecular Medicine Reports, 21, 1258-1266. https://doi.org/10.3892/mmr.2020.10941
MLA
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Funakoshi‑Tago, M., Tamura, H."Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation". Molecular Medicine Reports 21.3 (2020): 1258-1266.
Chicago
Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Funakoshi‑Tago, M., Tamura, H."Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation". Molecular Medicine Reports 21, no. 3 (2020): 1258-1266. https://doi.org/10.3892/mmr.2020.10941
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team