MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer

  • Authors:
    • Kai Li
    • Xiangrong Zhu
    • Xihua Chen
    • Xiongtie Wang
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/mmr.2020.10949
  • Pages: 1615-1622
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Abstract

NOVA alternative splicing regulator 1 (NOVA1) dysregulation has been detected in the gastric cancer microenvironment. Decreased NOVA1 expression has been linked to the progression and poor prognosis of gastric cancer; however, the role of NOVA1 in regulating epithelial‑mesenchymal transition (EMT) remains unclear in this disease. Experimental evidence has shown that miR‑27a‑3p is a potential oncogene in gastric cancer. In the present study, we observed that miR‑27a‑3p expression was increased in gastric cancer and was inversely associated with overall survival. Overexpression of miR‑27a‑3p promoted EMT in AGS gastric cancer cells. Additionally, overexpression of miR‑27a‑3p inhibited NOVA1 expression, while silencing of NOVA1 promoted EMT in AGS cells. A total of 108 gastric cancer samples were examined for NOVA1 expression by immunohistochemistry. Decreased NOVA1 expression was linked to lymph node metastasis, tumor‑node‑metastasis stage and shorter overall survival. Therefore, these results indicated that NOVA1 could be a potential tumor suppressive gene and that miR‑27a‑3p promotes EMT by targeting NOVA1 in gastric cancer.
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March 2020
Volume 21 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Li, K., Zhu, X., Chen, X., & Wang, X. (2020). MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer. Molecular Medicine Reports, 21, 1615-1622. https://doi.org/10.3892/mmr.2020.10949
MLA
Li, K., Zhu, X., Chen, X., Wang, X."MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer". Molecular Medicine Reports 21.3 (2020): 1615-1622.
Chicago
Li, K., Zhu, X., Chen, X., Wang, X."MicroRNA‑27a‑3p promotes epithelial‑mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer". Molecular Medicine Reports 21, no. 3 (2020): 1615-1622. https://doi.org/10.3892/mmr.2020.10949